Effects of tiotropium on hyperinflation and treadmill exercise tolerance in mild to moderate chronic obstructive pulmonary disease

Annals of the American Thoracic Society

Volumn 11, Issue 9, 2014, Pages 1351-1361

  Casaburi, Richard ^a   Maltais, François ^b   Porszasz, Janos ^a   Albers, Frank ^c   Deng, Qiqi ^c   Iqbal, Ahmar ^d   Paden, Heather A ^c   O'Donnell, Denis E ^e  

^a HARBOR UCLA MEDICAL CENTER   (United States)

^b LAVAL UNIVERSITY   (Canada)

^c BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

^d PFIZER INC   (United States)

^e QUEEN S UNIVERSITY   (Canada)

Author keywords

Chronic obstructive pulmonary disease; Dynamic hyperinflation; Dyspnea; Global initiative for chronic obstructive lung disease; Inspiratory capacity

Indexed keywords

PLACEBO; TIOTROPIUM BROMIDE; BRONCHODILATING AGENT; SCOPOLAMINE DERIVATIVE;

ADULT; ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG EFFICACY; DYSPNEA; EXERCISE TEST; EXERCISE TOLERANCE; FEMALE; HUMAN; HYPERINFLATION; INSPIRATORY CAPACITY; LUNG FUNCTION TEST; MAJOR CLINICAL STUDY; MALE; RANDOMIZED CONTROLLED TRIAL; TREADMILL EXERCISE; CLINICAL TRIAL; MIDDLE AGED; MULTICENTER STUDY; PATHOPHYSIOLOGY; PHYSIOLOGY; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SEVERITY OF ILLNESS INDEX;

BRONCHODILATOR AGENTS; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; EXERCISE TOLERANCE; FEMALE; HUMANS; INSPIRATORY CAPACITY; MALE; MIDDLE AGED; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SCOPOLAMINE DERIVATIVES; SEVERITY OF ILLNESS INDEX;

EID: 84914678627     PISSN: 23296933     EISSN: 23256621     Source Type: Journal    
DOI: 10.1513/AnnalsATS.201404-174OC     Document Type: Article

References (26)

1. World Health Organization. The global burden of disease: 2004 update. 2008 [accessed 2014 Mar 3]. Available from: http://www.who.int/healthinfo/global-burden-disease/GBD-report-2004update-full.pdf.
2. Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. 2014 Jan [accessed 2014 Mar 3]. Available from: http://www.goldcopd.org/Guidelines/guidelinesresources.html.
3. O'Donnell DE, Laveneziana P, Ora J, Webb KA, Lam YM, Ofir D. Evaluation of acute bronchodilator reversibility in patients with symptoms of GOLD stage I COPD. Thorax 2009;64:216-223.
4. Ofir D, Laveneziana P, Webb KA, Lam YM, O'Donnell DE. Mechanisms of dyspnea during cycle exercise in symptomatic patients with GOLD stage I chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2008;177:622-629.
5. O'Donnell DE, Maltais F, Porszasz J, Webb KA, Albers FC, Deng Q, Iqbal A, Paden HA, Casaburi R; 205.440 investigators. The continuum of physiological impairment during treadmill walking in patients with mild-to-moderate COPD: patient characterization phase of a randomized clinical trial. PLoS ONE 2014;9:e96574.
6. Decramer M, Rennard S, Troosters T, Mapel DW, Giardino N, Mannino D, Wouters E, Sethi S, Cooper CB. COPD as a lung disease with systemic consequences-clinical impact, mechanisms, and potential for early intervention. COPD 2008;5:235-256.
7. Troosters T, Sciurba F, Battaglia S, Langer D, Valluri SR, Martino L, Benzo R, Andre D, Weisman I, Decramer M. Physical inactivity in patients with COPD, a controlled multi-center pilot-study. Respir Med 2010;104:1005-1011.
8. McDonough JE, Yuan R, Suzuki M, Seyednejad N, Elliott WM, Sanchez PG, Wright AC, Gefter WB, Litzky L, Coxson HO, et al. Small-airway obstruction and emphysema in chronic obstructive pulmonary disease. N Engl J Med 2011;365:1567-1575.
9. Belfer MH, Reardon JZ. Improving exercise tolerance and quality of life in patients with chronic obstructive pulmonary disease. J Am Osteopath Assoc 2009;109:268-278.
10. Garcia-Aymerich J, Lange P, Benet M, Schnohr P, Antó JM. Regular physical activity modifies smoking-related lung function decline and reduces risk of chronic obstructive pulmonary disease: A population based cohort study. Am J Respir Crit Care Med 2007;175:458-463.
11. Waschki B, Kirsten A, Holz O, Müller KC, Meyer T, Watz H, Magnussen H. Physical activity is the strongest predictor of all-cause mortality in patients with COPD: A prospective cohort study. Chest 2011;140: 331-342.
12. Moy ML, Teylan M, Weston NA, Gagnon DR, Garshick E. Daily step count predicts acute exacerbations in a US cohort with COPD. PLoS ONE 2013;8:e60400.
13. O'Donnell DE, Flüge T, Gerken F, Hamilton A, Webb K, Aguilaniu B, Make B, Magnussen H. Effects of tiotropium on lung hyperinflation, dyspnoea and exercise tolerance in COPD. Eur Respir J 2004;23: 832-840.
14. Verkindre C, Bart F, Aguilaniu B, Fortin F, Gué rin JC, Le Merre C, Iacono P, Huchon G. The effect of tiotropium on hyperinflation and exercise capacity in chronic obstructive pulmonary disease. Respiration 2006;73:420-427.
15. Maltais F, Hamilton A, Marciniuk D, Hernandez P, Sciurba FC, Richter K, Kesten S, O'Donnell D. Improvements in symptom-limited exercise performance over 8 h with once-daily tiotropium in patients with COPD. Chest 2005;128:1168-1178.
16. Casaburi R, Maltais F, Porszasz J, Albers F, Deng Q, Iqbal A, Paden H, O'Donnell D. The effect of tiotropium on lung dynamic hyperinflation and treadmill exercise capacity in mild to moderate COPD [abstract]. Abstract P2100. Eur Respir J 2012;40:375s.
17. Casaburi R, Paden H, Deng Q, Iqbal A. Effects of mild-to-moderate chronic obstructive pulmonary disease on exercise responses and activity and the impact of treatment with tiotropium bromide. Presented at the American Association of Cardiovascular and Pulmonary Rehabilitation (AACVPR) 28th Annual Meeting, October 3-5, 2013, Nashville, TN.
18. Mahler DA, Weinberg DH, Wells CK, Feinstein AR. The measurement of dyspnea. Contents, inter observer agreement, and physiologic correlates of two new clinical indexes. Chest 1984;85:751-758.
19. Quanjer PH, Tammeling GJ, Cotes JE, Pedersen OF, Peslin R, Yernault JC; Official Statement of the European Respiratory Society. Lung volumes and forced ventilatory flows. Report Working Party Standardization of Lung Function Tests, European Community for Steel and Coal. Eur Respir J Suppl 1993;16:5-40.
20. Porszasz J, Casaburi R, Somfay A, Woodhouse LJ, Whipp BJ. A treadmill ramp protocol using simultaneous changes in speed and grade. Med Sci Sports Exerc 2003;35:1596-1603.
21. Mapel DW, Dalal AA, Blanchette CM, Petersen H, Ferguson GT. Severity of COPD at initial spirometry-confirmed diagnosis: data from medical charts and administrative claims. Int J Chron Obstruct Pulmon Dis 2011;6:573-581.
22. Casaburi R, Kukafka D, Cooper CB, Witek TJ Jr, Kesten S. Improvement in exercise tolerance with the combination of tiotropium and pulmonary rehabilitation in patients with COPD. Chest 2005;127:809-817.
23. Gagnon P, Saey D, Provencher S, Milot J, Bourbeau J, Tan WC, Martel S, Maltais F. Walking exercise response to bronchodilation in mild COPD: A randomized trial. Respir Med 2012;106:1695-1705.
24. Morgan MD, Singh SJ. Assessing the exercise response to a bronchodilator in COPD: Time to get off your bike? Thorax 2007;62:281-283.
25. Cooper CB, Abrazado M, Legg D, Kesten S. Development and implementation of treadmill exercise testing protocols in COPD. Int J Chron Obstruct Pulmon Dis 2010;5:375-385.
26. Casaburi R. Factors determining constant work rate exercise tolerance in COPD and their role in dictating the minimal clinically important difference in response to interventions. COPD 2005;2:131-136.