Light-induced termination of spiral wave arrhythmias by optogenetic engineering of atrial cardiomyocytes

Cardiovascular Research

Volumn 104, Issue 1, 2014, Pages 194-205

  Bingen, Brian O ^a   Engels, Marc C ^a   Schalij, Martin J ^a   Jangsangthong, Wanchana ^a   Neshati, Zeinab ^a   Feola, Iolanda ^a   Ypey, Dirk L ^a   Askar, Said F A ^a   Panfilov, Alexander V ^b   Pijnappels, Daniel A ^a   De Vries, Antoine A F ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b GHENT UNIVERSITY   (Belgium)

Author keywords

Atrial fibrillation; Cardiomyocyte; Lentiviral vector; Optical mapping; Optogenetics

Indexed keywords

ALPHA ACTININ; CALCIUM TRANSLOCATING CHANNEL RHODOPSIN; CATION CHANNEL; COLLAGEN TYPE 1; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; LENTIVIRUS VECTOR; RHODOPSIN; UNCLASSIFIED DRUG; YELLOW FLUORESCENT PROTEIN; BACTERIAL PROTEIN; CALCIUM CHANNEL; CATCH PROTEIN, RAT; PHOTOPROTEIN; YELLOW FLUORESCENT PROTEIN, BACTERIA;

ACTION POTENTIAL; ANIMAL CELL; ARTICLE; ATRIAL CARDIOMYOCYTE; BLUE LIGHT; CELL ENGINEERING; CONTROLLED STUDY; DEFIBRILLATION; HEART ATRIUM FIBRILLATION; HEART DEPOLARIZATION; HEART ELECTROPHYSIOLOGY; HEART MUSCLE CELL; HEART MUSCLE EXCITABILITY; LIGHT; LIGHT EMITTING DIODE; LONG TERM EXPOSURE; MONOLAYER CULTURE; NEWBORN; NONHUMAN; OPTOGENETICS; PROTEIN EXPRESSION; RAT; RESTRICTION MAPPING; SINUS RHYTHM; WHOLE CELL PATCH CLAMP; ANIMAL; ATRIAL FIBRILLATION; CELL CULTURE; FEASIBILITY STUDY; FLUORESCENT ANTIBODY TECHNIQUE; GENE VECTOR; GENETIC TRANSDUCTION; GENETIC TRANSFECTION; GENETICS; HEART ATRIUM; HEART PACING; LENTIVIRINAE; METABOLISM; PATCH CLAMP TECHNIQUE; PATHOPHYSIOLOGY; RADIATION RESPONSE; TIME; VOLTAGE SENSITIVE DYE IMAGING; WESTERN BLOTTING; WISTAR RAT;

ACTION POTENTIALS; ANIMALS; ANIMALS, NEWBORN; ATRIAL FIBRILLATION; BACTERIAL PROTEINS; BLOTTING, WESTERN; CALCIUM CHANNELS; CARDIAC PACING, ARTIFICIAL; CELLS, CULTURED; FEASIBILITY STUDIES; FLUORESCENT ANTIBODY TECHNIQUE; GENETIC VECTORS; HEART ATRIA; LENTIVIRUS; LIGHT; LUMINESCENT PROTEINS; MYOCYTES, CARDIAC; OPTOGENETICS; PATCH-CLAMP TECHNIQUES; RATS, WISTAR; RHODOPSIN; TIME FACTORS; TRANSDUCTION, GENETIC; TRANSFECTION; VOLTAGE-SENSITIVE DYE IMAGING;

EID: 84913600482     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvu179     Document Type: Article

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