Clinical features, outcome and cost of hyponatremiaassociated admission and hospitalization in elderly and very elderly patients: A single-center experience in Turkey

International Urology and Nephrology

Volumn 45, Issue 1, 2013, Pages 265-273

  Turgutalp, K ^a   Ozhan, O ^a   Oguz, E Gok ^a   Horoz, M ^a   Camsari, A ^a   Yilmaz, A ^a   Kiykim, A ^a   Arici, M ^b  

^a MERSIN UNIVERSITY   (Turkey)

^b HACETTEPE UNIVERSITY   (Turkey)

Author keywords

Elderly; Hospital cost; Hyponatremia; Mortality; Prevalence

Indexed keywords

ANGIOTENSIN ANTAGONIST; DIURETIC AGENT; LOOP DIURETIC AGENT; RENIN INHIBITOR; SODIUM; THIAZIDE DIURETIC AGENT;

AGE DISTRIBUTION; AGED; ARTICLE; CAUSE OF DEATH; CLINICAL EVALUATION; CLINICAL FEATURE; COMORBIDITY; COST OF ILLNESS; DIARRHEA; DISEASE ASSOCIATION; DISEASE SEVERITY; DRUG EFFECT; DRUG SAFETY; ELDERLY CARE; FEMALE; HOSPITAL ADMISSION; HOSPITALIZATION COST; HUMAN; HYPONATREMIA; INTENSIVE CARE; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; SEX DIFFERENCE; SODIUM BLOOD LEVEL; TURKEY (REPUBLIC); VERY ELDERLY; VOMITING;

ACUTE KIDNEY INJURY; AGE FACTORS; AGED; AGED, 80 AND OVER; ANALYSIS OF VARIANCE; ANGIOTENSIN RECEPTOR ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; BACTEREMIA; DIARRHEA; EMERGENCY SERVICE, HOSPITAL; HOSPITAL COSTS; HUMANS; HYPONATREMIA; INTENSIVE CARE; LENGTH OF STAY; PREVALENCE; RETROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX; SODIUM; SODIUM CHLORIDE SYMPORTER INHIBITORS; STATISTICS, NONPARAMETRIC; TIME FACTORS; TURKEY; VOMITING;

EID: 84873413122     PISSN: 03011623     EISSN: 15732584     Source Type: Journal    
DOI: 10.1007/s11255-012-0307-9     Document Type: Article

References (23)

1. Rao MY, Sudhir U, Anil Kumar T, Saravanan S, Mahesh E, Punith K (2010) Hospital-based descriptive study of symptomatic hyponatremia in elderly patients. J Assoc Physicians India 58:667-669
2. Chen LK, Lin MH, Hwang SJ, Chen TW (2006) Hyponatremia among the institutionalized elderly in 2 long-term care facilities in Taipei. J Chin Med Assoc 69(3):115-119
3. Callahan MA, Do HT, Caplan DW, Yoon-Flannery K (2009) Economic impact of hyponatremia in hospitalized patients: a retrospective cohort study. Postgrad Med 121(2):186-191
4. Miller M, Carter JM, Fredlander DA, Carter JM (1996) Apparent idiopathic hyponatremia in an ambulatory geratric population. J Am Geriatr Soc 44:404-408
5. http://www.tuik.gov.tr/PreHaberBultenleri.doid=8428
6. Soto ME, Secher M, Gillette-Guyonnet S, van Kan GA, Andrieu S, Nourhashemi F, Rolland Y, Vellas B (2012) Weight loss and rapid cognitive decline in communitydwelling patients with Alzheimer's disease. J Alzheimers Dis 28(3):647-654
7. Pihlajamaki M, Jauhiainen AM, Soininen H (2009) Structural and functional MRI in mild cognitive impairment. Curr Alzheimer Res 6:179-185
8. American Psychiatric Association (2000) Diagnostic and statistical manual of mental disorders (IV-TR), 4th edn-text revised. Washington, DC
9. Passare G, Viitanen M, Torring O, Winblad B, Fastbom J (2004) Sodium and potassium disturbances in the elderly: prevalence and association with drug use. Clin Drug Investig 24(9):535-544
10. Liamis G, Milionis H, Elisaf M (2008) Blood pressure drug therapy and electrolyte disturbances. Int J Clin Pract 62(10):1572-1580
11. Schoolwerth AC, Sica DA, Ballermann BJ, Wilcox CS (2001) Renal considerations in angiotensin converting enzyme inhibitor therapy: a statement for healthcare professionals from the council on the kidney in cardiovascular disease and the council for high blood pressure research of the American heart association. Circulation 104:1985-1991
12. Hume AL, Jack BW, Levinson P (1990) Severe hyponatremia: an association with lisinopril DICP 24(12): 1169-1172
13. Yawar A, Jabbar A, Haque NU, Zuberi LM, Islam N, Akhtar J (2008) Hyponatraemia: etiology, management and outcome. J Coll Physicians Surg Pak 18(8):467-471
14. Chow KM, Kwan BC, Szeto CC (2004) Clinical studies of thiazide induced hyponatremia. J Natl Med Assoc 96:1305-1308
15. Sharabi Y, Illan R, Kamari Y, Cohen H, Nadler M, Messerli FH, Grossman E (2002) Diuretic induced hyponatraemia in elderly hypertensive women. J Hum Hypertens 16(9):631-635
16. De Vecchis R, Ariano C, Esposito C, Giasi A, Cioppa C, Cantatrione S (2012) In right or biventricular chronic heart failure addition of thiazides to loop diuretics to achieve a sequential blockade of the nephron is associated with increased risk of dilutional hyponatremia: results of a casecontrol study. Minerva Cardioangiol. Jul 5. (Epub ahead of print)
17. Doshi SM, Shah P, Lei X, Lahoti A, Salahudeen AK (2012) Hyponatremia in hospitalized cancer patients and its impact on clinical outcomes. Am J Kidney Dis 59(2):222-228
18. Zilberberg MD, Exuzides A, Spalding J, Foreman A, Jones AG, Colby C, Shorr AF (2008) Epidemiology, clinical and economic outcomes of admission hyponatremia among hospitalized patients. Curr Med Res Opin 24(6):1601-1608
19. Adams D, de Jonge R, van der Cammen T, Zietse R, Hoorn EJ (2011) Acute kidney injury in patients presenting with hyponatremia. J Nephrol 24(6):749-755
20. Terzian C, Frye EB, Piotrowski ZH (1994) Admission hyponatremia in the elderly: factors influencing prognosis. J Gen Intern Med 9:89-91
21. Kim JH, Lee JS, Lee SH, Bae WK, Kim NH, Kim KA, Moon YS (2009) The association between the serum sodium level and the severity of complications in liver cirrhosis. Korean J Intern Med 24(2):106-112
22. Kang SH, Kim HW, Lee SY, Sun IO, Hwang HS, Choi SR, Chung BH, Park HS, Park CW, Yang CW, Kim YS, Choi BS (2012) Is the sodium level per se related to mortality in hospitalized patients with severe hyponatremia Clin Nephrol 77(3):182-187
23. Shorr AF, Tabak YP, Johannes RS, Gupta V, Saltzberg MT, Costanzo MR (2001) Burden of sodium abnormalities in patients hospitalized for heart failure. Congest Heart Fail 17(1):1-7