Adrenocortical carcinoma in children: First population-based clinicopathological study with long-term follow-up

Oncology Reports

Volumn 32, Issue 6, 2014, Pages 2836-2844

  Kerkhofs, T M A ^a   Ettaieb, M H T ^a   Verhoeven, R H A ^b   Kaspers, G J L ^c   Tissing, W J E ^d   Loeffen, J ^e   Van Den Heuvel Eibrink, M M ^f   De Krijger, R R ^g,h   Haak, H R ^a,i,j  

^a MÁXIMA MEDICAL CENTER   (Netherlands)

^b Eindhoven Cancer Registry   (Netherlands)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^d UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^e RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^f SOPHIA CHILDREN S HOSPITAL   (Netherlands)

^g REINIER DE GRAAF HOSPITAL   (Netherlands)

^h ERASMUS MEDICAL CENTER   (Netherlands)

ⁱ MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^j MAASTRICHT UNIVERSITY   (Netherlands)

more..

Author keywords

Adrenocortical carcinoma; Cancer registry; Histological characteristics; Incidence; Long term follow up; Pediatrics

Indexed keywords

ANDROSTENEDIONE; CISPLATIN; CYCLOPHOSPHAMIDE; DOXORUBICIN; ESTRADIOL; ETOPOSIDE; HYDROCORTISONE; MITOTANE; PRASTERONE SULFATE; STREPTOZOCIN; TESTOSTERONE; THALIDOMIDE;

ACNE; ADOLESCENT; ADRENAL CORTEX CARCINOMA; ADULT; ADVANCED CANCER; AGE DISTRIBUTION; ANDROGEN BLOOD LEVEL; ARTICLE; BODY HEIGHT; CANCER COMBINATION CHEMOTHERAPY; CANCER INCIDENCE; CANCER PROGNOSIS; CANCER STAGING; CANCER SURGERY; CANCER SURVIVAL; CHILD; CHILDHOOD CANCER; CLINICAL ARTICLE; CLINICAL FEATURE; CRYING; DATA ANALYSIS; DISEASE FREE SURVIVAL; DISEASE REGISTRY; DISTANT METASTASIS; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG RESPONSE; FEMALE; FOLLOW UP; GENITAL MALFORMATION; HIRSUTISM; HISTOPATHOLOGY; HORMONE RELEASE; HUMAN; HUMAN TISSUE; HYDROCORTISONE BLOOD LEVEL; INSOMNIA; LIVER METASTASIS; LUNG METASTASIS; MALE; MAXIMUM PLASMA CONCENTRATION; MEDICAL RECORD REVIEW; MONOTHERAPY; MOON FACE; NETHERLANDS; ONSET AGE; OUTCOME ASSESSMENT; SEX DIFFERENCE; SURVIVAL TIME; ADRENOCORTICAL CARCINOMA; DEMOGRAPHY; INFANT; PATHOLOGY; PRESCHOOL CHILD; YOUNG ADULT;

ADOLESCENT; ADRENOCORTICAL CARCINOMA; ADULT; CHILD; CHILD, PRESCHOOL; DEMOGRAPHY; FEMALE; FOLLOW-UP STUDIES; HUMANS; INFANT; MALE; NETHERLANDS; YOUNG ADULT;

EID: 84914695547     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2014.3506     Document Type: Article

References (66)

1. Kerkhofs TM, Verhoeven RH, Van der Zwan JM, et al: Adrenocortical carcinoma: a population-based study on incidence and survival in the Netherlands since 1993. Eur J Cancer 49: 2579-2586, 2013.
2. McAteer J P, Huaco JA and Gow KW: Predictors of survival in pediatric adrenocortical carcinoma: a Surveillance, Epidemiology, and End Results (SEER) program study. J Pediatr Surg 48: 1025-1031, 2013.
3. Redlich A, Boxberger N, Strugala D, et al: Systemic treatment of adrenocortical carcinoma in children: data from the German GPOh-MET 97 trial. Klin Padiatr 224: 366-371, 2012.
4. Michalkiewicz E, Sandrini R, Figueiredo B, et al: Clinical and outcome characteristics of children with adrenocortical tumors: a report from the international Pediatric Adrenocortical Tumor Registry. J Clin Oncol 22: 838-845, 2004.
5. Sabbaga CC, Avilla SG, Schulz C, Garbers JC and Blucher D: Adrenocortical carcinoma in children: clinical aspects and prognosis. J Pediatr Surg 28: 841-843, 1993.
6. Ciftci AO, Senocak ME, Tanyel FC and Büyükpamukçu N: Adrenocortical tumors in children. J Pediatr Surg 36: 549-554, 2001.
7. Dehner LP and Hill DA: Adrenal cortical neoplasms in children: why so many carcinomas and yet so many survivors? Pediatr Dev Pathol 12: 284-291, 2009.
8. Wieneke JA, Thompson LD and Heffess CS: Adrenal cortical neoplasms in the pediatric population: a clinicopathologic and immunophenotypic analysis of 83 patients. Am J Surg Pathol 27: 867-881, 2003.
9. Weiss LM: Comparative histologic study of 43 metastasizing and nonmetastasizing adrenocortical tumors. Am J Surg Pathol 8: 163-169, 1984.
10. van Slooten H, Schaberg A, Smeenk D and Moolenaar AJ: Morphologic characteristics of benign and malignant adrenocortical tumors. Cancer 55: 766-773, 1985.
11. Hubertus J, Boxberger N, Redlich A, von Schweinitz D and Vorwerk P: Surgical aspects in the treatment of adrenocortical carcinomas in children: data of the GPOh-MET 97 trial. Klin Padiatr 224: 143-147, 2012.
12. Doll R and Cook P: Summarizing indices for comparison of cancer incidence data. Int J Cancer 2: 269-279, 1967.
13. Casparie M, Tiebosch AT, Burger G, Blauwgeers H, van de Pol A, van Krieken JH and Meijer GA: Pathology databanking and biobanking in The Netherlands, a central role for PALGA, the nationwide histopathology and cytopathology data network and archive. Cell Oncol 29: 19-24, 2007.
14. Weiss LM, Medeiros LJ and Vickery AL Jr: Pathologic features of prognostic significance in adrenocortical carcinoma. Am J Surg Pathol 13: 202-206, 1989.
15. Fassnacht M, Terzolo M, Allolio B, et al: Combination chemotherapy in advanced adrenocortical carcinoma. N Engl J Med 366: 2189-2197, 2012.
16. Faria AM and Almeida MQ: Differences in the molecular mechanisms of adrenocortical tumorigenesis between children and adults. Mol Cell Endocrinol 351: 52-57, 2012.
17. Fassnacht M, Kroiss M and Allolio B: Update in adrenocortical carcinoma. J Clin Endocrinol Metab 98: 4551-4564, 2013.
18. Fassnacht M and Allolio B: Clinical management of adrenocortical carcinoma. Best Pract Res Clin Endocrinol Metab 23: 273-289, 2009.
19. Boechat GA, Stinghen ST, Custódio G, et al: Placental alkaline phosphatase in pediatric adrenocortical cancer. J Pediatr Hematol Oncol 33: e149-e153, 2011.
20. Wilkin F, Gagné N, Paquette J, Oligny LL and Deal C: Pediatric adrenocortical tumors: molecular events leading to insulin-like growth factor ii gene overexpression. J Clin Endocrinol Metab 85: 2048-2056, 2000.
21. Mastellaro MJ, Seindinger AL, Yunes JA, et al: Adrenocortical tumors in children: analysis of 105 patients from a single institution. The Fourth international Symposium on Adrenal Cancer, Paris, Abst, 2013.
22. Libe R, Borget I, Ronchi C, Terzolo M, Haaf M, Laino F, et al: Prognostic factors of advanced unresectable by stage iii and iV ENS@T adrenocortical carcinomas (ACC). The 15th European Congress of Endocrinology, Copenhagen, 2013. (abstract Endocrine Abst 32 OC4.3. doi: 10.1530/endoabs.32.OC4.3), 2013.
23. Terzolo M, Angeli A, Fassnacht M, et al: Adjuvant mitotane treatment for adrenocortical carcinoma. N Engl J Med 356: 2372-2380, 2007.
24. Terzolo M, Baudin E, Ardito A, et al: Mitotane levels predict the outcome of patients with adrenocortical carcinoma treated adjuvantly following radical resection. Eur J Endocrinol 169: 263-270, 2013.
25. Sandrini R, Ribeiro RC and DeLacerda L: Childhood adrenocortical tumors. J Clin Endocrinol Metab 82: 2027-2031, 1997.
26. Borges KS, Moreno DA, Martinelli CE Jr, et al: Spindle assembly checkpoint gene expression in childhood adrenocortical tumors (ACT): overexpression of Aurora kinases A and b is associated with a poor prognosis. Pediatr Blood Cancer 60: 1809-1816, 2013.
27. Sbragia L, Oliveira-Filho AG, Vassallo J, Pinto GA, Guerra-Junior G and Bustorff-Silva J: Adrenocortical tumors in brazilian children: immunohistochemical markers and prognostic factors. Arch Pathol Lab Med 129: 1127-1131, 2005.
28. Ribeiro RC, Sandrini Neto RS, Schell MJ, Lacerda L, Sambaio GA and Cat I: Adrenocortical carcinoma in children: a study of 40 cases. J Clin Oncol 8: 67-74, 1990.
29. Klein JD, Turner CG, Gray FL, et al: Adrenal cortical tumors in children: factors associated with poor outcome. J Pediatr Surg 46: 1201-1207, 2011.
30. Ribeiro RC, Sandrini F, Figueiredo B, et al: An inherited p53 mutation that contributes in a tissue-specific manner to pediatric adrenal cortical carcinoma. Proc Natl Acad Sci USA 98: 9330-9335, 2001.
31. Orhan D, Kale G, Caʇlar M, Göʇüş S and Karaaʇaoʇlu E: Histone mRNA in situ hybridization and Ki 67 immunohistochemistry in pediatric adrenocortical tumors. Virchows Arch 448: 591-596, 2006.
32. West AN, Neale GA, Pounds S, et al: Gene expression profiling of childhood adrenocortical tumors. Cancer Res 67: 600-608, 2007.
33. Martins AC, Cologna AJ, Tucci S Jr, Suaid HJ and Falconi RA: Clinical features and immunoexpression of p53, MIB-1 and proliferating cell nuclear antigen in adrenal neoplasms. J Urol 173: 2138-2142, 2005.
34. Hanna AM, Pham TH, Askegard-Giesmann JR, Grams JM, Iqbal CW, Stavlo P and Moir CR: Outcome of adrenocortical tumors in children. J Pediatr Surg 43: 843-849, 2008.
35. Chen QL, Su Z, Li YH, Ma HM, Chen HS and Du ML: Clinical characteristics of adrenocortical tumors in children. J Pediatr Endocrinol Metab 24: 535-541, 2011.
36. Cagle PT, Hough AJ, Pysher TJ, et al: Comparison of adrenal cortical tumors in children and adults. Cancer 57: 2235-2237, 1986.
37. Zancanella P, Pianovski MA, Oliveira BH, et al: Mitotane associated with cisplatin, etoposide, and doxorubicin in advanced childhood adrenocortical carcinoma: mitotane monitoring and tumor regression. J Pediatr Hematol Oncol 28: 513-524, 2006.
38. Narasimhan KL, Samujh R, Bhansali A, Marwaha RK, Chowdhary SK, Radotra BD and Rao KL: Adrenocortical tumors in childhood. Pediatr Surg Int 19: 432-435, 2003.
39. Stewart JN, Flageole H and Kavan P: A surgical approach to adrenocortical tumors in children: the mainstay of treatment. J Pediatr Surg 39: 759-763, 2004.
40. Magro G, Esposito G, Cecchetto G, et al: Pediatric adrenocortical tumors: morphological diagnostic criteria and immunohisto-chemical expression of matrix metalloproteinase type 2 and human leucocyte-associated antigen (hLA) class ii antigens. Results from the italian Pediatric Rare Tumor (TREP) Study project. Hum Pathol 43: 31-39, 2012.
41. McDonnell CM and Zacharin MR: Adrenal cortical tumours: 25 years' experience at the Royal Children's Hospital, Melbourne. J Paediatr Child Health 39: 682-685, 2003.
42. Ahmed AA: Adrenocortical neoplasms in young children: age as a prognostic factor. Ann Clin Lab Sci 39: 277-282, 2009.
43. Cho MJ, Kim DY, Kim SC, Kim TH and Kim IK: Adrenocortical tumors in children 18 years old and younger. J Korean Surg Soc 82: 246-250, 2012.
44. Pusantisampan T, Sangkhathat S, Kayasut K, Kanngurn S, Jaruratanasirikul S, Chotsampancharoen T and Kritsaneepaiboon S: Cushing's syndrome in an infant secondary to malignant adreno-cortical tumors with somatic mutation of beta-catenin. Pediatr Dev Pathol 13: 238-242, 2010.
45. Lima Lde O, Lerario AM, Alencar GA, et al: Clinical and molecular aspects of a pediatric metachronous adrenocortical tumor. Arq Bras Endocrinol Metabol 55: 72-77, 2011.
46. Aricò M, Bossi G, Livieri C, Raiteri E and Severi F: Partial response after intensive chemotherapy for adrenal cortical carcinoma in a child. Med Pediatr Oncol 20: 246-248, 1992.
47. Delaney HM, Prauner RD and Person DA: Germline p53 mutation in a Micronesian child with adrenocortical carcinoma and subsequent osteosarcoma. J Pediatr Hematol Oncol 30: 803-806, 2008.
48. De León DD, Lange BJ, Walterhouse D and Moshang T: Long-term (15 years) outcome in an infant with metastatic adrenocortical carcinoma. J Clin Endocrinol Metab 87: 4452-4456, 2002.
49. Fiszer-Maliszewska L, Kazanowska B, Padzik J; Regional Blood Transfusion Center: p53 Tetramerization domain mutations: germline R342X and R342P, and somatic R337G identified in pediatric patients with Li-Fraumeni syndrome and a child with adrenocortical carcinoma. Fam Cancer 8: 541-546, 2009.
50. Fudge EB, von Allmen D, Volmar KE and Calikoglu AS: Cushing syndrome in a 6-month-old infant due to adrenocortical tumor. Int J Pediatr Endocrinol 2009: e168749, 2009.
51. Ghazizadeh F, Ebadi M, Alavi S, Arzanian M, Shamsian B and Jadali F: Adrenocortical carcinoma presenting with heterosexual pseudoprecocious puberty shortly after birth: case report and review. Ecancermedicalscience 7: e289, 2013.
52. Godil MA, Atlas M P, Parker RI, et al: Metastatic congenital adrenocortical carcinoma: a case report with tumor remission at 3 1/2 years. J Clin Endocrinol Metab 85: 3964-3967, 2000.
53. Hah JO: Intensive chemotherapy with autologous PBSCT for advanced adrenocortical carcinoma in a child. J Pediatr Hematol Oncol 30: 332-334, 2008.
54. Hara F, Kishikawa T, Tomishige H, Nishikawa O, Nishida Y and Kongo M: A child with adrenocortical carcinoma who underwent percutaneous ethanol injection therapy for liver metastasis. J Pediatr Surg 38: 1237-1240, 2003.
55. Inage E, Saito M, Saito Y, Takata O, Fujimura J, Yamataka A and Shimizu T: Contralateral pleural recurrence of adrenocortical carcinoma after surgical resection. Pediatr Int 53: 600-603, 2011.
56. Kanmaz T, Demirbilek S, Ozardali I, Safali M, Guran S and Yucesan S: Nonfunctioning adrenocortical carcinoma in a child. Pediatr Pathol Mol Med 22: 405-410, 2003.
57. Khayat CM and Johnston DL: Rhabdomyosarcoma, osteosarcoma, and adrenocortical carcinoma in a child with a germline p53 mutation. Pediatr Blood Cancer 43: 683-686, 2004.
58. Ko JH, Lee HS, Hong J and Hwang JS: Virilizing adrenocortical carcinoma in a child with Turner syndrome and somatic TP53 gene mutation. Eur J Pediatr 169: 501-504, 2010.
59. Lin MT, Shieh JJ, Chang JH, Chang SW, Chen TC and Hsu WH: Early detection of adrenocortical carcinoma in a child with Li-Fraumeni syndrome. Pediatr Blood Cancer 52: 541-544, 2009.
60. Mertens F, Kullendorff CM, Moell C, Alumets J and Mandahl N: Complex karyotype in a childhood adrenocortical carcinoma. Cancer Genet Cytogenet 105: 190-192, 1998.
61. Miyoshi Y, Oue T, Oowari M, et al: A case of pediatric virilizing adrenocortical tumor resulting in hypothalamic-pituitary activation and central precocious puberty following surgical removal. Endocr J 56: 975-982, 2009.
62. Pivnick EK, Furman WL, Velagaleti GV, Jenkins JJ, Chase NA and Ribeiro RC: Simultaneous adrenocortical carcinoma and ganglioneuroblastoma in a child with Turner syndrome and germline p53 mutation. J Med Genet 35: 328-332, 1998.
63. Romaguera RL, Minagar A, Bruce JH, et al: Adrenocortical carcinoma with cerebral metastasis in a child: case report and review of the literature. Clin Neurol Neurosurg 103: 46-50, 2001.
64. Sorgo W, Meyer D, Rodens K, Homoki J, Heinze E, Heymer B and Siebenmann R: Testosterone-secreting adrenocortical tumor in a pubertal girl. Case report and review of the literature. Horm Res 30: 217-223, 1988.
65. Wagner AS, Fleitz JM and Kleinschmidt-Demasters BK: Pediatric adrenal cortical carcinoma: brain metastases and relationship to NF-1, case reports and review of the literature. J Neurooncol 75: 127-133, 2005.
66. Wong LM, Li CH, Chan OK, Shek CC and Kwong NS: A 12-year-old Chinese girl with Cushing syndrome and virilization due to adrenocortical carcinoma. J Pediatr Endocrinol Metab 24: 193-196, 2011.