Olanzapine-activated AMPK signaling in the dorsal vagal complex is attenuated by Histamine H1 receptor agonist in female rats

Endocrinology

Volumn 155, Issue 12, 2014, Pages 4895-4904

  He, Meng ^a   Zhang, Qingsheng ^a   Deng, Chao ^b   Wang, Hongqin ^a   Huang, Xu Feng ^a,b  

^a UNIVERSITY OF WOLLONGONG   (Australia)

^b SCHIZOPHRENIA RESEARCH INSTITUTE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BENZODIAZEPINE DERIVATIVE; HISTAMINE AGONIST; HISTAMINE H1 RECEPTOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; NEUROLEPTIC AGENT; OLANZAPINE;

ANIMAL; BODY WEIGHT; CHEMICALLY INDUCED; DRINKING; DRUG EFFECTS; EATING; FEMALE; HYPERPHAGIA; MEDULLA OBLONGATA; METABOLISM; OBESITY; RANDOMIZATION; SPRAGUE DAWLEY RAT;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; ANTIPSYCHOTIC AGENTS; BENZODIAZEPINES; BODY WEIGHT; DRINKING; EATING; FEMALE; HISTAMINE AGONISTS; HYPERPHAGIA; MEDULLA OBLONGATA; OBESITY; RANDOM ALLOCATION; RATS, SPRAGUE-DAWLEY; RECEPTORS, HISTAMINE H1;

EID: 84914141394     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2014-1326     Document Type: Article

References (54)

1. Ratzoni G, Gothelf D, Brand-Gothelf A, et al. Weight gain associated with olanzapine and risperidone in adolescent patients: a comparative prospective study. J Am Acad Child Adolesc Psychiatry. 2002;41(3):337-343.
2. Roerig JL, Steffen KJ, Mitchell JE. Atypical antipsychotic-induced weight gain: insights into mechanisms of action. CNS Drugs. 2011;25(12):1035-1059.
3. Deng C, Weston-Green K, Huang XF. The role of histaminergic H1 and H3 receptors in food intake: a mechanism for atypical antipsy-chotic-induced weight gain? Prog Neuropsychopharmacol Biol Psychiatry. 2010;34(1):1-4.
4. Correll CU, Lencz T, Malhotra AK. Antipsychotic drugs and obesity. Trends Mol Med. 2011;17(2):97-107.
5. Ferno J, Varela L, Skrede S, et al. Olanzapine-induced hyperphagia and weight gain associate with orexigenic hypothalamic neuropeptide signaling without concomitant AMPK phosphorylation. PLoS One. 2011;6(6):e20571.
6. Weston-Green K, Huang X-F, Deng C. Alterations to melanocortinergic, GABAergic and cannabinoid neurotransmission associated with olanzapine-induced weight gain. PLoS One. 2012;7(3):e33548.
7. Zhang Q, He M, Deng C, Wang H, Lian J, Huang XF. Hypothalamic ghrelin signalling mediates olanzapine-induced hyperphagia and weight gain in female rats. Int J Neuropsychopharmacol. 2014;17(5):807-818.
8. Schwartz GJ. Integrative capacity of the caudal brainstem in the control of food intake. Philos Trans R Soc Lond B Biol Sci. 2006;361(1471):1275-1280.
9. Cone RD. Anatomy and regulation of the central melanocortin system. Nat Neurosci. 2005;8(5):571-578.
10. Minokoshi Y, Alquier T, Furukawa N, et al. AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature. 2004;428(6982):569-574.
11. Meltzer HY. Illuminating the molecular basis for some antipsychotic drug-induced metabolic burden. Proc Natl Acad Sci USA. 2007;104(9):3019-3020.
12. Lage R, Diéguez C, Vidal-Puig A, López M. AMPK: a metabolic gauge regulating whole-body energy homeostasis. Trends Mol Med. 2008;14(12):539-549.
13. Hayes MR, Leichner TM, Zhao S, et al. Intracellular signals mediating the food intake-suppressive effects of hindbrain glucagon-like peptide-1 receptor activation. Cell Metab. 2011;13(3):320-330.
14. Hayes MR, Skibicka KP, Bence KK, Grill HJ. Dorsal hindbrain 5'-adenosine monophosphate-activated protein kinase as an intracellular mediator of energy balance. Endocrinology. 2009;150(5):2175-2182.
15. Deng C, Weston-Green KL, Han M, Huang XF. Olanzapine treatment decreases the density of muscarinic M2 receptors in the dorsal vagal complex of rats. Prog Neuropsychopharmacol Biol Psychiatry. 2007;31(4):915-920.
16. Weston-Green K, Huang XF, Han M, Deng C. The effects of antipsychotics on the density of cannabinoid receptors in the dorsal vagal complex of rats: implications for olanzapine-induced weight gain. Int J Neuropsychopharmacol. 2008;11(6):827-835.
17. Allison DB, Casey DE. Antipsychotic-induced weight gain: a review of the literature. J Clin Psychiatry. 2001;62:22-31.
18. Pai N, Deng C, Vella SL, Castle D, Huang XF. Are there different neural mechanisms responsible for three stages of weight gain development in anti-psychotic therapy: temporally based hypothesis. Asian J Psychiatr. 2012;5(4):315-318.
19. Huang XF, Han M, Huang X, Zavitsanou K, Deng C. Olanzapine differentially affects 5-HT2Aand2C receptor mRNA expression in the rat brain. Behav Brain Res. 2006;171(2):355-362.
20. Skrede S, Martins L, Berge RK, Steen VM, López M, Ferno J. Olanzapine depot formulation in rat: a step forward in modelling antidoi: psychotic-induced metabolic adverse effects. Int J Neuropsychopharmacol. 2014;17(1):91-104.
21. Martins PJ, Haas M, Obici S. Central nervous system delivery of the antipsychotic olanzapine induces hepatic insulin resistance. Diabetes. 2010;59(10):2418-2425.
22. Sejima E, Yamauchi A, Nishioku T, et al. A role for hypothalamic AMP-activated protein kinase in the mediation of hyperphagia and weight gain induced by chronic treatment with olanzapine in female rats. Cell Mol Neurobiol. 2011;31(7):985-989.
23. Kim SF, Huang AS, Snowman AM, Teuscher C, Snyder SH. From the cover:antipsychotic drug-induced weight gain mediated by histamine H-1 receptor-linked activation of hypothalamic AMP-kinase. Proc Natl Acad Sci USA. 2007;104(9):3456-3459.
24. Paxinos G, Watson C. The Rat Brain in Stereotaxic Coordinates. 6th ed. Amsterdam, The Netherlands: Elsevier; 2007.
25. Lecklin A, Etu-Seppala P, Stark H, Tuomisto L. Effects of intracerebroventricularly infused histamine and selective H-1, H-2 and H-3 agonists on food and water intake and urine flow in Wistar rats. Brain Res. 1998;793(1-2):279-288.
26. He M, Zhang Q, Deng C, Wang H, Lian J, Huang XF. Hypothalamic histamine H1 receptor-AMPK signaling time-dependently mediates olanzapine-induced hyperphagia and weight gain in female rats. Psychoneuroendocrinology. 2014;42:153-164.
27. Weixel KM, Marciszyn A, Alzamora R, et al. Resveratrol inhibits the epithelial sodium channel via phopshoinositides and AMP-activated protein kinase in kidney collecting duct cells. PLoS One. 2013;8(10):e78019.
28. Han M, Deng C, Burne TH, Newell KA, Huang XF. Short- and long-term effects of antipsychotic drug treatment on weight gain and H1 receptor expression. Psychoneuroendocrinology. 2008;33(5):569-580.
29. Weston-Green K, Huang XF, Deng C. Olanzapine treatment and metabolic dysfunction: a dose response study in female Sprague Dawley rats. Behav Brain Res. 2011;217(2):337-346.
30. Matsui-Sakata A, Ohtani H, Sawada Y. Receptor occupancy-based analysis of the contributions of various receptors to antipsychoticsinduced weight gain and diabetes mellitus. Drug Metab Pharmacokinet. 2005;20(5):368-378.
31. Albaugh VL, Henry CR, Bello NT, et al. Hormonal and metabolic effects of olanzapine and clozapine related to body weight in rodents. Obesity. 2006;14(1):36-51.
32. van der Zwaal EM, Merkestein M, Lam YK, et al. The acute effects of olanzapine on ghrelin secretion, CCK sensitivity, meal size, locomotor activity and body temperature. Int J Obesity. 2012;36(2):254-261.
33. Stefanidis A, Verty AN, Allen AM, Owens NC, Cowley MA, Oldfield BJ. The role of thermogenesis in antipsychotic drug-induced weight gain. Obesity. 2009;17(1):16-24.
34. Jacobowitz W, Derbabian B, Saunders A. The effect of a calorierestricted diet on weight gain in short-term psychiatric inpatients receiving atypical antipsychotic medications. J Psychosoc Nurs Ment Health Serv. 2014;52(7):30-37.
35. Giannopoulou I, Botonis P, Kostara C, Skouroliakou M. Diet and exercise effects on aerobic fitness and body composition in seriously mentally ill adults. Eur J Sport Sci. 2014;14(6):620-627.
36. Muller AP, Tort AH, Gnoatto J, et al. Metabolic and behavioral effects of chronic olanzapine treatment and cafeteria diet in rats. Behav Pharmacol. 2010;21(7):668-675.
37. Sharpe JK, Stedman TJ, Byrne NM, Wishart C, Hills AP. Energy expenditure and physical activity in clozapine use: implications for weight management. Aust NZ J Psychiatry. 2006;40(9):810-814.
38. Cuerda C, Merchan-Naranjo J, Velasco C, et al. Influence of resting energy expenditure on weight gain in adolescents taking secondgeneration antipsychotics. Clin Nutr. 2011;30(5):616-623.
39. Sharpe JK, Byrne NM, Stedman TJ, Hills AP. Resting energy expenditure is lower than predicted in people taking atypical antipsychotic medication. J Am Diet Assoc. 2005;105(4):612-615.
40. Skouroliakou M, Giannopoulou I, Kostara C, Vasilopoulou M. Comparison of predictive equations for resting metabolic rate in obese psychiatric patients taking olanzapine. Nutrition. 2009;25(2): 188-193.
41. Blessing WW, Zilm A, Ootsuka Y. Clozapine reverses increased brown adipose tissue thermogenesis induced by 3,4-methylenedioxymethamphetamine and by cold exposure in conscious rats. Neuroscience. 2006;141(4):2067-2073.
42. Zhang Q, Lian J, He M, Deng C, Wang H, Huang XF. Olanzapine reduced brown adipose tissue thermogenesis and locomotor activity in female rats. Prog Neuropsychopharmacol Biol Psychiatry. 2014;51:172-180.
43. Watanabe T, Taguchi Y, Shiosaka S, et al. Distribution of the histaminergic neuron system in the central nervous system of rats; a fluorescent immunohistochemical analysis with histidine decarboxylase as a marker. Brain Res. 1984;295(1):13-25.
44. Bhuiyan ME, Waki H, Gouraud SS, Takagishi M, Kohsaka A, Maeda M. Histamine receptor H1 in the nucleus tractus solitarii regulates arterial pressure and heart rate in rats. Am J Physiol Heart Circ Physiol. 2011;301(2):H523-H529.
45. Blevins JE, Baskin DG. Hypothalamic-brainstem circuits controlling eating. Forum Nutr. 2010;63:133-140.
46. Blouet C, Schwartz GJ. Brainstem nutrient sensing in the nucleus of the solitary tract inhibits feeding. Cell Metab. 2012;16(5):579-587.
47. Martin TL, Alquier T, Asakura K, Furukawa N, Preitner F, Kahn BB. Diet-induced obesity alters AMP kinase activity in hypothalamus and skeletal muscle. J Biol Chem. 2006;281(28):18933-18941.
48. Tiwari AK, Brandl EJ, Weber C, et al. Association of a functional polymorphism in neuropeptide Y with antipsychotic-induced weight gain in schizophrenia patients. J Clin Psychopharmacol. 2013;33(1):11-17.
49. Wallingford NM, Sinnayah P, Bymaster FP, et al. Zonisamide prevents olanzapine-associated hyperphagia, weight gain, and elevated blood glucose in rats. Neuropsychopharmacology. 2008;33(12):2922-2933.
50. Woolf PJ, Linderman JJ. Untangling ligand induced activation and desensitization of G-protein-coupled receptors. Biophys J. 2003;84(1):3-13.
51. Pype JL, Mak JC, Dupont LJ, Verleden GM, Barnes PJ. Desensitization of the histamine H1-receptor and transcriptional down-regulation of histamine H1-receptor gene expression in bovine tracheal smooth muscle. Br J Pharmacol. 1998;125(7):1477-1484.
52. Bristow DR, Zamani MR. Desensitization of histamine H1 receptor-mediated inositol phosphate production inHeLacells. Br J Pharmacol. 1993;109(2):353-359.
53. Singh RK, Jia C, Garcia F, Carrasco GA, Battaglia G, Muma NA. Activation of the JAK-STAT pathway by olanzapine is necessary for desensitization of serotonin2A receptor-stimulated phospholipase C signaling in rat frontal cortex but not serotonin2A receptor-stimulated hormone release. J Psychopharmacol. 2010;24(7):1079-1088.
54. Hanley NR, Hensler JG. Mechanisms of ligand-induced desensitization of the 5-hydroxytryptamine(2A) receptor. J Pharmacol Exp Ther. 2002;300(2):468-477.