Refined mapping of a hypertension susceptibility locus on rat chromosome 12

Hypertension

Volumn 64, Issue 4, 2014, Pages 883-890

  Prisco, Sasha Z ^a   Prokop, Jeremy W ^a   Sarkis, Allison B ^a   Yeo, Nan Cher ^a   Hoffman, Matthew J ^a   Hansen, Colin C ^a   Jacob, Howard J ^a   Flister, Michael J ^a   Lazar, Jozef ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Hypertension; Inbred BN; Inbred Dahl; Rats

Indexed keywords

SALT INTAKE;

ANIMAL; BLOOD PRESSURE; BROWN NORWAY RAT; CHROMOSOME; CHROMOSOME 7; CHROMOSOME MAP; DAHL RAT; DRUG EFFECTS; GENE EXPRESSION; GENETIC PREDISPOSITION; GENETICS; HUMAN; HYPERTENSION; KIDNEY CORTEX; KIDNEY MEDULLA; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; PROCEDURES; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SALT INTAKE; SYNTENY; WISTAR KYOTO RAT;

ANIMALS; BLOOD PRESSURE; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 7; CHROMOSOMES, MAMMALIAN; GENE EXPRESSION; GENETIC PREDISPOSITION TO DISEASE; HUMANS; HYPERTENSION; KIDNEY CORTEX; KIDNEY MEDULLA; RATS; RATS, INBRED BN; RATS, INBRED DAHL; RATS, INBRED WKY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SODIUM CHLORIDE, DIETARY; SYNTENY;

EID: 84914703209     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.114.03550     Document Type: Article

References (47)

1. Go AS, Mozaffarian D, Roger VL, et al; American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics-2014 update: A report from the American Heart Association. Circulation. 2014;129: E28-e292.
2. Go AS, Mozaffarian D, Roger VL, et al; American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics-2013 update: A report from the American Heart Association. Circulation. 2013;127: E6-e245.
3. Flister MJ, Prisco SZ, Sarkis AB, O'Meara CC, Hoffman M, Wendt- Andrae J, Moreno C, Lazar J, Jacob HJ. Identification of hypertension susceptibility loci on rat chromosome 12. Hypertension. 2012;60: 942-948.
4. Ramensky V, Bork P, Sunyaev S. Human non-synonymous SNPs: Server and survey. Nucleic Acids Res. 2002;30: 3894-3900.
5. Atwood LD, Samollow PB, Hixson JE, Stern MP, MacCluer JW. Genome-wide linkage analysis of pulse pressure in Mexican Americans. Hypertension. 2001;37(2 pt 2): 425-428.
6. Atwood LD, Samollow PB, Hixson JE, Stern MP, MacCluer JW. Genomewide linkage analysis of blood pressure in Mexican Americans. Genet Epidemiol. 2001;20: 373-382.
7. Hunt SC, Ellison RC, Atwood LD, Pankow JS, Province MA, Leppert MF. Genome scans for blood pressure and hypertension: The National Heart, Lung, and Blood Institute Family Heart Study. Hypertension. 2002;40: 1-6.
8. Cheng LS, Davis RC, Raffel LJ, Xiang AH, Wang N, Quiñones M, Wen PZ, Toscano E, Diaz J, Pressman S, Henderson PC, Azen SP, Hsueh WA, Buchanan TA, Rotter JI. Coincident linkage of fasting plasma insulin and blood pressure to chromosome 7q in hypertensive hispanic families. Circulation. 2001;104: 1255-1260.
9. Tayo BO, Luke A, Zhu X, Adeyemo A, Cooper RS. Association of regions on chromosomes 6 and 7 with blood pressure in Nigerian families. Circ Cardiovasc Genet. 2009;2: 38-45.
10. Adeyemo A, Luke A, Wu X, Cooper RS, Kan D, Omotade O, Zhu X. Genetic effects on blood pressure localized to chromosomes 6 and 7. J Hypertens. 2005;23: 1367-1373.
11. McDonough CW, Palmer ND, Hicks PJ, et al. A genome-wide association study for diabetic nephropathy genes in African Americans. Kidney Int. 2011;79: 563-572.
12. Turner ST, Kardia SL, Mosley TH, Rule AD, Boerwinkle E, de Andrade M. Influence of genomic loci on measures of chronic kidney disease in hypertensive sibships. J Am Soc Nephrol. 2006;17: 2048-2055.
13. Bowden DW, Colicigno CJ, Langefeld CD, Sale MM, Williams A, Anderson PJ, Rich SS, Freedman BI. A genome scan for diabetic nephropathy in African Americans. Kidney Int. 2004;66: 1517-1526.
14. O'Meara CC, Lazar J, Hoffman M, Moreno C, Jacob HJ. Refined mapping of the renal failure RF-3 quantitative trait locus. J Am Soc Nephrol. 2011;22: 518-525.
15. Flister MJ, Hoffman MJ, Reddy P, Jacob HJ, Moreno C. Congenic mapping and sequence analysis of the Renin locus. Hypertension. 2013;61: 850-856.
16. Adzhubei IA, Schmidt S, Peshkin L, Ramensky VE, Gerasimova A, Bork P, Kondrashov AS, Sunyaev SR. A method and server for predicting damaging missense mutations. Nat Methods. 2010;7: 248-249.
17. McLaren W, Pritchard B, Rios D, Chen Y, Flicek P, Cunningham F. Deriving the consequences of genomic variants with the Ensembl API and SNP Effect Predictor. Bioinformatics. 2010;26: 2069-2070.
18. Krieger E, Koraimann G, Vriend G. Increasing the precision of comparative models with YASARA NOVA-a self-parameterizing force field. Proteins. 2002;47: 393-402.
19. Roy A, Kucukural A, Zhang Y. I-TASSER: A unified platform for automated protein structure and function prediction. Nat Protoc. 2010;5: 725-738.
20. Larkin MA, Blackshields G, Brown NP, Chenna R, McGettigan PA, McWilliam H, Valentin F, Wallace IM, Wilm A, Lopez R, Thompson JD, Gibson TJ, Higgins DG. Clustal W and Clustal X version 2.0. Bioinformatics. 2007;23: 2947-2948.
21. Ashkenazy H, Erez E, Martz E, Pupko T, Ben-Tal N. ConSurf 2010: Calculating evolutionary conservation in sequence and structure of proteins and nucleic acids. Nucleic Acids Res. 2010;38: W529-W533.
22. Konagurthu AS, Whisstock JC, Stuckey PJ, Lesk AM. MUSTANG: A multiple structural alignment algorithm. Proteins. 2006;64: 559-574.
23. Hoffman MJ, Flister MJ, Nunez L, Xiao B, Greene AS, Jacob HJ, Moreno C. Female-specific hypertension loci on rat chromosome 13. Hypertension. 2013;62: 557-563.
24. Kato N, Hyne G, Bihoreau MT, Gauguier D, Lathrop GM, Rapp JP. Complete genome searches for quantitative trait loci controlling blood pressure and related traits in four segregating populations derived from Dahl hypertensive rats. Mamm Genome. 1999;10: 259-265.
25. Herrera VL, Tsikoudakis A, Ponce LR, Matsubara Y, Ruiz-Opazo N. Sexspecific QTLs and interacting loci underlie salt-sensitive hypertension and target organ complications in Dahl S/jrHS hypertensive rats. Physiol Genomics. 2006;26: 172-179.
26. Stoll M, Cowley AW Jr, Tonellato PJ, Greene AS, Kaldunski ML, Roman RJ, Dumas P, Schork NJ, Wang Z, Jacob HJ. A genomic-systems biology map for cardiovascular function. Science. 2001;294: 1723-1726.
27. Matys V, Kel-Margoulis OV, Fricke E, et al. TRANSFAC and its module TRANSCompel: Transcriptional gene regulation in eukaryotes. Nucleic Acids Res. 2006;34: D108-D110.
28. Johnson RJ, Gordon KL, Giachelli C, Kurth T, Skelton MM, Cowley AW Jr. Tubulointerstitial injury and loss of nitric oxide synthases parallel the development of hypertension in the Dahl-SS rat. J Hypertens. 2000;18: 1497-1505.
29. Dahl LK, Heine M, Thompson K. Genetic influence of the kidneys on blood pressure. Evidence from chronic renal homografts in rats with opposite predispositions to hypertension. Circ Res. 1974;40: 94-101.
30. Flister MJ, Tsaih SW, O'Meara CC, Endres B, Hoffman MJ, Geurts AM, Dwinell MR, Lazar J, Jacob HJ, Moreno C. Identifying multiple causative genes at a single GWAS locus. Genome Res. 2013;23: 1996-2002.
31. Alonso F, Krattinger N, Mazzolai L, Simon A, Waeber G, Meda P, Haefliger JA. An angiotensin II- And NF-kappaB-dependent mechanism increases connexin 43 in murine arteries targeted by renin-dependent hypertension. Cardiovasc Res. 2010;87: 166-176.
32. Luft FC. Workshop: Mechanisms and cardiovascular damage in hypertension. Hypertension. 2001;37(2 pt 2): 594-598.
33. Kubo T, Kinjyo N, Ikezawa A, Kambe T, Fukumori R. Sp1 decoy oligodeoxynucleotide decreases angiotensin receptor expression and blood pressure in spontaneously hypertensive rats. Brain Res. 2003; 992: 1-8.
34. Menzaghi C, Paroni G, De Bonis C, Soccio T, Marucci A, Bacci S, Trischitta V. The -318 C>G single-nucleotide polymorphism in GNAI2 gene promoter region impairs transcriptional activity through specific binding of Sp1 transcription factor and is associated with high blood pressure in Caucasians from Italy. J Am Soc Nephrol. 2006;17(4 suppl 2): S115-S119.
35. Negoro N, Kanayama Y, Haraguchi M, Umetani N, Nishimura M, Konishi Y, Iwai J, Okamura M, Inoue T, Takeda T. Blood pressure regulates platelet- derived growth factor A-chain gene expression in vascular smooth muscle cells in vivo. An autocrine mechanism promoting hypertensive vascular hypertrophy. J Clin Invest. 1995;95: 1140-1150.
36. Savinkova LK, Ponomarenko MP, Ponomarenko PM, Drachkova IA, Lysova MV, Arshinova TV, Kolchanov NA. TATA box polymorphisms in human gene promoters and associated hereditary pathologies. Biochemistry (Mosc). 2009;74: 117-129.
37. Hiraoka N, Nakagawa H, Ong E, Akama TO, Fukuda MN, Fukuda M. Molecular cloning and expression of two distinct human chondroitin 4-O-sulfotransferases that belong to the HNK-1 sulfotransferase gene family. J Biol Chem. 2000;275: 20188-20196.
38. Izumikawa T, Koike T, Kitagawa H. Chondroitin 4-O-sulfotransferase-2 regulates the number of chondroitin sulfate chains initiated by chondroitin N-acetylgalactosaminyltransferase-1. Biochem J. 2012;441: 697-705.
39. Melo-Filho NM, Belmiro CL, Gonçalves RG, Takiya CM, Leite M Jr, Pavão MS, Mourão PA. Fucosylated chondroitin sulfate attenuates renal fibrosis in animals submitted to unilateral ureteral obstruction: A P-selectinmediated event? Am J Physiol Renal Physiol. 2010;299: F1299-F1307.
40. Belforte N, Sande P, de Zavalía N, Knepper PA, Rosenstein RE. Effect of chondroitin sulfate on intraocular pressure in rats. Invest Ophthalmol Vis Sci. 2010;51: 5768-5775.
41. Reynertson RH, Oparil S, Rodén L. Proteoglycans and hypertension: III: Aorta proteoglycans in Dahl salt-sensitive hypertensive rats. Am J Med Sci. 1987;293: 171-176.
42. Ehret GB, Munroe PB, Rice KM, et al. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature. 2011;478: 103-109.
43. Wain LV, Verwoert GC, O'Reilly PF, et al; LifeLines Cohort Study; EchoGen consortium; AortaGen Consortium; CHARGE Consortium Heart Failure Working Group; KidneyGen consortium; CKDGen consortium; Cardiogenics consortium; CardioGram. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nat Genet. 2011;43: 1005-1011.
44. Hendrickx A, Beullens M, Ceulemans H, Den Abt T, Van Eynde A, Nicolaescu E, Lesage B, Bollen M. Docking motif-guided mapping of the interactome of protein phosphatase-1. Chem Biol. 2009;16: 365-371.
45. Shen GQ, Ikegami H, Fujisawa T, Hamada Y, Kamide K, Rakugi H, Higaki J, Murakami H, Shimamoto K, Ogihara T. Asp905Tyr polymorphism of protein phosphatase 1 G subunit gene in hypertension. Hypertension. 1997;30(2 pt 1): 236-239.
46. Gupta RC, Mishra S, Rastogi S, Imai M, Habib O, Sabbah HN. Cardiac SR-coupled PP1 activity and expression are increased and inhibitor 1 protein expression is decreased in failing hearts. Am J Physiol Heart Circ Physiol. 2003;285: H2373-H2381.
47. Lovren F, Pan Y, Quan A, Singh KK, Khan R, Gupta N, Brezden-Masley C, Teoh H, Wheatcroft MD, Al-Omran M, Verma S. BRCA1 shields vascular smooth muscle cells from oxidative stress. J Thorac Cardiovasc Surg. 2014;147: 1946-1955.e1.