Bayesian Network and Mechanistic Hierarchical Structure Modeling of Increased likelihood of Developing Intractable Childhood Epilepsy from the Combined Effect of mtDNA Variants, Oxidative Damage, and Copy Number

Journal of Molecular Neuroscience

Volumn 54, Issue 4, 2014, Pages 752-766

  Luna, Brenda ^a   Bhatia, Sanjiv ^b   Yoo, Changwon ^a   Felty, Quentin ^a   Sandberg, David I ^c   Duchowny, Michael ^b   Khatib, Ziad ^b   Miller, Ian ^b   Ragheb, John ^b   Prasanna, Jayakar ^b   Roy, Deodutta ^a  

^a FLORIDA INTERNATIONAL UNIVERSITY   (United States)

^b MIAMI CHILDREN'S HOSPITAL   (United States)

^c UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

Copy number; mtDNA damages; mtDNA variants; Pediatric epilepsy

Indexed keywords

MITOCHONDRIAL DNA;

ADOLESCENT; ADULT; ALLELE; ARTICLE; BAYESIAN LEARNING; BENIGN CHILDHOOD EPILEPSY; BRAIN TISSUE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CORTICAL DYSPLASIA; DOT HYBRIDIZATION; FEMALE; GENE DOSAGE; HUMAN; HUMAN TISSUE; INTRACTABLE EPILEPSY; MALE; MITOCHONDRIAL GENETICS; MITOCHONDRIAL HAPLOGROUP; MONTE CARLO METHOD; OXIDATIVE STRESS; POLYMERASE CHAIN REACTION; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; BAYES THEOREM; BIOLOGICAL MODEL; CASE CONTROL STUDY; COPY NUMBER VARIATION; EPILEPSY; GENETICS; METABOLISM; SEX DIFFERENCE; STATISTICAL MODEL;

BAYES THEOREM; CASE-CONTROL STUDIES; CHILD; DNA COPY NUMBER VARIATIONS; DNA, MITOCHONDRIAL; EPILEPSY; FEMALE; HUMANS; LIKELIHOOD FUNCTIONS; MALE; MODELS, GENETIC; OXIDATIVE STRESS; POLYMORPHISM, SINGLE NUCLEOTIDE; SEX FACTORS;

EID: 84914102148     PISSN: 08958696     EISSN: 15591166     Source Type: Journal    
DOI: 10.1007/s12031-014-0364-x     Document Type: Article

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