Hyponatraemia in older medical patients: Implications for falls and adverse outcomes of hospitalisation

Internal Medicine Journal

Volumn 44, Issue 10, 2014, Pages 991-997

  Ahamed, S ^a   Anpalahan, Mahesan ^b,c   Savvas, S ^d   Gibson, S ^d,e   Torres, J ^a   Janus, E ^a,c  

^a WESTERN HEALTH   (Australia)

^b EASTERN HEALTH   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d NATIONAL AGEING RESEARCH INSTITUTE   (Australia)

^e Caulfield Pain Management and Research Centre   (Australia)

Author keywords

Adverse outcome; Elderly; Fall; Hospitalisation; Hyponatraemia

Indexed keywords

DIURETIC AGENT; NEUROLEPTIC AGENT; SEROTONIN UPTAKE INHIBITOR;

ADVERSE OUTCOME; AGED; ARTICLE; CARDIOVASCULAR DISEASE; CASE CONTROL STUDY; CHARLSON COMORBIDITY INDEX; CONTROLLED STUDY; DISEASE ASSOCIATION; FALLING; FEMALE; FOLLOW UP; HOSPITAL ADMISSION; HOSPITAL READMISSION; HOSPITALIZATION; HUMAN; HYPONATREMIA; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; METABOLIC DISORDER; MORTALITY; PREVALENCE; RESIDENTIAL CARE; RISK FACTOR; CARDIOVASCULAR DISEASES; COMORBIDITY; COMPLICATION; METABOLIC DISEASES; METABOLISM; PREVENTION AND CONTROL; RISK; STATISTICS AND NUMERICAL DATA; VERY ELDERLY;

ACCIDENTAL FALLS; AGED; AGED, 80 AND OVER; CARDIOVASCULAR DISEASES; CASE-CONTROL STUDIES; COMORBIDITY; DIURETICS; FEMALE; HOSPITALIZATION; HUMANS; HYPONATREMIA; MALE; METABOLIC DISEASES; ODDS RATIO; PREVALENCE; RISK FACTORS;

EID: 84913549501     PISSN: 14440903     EISSN: 14455994     Source Type: Journal    
DOI: 10.1111/imj.12535     Document Type: Article

References (29)

1. Miller M, Hecker MS, Friedlander DA, Carter JM. Apparent idiopathic hyponatremia in an ambulatory geriatric population. J Am Geriatr Soc 1996; 44: 406-408.
2. Miller M, Morley JE, Rubenstein LZ. Hyponatremia in a nursing home population. J Am Geriatr Soc 1995; 43: 1410-1413.
3. Upadhyay A, Jaber BL, Madias NE. Incidence and prevalence of hyponatremia. Am J Med 2006; 119: S30-35.
4. Kennedy PG, Mitchell DM, Hoffbrand BI. Severe hyponatraemia in hospital inpatients. Br Med J 1978; 2: 1251-1253.
5. Shapiro DS, Sonnenblick M, Galperin I, Melkonyan L, Munter G. Severe hyponatraemia in elderly hospitalized patients: prevalence, aetiology and outcome. Intern Med J 2010; 40: 574-580.
6. Schrier RW, Gross P, Gheorghiade M, Berl T, Verbalis JG, Czerwiec FS etal. Tolvaptan, a selective oral vasopressin V2-receptor antagonist, for hyponatremia. N Engl J Med 2006; 355: 2099-2112.
7. Wald R, Jaber BL, Price LL, Upadhyay A, Madias NE. Impact of hospital-associated hyponatremia on selected outcomes. Arch Intern Med 2010; 170: 294-302.
8. Callahan MA, Do HT, Caplan DW, Yoon-Flannery K. Economic impact of hyponatremia in hospitalized patients: a retrospective cohort study. Postgrad Med 2009; 121: 186-1918.
9. Amin A, Deitelzweig S, Christian R, Friend K, Lin J, Belk K etal. Evaluation of incremental healthcare resource burden and readmission rates associated with hospitalized hyponatremic patients in the US. J Hosp Med 2012; 7: 634-639.
10. Terzian C, Frye EB, Piotrowski ZH. Admission hyponatremia in the elderly: factors influencing prognosis. J Gen Intern Med 1994; 9: 89-91.
11. Baran D, Hutchinson TA. The outcome of hyponatremia in a general hospital population. Clin Nephrol 1984; 22: 72-76.
12. Turgutalp K, Ozhan O, Gok Oguz E, Yilmaz A, Horoz M, Helvaci I. Clinical features, outcome and cost of hyponatremia-associated admission and hospitalization in elderly and very elderly patients: a single-center experience in Turkey. Int Urol Nephrol 2013; 45: 265-273.
13. Waikar SS, Mount DB, Curhan GC. Mortality after hospitalization with mild, moderate, and severe hyponatremia. Am J Med 2009; 122: 857-865.
14. Anpalahan M. Chronic idiopathic hyponatremia in older people due to syndrome of inappropriate antidiuretic hormone secretion (SIADH) possibly related to aging. J Am Geriatr Soc 2001; 49: 788-792. Erratum in: J Am Geriatric Soc 2002; 50: 204.
15. Renneboog B, Musch W, Vandemergel X, Manto MU, Decaux G. Mild chronic hyponatremia is associated with falls, unsteadiness, and attention deficits. Am J Med 2006; 119: e71-78.
16. Tolouian R, Alhamad T, Farazmand T, Mulla ZD. The correlation of hip fracture and hyponatremia in the elderly. J Nephrol 2012; 25: 789-793.
17. Gunathilake R, Oldmeadow C, McEvoy M, Kelly B, Inder K, Schofield P etal. Mild hyponatremia is associated with impaired cognition and falls in community-dwelling older persons. J Am Geriatr Soc 2013; 61: 1838-1839.
18. Verbalis JG, Barsony J, Sugimura Y, Tian Y, Adams DJ, Carter EA etal. Hyponatremia-induced osteoporosis. J Bone Miner Res 2010; 25: 554-563.
19. Kinsella S, Moran SO, Sullivan M, Molloy MG, Eustace JA. Hyponatremia independent of osteoporosis is associated with fracture occurrence. Clin J Am Soc Nephrol 2010; 5: 275-280.
20. Hoorn EJ, Rivadeneira F, van Meurs JB, Ziere G, Stricker BH, Hofman A etal. Mild hyponatremia as a risk factor for fractures: the Rotterdam Study. J Bone Miner Res 2011; 26: 1822-1828.
21. Sandhu HS, Gilles E, DeVita MV, Panagopoulos G, Michelis MF. Hyponatremia associated with large-bone fracture in elderly patients. Int Urol Nephrol 2009; 41: 733-737.
22. Gankam Kengne F, Andres C, Sattar L, Melot C, Decaux G. Mild hyponatremia and risk of fracture in the ambulatory elderly. QJM 2008; 101: 583-588.
23. Gosch M, Joosten-Gstrein B, Heppner H, Lechleitner M. Hyponatremia in geriatric inhospital patients: effects on results of a comprehensive geriatric assessment. Gerontology 2012; 58: 430-440.
24. Bagshaw SM, Townsend DR, McDermid RC. Disorders of sodium and water balance in hospitalized patients. Can J Anesth 2009; 56: 151-167.
25. Feder G, Cryer C, Donovan S, Carter Y. Guidelines for the prevention of falls in people over 65. Br Med J 2000; 321: 1007-1011.
26. Blake AJ, Morgan K, Bendall MJ, Dallosso H, Ebrahim SB, Arie TH etal. Falls by elderly people at home: prevalence and associated factors. Age Ageing 1988; 17: 365-372.
27. Lim LS, Fink HA, Blackwell T, Taylor BC, Ensrud KE. Loop diuretic use and rates of hip bone loss, and risk of falls and fractures in older women. J Am Geriatr Soc 2009; 57: 855-862.
28. Anpalahan M, Gibson SJ. Geriatric syndromes as predictors of adverse outcomes of hospitalization. Intern Med J 2008; 38: 16-23.
29. Adrogué HJ, Madias NE. Hypernatremia. N Engl J Med 2000; 342: 1493-1499.