Adrenal cortical neoplasms in children: Why so many carcinomas and yet so many survivors?

Pediatric and Developmental Pathology

Volumn 12, Issue 4, 2009, Pages 284-291

  Dehner, Louis P ^a   Hill, D Ashley ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Adrenal gland; Adrenocortical adenoma; Adrenocortical carcinoma; Beckwith wiedemann syndrome; Li fraumeni syndrome; P53

Indexed keywords

ADRENAL CORTEX CARCINOMA; ADRENALECTOMY; CANCER RISK; CANCER STAGING; CANCER SURVIVAL; HISTOPATHOLOGY; HUMAN; METASTASIS; MICROSCOPY; MOLECULAR GENETICS; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROGNOSIS; REVIEW; RISK ASSESSMENT; TUMOR LOCALIZATION; TUMOR VOLUME;

ADRENAL CORTEX NEOPLASMS; ADRENOCORTICAL CARCINOMA; BECKWITH-WIEDEMANN SYNDROME; CHILD, PRESCHOOL; HUMANS; INFANT; INFANT, NEWBORN; LI-FRAUMENI SYNDROME; NEOPLASM STAGING; PROGNOSIS; RISK ASSESSMENT; SURVIVORS;

EID: 70049118855     PISSN: 10935266     EISSN: 16155742     Source Type: Journal    
DOI: 10.2350/08-06-0489.1     Document Type: Review

References (61)

1. Allolio B, Fassnacht M. Adrenocortical carcinoma: clinical update. J Clin Endocrinol Metab 2006;91:2027-2037.
2. Icard P, Goudet P, Charpenay C, et al. Adrenocortical carcinomas: surgical trends and results of a 253-patient series from the French Association of Endocrine Surgeons study group. World J Surg 2001;25:891-897. (Pubitemid 32666390)
3. Stojadinovic A, Ghossein RA, Hoss A, et al. Adrenocortical carcinoma: clinical, morphologic, and molecular characterization. J Clin Oncol 2002;20:941-950. (Pubitemid 34141836)
4. Paton BL, Novitsky YW, Zerey M, et al. Outcome of adrenal cortical carcinoma in the United States. Surgery 2006;140:914-920. (Pubitemid 44937380)
5. Wajchenberg BL, Pereira MA, Medonca BB, et al. Adrenocortical carcinoma. Clinical and laboratory observations. Cancer 2000;88:711-736.
6. Norton JA. Adrenal tumors. In: Devita VT, Hellman S, Rosenberg SA, eds. Cancer: Principles and Practices of Oncology, 7th ed. Philadelphia: Lippincott Williams & Wilkins, 2005;1528-1540.
7. Koch CA, Pacak IC, Chroosos GP. Endocrine tumors. In: Pizzo PA, Poplack DG, eds. Principles and Practice of Pediatric Oncology, 4th ed. Philadelphia: Lippincott Williams & Wilkins, 2002;1130-1133.
8. Driver CP, Birch J, Gough DC, Bruce J. Adrenal cortical tumors in childhood. Pediatr Hematol Oncol 1998;15:527-532.
9. McDonnell CM, Zacharin MR. Adrenal cortical tumours: 25 years' experience at the Royal Children's Hospital, Melbourne. J Paediatr Child Health 2003;39:682-685.
10. Lack EE, Mulvihill JJ, Travis WD, Kozakewich HP. Adrenal cortical neoplasms in the pediatric and adolescent age group. Clinicopathologic study of 30 cases with emphasis on epidemiological and prognostic factors. Pathol Annu 1992;27(Pt 1):1-53.
11. Narasimhan KL, Samujh R, Bhansali A, et al. Adrenocortical tumors in childhood. Pediatr Surg Int 2003;19:432-435.
12. Liou LS, Kay R. Adrenocortical carcinoma in children. Review and recent innovations. Urol Clin North Am 2000;27:403-421.
13. Ciftci AO, Senocak ME, Tanyel FC, Buyukpamukcu N. Adrenocortical tumors in children. J Pediatr Surg 2001;36:549-554.
14. Ribeiro RC, Figueiredo B. Childhood adrenocortical tumours. Eur J Cancer 2004;40:1117-1126.
15. Hartley AL, Birch JM, Marsden HB, Reid H, Harris M, Blair V. Adrenal cortical tumours: epidemiological and familial aspects. Arch Dis Child 1987;62:683-689.
16. McWhirter WR, Stiller CA, Lennox EL. Carcinomas in childhood. A registry-based study of incidence and survival. Cancer 1989;63:2242-2246.
17. al-Sheyyab M, Muir KR, Cameron AH, et al. Malignant epithelial tumours in children: incidence and aetiology. Med Pediatr Oncol 1993;21:421-428.
18. Ries LAG, Percy CL, Bunin GR. In: Ries LAG, Smith MA, Gurnet JG, et al., eds. Cancer Incidence and Survival among Children and Adolescents: United States SEER Program 1975-1995, National Cancer Institute, SEER Program. National Institutes of Health publication No. 99-4649. Bethesda: National Institutes of Health, 1999;1-15.
19. Sandrini R, Ribeiro RC, DeLacerda L. Childhood adrenocortical tumors. J Clin Endocrinol Metab 1997;82:2027-2031.
20. Bernstein L, Gurney JG. Carcinomas and other malignant epithelial neoplasms. In: Ries LAG, Smith MA, Gurney JG, et al., eds. Cancer Incidence and Survival among Children and Adolescents: United States SEER Program 1975-1995, National Cancer Institute, SEER Program. National Institutes of Health Publication No. 99-4649. Bethesda: National Institutes of Health, 1999;139-147.
21. Stojadinovic A, Ghossein RA, Hoos A, et al. Adrenocortical carcinoma: clinical, morphologic, and molecular characterization. J Clin Oncol 2002;20:941-950. (Pubitemid 34141836)
22. Thompson LD. Pheochromocytoma of the Adrenal gland Scaled Score (PASS) to separate benign from malignant neoplasms: a clinicopathologic and immunophenotypic study of 100 cases. Am J Surg Pathol 2002;26:551-566.
23. Elder EE, Xu D, Hoog A, et al. KI-67 and hTERT expression can aid in the distinction between malignant and benign pheochromocytoma and paraganglioma. Mod Pathol 2003;16:246-255. (Pubitemid 36337431)
24. Kimura N, Watanabe T, Noshiro T, Shizawa S, Miura Y. Histological grading of adrenal and extra-adrenal pheochromocytomas and relationship to prognosis: a clinicopathological analysis of 116 adrenal pheochromocytomas and 30 extra-adrenal sympathetic paragangliomas including 38 malignant tumors. Endocr Pathol 2005;16:23-32. (Pubitemid 41278311)
25. Brown HM, Komorowski RA, Wilson SD, Demeure MJ, Zhu YR. Predicting metastasis of pheochromocytomas using DNA flow cytometry and immunohistochemical markers of cell proliferation: a positive correlation between MIB-1 staining and malignant tumor behavior. Cancer 1999;86:1583-1589.
26. Gupta D, Shidham V, Holden J, Layfield L. Prognostic value of immunohistochemical expression of topoisomerase alpha II, MIB-1, p53, E-cadherin, retinoblastoma gene protein product, and HER-2/neu in adrenal and extra-adrenal pheochromocytomas. Appl Immunohistochem Mol Morphol 2000;8:267-274.
27. August C, August K, Schroeder S, et al. CGH and CD 44/MIB-1 immunohistochemistry are helpful to distinguish metastasized from nonmetastasized sporadic pheochromocytomas. Mod Pathol 2004;17:1119-1128. (Pubitemid 39128238)
28. Wachenfeld C, Beuschlein F, Zwermann O, et al. Discerning malignancy in adrenocortical tumors: are molecular markers useful? Eur J Endocrinol 2001;145:335-341.
29. Stojadinovic A, Brennan MF, Hoos A, et al. Adrenocortical adenoma and carcinoma: histopathological and molecular comparative analysis. Mod Pathol 2003;16:742-751. (Pubitemid 37011068)
30. Hough AJ, Hollifield JW, Page DL, Hartmann WH. Prognostic factors in adrenal cortical tumors. A mathematical analysis of clinical and morphologic data. Am J Clin Pathol 1979;72:390-399.
31. Van Slooten H, Schaberg A, Smeenk D, Moolenaar AJ. Morphologic characteristics of benign and malignant adrenocortical tumors. Cancer 1985;55:766-773. (Pubitemid 15173514)
32. Cagle PT, Hough AJ, Pysher T, et al. Comparison of adrenal cortical tumors in children and adults. Cancer 1986;57:2235-2237. (Pubitemid 16121763)
33. Weiss LM, Medeiros LJ, Vickery AL Jr. Pathologic features of prognostic significance in adrenocortical carcinoma. Am J Surg Pathol 1989;13:202-206. (Pubitemid 19081702)
34. Evans HL, Vassilopoulou-Sellin R. Adrenal cortical neoplasms. A study of 56 cases. Am J Clin Pathol 1996;105:76-86. (Pubitemid 26024771)
35. Sbragia L, Oliveira-Filho AG, Vassallo J, et al. Adrenocortical tumors in Brazilian children. Immunohistochemical markers and prognostic features. Arch Pathol Lab Med 2005;129:1127-1131.
36. Blanes J, Diaz-Cano SJ. Histologic criteria for adrenocortical proliferative lesions. Value of mitotic figure variability. Am J Clin Pathol 2007;127:398-408.
37. Michalkiewicz E, Sandrini R, Figueiredo B, et al. Clinical outcome characteristics of children with adrenocortical tumors: a report from the International Pediatric Adrenocortical Tumor Registry. J Clin Oncol 2004;22:838-845. (Pubitemid 41103595)
38. Wieneke JA, Thompson L, Heffess CS. Adrenal cortical neoplasms in the pediatric population. Am J Surg Pathol 2003;27:867-881.
39. Sturgeon C, ShenWT, ClarkOH,DuhQY,KebebewE. Risk assessment in 457 adrenal cortical carcinomas: how much does tumor size predict the likelihood of malignancy? J Am Coll Surg 2006;202:423-430.
40. Greene FL, Page DL, Fleming ID, Fritz AG, Haller DG, Morrow M. AJCCCancer StagingManual, 6th ed.NewYork: Springer-Verlag, 2002.
41. Lack EE. Tumors of the Adrenal Gland and Extra-Adrenal Paraganglia. Washington, DC: Armed Forces Institute of Pathology, 1997;123-168.
42. Tucci S Jr, Martins A, Suaid H, et al. The impact of tumor stage on prognosis in children with adrenocortical carcinoma. J Urol 2005;174:2338-2342. (Pubitemid 41611817)
43. Mayer SK, Oligny LL, Yazbeck S, et al. Childhood adrenocortical tumors: case series and reevaluation of prognosis - a 24-year experience. J Pediatr Surg 1997;32:911-915. (Pubitemid 27264058)
44. Stewart JN, Flageole H, Kavan P. A surgical approach to adrenocortical tumors in children: the mainstay of treatment. J Pediatr Surg 2004;39:759-763. (Pubitemid 38637930)
45. Parlowsky T, Bucksy P, Hof M, et al. Malignant endocrine tumors in childhood and adolescence-results of a retrospective analysis. Klin Padiatr 1996;208:205-209. (Pubitemid 26246752)
46. Driver CP, Birch J, Gough DC, et al. Adrenal cortical tumors in childhood. Pediatr Hematol Oncol 1998;15:527-532.
47. Ciftci AO, Senocak ME, Tanyel FC, et al. Adrenocortical tumors in children. J Pediatr Surg 2001;36:549-554.
48. Bergada I,Venara M, Maglio S, et al. Functional adrenal cortical tumors in pediatric patients: a clinicopathologic and immunohistochemical study of a long term follow-up series. Cancer 1996;77:771-777. (Pubitemid 26055404)
49. Dehner LP. Pediatric adrenocortical neoplasms. On the road to some clarity. Am J Surg Pathol 2003;27:1005-1007.
50. Grundy PE, Green DM, Coppes MJ, et al. Renal tumors: In: Pizzo PA, Poplack DG, eds. Principles and Practice of Pediatric Oncology, 4th ed. Philadelphia: Lippincott Williams & Wilkins, 2002;865-893.
51. Choi SH, Kim SM, Oh JT, et al. Solid pseudopapillary tumor of the pancreas: a multicenter study of 23 pediatric cases. J Pediatr Surg 2006;41:1992-1995. (Pubitemid 44854963)
52. Vassal G, Flamant F, Caillaud JM, et al. Juvenile granulosa cell tumor of the ovary in children: a clinical study of 15 cases. J Clin Oncol 1988;6:990-995. (Pubitemid 18151189)
53. Sutter JA, Grimberg A. Adrenocortical tumors and hyperplasias in childhood - etiology, genetics, clinical presentation and therapy. Pediatr Endocrinol Rev 2006;4:32-39. (Pubitemid 44519170)
54. Olivier M, Goldgar DE, Sodha N, et al. Li-Fraumeni and related syndromes: correlation between tumor type, family structure, and TP53 genotype. Cancer Res 2003;63:6643-6650. (Pubitemid 37322942)
55. Figueiredo BC, Sandrini R, Zambetti GP, et al. Penetrance of adrenocortical tumours associated with germline R337H mutation. J Med Genet 2006;43:91-96. (Pubitemid 43099998)
56. Barlaskar FM, Hammer GD. The molecular genetics of adrenocortical carcinoma. Rev Endocr Metab Disord 2007;8:343-348.
57. Almeida MQ, Latronico AC. The molecular pathogenesis of childhood adrenocortical tumors. Horm Metab Res 2007;39:431-466.
58. Varley JM, McGown G, Thorncroft M, et al. Are there low-penetrance TP53 alleles? Evidence from childhood adrenocortical tumors. Am J Hum Genet 1999;65:995-1006. (Pubitemid 30462956)
59. Orozco-Florian R, McBride JA, Favara BE, et al. Congenital hepatoblastoma and Beckwith-Wiedemann syndrome: a case study including DNA ploidy profiles of tumor and adrenal cytomegaly. Pediatr Pathol 1991;11:131-142.
60. Cooper WN, Luharia A, Evans GA, et al. Molecular subtypes and phenotypic expression of Beckwith-Wiedemann syndrome. Eur J Hum Genet 2005;13:1025-1032. (Pubitemid 43073609)
61. Wilkin F, Gagne N, Paquette J, et al. Pediatric adrenocortical tumors: molecular events leading to insulin-like growth factor II gene overexpression. J Clin Endocrinol Metab 2000;85:2048-2056. (Pubitemid 32269319)