Measuring microangiopathy abnormalities in systemic sclerosis patients: The role of capillaroscopy-based scoring models

American Journal of the Medical Sciences

Volumn 348, Issue 4, 2014, Pages 331-336

  Sebastiani, Marco ^a   Manfredi, Andreina ^a   Cassone, Giulia ^a   Giuggioli, Dilia ^a   Ghizzoni, Cecilia ^a   Ferri, Clodoveo ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

Digital ulcers; Mortality.; Nailfold capillaroscopy; Pulmonary arterial hypertension; Systemic sclerosis

Indexed keywords

CAPILLAROSCOPY; DISEASE SEVERITY; FINGER ULCER; FOLLOW UP; HUMAN; MICROANGIOPATHY; MORTALITY; PULMONARY HYPERTENSION; QUANTITATIVE ANALYSIS; REVIEW; SCORING SYSTEM; SYSTEMIC SCLEROSIS; ANGIOSCOPY; METHODOLOGY; MICROCIRCULATION; PATHOPHYSIOLOGY; PHYSIOLOGY; RADIOGRAPHY; STANDARDS;

HUMANS; MICROCIRCULATION; MICROSCOPIC ANGIOSCOPY; RESEARCH DESIGN; SCLERODERMA, SYSTEMIC;

EID: 84914122297     PISSN: 00029629     EISSN: 15382990     Source Type: Journal    
DOI: 10.1097/MAJ.0000000000000282     Document Type: Article

References (64)

1. Maricq HR, Spencer-Green G, LeRoy EC. Skin capillary abnormalities as indicators of organ involvement in scleroderma (systemic sclerosis), Raynaud's syndrome and dermatomyositis. Am J Med 1976;61: 862-70 .
2. Carpentier PH, Maricq HR. Microvasculature in systemic sclerosis. Rheum Dis Clin North Am 1990;16:75-91.
3. Grassi W, De Angelis R. Capillaroscopy: questions and answers. Clin Rheumatol 2007;26:2009-16.
4. Ingegnoli F, Ardoino I, Boracchi P, et al. Nailfold capillaroscopy in systemic sclerosis: data from the EULAR scleroderma trials and research (EUSTAR) data base. Microvasc Res 2013;89:122-8.
5. Brown GE, O'Leary PA. Skin capillaries in scleroderma. Arch Intern Med 1925;36:73-88.
6. Hachulla E, Launay D. Diagnosis and classification of systemic sclerosis. Clin Rev Allergy Immunol 2011;40:78-83.
7. Hudson M, Taillefer S, Steele R, et al. Improving the sensitivity of the American college of rheuma tology classification criteria for systemic sclerosis. Clin Exp Rheumatol 2007;25:754-7.
8. Avouac J, Fransen J, Walker UA, et al. Preliminary criteria for the very early diagnosis of systemic sc lerosis: results of a Delphi Consensus Study from EULAR Scleroderma Trials and Research Group. Ann Rheum Dis 2011;70:476-81.
9. van den Hoogen F, Khanna D, Fransen J, et al. 2013 classification criteria for systemic sclerosis: an American college of rheumatology/European league against rheumatism collaborative initiative. Arthritis Rheum 2013; 65:2737-47.
10. Della Rossa A, Cazzato M, d'Ascani o A, et al. Alteration of microcirculation is a hallmark of very early systemic sclerosis patients: a laser speckle contrast analysis. Clin Exp Rheumatol 2013;31:109-14.
11. Lambova SN, Müller-Ladner U. Capillaroscopic pattern in systemic sclerosis-an association with dynamics of processes of angio-and vasculogenesis. Microvasc Res 2010;80:534-9.
12. Smith V, Pizzorni C, De Keyser F, et al. Re liability of the qualitative and semiquantitative nailfold videocapillaroscopy assessment in a systemic sclerosis cohort: a two-centre study. Ann Rheum Dis 2010;69:1092-6.
13. Cutolo M,Sulli A,Pizzorni C,et al. Nailfold videocapillaroscopy assessment of microvascular damage in systemic sclerosis J Rheumatol 2000 27, 155-60.
14. Cutolo M, Pizzorni C, Tuccio M, et al. Nailfold videocapillaroscopic patterns and serum autoantibodies in systemic sclerosis. Rheumatology (Oxford) 2004;43:719-26.
15. Ingegnoli F, Gualtierotti R, Lubatti C, et al. Feasibility of different capillaroscopic measures for identifying nailfold microvascular alterations. Semin Arthritis Rheum 2009;38:289-95.
16. Simeón CP, Fonollosa V, Vilardell M, et al. Study of the capillary microscopy changes in scleroderma and their association with organ disease, clinical manifestation and disease progression [in Spanish]. Med Clin (Barc ) 1991;97:561-4.
17. Caramaschi P, Canestrini S, Martinelli N, et al. Scleroderma patients nailfold videocapillaroscopic patterns are associated with disease subset and disease severity. Rheumato logy (Oxford) 2007; 46:1566-9.
18. Lovy M, MacCarter D, Steigerwald JC. Relationship between nailfold capillary abnormalities and organ involvement in systemic sclerosis. Arthritis Rheum 1985;28:496-501.
19. Joyal F, Choquette D, Roussin A, et al. Evaluation of severity of systemic sclerosis by nailfold capillary microscopy in 112 patients. Angiology 1992;43:203-9.
20. Smith V, Riccieri V, Pizzorni C, et al. Nailfold capillaroscopy for prediction of novel future severe organ involvement in systemic sclerosis. J Rheumatol 2013;40:2023-8.
21. Pu cinelli ML, Atra E, Sato EI, et al. Nailfold capillaroscopy in systemic sclerosis: correlations with involvement of lung and esophagus. Rev Bras Rheumatol 1995;35:136.
22. Lee P, Leung FY, Alderdice C, et al. Nailfold capillary microscopy in the connective tissue diseases: a semiquantitative assessment. J Rheumatol 1983;10:930-8.
23. Sulli A, Secchi ME, Pizzorni C, et al. Scoring the nailfold microvascular changes during the capillaroscopic analysis in systemic sclerosis patients. Ann Rheum Dis 2008;67:885-7.
24. Lambova S, Müller-Ladner U. Capillaroscopic findings in systemic sclerosis-are they associated with disease duration and presence of digital ulcers? Discov Med 2011;12:413-8.
25. Smith V, De Keyser F, Pizzorni C, et al. Nailfold capillaroscopy for day-to-d ay clinical use: construction of a simple scoring modality as a clinical prognostic index for digital trophic lesions. Ann Rheum Dis 2011;70:180-3.
26. Sebastiani M, Manfredi A, Lo Monaco A, et al. Capillaroscopic skin ulcers risk index (CSURI) calculated with different videocapillaroscopy devices: how its predictive values change. Clin Exp Rheumatol 2013; 31:115-7.
27. Ohtsuka T, Hasegawa A, N akano A, et al. Nailfold capillary abnormality and pulmonary hypertension in systemic sclerosis. Int J Dermatol 1997;36:116-22.
28. Hofstee HM, Vonk Noordegraaf A, Voskuyl AE, et al. Nai lfold capillary density is associated with the presence and severity of pulmonary arterial hypertension in systemic sclerosis. Ann Rheum Dis 2009; 68:191-5.
29. Riccieri V, Vasile M, Iannace N, et al. Systemic sclerosis patients with and without pulmonary arterial hypertension: a nailfold capillaroscopy study. Rheumatology (Oxford) 2013;52:1525-8.
30. Scussel-Lonzetti L, Joyal F, Raynauld JP, et al. Predicting mortality in systemic sclerosis: analysis of a cohort of 309 French Canadian patients with emphasis on features at diagnosis as predictive factors for survival. Medicine 2002;81:154-67.
31. Kayser C, Sekiyama JY, Próspero LC, et al. Nailfold capillaroscopy abnormalities as predictors of mortality in patients with systemic sclerosis. Clin Exp Rheuma tol 2013;31:103-8.
32. Miniati I, Guiducci S, Conforti ML, et al. Autologous stem cell transplantation improves microcirculation in systemic sclerosis. Ann Rheum Dis 2009;68:94-8.
33. Caramaschi P, Martinelli N, Volpe A, et al. A score of risk factors associated with ischemic digital ulcers in patients affected by systemic sclerosis treated with iloprost. Clin Rheumatol 2009;28 :807-13.
34. Guillevin L,Hunsche E,Denton CP,et al. Functional impairment of systemic scleroderma patients with digital ulcerations: results from the DUO registry Clin Exp Rheumatol 2013, 31, 71-80.
35. Ong YY, Nikoloutsopoulos T, Bond CP, et al. Decreased nailfold capillary density in limited scleroderma with pulmonary hypertension. Asian Pac J Allergy Immunol 1998;16:81-6.
36. Andrade LE, Gabriel Júnior A, Assad RL, et al. Panoramic nailfold capillaroscopy: a new reading method and normal range. Semin Arthritis Rheum 1990;20:21-31.
37. Nihtyanova SI, Brough GM, Black CM, et al. Clinical burden of digital vasculopathy in limited and diffuse cutaneous systemic sclerosis. Ann Rheum Dis 2008;67:120-3.
38. Herric k A. Diagnosis and management of scleroderma peripheral vascular disease. Rheum Dis Clin North Am 2008;34:89-114.
39. Mawdsley AH. Patient perception of UK scleroderma services-results of an anonymous questionnaire. Rheumatology (Oxford) 2006;45:1573.
40. Ferri C, Valentini G, Cozzi F, et al. Systemic sclerosis: demographic, clinical, and serologic features and survival in 1,012 Italian patient s. Medicine (Baltimore) 2002;81:139-53.
41. Korn JH, Mayes M, Matucci Cerinic M, et al. Digital ulcers in systemic sclerosis: prevention by treatment with bosentan, an oral endothelin receptor an tagonist. Arthritis Rheum 2004;50:3985-93.
42. Chung L, Fiorentino D. Digital ulcers in patients with systemic sclerosis. Autoimmun Rev 2006;5:125-8.
43. Steen V, Denton CP, Pope JE, et al. Digital ulcers: overt vascular disease in systemic sclerosis. Rheumatology (Oxford) 2009;48:19-24.
44. Alivernini S, De Santis M, T olusso B, et al. Skin ulcers in systemic sclerosis: determinants of presence and predictive factors of healing. J Am Acad Dermatol 2009;60:426-35.
45. Sebastiani M, Manfredi A, Colaci M, et a l. Capillaroscopic skin ulcer risk index: a new prognostic tool for digital skin ulcer development in systemic sclerosis patients. Arthritis Rheum 2009;61:688-94.
46. Sebastiani M, Manfredi A, Vukata na G, et al. Predictive role of capillaroscopic skin ulcer risk index in systemic sclerosis: a multicentre validation study. Ann Rheum Dis 2012;71:67-70.
47. Galié N, Hoeper MM, Humbert M, e t al. Guidelines for the diagnosis and treatment of pulmonary hypertension: the task force for the diagnosis and treatment of pulmonary hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS), endorsed by the International Society of Heart and Lung Transplantation( ISHLT). Eur Heart J 2009;30:2493-537.
48. Mukerjee D, St George D, Coleiro B, et al. Prevalence and outcome in systemic sclerosis associ ated pulmonary arterial hypertension: application of a registry approach. Ann Rheum Dis 2003;62: 1088-93.
49. McLaughlin VV, Archer SL, Badesch DB, et al. ACCF/AHA 2009 expert consensus docum ent on pulmonary hypertension a report of the American college of Cardiology Foundation Task Force on expert consensus documents and the American heart association developed in collaboration with the American college of chest physicians; American Thoracic Society, Inc.; and the Pulmonary Hypertension Association. J Am Coll Cardiol 2009;53:1573-619.
50. Grassi W, Del Medico P. Atlas of capillaroscopy, 1st ed. Milan, Italy: Edra; 2004.
51. . Hofstee HM, SernéEH, Roberts C, et al. A multicentre study on the reliability of qualitative and quantitative nail-fold videocapillaroscopy assessment. Rheumatology (Oxford) 2012;51:749-55.
52. Anderson ME, Allen PD, Moore T, et al. Computerized nailfold video capillaroscopy-a new tool for assessment of Raynaud's phenomenon. J Rheumatol 2005;32:841-8.
53. Scheja A, Akesson A, Niewierowicz I, et al. Computer based quantitative analysis of capillary abnormalities in systemic sclerosis and its relation to plasma concentration of von Willebrand factor. Ann Rheum Dis 1996;55:52-6.
54. Bredemeier M, Xavier RM, Capobianco KG, et al. Nailfold capillary microscopy can suggest pulmonary disease activity in systemic sclerosis. J Rheumatol 2004;31:286-94.
55. Corrado A,Carpagnano GE,Gaudio A,et al. Nailfold capillaroscopic findings in systemic sclerosis related lung fibrosis and in idiopathic lung fibrosis Joint Bone Spine 2010 77, 570-4.
56. Ingegnoli F, B oracchi P, Gualtierotti R, et al. Prognostic model based on nailfold capillaroscopy for identifying Raynaud's phenomenon patients at high risk for the development of a scleroderma spectrum disorder: PRINCE (prognostic index for nailfold capil laroscopic examination). Arthritis Rheum 2008;58:2174-82.
57. Wildt M, Wuttge DM, Hesselstrand R, et al. Assessment of capillary density in systemic sclerosis with three different capillaroscopic methods. Clin Exp Rheumatol 2012;30:S50-4.
58. Altman DG. Practical Statistics for Medical Research, 1st ed. London, United Kingdom: Chapman & All; 1991.
59. Wilks SS. The large-sample distribution of the likelihood ratio for testing composite hypotheses. Ann Math Stat 1938;9:60-2.
60. Cipriani P, Marrelli A, Benedetto PD, et al. Scleroderma mesenchymal stem cells display a different phenotype from healthy controls; implications for regenerative medicine. Angiogenesis 2013;16:595-607.
61. Valentini G, Marcoccia A, Cuomo G, et al. Early systemic sclerosis: marker autoantibodies and videocapillaroscopy patterns are each associated with distinct cli nical, functional and cellular activation markers. Arthritis Res Ther 2013;15:R63.
62. Riccieri V, Germano V, Alessandri C, et al. More severe nailfold capillaroscopy findings and anti-endotheli al cell antibodies. Are they useful tools for prognostic use in systemic sclerosis? Clin Exp Rheumatol 2008;26:992-7.
63. Castelino FV, Varga J. Current status of systemic sclerosis biomarkers: applications for diagnosis, management and drug development. Expert Rev Clin Immunol 2013;9:1077-90.
64. Kim HS, Park MK, Kim HY, et al. Capillary dimension measured by computer-based digitalized image c orrelated with plasma endothelin-1 levels in patients with systemic sclerosis. Clin Rheumatol 2010;29:247-54.