Computer simulations and in vivo convection-enhanced delivery of fluorescent nanoparticles demonstrate variable distribution geometry

Computers and Chemical Engineering

Volumn 71, Issue , 2014, Pages 672-676

  Lueshen, Eric ^a   LaRiviere, Michael ^b   Yamini, Bakhtiar ^b   Linninger, Andreas ^a  

^a University of Illinois at Chicago   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

Blood brain barrier; Brain cancer; Convection enhanced delivery; Drug delivery; Nanoparticles

Indexed keywords

BLOOD; CATHETERS; CONTROLLED DRUG DELIVERY; DIFFUSION TENSOR IMAGING; DRUG DELIVERY; FLUORESCENCE; FLUORESCENCE MICROSCOPY; GEOMETRY; MAGNETIC RESONANCE IMAGING; NANOPARTICLES; RATS; TENSORS; TISSUE;

BLOOD-BRAIN BARRIER; BRAIN CANCER; CONVECTION ENHANCED DELIVERIES (CED); CONVECTION-ENHANCED DELIVERY; DISTRIBUTION PATTERNS; FLUORESCENT NANOPARTICLES; NON-UNIFORM DISTRIBUTION; VARIABLE DISTRIBUTION;

TARGETED DRUG DELIVERY;

EID: 84914167645     PISSN: 00981354     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.compchemeng.2014.09.008     Document Type: Article

References (27)

1. Allard E., Passirani C., Benoit J.-P. Convection-enhanced delivery of nanocarriers for the treatment of brain tumors. Biomaterials 2009, 30:2302-2318.
2. Bobo R.H., Laske D.W., Akbasak A., Morrison P.F., Dedrick R.L., Oldfield E.H. Convection-enhanced delivery of macromolecules in the brain. Proc Natl Acad Sci U S A 1994, 91:2076-2208.
3. Chen M.Y., Lonser R.R., Morrison P.F., Governale L.S., Oldfield E.H. Variables affecting convection-enhanced delivery to the striatum: a systematic examination of rate of infusion, cannula size, infusate concentration and tissue-cannula sealing time. J Neurosurg 1999, 90:315-320.
4. Hadaczek P., Yamashita Y., Mirek H., Tamas L., Bohn M.C., Noble C., et al. The perivascular pump driven by arterial pulsation is a powerful mechanism for the distribution of therapeutic molecules within the brain. Mol Ther 2006, 14:69-78.
5. Hamilton J.F., Morrison P.F., Chen M.Y., Harvey-White J., Pernaute R.S., Phillips H., et al. Heparin coinfusion during convection-enhanced delivery (CED) increases the distribution of the glial-derived neurotrophic factor (GDNF) ligand family in rat striatum and enhances the pharmacological activity of neurturin. Exp Neurol 2001, 168:155-161.
6. Herdeg C., Oberhoff M., Baumbach A., Haase K.K., Horch B., Kranzhoefer A., et al. Local drug delivery with porous balloons in the rabbit: assessment of vascular injury for an improvement of application parameters. Cathet Cardiovasc Diagn 1997, 41:308-314.
7. Husain S.R., Joshi B.H., Puri R.K. Interleukin-13 receptor as a unique target for anti-glioblastoma therapy. Int J Cancer 2001, 92:168-175.
8. Iliff J.J., Wang M., Liao Y., Plogg B.A., Peng W., Gundersen G.A., et al. A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid beta. Sci Transl Med 2012, 4:147ra111.
9. ImageJ, 2014. NIH. http://imagej.nih.gov/ij/.
10. Krauze M.T., Saito R., Noble C., Tamas M., Bringas J., Park J.W., et al. Reflux-free cannula for convection-enhanced high-speed delivery of therapeutic agents. J Neurosurg 2005, 103:923-929.
11. Kunwar S., Chang S., Westphal M., Vogelbaum M., Sampson J., Barnett G., et al. Phase III randomized trial of CED of IL13-PE38QQR vs Gliadel wafers for recurrent glioblastoma. Neuro-Oncology 2010, 12:871-881.
12. Lang A.E., Gill S., Patel N.K., Lozano A., Nutt J.G., Penn R., et al. Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease. Ann Neurol 2006, 59:459-466.
13. LaRiviere M.J., Mansour N., Galanopoulos N., Rawlani V., Prem K., Ferguson S., et al. Convection enhanced delivery of biodegradable nanoparticles for the treatment of malignant glioma. Congress of Neurological Surgeons Annual Meeting 2010.
14. Laske D.W., Ilercil O., Akbasak A., Youle R.J., Oldfield E.H. Efficacy of direct intratumoral therapy with targeted protein toxins for solid human gliomas in nude mice. J Neurosurg 1994, 80:520-526.
15. Linninger A.A., Somayaji M.R., Erickson T., Guo X., Penn R.D. Computational methods for predicting drug transport in anisotropic and heterogeneous brain tissue. J Biomech 2008, 41:2176-2187.
16. Linninger A.A., Somayaji M.R., Mekarski M., Zhang L. Prediction of convection-enhanced drug delivery to the human brain. J Theor Biol 2008, 250:125-138.
17. Mamot C., Nguyen J., Pourdehnad M., Hadaczek P., Saito R., Bringas J., et al. Extensive distribution of liposomes in rodent brains and brain tumors following convection-enhanced delivery. J Neuro-Oncol 2004, 68:1-9.
18. Mastakov M.Y., Baer K., Xu R., Fitzsimons H., During M.J. Combined Injection of rAAV with mannitol enhances gene expression in the rat brain. Mol Ther 2001, 3:225-232.
19. MATLAB, 2014. The MathWorks, Inc. http://mathworks.com/products/matlab/.
20. Mimics, 2014. Materialise, Inc. http://biomedical.materialise.com/mimics.
21. Morrison P.F., Chen M.Y., Chadwick R.S., Lonser R.R., Oldfield E.H. Focal delivery during direct infusion to brain: role of flow rate, catheter diameter, and tissue mechanics. Am J Physiol - Regul Integr Comp Physiol 1999, 277:R1218-R1229.
22. Neeves K.B., Lo C.T., Foley C.P., Saltzman W.M., Olbricht W.L. Fabrication and characterization of microfluidic probes for convection enhanced drug delivery. J Control Release 2006, 111:252-262.
23. Neeves K.B., Sawyer A.J., Foley C.P., Saltzman W.M., Olbricht W.L. Dilation and degradation of the brain extracellular matrix enhances penetration of infused polymer nanoparticles. Brain Res 2007, 1180:121-132.
24. Salvatore M.F., Ai Y., Fischer B., Zhang A.M., Grondin R.C., Zhang Z., et al. Point source concentration of GDNF may explain failure of phase II clinical trial. Exp Neurol 2006, 202:497-505.
25. Sampson J.H., Archer G., Pedain C., Wembacher-Schröder E., Westphal M., Kunwar S., et al. Poor drug distribution as a possible explanation for the results of the PRECISE trial. J Neurosurg 2009, 113:301-309.
26. Somayaji M.R., Xenos M., Zhang L., Mekarski M., Linninger A.A. Systematic design of drug delivery therapies. Comput Chem Eng 2008, 32:89-98.
27. Vogelbaum M. Convection enhanced delivery for treating brain tumors and selected neurological disorders: symposium review. J Neuro-Oncol 2007, 83:97-109.