The transient HIV remission in the Mississippi baby: Why is this good news?

Journal of the International AIDS Society

Volumn 17, Issue , 2014, Pages

  Ananworanich, Jintanat ^a,b   Robb, Merlin L ^a,b  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^b HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS DNA; ANTIRETROVIRUS AGENT;

CD4+ T LYMPHOCYTE; DNA CONTENT; EDITORIAL; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LATENT VIRUS INFECTION; REMISSION; VIREMIA; VIRUS LOAD; VIRUS REPLICATION; AGE; FEMALE; HIV INFECTIONS; INFANT; NEWBORN; PRESCHOOL CHILD; TREATMENT OUTCOME;

AGE FACTORS; ANTI-RETROVIRAL AGENTS; CHILD, PRESCHOOL; FEMALE; HIV INFECTIONS; HUMANS; INFANT; INFANT, NEWBORN; REMISSION INDUCTION; TREATMENT OUTCOME;

EID: 84915748829     PISSN: None     EISSN: 17582652     Source Type: Journal    
DOI: 10.7448/IAS.17.1.19859     Document Type: Editorial

References (13)

1. Hutter G, Nowak D, Mossner M, Ganepola S, Mussig A, Allers K, et al. Longterm control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation. N Engl J Med. 2009;360(7):692-8.
2. Persaud D, Gay H, Ziemniak C, Chen YH, Piatak M, Jr., Chun TW, et al. Absence of detectable HIV-1 viremia after treatment cessation in an infant. N Engl J Med. 2013;369(19):1828-35.
3. Henrich TJ, Hanhauser E, Marty FM, Sirignano MN, Keating S, Lee TH, et al. Antiretroviral-free HIV-1 remission and viral rebound after allogeneic stem cell transplantation: report of 2 cases. Ann Intern Med. 2014;161(5):319-27.
4. Brophy J, Chun TW, Samson L, Kakkar F, Soudeyns H, Ostrowski M, et al., editors. Impact of early initiation of combination antiretroviral therapy on measures of virus in peripheral blood of vertically HIV-1-infected children. 20th International AIDS Conference; 2014 July 19-25; Melbourne, Australia; 2014. Abstract No. TUAB 0206LB.
5. Giacomet V, Trabattoni D, Zanchetta N, Biasin M, Gismondo M, Clerici M, et al. No cure of HIV infection in a child despite early treatment and apparent viral clearance. Lancet. 2014;384(9950):1320.
6. Persaud D, Palumbo PE, Ziemniak C, Hughes MD, Alvero CG, Luzuriaga K, et al. Dynamics of the resting CD4(+) T-cell latent HIV reservoir in infants initiating HAART less than 6 months of age. AIDS. 2012;26(12):1483-90.
7. Bitnun A, Samson L, Chun TW, Kakkar F, Brophy J, Murray D, et al. Early initiation of combination antiretroviral therapy in HIV-1-infected newborns can achieve sustained virologic suppression with low frequency of CD4 + T cells carrying HIV in peripheral blood. Clin Infect Dis. 2014;59(7):1012-9.
8. Persaud D, Deveikis A, Gay H, Batra J, Chen T, Michalik DE, et al., editors. Very early combination antiretroviral therapy in perinatal HIV infection: two case studies. 21st Conference on Retroviruses and Opportunistic Infections; 2014 March 3-5; Boston, MA, 2014. Abstract No. 75LB.
9. Luzuriaga K, Tabak B, Garber M, Chen YH, Ziemniak C, McManus MM, et al. HIV type 1 (HIV-1) proviral reservoirs decay continuously under sustained virologic control in HIV-1-infected children who received early treatment. J Infect Dis. 2014;210(10):1529-38.
10. Ho YC, Shan L, Hosmane NN, Wang J, Laskey SB, Rosenbloom DI, et al. Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure. Cell. 2013;155(3):540-51. doi: 10.1016/j.cell.2013.09.020.
11. Barouch DH, Deeks SG. Immunologic strategies for HIV-1 remission and eradication. Science. 2014;345(6193):169-74.
12. Hill AL, Rosenbloom DI, Fu F, Nowak MA, Siliciano RF. Predicting the outcomes of treatment to eradicate the latent reservoir for HIV-1. Proc Natl Acad Sci USA. 2014;111(37):13475-80.
13. Muenchhoff M, Prendergast AJ, Goulder PJ. Immunity to HIV in early life. Front Immunol. 2014;5:391.