ProNGF correlates with Gleason score and is a potential driver of nerve infiltration in prostate cancer

American Journal of Pathology

Volumn 184, Issue 12, 2014, Pages 3156-3162

  Pundavela, Jay ^a   Demont, Yohann ^b,e   Jobling, Phillip ^a   Lincz, Lisa F ^a,c   Roselli, Severine ^a   Thorne, Rick F ^a   Bond, Danielle ^a   Bradshaw, Ralph A ^d   Walker, Marjorie M ^a   Hondermarck, Hubert ^a  

^a UNIVERSITY OF NEWCASTLE   (Australia)

^b INSERM   (France)

^c NEWCASTLE MATER HOSPITAL   (Australia)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e CENTRE DE RECHERCHE DES CORDELIERS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; BLOCKING ANTIBODY; NERVE GROWTH FACTOR; PRECURSOR OF NERVE GROWTH FACTOR; UNCLASSIFIED DRUG; TUMOR MARKER;

ARTICLE; CANCER INFILTRATION; COCULTURE; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOPLASM; EPITHELIUM CELL; GLEASON SCORE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMORTALIZED CELL LINE; IN VITRO STUDY; LNCAP CELL LINE; MALE; NERVE CELL GROWTH; NERVE FIBER GROWTH; PROSTATE CANCER; PROSTATE EPITHELIUM; PROSTATE HYPERTROPHY; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; CANCER GRADING; IMMUNOHISTOCHEMISTRY; INNERVATION; METABOLISM; NERVE CELL; NERVE FIBER; PROSTATE; PROSTATIC NEOPLASMS; TUMOR CELL LINE;

AXONS; CELL LINE, TUMOR; COCULTURE TECHNIQUES; CYTOPLASM; EPITHELIAL CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; NEOPLASM GRADING; NERVE GROWTH FACTOR; NEURONS; PROSTATE; PROSTATIC HYPERPLASIA; PROSTATIC NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 84913556244     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2014.08.009     Document Type: Article

References (25)

1. C. Magnon, S.J. Hall, J. Lin, X. Xue, L. Gerber, S.J. Freedland, and P.S. Frenette Autonomic nerve development contributes to prostate cancer progression Science 341 2013 1236361
2. M.V. Chao Neurotrophins and their receptors: a convergence point for many signalling pathways Nat Rev Neurosci 4 2003 299 309
3. R. Lee, P. Kermani, K.K. Teng, and B.L. Hempstead Regulation of cell survival by secreted proneurotrophins Science 294 2001 1945 1948
4. A. Nykjaer, R. Lee, K.K. Teng, P. Jansen, P. Madsen, M.S. Nielsen, E. Schwarz, T.E. Willnow, B.L. Hempstead, and C.M. Petersen Sortilin is essential for proNGF-induced neuronal cell death Nature 427 2004 843 848
5. M. Fahnestock, G. Yu, B. Michalski, S. Mathew, A. Colquhoun, G.M. Ross, and M.D. Coughlin The nerve growth factor precursor proNGF exhibits neurotrophic activity but is less active than mature nerve growth factor J Neurochem 89 2004 581 592
6. O. Clewes, M.S. Fahey, S.J. Tyler, J.J. Watson, H. Seok, C. Catania, K. Cho, D. Dawbarn, and S.J. Allen Human ProNGF: biological effects and binding profiles at TrkA, P75NTR and sortilin J Neurochem 107 2008 1124 1135
7. R. Masoudi, M.S. Ioannou, M.D. Coughlin, P. Pagadala, K.E. Neet, O. Clewes, S.J. Allen, D. Dawbarn, and M. Fahnestock Biological activity of nerve growth factor precursor is dependent upon relative levels of its receptors J Biol Chem 284 2009 18424 18433
8. A. Kalous, M.R. Nangle, A. Anastasia, B.L. Hempstead, and J.R. Keast Neurotrophic actions initiated by proNGF in adult sensory neurons may require peri-somatic glia to drive local cleavage to NGF J Neurochem 122 2012 523 536
9. L. Howard, S. Wyatt, G. Nagappan, and A.M. Davies ProNGF promotes neurite growth from a subset of NGF-dependent neurons by a p75NTR-dependent mechanism Development 140 2013 2108 2117
10. R. Delsite, and D. Djakiew Characterization of nerve growth factor precursor protein expression by human prostate stromal cells: a role in selective neurotrophin stimulation of prostate epithelial cell growth Prostate 41 1999 39 48
11. J.I. Epstein, W.C. Allsbrook Jr., M.B. Amin, and L.L. Egevad The 2005 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma Am J Surg Pathol 29 2005 1228 1242
12. E. Adriaenssens, E. Vanhecke, P. Saule, A. Mougel, A. Page, R. Romon, V. Nurcombe, X. Le Bourhis, and H. Hondermarck Nerve growth factor is a potential therapeutic target in breast cancer Cancer Res 68 2008 346 351
13. E. Lobos, C. Gebhardt, A. Kluge, and K. Spanel-Borowski Expression of nerve growth factor (NGF) isoforms in the rat uterus during pregnancy: accumulation of precursor proNGF Endocrinology 146 2005 1922 1929
14. D. Djakiew, R. Delsite, B. Pflug, J. Wrathall, J.H. Lynch, and M. Onoda Regulation of growth by a nerve growth factor-like protein which modulates paracrine interactions between a neoplastic epithelial cell line and stromal cells of the human prostate Cancer Res 51 1991 3304 3310
15. J. Boutilier, C. Ceni, P.C. Pagdala, A. Forgie, K.E. Neet, and P.A. Barker Proneurotrophins require endocytosis and intracellular proteolysis to induce TrkA activation J Biol Chem 283 2008 12709 12716
16. D. Djakiew, B.R. Pflug, R. Delsite, M. Onoda, J.H. Lynch, G. Arand, and E.W. Thompson Chemotaxis and chemokinesis of human prostate tumor cell lines in response to human prostate stromal cell secretory proteins containing a nerve growth factor-like protein Cancer Res 53 1993 1416 1420
17. M.A. Sortino, F. Condorelli, C. Vancheri, A. Chiarenza, R. Bernardini, U. Consoli, U. Consoli, and P.L. Canonico Mitogenic effect of nerve growth factor (NGF) in LNCaP prostate adenocarcinoma cells: role of the high- and low-affinity NGF receptors Mol Endocrinol 14 2000 124 136
18. A.T. Weeraratna, S.L. Dalrymple, J.C. Lamb, S.R. Denmeade, S. Miknyoczki, C.A. Dionne, and J.T. Isaacs Pan-trk inhibition decreases metastasis and enhances host survival in experimental models as a result of its selective induction of apoptosis of prostate cancer cells Clin Cancer Res 7 2001 2237 2245
19. S.J. Miknyoczki, W. Wan, H. Chang, P. Dobrzanski, B.A. Ruggeri, C.A. Dionne, and K. Buchkovich The neurotrophin-trk receptor axes are critical for the growth and progression of human prostatic carcinoma and pancreatic ductal adenocarcinoma xenografts in nude mice Clin Cancer Res 8 2002 1924 1931
20. Y. Glinka, M. Gassen, and M.B. Youdim Mechanism of 6-hydroxydopamine neurotoxicity J Neural Transm Suppl 50 1997 55 66
21. S. Pezet, and S.B. McMahon Neurotrophins: mediators and modulators of pain Annu Rev Neurosci 29 2006 507 538
22. B.L. Schmidt, D.T. Hamamoto, D.A. Simone, and G.L. Wilcox Mechanism of cancer pain Mol Interv 10 2010 164 178
23. K.G. Halvorson, K. Kubota, M.A. Sevcik, T.H. Lindsay, J.E. Sotillo, J.R. Ghilardi, T.J. Rosol, L. Boustany, D.L. Shelton, and P.W. Mantyh A blocking antibody to nerve growth factor attenuates skeletal pain induced by prostate tumor cells growing in bone Cancer Res 65 2005 9426 9435
24. J.M. Jimenez-Andrade, J.R. Ghilardi, G. Castaneda-Corral, M.A. Kuskowski, and P.W. Mantyh Preventive or late administration of anti-NGF therapy attenuates tumor-induced nerve sprouting, neuroma formation, and cancer pain Pain 152 2011 2564 2574
25. A. Cattaneo Tanezumab, a recombinant humanized mAb against nerve growth factor for the treatment of acute and chronic pain Curr Opin Mol Ther 12 2010 94 106