MiRNA-205 is a candidate tumor suppressor that targets ZEB2 in renal cell carcinoma

Oncology Research and Treatment

Volumn 37, Issue 11, 2014, Pages 658-664

  Chen, Zhi ^a   Tang, Zheng Yan ^a   He, Yao ^a   Liu, Long Fei ^a   Li, Dong Jie ^a   Chen, Xiang ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Epithelial to mesenchymal transition; MiR 205; Renal cell carcinoma; ZEB2

Indexed keywords

LUCIFERASE; MICRORNA 205; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ZEB2; UNCLASSIFIED DRUG; UVOMORULIN; VIMENTIN; CADHERIN; HOMEODOMAIN PROTEIN; MICRORNA; MIRN205 MICRORNA, HUMAN; REPRESSOR PROTEIN; ZEB2 PROTEIN, HUMAN;

ADULT; AGED; APOPTOSIS; ARTICLE; CANCER PATIENT; CANCER TISSUE; CARCINOMA CELL LINE; CELL INVASION; CELL INVASION ASSAY; CELL MIGRATION; CELL PROLIFERATION; CLINICAL ARTICLE; CLINICAL ASSESSMENT; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; GENE OVEREXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; KIDNEY CARCINOMA; LUCIFERASE ASSAY; MALE; MIDDLE AGED; MTT ASSAY; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; TUMOR DIFFERENTIATION; TUMOR SUPPRESSOR GENE; TUMOR VOLUME; WESTERN BLOTTING; CELL MOTION; DOWN REGULATION; GENETIC TRANSFECTION; GENETICS; KIDNEY TUMOR; METABOLISM; PATHOLOGY; PHYSIOLOGY; TUMOR CELL CULTURE; TUMOR CELL LINE;

ADULT; AGED; APOPTOSIS; BLOTTING, WESTERN; CADHERINS; CARCINOMA, RENAL CELL; CELL LINE, TUMOR; CELL MOVEMENT; DOWN-REGULATION; FEMALE; FLOW CYTOMETRY; GENES, TUMOR SUPPRESSOR; HOMEODOMAIN PROTEINS; HUMANS; KIDNEY NEOPLASMS; MALE; MICRORNAS; MIDDLE AGED; REAL-TIME POLYMERASE CHAIN REACTION; REPRESSOR PROTEINS; TRANSFECTION; TUMOR CELLS, CULTURED; VIMENTIN;

EID: 84913588144     PISSN: 22965270     EISSN: 22965262     Source Type: Journal    
DOI: 10.1159/000368792     Document Type: Article

References (28)

1. White NM, Yousef GM: MicroRNAs: exploring a new dimension in the pathogenesis of kidney cancer. BMC Med 2010;8:65.
2. Ljungberg B, Cowan NC, Hanbury DC, et al.: EAU guidelines on renal cell carcinoma: the 2010 update. Eur Urol 2010;58:398-406.
3. Pantuck AJ, Zisman A, Belldegrun AS: The changing natural history of renal cell carcinoma. J Urol 2001;166:1611-23.
4. DiBiase SJ, Valicenti RK, Schultz D, et al.: Palliative irradiation for focally symptomatic metastatic renal cell carcinoma: support for dose escalation based on a biological model. J Urol 1997;158:746-9.
5. Miska EA: How microRNAs control cell division, differentiation and death. Curr Opin Genet Dev 2005;15:563-8.
6. Ambros V: The functions of animal microRNAs. Nature 2004;431:350-5.
7. Bartel DP: MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004;116:281-97.
8. Alvarez-Garcia I, Miska EA: MicroRNA functions in animal development and human disease. Development 2005;132:4653-62.
9. Croce CM: Causes and consequences of micro-RNA dysregulation in cancer. Nat Rev Genet 2009;10:704-14.
10. Volinia S, Calin GA, Liu CG, et al.: A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci USA 2006;103:2257-61.
11. Gottardo F, Liu CG, Ferracin M, et al.: Micro-RNA profiling in kidney and bladder cancers. Urol Oncol 2007;25:387-92.
12. Tran N, McLean T, Zhang X, et al.: MicroRNA expression profiles in head and neck cancer cell lines. Biochem Biophys Res Commun 2007;358:12-7.
13. Iorio MV, Visone R, Di Leva G, et al.: MicroRNA signatures in human ovarian cancer. Cancer Res 2007;67:8699-707.
14. Yanaihara N, Caplen N, Bowman E, et al.: Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell 2006;9:189-98.
15. Iorio MV, Casalini P, Piovan C, et al.: micro-RNA-205 regulates HER3 in human breast cancer. Cancer Res 2009;69:2195-200.
16. Gandellini P, Folini M, Longoni N, et al.: miR-205 exerts tumor-suppressive functions in human prostate through down-regulation of protein kinase cepsilon. Cancer Res 2009;69:2287-95.
17. Yue X, Wang P, Xu J, et al.: MicroRNA-205 functions as a tumor suppressor in human glioblastoma cells by targeting VEGF-A. Oncol Rep 2012;27: 1200-6.
18. Kalluri R, Weinberg RA: The basics of epithelialmesenchymal transition. J Clin Invest 2009;119: 1420-8.
19. Gregory PA, Bracken CP, Bert AG, Goodall GJ: MicroRNAs as regulators of epithelial-mesenchymal transition. Cell Cycle 2008;7:3112-8.
20. Gregory PA, Bert AG, Paterson EL, et al.: The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nat Cell Biol 2008;10:593-601.
21. Majid S, Saini S, Dar AA, et al.: MicroRNA-205 inhibits Src-mediated oncogenic pathways in renal cancer. Cancer Res 2011;71:2611-21.
22. Gregory PA, Bert AG, Paterson EL, et al.: The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nat Cell Biol 2008;10:593-601.
23. Matsushima K, Isomoto H, Yamaguchi N, et al.: MiRNA-205 modulates cellular invasion and migration via regulating zinc finger E-box binding homeobox 2 expression in esophageal squamous cell carcinoma cells. J Transl Med 2011;9:30.
24. Postigo AA, Depp JL, Taylor JJ, Kroll KL: Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins. EMBO J 2003;22:2453-62.
25. Sayan AE, Griffiths TR, Pal R, et al.: SIP1 protein protects cells from DNA damage-induced apoptosis and has independent prognostic value in bladder cancer. Proc Natl Acad Sci USA 2009;106: 14884-9.
26. Elloul S, Elstrand MB, Nesland JM, et al.: Snail, Slug, and Smad-interacting protein 1 as novel parameters of disease aggressiveness in metastatic ovarian and breast carcinoma. Cancer 2005;103: 1631-43.
27. Sakamoto K, Imanishi Y, Tomita T, et al.: Overexpression of SIP1 and downregulation of E-cadherin predict delayed neck metastasis in stage I/II oral tongue squamous cell carcinoma after partial glossectomy. Ann Surg Oncol 2012;19:612-9.
28. Fang Y, Wei J, Cao J, et al.: Protein expression of ZEB2 in renal cell carcinoma and its prognostic significance in patient survival. PLoS One 2013; 8:e62558.