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Volumn 49, Issue 1, 2015, Pages 45-56

The contributions of oxidative stress, oxidised lipoproteins and AMPK towards exercise-associated PPARγ signalling within human monocytic cells

Author keywords

AMPK; Antioxidant supplementation; Exercise associated oxidative stress; Monocytes; PPAR

Indexed keywords

ABC TRANSPORTER A1; ALPHA TOCOPHEROL; ASCORBIC ACID; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LIVER X RECEPTOR ALPHA; LOW DENSITY LIPOPROTEIN; MENADIONE; OLIGOMYCIN; OXIDIZED LOW DENSITY LIPOPROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; REACTIVE OXYGEN METABOLITE; ANTIOXIDANT; PPARGC1A PROTEIN, HUMAN; PRKAA1 PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

EID: 84915748066     PISSN: 10715762     EISSN: 10292470     Source Type: Journal    
DOI: 10.3109/10715762.2014.978311     Document Type: Article
Times cited : (16)

References (53)
  • 1
    • 80052990795 scopus 로고    scopus 로고
    • Control of reactive oxygen species production in contracting skeletal muscle
    • Jackson MJ. Control of reactive oxygen species production in contracting skeletal muscle. Antioxid Redox Signal 2011;15:2477-2486.
    • (2011) Antioxid Redox Signal , vol.15 , pp. 2477-2486
    • Jackson, M.J.1
  • 2
    • 55949118714 scopus 로고    scopus 로고
    • Exercise-induced oxidative stress: Cellular mechanisms and impact on muscle force production
    • Powers SK, Jackson MJ. Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production. Physiol Rev 2008;88:1243-1276.
    • (2008) Physiol Rev , vol.88 , pp. 1243-1276
    • Powers, S.K.1    Jackson, M.J.2
  • 3
    • 77955556016 scopus 로고    scopus 로고
    • Effect of physical training on mitochondrial respiration and reactive oxygen species release in skeletal muscle in patients with obesity and type 2 diabetes
    • Hey-Mogensen M, Højlund K, Vind BF, Wang L, Dela F, Beck-Nielsen H, et al. Effect of physical training on mitochondrial respiration and reactive oxygen species release in skeletal muscle in patients with obesity and type 2 diabetes. Diabetologia 2010;53:1976-1985.
    • (2010) Diabetologia , vol.53 , pp. 1976-1985
    • Hey-Mogensen, M.1    Højlund, K.2    Vind, B.F.3    Wang, L.4    Dela, F.5    Beck-Nielsen, H.6
  • 6
    • 51749101734 scopus 로고    scopus 로고
    • In situ detection and measurement of intracellular reactive oxygen species in single isolated mature skeletal muscle fibers by real time fluorescence microscopy
    • Palomero J, Pye D, Kabayo T, Spiller DG, Jackson MJ. In situ detection and measurement of intracellular reactive oxygen species in single isolated mature skeletal muscle fibers by real time fluorescence microscopy. Antioxid Redox Signal 2008;10:1463-1474.
    • (2008) Antioxid Redox Signal , vol.10 , pp. 1463-1474
    • Palomero, J.1    Pye, D.2    Kabayo, T.3    Spiller, D.G.4    Jackson, M.J.5
  • 7
    • 9244223545 scopus 로고    scopus 로고
    • Preconditioning of skeletal muscle against contraction-induced damage: The role of adaptations to oxidants in mice
    • McArdle F, Spiers S, Aldemir H, Vasilaki A, Beaver A, Iwanejko L, et al. Preconditioning of skeletal muscle against contraction-induced damage: the role of adaptations to oxidants in mice. J Physiol 2004;561:233-244.
    • (2004) J Physiol , vol.561 , pp. 233-244
    • McArdle, F.1    Spiers, S.2    Aldemir, H.3    Vasilaki, A.4    Beaver, A.5    Iwanejko, L.6
  • 8
    • 34347384587 scopus 로고    scopus 로고
    • Long-term exercise increases the DNA binding activity of peroxisome proliferator-activated receptor gamma in rat adipose tissue
    • Petridou A, Tsalouhidou S, Tsalis G, Schulz T, Michna H, Mougios V. Long-term exercise increases the DNA binding activity of peroxisome proliferator-activated receptor gamma in rat adipose tissue. Metabolism 2007;56:1029-1036.
    • (2007) Metabolism , vol.56 , pp. 1029-1036
    • Petridou, A.1    Tsalouhidou, S.2    Tsalis, G.3    Schulz, T.4    Michna, H.5    Mougios, V.6
  • 9
    • 64349111923 scopus 로고    scopus 로고
    • Brief intense interval exercise activates AMPK and p38 MAPK signaling and increases the expression of PGC-1alpha in human skeletal muscle
    • Gibala MJ, McGee SL, Garnham AP, Howlett KF, Snow RJ, Hargreaves M. Brief intense interval exercise activates AMPK and p38 MAPK signaling and increases the expression of PGC-1alpha in human skeletal muscle. J Appl Physiol 2009;106:929-934.
    • (2009) J Appl Physiol , vol.106 , pp. 929-934
    • Gibala, M.J.1    McGee, S.L.2    Garnham, A.P.3    Howlett, K.F.4    Snow, R.J.5    Hargreaves, M.6
  • 10
    • 24644478044 scopus 로고    scopus 로고
    • Analysis of global mRNA expression in human skeletal muscle during recovery from endurance exercise
    • Mahoney DJ, Parise G, Melov S, Safdar A, Tarnopolsky MA. Analysis of global mRNA expression in human skeletal muscle during recovery from endurance exercise. FASEB J 2005;19:1498-1500.
    • (2005) FASEB J , vol.19 , pp. 1498-1500
    • Mahoney, D.J.1    Parise, G.2    Melov, S.3    Safdar, A.4    Tarnopolsky, M.A.5
  • 12
    • 0141611975 scopus 로고    scopus 로고
    • The potential role of PPARs on inflammation in type 2 diabetes and atherosclerosis
    • Plutzky J. The potential role of PPARs on inflammation in type 2 diabetes and atherosclerosis. Am J Cardiol 2003;92:34-41.
    • (2003) Am J Cardiol , vol.92 , pp. 34-41
    • Plutzky, J.1
  • 13
    • 0347931775 scopus 로고    scopus 로고
    • Central role of the adipocyte in the insulin-sensitizing and cardiovascular risk modifying actions of the thiazolidinediones
    • Smith SA. Central role of the adipocyte in the insulin-sensitizing and cardiovascular risk modifying actions of the thiazolidinediones. Biochimie 2003;85:1219-1230.
    • (2003) Biochimie , vol.85 , pp. 1219-1230
    • Smith, S.A.1
  • 14
    • 0029016829 scopus 로고
    • An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)
    • Lehmann JM, Moore LB, Smith-Oliver TA, Wilkison WO, Willson TM, Kliewer SA. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma). J Biol Chem 1995;270:12953-12956.
    • (1995) J Biol Chem , vol.270 , pp. 12953-12956
    • Lehmann, J.M.1    Moore, L.B.2    Smith-Oliver, T.A.3    Wilkison, W.O.4    Willson, T.M.5    Kliewer, S.A.6
  • 15
    • 33748748206 scopus 로고    scopus 로고
    • Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: A randomised controlled trial
    • DREAM (Diabetes REduction Assessment with ramipril and rosiglitazone Medication) Trial Investigators, Gerstein HC, Yusuf S, Bosch J, Pogue J, Sheridan P, Dinccag N, et al. Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: a randomised controlled trial. Lancet 2006;368:1096-1105.
    • (2006) Lancet , vol.368 , pp. 1096-1105
    • Gerstein, H.C.1    Yusuf, S.2    Bosch, J.3    Pogue, J.4    Sheridan, P.5    Dinccag, N.6
  • 16
    • 34250212715 scopus 로고    scopus 로고
    • Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes
    • Nissen SE, Wolski K. Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes, N. Eng J Med 2007;356:2457-2471.
    • (2007) N. Eng J Med , vol.356 , pp. 2457-2471
    • Nissen, S.E.1    Wolski, K.2
  • 17
    • 34547700735 scopus 로고    scopus 로고
    • Thiazolidinediones and Heart Failure: A Teleo-Analysis
    • Singh S, Loke YK, Furberg CD. Thiazolidinediones and Heart Failure: A Teleo-Analysis. Diabetes Care 2007;30:2148-2153.
    • (2007) Diabetes Care , vol.30 , pp. 2148-2153
    • Singh, S.1    Loke, Y.K.2    Furberg, C.D.3
  • 18
    • 77956018353 scopus 로고    scopus 로고
    • Revisiting the Rosiglitazone story - Lessons learned
    • Rosen CJ. Revisiting the Rosiglitazone story - lessons learned. New England Journal of Medicine 2010;363:803-806.
    • (2010) New England Journal of Medicine , vol.363 , pp. 803-806
    • Rosen, C.J.1
  • 19
    • 84873419516 scopus 로고    scopus 로고
    • Prescribing pattern of glucose lowering drugs in the United Kingdom in the last decade: A focus on the effects of safety warnings about rosiglitazone
    • Leal I, Romio SA, Schuemie M, Oteri A, Sturkenboom M, Trifirò G. Prescribing pattern of glucose lowering drugs in the United Kingdom in the last decade: a focus on the effects of safety warnings about rosiglitazone. Br J Clin Pharmacol 2013;75:861-868.
    • (2013) Br J Clin Pharmacol , vol.75 , pp. 861-868
    • Leal, I.1    Romio, S.A.2    Schuemie, M.3    Oteri, A.4    Sturkenboom, M.5    Trifirò, G.6
  • 20
    • 34447093179 scopus 로고    scopus 로고
    • The integration of lipid-sensing and anti-inflammatory effects: How the PPARs play a role in metabolic balance
    • Nunn AV, Bell J, Barter P. The integration of lipid-sensing and anti-inflammatory effects: how the PPARs play a role in metabolic balanceNucl Recept 2007;5:1-13.
    • (2007) Nucl Recept , vol.5 , pp. 1-13
    • Nunn, A.V.1    Bell, J.2    Barter, P.3
  • 22
    • 38149131289 scopus 로고    scopus 로고
    • Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance
    • Gomez-Cabrera MC, Domenech E, Romagnoli M, Arduini A, Borras C, et al. Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance. Am J Clin Nutr 2008;87:142-149.
    • (2008) Am J Clin Nutr , vol.87 , pp. 142-149
    • Gomez-Cabrera, M.C.1    Domenech, E.2    Romagnoli, M.3    Arduini, A.4    Borras, C.5
  • 23
    • 70350020773 scopus 로고    scopus 로고
    • Exercise activation of muscle peroxisome proliferator-activated receptor-gamma coactivator-1alpha signaling is redox sensitive
    • Kang C, O'Moore KM, Dickman JR, Ji LL. Exercise activation of muscle peroxisome proliferator-activated receptor-gamma coactivator-1alpha signaling is redox sensitive. Free Radic Biol Med 2009;47:1394-1400.
    • (2009) Free Radic Biol Med , vol.47 , pp. 1394-1400
    • Kang, C.1    O'Moore, K.M.2    Dickman, J.R.3    Ji, L.L.4
  • 24
    • 0037834474 scopus 로고    scopus 로고
    • Effect of vitamin C supplements on anti-oxidant defence and stress proteins in human lymphocytes and skeletal muscle
    • Khassaf M, McArdle A, Esanu C, Vasilaki A, McArdle F, Griffiths RD, et al. Effect of vitamin C supplements on anti-oxidant defence and stress proteins in human lymphocytes and skeletal muscle. J Physiol 2003;549:645-652.
    • (2003) J Physiol , vol.549 , pp. 645-652
    • Khassaf, M.1    McArdle, A.2    Esanu, C.3    Vasilaki, A.4    McArdle, F.5    Griffiths, R.D.6
  • 28
    • 0028863240 scopus 로고
    • Muscle function and protein metabolism after initiation of eccentric contraction-induced injury
    • Lowe DA, Warren GL, Ingalls CP, Boorstein DB, Armstrong RB. Muscle function and protein metabolism after initiation of eccentric contraction-induced injury. J Appl Physiol 1995;79:1260-1270.
    • (1995) J Appl Physiol , vol.79 , pp. 1260-1270
    • Lowe, D.A.1    Warren, G.L.2    Ingalls, C.P.3    Boorstein, D.B.4    Armstrong, R.B.5
  • 29
    • 0032737858 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor(PPARgamma) as a regulator of monocyte/macrophage function
    • Ricote M, Huang JT, Welch JS, Glass CK. The peroxisome proliferator-activated receptor(PPARgamma) as a regulator of monocyte/macrophage function. J Leukoc Biol 1999;66:733-739.
    • (1999) J Leukoc Biol , vol.66 , pp. 733-739
    • Ricote, M.1    Huang, J.T.2    Welch, J.S.3    Glass, C.K.4
  • 30
    • 34249907880 scopus 로고    scopus 로고
    • Macrophage PPARγ is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones
    • Hevener AL, Olefsky JM, Reichart D, Nguyen MT, Bandyopadyhay G, Leung HY, et al. Macrophage PPARγ is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones. J Clin Invest 2007;117:1658-1669.
    • (2007) J Clin Invest , vol.117 , pp. 1658-1669
    • Hevener, A.L.1    Olefsky, J.M.2    Reichart, D.3    Nguyen, M.T.4    Bandyopadyhay, G.5    Leung, H.Y.6
  • 33
    • 77951951089 scopus 로고    scopus 로고
    • Exercise-induced Immuno-suppression: The roles of reactive oxygen species and AMPK dephosphorylation within immune cells
    • Moir H, Hughes MG, Potter S, Sims C, Butcher LR, Davies NA, et al. Exercise-induced Immuno-suppression: The roles of reactive oxygen species and AMPK dephosphorylation within immune cells. J Applied Physiol 2010;108:1284-1292.
    • (2010) J Applied Physiol , vol.108 , pp. 1284-1292
    • Moir, H.1    Hughes, M.G.2    Potter, S.3    Sims, C.4    Butcher, L.R.5    Davies, N.A.6
  • 34
    • 84859594100 scopus 로고    scopus 로고
    • Exercise-associated generation of PPARγ ligands activates PPARγ signalling events and upregulates genes related to lipid metabolism
    • Thomas AW, Davies NA, Moir H, Watkeys L, Ruffino JS, Isa SA, et al. Exercise-associated generation of PPARγ ligands activates PPARγ signalling events and upregulates genes related to lipid metabolism. J Appl Physiol 2012;112:806-815.
    • (2012) J Appl Physiol , vol.112 , pp. 806-815
    • Thomas, A.W.1    Davies, N.A.2    Moir, H.3    Watkeys, L.4    Ruffino, J.S.5    Isa, S.A.6
  • 35
    • 77957712861 scopus 로고    scopus 로고
    • Low-intensity exercise triggers monocyte polarisation into the M2 anti-inflammatory phenotype
    • Yakeu G, Butcher LR, Isa SA, Webb R, Roberts AW, Thomas AW, et al. Low-intensity exercise triggers monocyte polarisation into the M2 anti-inflammatory phenotype. Atherosclerosis 2010;212:668-673.
    • (2010) Atherosclerosis , vol.212 , pp. 668-673
    • Yakeu, G.1    Butcher, L.R.2    Isa, S.A.3    Webb, R.4    Roberts, A.W.5    Thomas, A.W.6
  • 36
    • 0032540325 scopus 로고    scopus 로고
    • Oxidized LDL regulates macrophage gene expression through ligand activation of PPARγ
    • Nagy L, Tontonoz P, Alvarez JGA, Chen H, Evans RM. Oxidized LDL regulates macrophage gene expression through ligand activation of PPARγ. Cell 1998;93:229-240.
    • (1998) Cell , vol.93 , pp. 229-240
    • Nagy, L.1    Tontonoz, P.2    Alvarez, J.G.A.3    Chen, H.4    Evans, R.M.5
  • 37
    • 0037163076 scopus 로고    scopus 로고
    • The stimulation of glycolysis by hypoxia in activated monocytes is mediated by AMP-activated protein kinase and inducible 6-phosphofructo-2-kinase
    • Marsin AS, Bouzin C, Bertrand L, Hue L. The stimulation of glycolysis by hypoxia in activated monocytes is mediated by AMP-activated protein kinase and inducible 6-phosphofructo-2-kinase. J Biol Chem 2002;277:30778-30783.
    • (2002) J Biol Chem , vol.277 , pp. 30778-30783
    • Marsin, A.S.1    Bouzin, C.2    Bertrand, L.3    Hue, L.4
  • 38
    • 3042701605 scopus 로고    scopus 로고
    • Possible involvement of AMPKα1 in oxidative stress-stimulated glucose transport in skeletal muscle
    • Toyoda T, Hayashi T, Miyamoto L, Yonemitsu S, Nakano M, Tanaka S. Possible involvement of AMPKα1 in oxidative stress-stimulated glucose transport in skeletal muscle. Am J Physiol 2004;287:E166-E173.
    • (2004) Am J Physiol , vol.287 , pp. E166-E173
    • Toyoda, T.1    Hayashi, T.2    Miyamoto, L.3    Yonemitsu, S.4    Nakano, M.5    Tanaka, S.6
  • 39
    • 34547545892 scopus 로고    scopus 로고
    • AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha
    • Jäger S, Handschin C, St-Pierre J, Spiegelman BM. AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha. Proc Natl Acad Sci U S A 2007;104:12017-12022.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 12017-12022
    • Jäger, S.1    Handschin, C.2    St-Pierre, J.3    Spiegelman, B.M.4
  • 40
    • 58349118928 scopus 로고    scopus 로고
    • Interactions between ROS and AMPK activity in the regulation of PGC-1alpha transcription in skeletal muscle cells
    • Irrcher I, Ljubicic V, Hood DA. Interactions between ROS and AMPK activity in the regulation of PGC-1alpha transcription in skeletal muscle cells Am J Physiol Cell Physiol 2009;296:C116-C123.
    • (2009) Am J Physiol Cell Physiol , vol.296 , pp. C116-C123
    • Irrcher, I.1    Ljubicic, V.2    Hood, D.A.3
  • 41
    • 0018871095 scopus 로고
    • Establishment and Characterization of a Human Acute Monocytic Leukemia Cell line (THP-1 cells)
    • Tsuchiya S, Yamabe M, Yamaguchi Y, Kobayashi Y, Konno T, Tada K. Establishment and Characterization of a Human Acute Monocytic Leukemia Cell line (THP-1 cells). Int J Cancer 1980;26:171-176.
    • (1980) Int J Cancer , vol.26 , pp. 171-176
    • Tsuchiya, S.1    Yamabe, M.2    Yamaguchi, Y.3    Kobayashi, Y.4    Konno, T.5    Tada, K.6
  • 42
    • 0035808388 scopus 로고    scopus 로고
    • Intracellular acidification triggered by mitochondrial-derived hydrogen peroxide is an effector mechanism for drug-induced apoptosis in tumor cells
    • Hirpara JL, Clément MV, Pervaiz S. Intracellular acidification triggered by mitochondrial-derived hydrogen peroxide is an effector mechanism for drug-induced apoptosis in tumor cells. J Biol Chem 2001;276:514-521.
    • (2001) J Biol Chem , vol.276 , pp. 514-521
    • Hirpara, J.L.1    Clément, M.V.2    Pervaiz, S.3
  • 43
    • 33745225026 scopus 로고    scopus 로고
    • AMP-activated protein kinase - Development of the energy sensor concept
    • Hardie DG, Hawley SA, Scott JW. AMP-activated protein kinase - development of the energy sensor concept. J Physiol 2006;574:7-15.
    • (2006) J Physiol , vol.574 , pp. 7-15
    • Hardie, D.G.1    Hawley, S.A.2    Scott, J.W.3
  • 44
    • 0042666789 scopus 로고    scopus 로고
    • Microarray analysis of peroxisome proliferator-activated receptor-gamma induced changes in gene expression in macrophages
    • Hodgkinson CP, Ye S. Microarray analysis of peroxisome proliferator-activated receptor-gamma induced changes in gene expression in macrophages. Biochem Biophys Res Commun 2003;308:505-510.
    • (2003) Biochem Biophys Res Commun , vol.308 , pp. 505-510
    • Hodgkinson, C.P.1    Ye, S.2
  • 45
    • 33646782581 scopus 로고    scopus 로고
    • Thiazolidinediones and rexinoids induce peroxisome proliferator-activated receptor-coactivator (PGC)-1alpha gene transcription: An autoregulatory loop controls PGC-1alpha expression in adipocytes via peroxisome proliferator-activated receptor-gamma coactivation
    • Hondares E, Mora O, Yubero P, Rodriguez de la Concepción M, Iglesias R, Giralt M, Villarroya F. Thiazolidinediones and rexinoids induce peroxisome proliferator-activated receptor-coactivator (PGC)-1alpha gene transcription: an autoregulatory loop controls PGC-1alpha expression in adipocytes via peroxisome proliferator-activated receptor-gamma coactivation. Endocrinology 2006;147:2829-2838.
    • (2006) Endocrinology , vol.147 , pp. 2829-2838
    • Hondares, E.1    Mora, O.2    Yubero, P.3    Rodriguez De La Concepción, M.4    Iglesias, R.5    Giralt, M.6    Villarroya, F.7
  • 46
    • 36348953730 scopus 로고    scopus 로고
    • Nitric oxide and mitochondrial signaling: From physiology to pathophysiology
    • Erusalimsky JD, Moncada S. Nitric oxide and mitochondrial signaling: from physiology to pathophysiology. Arterioscler Thromb Vasc Biol 2007;27:2524-2531.
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , pp. 2524-2531
    • Erusalimsky, J.D.1    Moncada, S.2
  • 47
    • 33645770953 scopus 로고    scopus 로고
    • Mitochondria as signalling organelles in the vascular endothelium
    • Quintero M, Colombo SL, Godfrey A, Moncada S. Mitochondria as signalling organelles in the vascular endothelium. Proc Nat Acad Sci 2006;103:5379-5384.
    • (2006) Proc Nat Acad Sci , vol.103 , pp. 5379-5384
    • Quintero, M.1    Colombo, S.L.2    Godfrey, A.3    Moncada, S.4
  • 48
    • 0033635490 scopus 로고    scopus 로고
    • Vitamin C suppresses oxidative lipid damage in vivo, even in the presence of iron overload
    • Chen K, Suh J, Carr AC, Morrow JD, Zeind J, Frei B. Vitamin C suppresses oxidative lipid damage in vivo, even in the presence of iron overload. Am J Physiol Endocrinol Metab 2000;279:E1406-E1412.
    • (2000) Am J Physiol Endocrinol Metab , vol.279 , pp. E1406-E1412
    • Chen, K.1    Suh, J.2    Carr, A.C.3    Morrow, J.D.4    Zeind, J.5    Frei, B.6
  • 50
    • 67651236115 scopus 로고    scopus 로고
    • Role of AMPK in regulating fatty acid metabolism during exercise
    • Steinberg GR. Role of AMPK in regulating fatty acid metabolism during exercise. Appl Physiol Nutr Metab 2009;34:315-322.
    • (2009) Appl Physiol Nutr Metab , vol.34 , pp. 315-322
    • Steinberg, G.R.1
  • 51
    • 0037477855 scopus 로고    scopus 로고
    • Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1
    • Patti ME, Butte AJ, Crunkhorn S, Cusi K, Berria R, Kashyap S, et al. Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1. Proc Natl Acad Sci U S A 2003;100:8466-8471.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 8466-8471
    • Patti, M.E.1    Butte, A.J.2    Crunkhorn, S.3    Cusi, K.4    Berria, R.5    Kashyap, S.6
  • 52
    • 0033867178 scopus 로고    scopus 로고
    • Potential role of TNF-alpha in the pathogenesis of insulin resistance and type 2 diabetes
    • Moller DE. Potential role of TNF-alpha in the pathogenesis of insulin resistance and type 2 diabetes. Trends Endocrinol Metab 2000;11:212-217.
    • (2000) Trends Endocrinol Metab , vol.11 , pp. 212-217
    • Moller, D.E.1
  • 53
    • 77955508579 scopus 로고    scopus 로고
    • Exercise training increases mitochondrial content and ex vivo mitochondrial function similarly in patients with type 2 diabetes and in control individuals
    • Phielix E, Meex R, Moonen-Kornips E, Hesselink MK, Schrauwen P. Exercise training increases mitochondrial content and ex vivo mitochondrial function similarly in patients with type 2 diabetes and in control individuals. Diabetologia 2010;53:1714-1721.
    • (2010) Diabetologia , vol.53 , pp. 1714-1721
    • Phielix, E.1    Meex, R.2    Moonen-Kornips, E.3    Hesselink, M.K.4    Schrauwen, P.5


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