Elevated expression level of long noncoding RNA MALAT-1 facilitates cell growth, migration and invasion in pancreatic cancer

Oncology Reports

Volumn 32, Issue 6, 2014, Pages 2485-2492

  Jiao, Feng ^a   Hu, Hai ^a   Yuan, Cuncun ^a   Wang, Lei ^a   Jiang, Weihua ^a   Jin, Ziliang ^a   Guo, Zhen ^a   Wang, Liwei ^a  

^a SHANGHAI FIRST PEOPLE S HOSPITAL   (China)

Author keywords

Epithelial mesenchymal transition; Invasion; Long noncoding RNA; Metastasis associated lung adenocarcinoma transcript 1; Pancreatic cancer

Indexed keywords

ALDEHYDE DEHYDROGENASE; CD24 ANTIGEN; HERMES ANTIGEN; LONG UNTRANSLATED RNA; METASTASIS ASSOCIATED LUNG ADENOCARCINOMA TRANSCRIPT 1; UNCLASSIFIED DRUG; MALAT1 LONG NON-CODING RNA, HUMAN; TUMOR MARKER;

APOPTOSIS; ARTICLE; CANCER GROWTH; CANCER STEM CELL; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; PANCREAS CANCER; PANCREATIC CANCER CELL LINE; TUMOR GROWTH; UPREGULATION; CELL MOTION; GENE EXPRESSION; GENETICS; METABOLISM; PANCREAS TUMOR; PATHOLOGY; TUMOR CELL LINE; TUMOR INVASION;

APOPTOSIS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; EPITHELIAL-MESENCHYMAL TRANSITION; G2 PHASE CELL CYCLE CHECKPOINTS; GENE EXPRESSION; HUMANS; NEOPLASM INVASIVENESS; NEOPLASTIC STEM CELLS; PANCREATIC NEOPLASMS; RNA, LONG NONCODING; TUMOR MARKERS, BIOLOGICAL; UP-REGULATION;

EID: 84914688056     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2014.3518     Document Type: Article

References (22)

1. Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin 61: 69-90, 2011.
2. He Y, Meng XM, Huang C, Wu BM, Zhang L, Lv XW and Li J: Long noncoding RNAs: novel insights into hepatocelluar carcinoma. Cancer Lett 344: 20-27, 2014.
3. Ji P, Diederichs S, Wang W, Böing S, Metzger R, Schneider PM, Tidow N, Brandt B, Buerger H, Bulk E, Thomas M, Berdel WE, Serve H and Müller-Tidow C: MALAT-1, a novel noncoding RNA, and thymosin beta4 predict metastasis and survival in early-stage non-small cell lung cancer. Oncogene 22: 8031-8041, 2003.
4. Gutschner T, Hämmerle M and Diederichs S: MALAT1 - a paradigm for long noncoding RNA function in cancer. J Mol Med (Berl) 91: 791-801, 2013.
5. Thon JN, Devine MT, Jurak Begonja A, Tibbitts J and Italiano JE Jr: High-content live-cell imaging assay used to establish mechanism of trastuzumab emtansine (T-DM1)-mediated inhibition of platelet production. Blood 120: 1975-1984, 2012.
6. 2/M cell-cycle arrest and apoptosis. Cancer Sci 101: 1226-1233, 2010.
7. 2/M transition. Mol Biotechnol 32: 227-248, 2006.
8. Ayyagari VN and Brard L: Bithionol inhibits ovarian cancer cell growth in vitro - studies on mechanism(s) of action. BMC Cancer 14: e61, 2014.
9. Pan JJ and Yang MH: The role of epithelial-mesenchymal transition in pancreatic cancer. J Gastrointest Oncol 2: 151-156, 2011.
10. Min C, Eddy SF, Sherr DH and Sonenshein GE: NF-kappaB and epithelial to mesenchymal transition of cancer. J Cell Biochem 104: 733-744, 2008.
11. Mani SA, Guo W, Liao MJ, Eaton EN, Ayyanan A, Zhou AY, Brooks M, Reinhard F, Zhang CC, Shipitsin M, Campbell LL, Polyak K, Brisken C, Yang J and Weinberg RA: The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 133: 704-715, 2008.
12. Lee CJ, Dosch J and Simeone DM: Pancreatic cancer stem cells. J Clin Oncol 26: 2806-2812, 2008.
13. Rasheed ZA, Yang J, Wang Q, Kowalski J, Freed I, Murter C, Hong SM, Koorstra JB, Rajeshkumar NV, He X, Goggins M, Iacobuzio-Donahue C, Berman DM, Laheru D, Jimeno A, Hidalgo M, Maitra A and Matsui W: Prognostic significance of tumorigenic cells with mesenchymal features in pancreatic adenocarcinoma. J Natl Cancer Inst 102: 340-351, 2010.
14. Maruyama R and Suzuki H: Long noncoding RNA involvement in cancer. BMB Rep 45: 604-611, 2012.
15. Lai MC, Yang Z, Zhou L, Zhu QQ, Xie HY, Zhang F, Wu LM, Chen LM and Zheng SS: Long non-coding RNA MALAT-1 overexpression predicts tumor recurrence of hepatocellular carcinoma after liver transplantation. Med Oncol 29: 1810-1816, 2012.
16. Wang J, Su L, Chen X, Li P, Cai Q, Yu B, Liu B, Wu W and Zhu Z: MALAT1 promotes cell proliferation in gastric cancer by recruiting SF2/ASF. Biomed Pharmacother 68: 557-564, 2014.
17. Wu XS, Wang XA, Wu WG, Hu YP, Li ML, Ding Q, Weng H, Shu YJ, Liu TY, Jiang L, Cao Y, Bao RF, Mu JS, Tan ZJ, Tao F and Liu YB: MALAT1 promotes the proliferation and metastasis of gallbladder cancer cells by activating the ERK/MAPK pathway. Cancer Biol Ther 15: 806-814, 2014.
18. Liu JH, Chen G, Dang YW, Li CJ and Luo DZ: Expression and prognostic significance of lncRNA MALAT1 in pancreatic cancer tissues. Asian Pac J Cancer Prev 15: 2971-2977, 2014.
19. Łukaszewicz M, Mroczko B and Szmitkowski M: The role of metalloproteinases and their inhibitors in pancreatic cancer. Postepy Hig Med Dosw (Online) 62: 141-147, 2008 (In Polish).
20. Li Y, Kong D, Ahmad A, Bao B and Sarkar FH: Pancreatic cancer stem cells: emerging target for designing novel therapy. Cancer Lett 338: 94-100, 2013.
21. Sarkar FH, Li Y, Wang Z and Kong D: Pancreatic cancer stem cells and EMT in drug resistance and metastasis. Minerva Chir 64: 489-500, 2009.
22. Thiery J P, Acloque H, Huang RY and Nieto MA: Epithelial-mesenchymal transitions in development and disease. Cell 139: 871-890, 2009.