Lack of nephroprotective efficacy of Althaea officinalis flower extract against gentamicin renal toxicity in male rats

International Journal of Preventive Medicine

Volumn 5, Issue 11, 2014, Pages 1360-1363

  Talebi, Ardeshir ^a   Karimi, Amirhossein ^b   Ouguerram, Khadija ^b   Vahidi Ataabadi, Nasrin ^a   Eshraghi Jazi, Fatemeh ^a   Mansouri, Azam ^a   Nematbakhsh, Mehdi ^a,c  

^a ISFAHAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b UNIVERSITÉ DE NANTES   (France)

^c Isfahan MN Institute of Basic and Applied Sciences Research   (Iran)

Author keywords

Althaea officinalis; Gentamicin; Nephrotoxicity; Rat

Indexed keywords

ALTHAEA OFFICINALIS FLOWER EXTRACT; ANTIOXIDANT; CREATININE; GENTAMICIN; PLANT EXTRACT; UNCLASSIFIED DRUG;

ADULT; ALTHAEA; ALTHAEA OFFICINALIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DOSE RESPONSE; DRUG MEGADOSE; FLOWER; HISTOPATHOLOGY; KIDNEY INJURY; LOW DRUG DOSE; MALE; NEPHROTOXICITY; NONHUMAN; RAT; RENAL PROTECTION; UREA NITROGEN BLOOD LEVEL;

EID: 84914169503     PISSN: 20087802     EISSN: 20088213     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Kagan BM. Gentamicin in the treatment of gram-negative infections. Calif Med 1970;112:60-1.
2. Noone P, Parsons TM, Pattison JR, Slack RC, Garfield-Davies D, Hughes K. Experience in monitoring gentamicin therapy during treatment of serious gramnegative sepsis. Br Med J 1974;1:477-81.
3. Tavafi M. Protection of renal tubules against gentamicin induced nephrotoxicity. J Ren Inj Prev 2013;2:5-6.
4. Walker PD, Shah SV. Evidence suggesting a role for hydroxyl radical in gentamicin-induced acute renal failure in rats. J Clin Invest 1988;81:334-41.
5. rd, DeFehr JM, Bennett WM, Porter G, Gilbert D. Gentamicin and tobramycin nephrotoxicity. A morphologic and functional comparison in the rat. Am J Pathol 1978;93:137-52.
6. Karaha n I, Atessahin A, Yilmaz S, Ceribasi AO, Sakin F. Protective effect of lycopene on gentamicin-induced oxidative stress and nephrotoxicity in rats. Toxicology 2005;215:198-204.
7. Pedraz a-Chaverrí J, Maldonado PD, Medina-Campos ON, Olivares-Corichi IM, Granados-Silvestre MA, Hernández-Pando R, et al. Garlic ameliorates gentamicin nephrotoxicity: Relation to antioxidant enzymes. Free Radic Biol Med 2000;29:602-11.
8. Rafieian -Kopaei M, Baradaran A, Merrikhi A, Nematbakhsh M, Madihi Y, Nasri H. Efficacy of co-administration of garlic extract and metformin for prevention of gentamicin-renal toxicity in wistar rats: A biochemical study. Int J Prev Med 2013;4:258-64.
9. Abdel-Na im AB, Abdel-Wahab MH, Attia FF. Protective effects of vitamin e and probucol against gentamicin-induced nephrotoxicity in rats. Pharmacol Res 1999;40:183-7.
10. Rafieia n-Kopaei M, Nasri H, Nematbakhsh M, Baradaran A, Gheissari A, Rouhi H, et al. Erythropoietin ameliorates genetamicin-induced renal toxicity: A biochemical and histopathological study. J Nephropathol 2012;1:109-16.
11. Naidu M U, Shifow AA, Kumar KV, Ratnakar KS. Ginkgo biloba extract ameliorates gentamicin-induced nephrotoxicity in rats. Phytomedicine 2000;7:191-7.
12. Sharma RK, Rajani G, Sharma V, Komala N. Effect of ethanolic and aqueous extracts of Bauhinia variegata Linn. On gentamicin-induced nephrotoxicity in rats. Indian J Pharm Educ Res 2011;45:192-8.
13. Shirwai kar A, Malini S, Kumari SC. Protective effect of Pongamia pinnata flowers against cisplatin and gentamicin induced nephrotoxicity in rats. Indian J Exp Biol 2003;41:58-62.
14. El-Ashm awy IM, El-Nahas AF, Salama OM. Grape seed extract prevents gentamicin-induced nephrotoxicity and genotoxicity in bone marrow cells of mice. Basic Clin Pharmacol Toxicol 2006;99:230-6.
15. Elmasta s M, Ozturk L, Gokce I, Erenler R, Aboul-Enein HY. Determination of antioxidant activity of marshmallow flower (Althaea officinalis L.). Anal Lett 2004;37:1859-69.
16. Shah S, Akhtar N, Akram M, Shah PA, Saeed T, Ahmed K, et al. Pharmacological activity of Althaea officinalis L. J Med Plants Res 2011;5:5662-6.
17. Hage-Sl eiman R, Mroueh M, Daher CF. Pharmacological evaluation of aqueous extract of Althaea officinalis flower grown in Lebanon. Pharm Biol 2011;49:327-33.
18. Valiei M, Shafaghat A, Salimi F. Chemical composition and antimicrobial activity of the flower and root hexane extracts of Althaea officinalis in Northwest Iran. J Med Plants Res 2011;5:6972-6.
19. Romero F, Pérez M, Chávez M, Parra G, Durante P. Effect of uric acid on gentamicin-induced nephrotoxicity in rats-role of matrix metalloproteinases 2 and 9. Basic Clin Pharmacol Toxicol 2009;105:416-24.
20. Zhou Y, V aidya VS, Brown RP, Zhang J, Rosenzweig BA, Thompson KL, et al. Comparison of kidney injury molecule-1 and other nephrotoxicity biomarkers in urine and kidney following acute exposure to gentamicin, mercury, and chromium. Toxicol Sci 2008;101:159-70.
21. Padmini M P, Kumar JV. A histopathological study on gentamycin induced nephrotoxicity in experimental albino rats. IOSR J Dent Med Sci 2012;1:14-7.
22. Erdem A, Gündogan NU, Usubütün A, Kilinç K, Erdem SR, Kara A, et al. The protective effect of taurine against gentamicin-induced acute tubular necrosis in rats. Nephrol Dial Transplant 2000;15:1175-82.
23. rd , Pastor-Barriuso R, Dalal D, Riemersma RA, Appel LJ, Guallar E. Meta-analysis: High-dosage vitamin E supplementation may increase all-cause mortality. Ann Intern Med 2005;142:37-46.
24. Bairati I, Meyer F, Jobin E, Gélinas M, Fortin A, Nabid A, et al. Antioxidant vitamins supplementation and mortality: A randomized trial in head and neck cancer patients. Int J Cancer 2006;119:2221-4.