Improving safety and efficacy of meningococcal vaccines: Vaccines based on a relatively sparse surface lipoprotein extend coverage to serogroup B; amino acid changes could lead to further enhancements

Microbe

Volumn 9, Issue 8, 2014, Pages 321-327

  Granoff, Dan M ^a  

^a CHILDREN S HOSPITAL OAKLAND RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84914704101     PISSN: 15587452     EISSN: 15587460     Source Type: Journal    
DOI: 10.1128/microbe.9.321.1     Document Type: Note

References (10)

1. Beernink, P. T., and D. M. Granoff. 2009. The modular architecture of meningococcal factor H-binding protein. Microbiology 155:2873–2883.
2. Beernink, P. T., J. Shaughnessy, E. M. Braga, Q. Liu, P. A. Rice, S. Ram, and D. M. Granoff. 2011. A meningococcal factor H binding protein mutant that eliminates factor H binding enhances protective antibody responses to vaccination. J. Immunol. 186: 3606–3614.
3. Beernink, P. T., J. Shaughnessy, R. Pajon, E. M. Braga, S. Ram, and D. M. Granoff. 2012. The effect of human factor H on immunogenicity of meningococcal native outer membrane vesicle vaccines with overexpressed factor H binding protein. PLoS Pathog 8:e1002688.
4. Granoff, D. M., S. Ram, and P. T. Beernink. 2013. Does binding of complement factorHto the meningococcal vaccine antigen, factor H binding protein, decrease protective serum antibody responses? Clin. Vaccine Immunol. 20:1099–1107.
5. Granoff, D. M., J. A. Welsch, and S. Ram. 2009. Binding of complement factorH(fH) to Neisseria meningitides is specifıc for human fH and inhibits complement activation by rat and rabbit sera. Infect Immun 77: 764–769.
6. Madico, G., J. A. Welsch, L. A. Lewis, A. Mcnaughton, D. H. Perlman, C. E. Costello, J. Ngampasutadol, U. Vogel, D. M. Granoff, and S. Ram. 2006. The meningococcal vaccine candidate GNA1870 binds the complement regulatory protein factor H and enhances serum resistance. J. Immunol. 177:501–510.
7. Masignani, V., M. Comanducci, M. M. Giuliani, S. Bambini, J. Adu-Bobie, B. Arico, B. Brunelli, A. Pieri, L. Santini, S. Savino, D. Serruto, D. Litt, S. Kroll, J. A. Welsch, D. M. Granoff, R. Rappuoli, and M. Pizza. 2003. Vaccination against Neisseria meningitides using three variants of the lipoprotein GNA1870. J. Exp. Med. 197:789–799.
8. Schneider, M. C., B. E. Prosser, J. J. Caesar, E. Kugelberg, S. Li, Q. Zhang, S. Quoraishi, J. E. Lovett, J. E. Deane, R. B. Sim, P. Roversi, S. Johnson, C. M. Tang, and S. M. Lea. 2009. Neisseria meningitidis recruits factorHusing protein mimicry of host carbohydrates. Nature 458:890–893.
9. Welsch, J. A., S. Ram, O. Koeberling, and D. M. Granoff. 2008. Complement-dependent synergistic bactericidal activity of antibodies against factor H-binding protein, a sparsely distributed meningococcal vaccine antigen. J. Infect. Dis. 197:1053–1061.
10. Welsch, J. A., R. Rossi, M. Comanducci, and D. M. Granoff. 2004. Protective activity of monoclonal antibodies to genome-derived neisserial antigen 1870, a Neisseria meningitidis candidate vaccine. J. Immunol. 172:5606–5615.