Serum triglycerides, but not cholesterol or leptin, are decreased in suicide attempters with mood disorders

Journal of Affective Disorders

Volumn 172, Issue , 2015, Pages 403-409

  Da Graça Cantarelli, Maria ^a   Nardin, Patrícia ^a   Buffon, Andréia ^a   Eidt, Murilo Castilhos ^b   Antônio Godoy, Luiz ^c   Fernandes, Brisa S ^a   Gonçalves, Carlos Alberto ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b José de Barros Falcão Study Center   (Brazil)

^c HOSPITAL SÃO JOSÉ   (Brazil)

Author keywords

Cholesterol Mood affective disorders Leptin Suicide Triglycerides

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; C REACTIVE PROTEIN; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN; LEPTIN; LOW DENSITY LIPOPROTEIN; PROTEIN S100B; TRIACYLGLYCEROL; BIOLOGICAL MARKER; BRAIN-DERIVED NEUROTROPHIC FACTOR, HUMAN;

ADIPOSE TISSUE; ADULT; ARTICLE; BODY MASS; BRAIN; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CROSS-SECTIONAL STUDY; DISEASE ASSOCIATION; FEMALE; HUMAN; HYPOTHESIS; LIPID ANALYSIS; LIPOPROTEIN BLOOD LEVEL; LOSS OF APPETITE; MALE; MOOD; MOOD DISORDER; SUICIDAL BEHAVIOR; SUICIDAL IDEATION; SUICIDE ATTEMPT; TRIACYLGLYCEROL BLOOD LEVEL; WAIST CIRCUMFERENCE; WEIGHT REDUCTION; BIPOLAR DISORDER; BLOOD; COMPLICATION; MAJOR DEPRESSION; METABOLISM; MIDDLE AGED;

ADULT; BIOMARKERS; BIPOLAR DISORDER; BRAIN-DERIVED NEUROTROPHIC FACTOR; C-REACTIVE PROTEIN; CHOLESTEROL; CROSS-SECTIONAL STUDIES; DEPRESSIVE DISORDER, MAJOR; FEMALE; HUMANS; LEPTIN; MALE; MIDDLE AGED; MOOD DISORDERS; SUICIDAL IDEATION; SUICIDE, ATTEMPTED; TRIGLYCERIDES;

EID: 84913554290     PISSN: 01650327     EISSN: 15732517     Source Type: Journal    
DOI: 10.1016/j.jad.2014.10.033     Document Type: Article

References (85)

1. L.G. Almeida-Montes, V. Valles-Sanchez, J. Moreno-Aguilar, R.A. Chavez-Balderas, J.A. Garcia-Marin, J.F. Cortes Sotres, and G. Hheinze-Martin Relation of serum cholesterol, lipid, serotonin and tryptophan levels to severity of depression and to suicide attempts J. of Psychiatry Neurosci. 25 2000 371 377
2. A.C. Andreazza, C. Cassini, A.R. Rosa, M.C. Leite, L.M. de Almeida, P. Nardin, A.B. Cunha, K.M. Cereser, A. Santin, C. Gottfried, M. Salvador, F. Kapczinski, and C.A. Goncalves Serum S100B and antioxidant enzymes in bipolar patients J. Psychiatr. Res. 41 2007 523 529
3. V. Arango, Y.Y. Huang, M.D. Underwood, and J.J. Mann Genetics of the serotonergic system in suicidal behavior J.Psychiatr. Res. 37 2003 375 386
4. V. Arango, M.D. Underwood, A.V. Gubbi, and J.J. Mann Localized alterations in pre- and postsynaptic serotonin binding sites in the ventrolateral prefrontal cortex of suicide victims Brain Res. 688 1995 121 133
5. V. Arango, M.D. Underwood, and J.J. Mann Serotonin brain circuits involved in major depression and suicide Prog. Brain Res. 136 2002 443 453
6. P. Asellus, P. Nordstrom, and J. Jokinen Cholesterol and CSF 5-HIAA in attempted suicide J.Affect. Disord. 125 2010 388 392
7. M. Atmaca, M. Kuloglu, E. Tezcan, and B. Ustundag Serum leptin and cholesterol values in violent and non-violent suicide attempters Psychiatry Res. 158 2008 87 91
8. M. Atmaca, M. Kuloglu, E. Tezcan, B. Ustundag, O. Gecici, and B. Firidin Serum leptin and cholesterol values in suicide attempters Neuropsychobiology 45 2002 124 127
9. M. Atmaca, E. Tezcan, S. Parmaksiz, M. Saribas, S. Ozler, and B. Ustundag Serum ghrelin and cholesterol values in suicide attempters Neuropsychobiology 54 2006 59 63
10. J.H. Baek, E.S. Kang, M. Fava, D. Mischoulon, A.A. Nierenberg, B.H. Yu, D. Lee, and H.J. Jeon Serum lipids, recent suicide attempt and recent suicide status in patients with major depressive disorder Prog. Neuro-psychopharmacol. Biol. Psychiatry 51 2014 113 118
11. A.T. Beck, C.J. Frederick, S. Perlin, A.D. Pokorny, and R.E. Schulman Classification and nomenclatureSuperintendent of Documents, U.S. Superintendent of Documents, U.S. H.L.P. Resnik, B.C. Hathorne, Suicide Prevention in the Seventies 1973 Government Printing Office Washington, D.C. 7 12
12. J.M. Bertolote, and A. Fleischmann A global perspective in the epidemiology of suicide Suicidology 2002 6 8
13. G. Borges, M.K. Nock, J.M. Haro Abad, I. Hwang, N.A. Sampson, J. Alonso, L.H. Andrade, M.C. Angermeyer, A. Beautrais, E. Bromet, R. Bruffaerts, G. de Girolamo, S. Florescu, O. Gureje, C. Hu, E.G. Karam, V. Kovess-Masfety, S. Lee, D. Levinson, M.E. Medina-Mora, J. Ormel, J. Posada-Villa, R. Sagar, T. Tomov, H. U.d.a, D.R. Williams, and R.C. Kessler Twelve-month prevalence of and risk factors for suicide attempts in the World Health Organization World Mental Health Surveys J. Clin. Psychiatry 71 2010 1617 1628
14. L. Brundin, M. Bjorkqvist, A. Petersen, and L. Traskman-Bendz Reduced orexin levels in the cerebrospinal fluid of suicidal patients with major depressive disorder Eur. Neuropsychopharmacol. 17 2007 573 579
15. B. Carpiniello, F. Pinna, F. Velluzzi, and A. Loviselli Mental disorders in patients with metabolic syndrome. The key role of central obesity Eat. Weight Disord. 17 2012 e259 e266
16. S.S. Chang, C.P. Wen, M.K. Tsai, D.A. Lawlor, Y.C. Yang, and D. Gunnell Adiposity, its related biologic risk factors, and suicide: a cohort study of 542,088 taiwanese adults Am. J. Epidemiol. 175 2012 804 815
17. W. Coryell, and M. Schlesser Combined biological tests for suicide prediction Psychiatry Res. 150 2007 187 191
18. J. Cruickshank, and C.J. Tisdall The cholesterol content of the serum in mental diseases Br. J. Psychiatry 62 1916 168 173
19. V. DAmbrosio, V. Salvi, F. Bogetto, and G. Maina Serum lipids, metabolic syndrome and lifetime suicide attempts in patients with bipolar disorder Prog. Neuro-Psychopharmacol. Biol. Psychiatry 37 2012 136 140
20. T. Dawood, J. Anderson, D. Barton, E. Lambert, M. Esler, E. Hotchkin, D. Haikerwal, D. Kaye, and G. Lambert Reduced overflow of BDNF from the brain is linked with suicide risk in depressive illness Mol. Psychiatry 12 2007 981 983
21. D. De Berardis, N. Serroni, D. Campanella, A. Carano, F. Gambi, A. Valchera, C. Conti, G. Sepede, M. Scali, M. Fulcheri, R.M. Salerno, and F.M. Ferro Alexithymia and its relationships with C-reactive protein and serum lipid levels among drug naive adult outpatients with major depression Prog. Neuro-psychopharmacol. Biol. Psychiatry 32 2008 1982 1986
22. V. De Luca, S. Tharmalingam, N. King, J. Strauss, N. Bulgin, and J.L. Kennedy Association study of a novel functional polymorphism of the serotonin transporter gene in bipolar disorder and suicidal behaviour Psychopharmacology 182 2005 128 131
23. G.R. Dutton, L.P. Bodell, A.R. Smith, and T.E. Joiner Examination of the relationship between obesity and suicidal ideation Int. J. Obes. 37 2013 1282 1286
24. N. Eikelis, M. Esler, D. Barton, T. Dawood, G. Wiesner, and G. Lambert Reduced brain leptin in patients with major depressive disorder and in suicide victims Mol. Psychiatry 11 2006 800 801
25. A. Fagiolini, E. Frank, J.A. Scott, S. Turkin, and D.J. Kupfer Metabolic syndrome in bipolar disorder: findings from the Bipolar Disorder Center for Pennsylvanians Bipolar Disord. 7 2005 424 430
26. T. Falcone, V. Fazio, C. Lee, B. Simon, K. Franco, N. Marchi, and D. Janigro Serum S100B: a potential biomarker for suicidality in adolescents? PLoS one 5 2010 e11089
27. D.R. Farias, J. Pinto Tde, M.M. Teofilo, A.A. Vilela, S. Vaz Jdos, A.E. Nardi, and G. Kac Prevalence of psychiatric disorders in the first trimester of pregnancy and factors associated with current suicide risk Psychiatry Res. 210 2013 962 968
28. S. Fazel, M. Grann, J. Ahlner, and G. Goodwin Suicides by violent means in individuals taking SSRIs and other antidepressants: a postmortem study in Sweden, 1992-2004 J. Clin. Psychopharmacol. 27 2007 503 506
29. B.S. Fernandes, M. Berk, C.W. Turck, J. Steiner, and C.A. Goncalves Decreased peripheral brain-derived neurotrophic factor levels are a biomarker of disease activity in major psychiatric disorders: a comparative meta-analysis Mol. Psychiatry 2013
30. B.S. Fernandes, C.S. Gama, K.M. Cereser, L.N. Yatham, G.R. Fries, G. Colpo, D. de Lucena, M. Kunz, F.A. Gomes, and F. Kapczinski Brain-derived neurotrophic factor as a state-marker of mood episodes in bipolar disorders: a systematic review and meta-regression analysis J. Psychiatr. Res. 45 2011 995 1004
31. J.G. Fiedorowicz, N.M. Palagummi, V.L. Forman-Hoffman, D.D. Miller, and W.G. Haynes Elevated prevalence of obesity, metabolic syndrome, and cardiovascular risk factors in bipolar disorder Ann. Clin. Psychiatry 20 2008 131 137
32. C.A. Goncalves, M.C. Leite, and M.C. Guerra Adipocytes as an important source of serum S100B and possible roles of this protein in adipose tissue Cardiovasc. Psychiatry Neurol. 2010 2010 790431
33. C.A. Goncalves, M.C. Leite, and P. Nardin Biological and methodological features of the measurement of S100B, a putative marker of brain injury Clin.Biochem. 41 2008 755 763
34. S. Gross, J.J. Homan van der Heide, W.J. van Son, R.O. Gans, D. Foell, G. Navis, and S.J. Bakker Body mass index and creatinine clearance are associated with steady-state serum concentrations of the cell damage marker S100B in renal transplant recipients Med. Sci. Monit.: Int. Med. J. Exp. Clin. Res. 16 2010 CR318 CR324
35. D. Gunnell, and D. Ashby Antidepressants and suicide: what is the balance of benefit and harm Br. Med. J. 329 2004 34 38
36. T.A. Hammad, T.P. Laughren, and J.A. Racoosin Suicide rates in short-term randomized controlled trials of newer antidepressants J. Clin. Psychopharmacol. 26 2006 203 207
37. T. Huang, and S. Wu Serum cholesterol levels in paranoid and non-paranoid schizophrenia associated with physical violence or suicide attempts in Taiwanese Psychiatry Res. 96 2000 175 178
38. S.H. Jee, M. Kivimaki, H.C. Kang, I.S. Park, J.M. Samet, and G.D. Batty Cardiovascular disease risk factors in relation to suicide mortality in Asia: prospective cohort study of over one million Korean men and women Eur. Heart J. 32 2011 2773 2780
39. J. Jokinen, A.L. Nordstrom, and P. Nordstrom CSF 5-HIAA and DST non-suppression - orthogonal biologic risk factors for suicide in male mood disorder inpatients Psychiatry Res. 165 2009 96 102
40. J. Jokinen, A.L. Nordstrom, and P. Nordstrom Cholesterol, CSF 5-HIAA, violence and intent in suicidal men Psychiatry Res. 178 2010 217 219
41. J.M. Kim, R. Stewart, S.W. Kim, I.S. Shin, S.J. Yang, and J.S. Yoon Cholesterol and serotonin transporter polymorphism interactions in late-life depression Neurobiol. Aging 32 2011 336 343
42. A. Kleindienst, F. Hesse, M.R. Bullock, and M. Buchfelder The neurotrophic protein S100B: value as a marker of brain damage and possible therapeutic implications Prog. Brain Res. 161 2007 317 325
43. M.A. Kling, S. Alesci, G. Csako, R. Costello, D.A. Luckenbaugh, O. Bonne, R. Duncko, W.C. Drevets, H.K. Manji, D.S. Charney, P.W. Gold, and A. Neumeister Sustained low-grade pro-inflammatory state in unmedicated, remitted women with major depressive disorder as evidenced by elevated serum levels of the acute phase proteins C-reactive protein and serum amyloid A Biol. Psychiatry 62 2007 309 313
44. B.H. Lee, and Y.K. Kim Potential peripheral biological predictors of suicidal behavior in major depressive disorder Prog. Neuro-psychopharmacol. Biol. Psychiatry 35 2011 842 847
45. H.J. Lee, and Y.K. Kim Serum lipid levels and suicide attempts Acta Psychiatr. Scand. 108 2003 215 221
46. M.C. Leite, F. Galland, G. Brolese, M.C. Guerra, J.W. Bortolotto, R. Freitas, L.M. Almeida, C. Gottfried, and C.A. Goncalves A simple, sensitive and widely applicable ELISA for S100B: methodological features of the measurement of this glial protein J. Neurosci. Methods 169 2008 93 99
47. D. Lester Serum cholesterol levels and suicide: a meta-analysis Suicide Life-threat. Behav. 32 2002 333 346
48. A.L. Lopresti, and P.D. Drummond Obesity and psychiatric disorders: commonalities in dysregulated biological pathways and their implications for treatment Prog. Neuro-psychopharmacol. Biol. Psychiatry 45 2013 92 99
49. J.J. Mann The serotonergic system in mood disorders and suicidal behaviour Philos. Trans. R. Soc. Lond. B: Biol. Sci. 368 2013 20120537
50. D. Marcinko Antidepressants and suicidality: the basis of controversies Psychiatr. Danub. 19 2007 238 240
51. D. Marcinko, V. Marcinko, D. Karlovic, A. Marcinko, M. Martinac, D. Begic, and M. Jakovljevic Serum lipid levels and suicidality among male patients with schizoaffective disorder Prog. Neuro-Psychopharmacol. Biol. Psychiatry 32 2008 193 196
52. K. Marosi, and M.P. Mattson BDNF mediates adaptive brain and body responses to energetic challenges Trends Endocrinol. Metab.: 25 2014 89 98
53. M.G. McConway, D. Johnson, A. Kelly, D. Griffin, J. Smith, and A.M. Wallace Differences in circulating concentrations of total, free and bound leptin relate to gender and body composition in adult humans (Pt 5) Ann. Clin. Biochem. 37 2000 717 723
54. M. Miller, V. Pate, S.A. Swanson, D. Azrael, A. White, and T. Sturmer Antidepressant class, age, and the risk of deliberate self-harm: a propensity score matched cohort study of SSRI and SNRI users in the USA CNS Drugs 28 2014 79 88
55. K.J. Mukamal, and M. Miller BMI and risk factors for suicide: why is BMI inversely related to suicide? Obesity 17 2009 532 538
56. M.F. Muldoon, S.B. Manuck, A.B. Mendelsohn, J.R. Kaplan, and S.H. Belle Cholesterol reduction and non-illness mortality: meta-analysis of randomised clinical trials Br. Med. J. 322 2001 11 15
57. E.K. Nousen, J.G. Franco, and E.L. Sullivan Unraveling the mechanisms responsible for the comorbidity between metabolic syndrome and mental health disorders Neuroendocrinology 2014
58. E. Olie, M.C. Picot, S. Guillaume, M. Abbar, and P. Courtet Measurement of total serum cholesterol in the evaluation of suicidal risk J. Affect. Disord. 133 2011 234 238
59. G.N. Pandey Biological basis of suicide and suicidal behavior Bipolar Disord. 15 2013 524 541
60. G.N. Pandey, Y. Dwivedi, H.S. Rizavi, X. Ren, H. Zhang, and M.N. Pavuluri Brain-derived neurotrophic factor gene and protein expression in pediatric and adult depressed subjects Prog. Neuro-Psychopharmacol. Biol. Psychiatry 34 2010 645 651
61. A. Papadopoulou, M. Markianos, C. Christodoulou, and L. Lykouras Plasma total cholesterol in psychiatric patients after a suicide attempt and in follow-up J. Affect. Disord. 148 2013 440 443
62. K. Paplos, B. Havaki-Kontaxaki, P. Ferentinos, M. Dasopoulou, and V. Kontaxakis Alexithymia, depression and serum lipids in suicide attempters Psychiatrike=Psychiatriki 23 2012 149 152
63. S. Park, K.K. Yi, R. Na, A. Lim, and J.P. Hong No association between serum cholesterol and death by suicide in patients with schizophrenia, bipolar affective disorder, or major depressive disorder Behav. Brain Funct. 9 2013 45
64. J.E. Persons, W.H. Coryell, and J.G. Fiedorowicz Cholesterol fractions, symptom burden, and suicide attempts in mood disorders Psychiatry Res. 200 2012 1088 1089
65. M. Pompili, X. Gonda, G. Serafini, M. Innamorati, L. Sher, M. Amore, Z. Rihmer, and P. Girardi Epidemiology of suicide in bipolar disorders: a systematic review of the literature Bipolar Disord. 15 2013 457 490
66. E.G.T. Poynder, and R.J. Russell The Cholesterol Content of the Cerebro-Spinal Fluid in Certain Mental Diseases British Journal of Psychiatry 72 1926 62 66
67. V. Pylvanen, A. Pakarinen, M. Knip, and J. Isojarvi Insulin-related metabolic changes during treatment with valproate in patients with epilepsy Epilepsy Behav. 8 2006 643 648
68. Z. Rihmer, X. Gonda, P. Torzsa, L. Kalabay, H.S. Akiskal, and A. Eory Affective temperament, history of suicide attempt and family history of suicide in general practice patients J. Affect. Disord. 149 2013 350 354
69. M. Rothermundt, M. Peters, J.H. Prehn, and V. Arolt S100B in brain damage and neurodegeneration Microsc. Res. Tech. 60 2003 614 632
70. M.L. Schroeter, and J. Steiner Elevated serum levels of the glial marker protein S100B are not specific for schizophrenia or mood disorders Mol. Psychiatry 14 2009 235 237
71. M.L. Schroeter, J. Steiner, and K. Mueller Glial pathology is modified by age in mood disorders - a systematic meta-analysis of serum S100B in vivo studies J. Affect. Disord. 134 2011 32 38
72. J. Steiner, K. Schiltz, M. Walter, M.T. Wunderlich, G. Keilhoff, R. Brisch, H. Bielau, H.G. Bernstein, B. Bogerts, M.L. Schroeter, and S. Westphal S100B serum levels are closely correlated with body mass index: an important caveat in neuropsychiatric research Psychoneuroendocrinology 35 2010 321 324
73. J. Steiner, M. Walter, P. Guest, A.M. Myint, K. Schiltz, B. Panteli, M. Brauner, H.G. Bernstein, T. Gos, M. Herberth, M.L. Schroeter, M.J. Schwarz, S. Westphal, S. Bahn, and B. Bogerts Elevated S100B levels in schizophrenia are associated with insulin resistance Mol. Psychiatry 15 2010 3 4
74. L. Tondo, G. Isacsson, and R. Baldessarini Suicidal behaviour in bipolar disorder: risk and prevention CNS Drugs 17 2003 491 511
75. L. Traskman, M. Asberg, L. Bertilsson, and L. Sjostrand Monoamine metabolites in CSF and suicidal behavior Arch. Gen. Psychiatry 38 1981 631 636
76. A. Troisi Cholesterol in coronary heart disease and psychiatric disorders: same or opposite effects on morbidity risk? Neuroscience Biobehav. Rev. 33 2009 125 132
77. S.Y. Tsai, C.J. Kuo, C.C. Chen, and H.C. Lee Risk factors for completed suicide in bipolar disorder J. Clin. Psychiatry 63 2002 469 476
78. D. Vancampfort, K. Vansteelandt, C.U. Correll, A.J. Mitchell, A. De Herdt, P. Sienaert, M. Probst, and M. De Hert Metabolic syndrome and metabolic abnormalities in bipolar disorder: a meta-analysis of prevalence rates and moderators Am. J. Psychiatry 170 2013 265 274
79. A. Verrotti, R. la Torre, D. Trotta, A. Mohn, and F. Chiarelli Valproate-induced insulin resistance and obesity in children Horm. Res. 71 2009 125 131
80. B. Vuksan-Cusa, D. Marcinko, S. Nad, and M. Jakovljevic Differences in cholesterol and metabolic syndrome between bipolar disorder men with and without suicide attempts Prog. Neuro-Psychopharmacol. Biol. Psychiatry 33 2009 109 112
81. M.T. Walsh, and T.G. Dinan Selective serotonin reuptake inhibitors and violence: a review of the available evidence Acta Psychiatr. Scand. 104 2001 84 91
82. S. Westling, B. Ahren, L. Traskman-Bendz, and A. Westrin Low CSF leptin in female suicide attempters with major depression J. Affect. Disord. 81 2004 41 48
83. P.G. Weston The cholesterol content of cerebrospinal fluid J. Med. Res. 33 1915 119 126
84. J. Zhang Epidemiological link between low cholesterol and suicidality: a puzzle never finished Nutr. Neurosci. 14 2011 268 287
85. Y. Zhang, E.M. Smith, T.M. Baye, J.V. Eckert, L.J. Abraham, E.K. Moses, A.H. Kissebah, L.J. Martin, and M. Olivier Serotonin (5-HT) receptor 5A sequence variants affect human plasma triglyceride levels Physiol. Genomics 42 2010 168 176