Molecular probes for imaging of hypoxia in the retina

Bioconjugate Chemistry

Volumn 25, Issue 11, 2014, Pages 2030-2037

  Evans, Stephanie M ^a   Kim, Kwangho ^b   Moore, Chauca E ^a   Uddin, Md Imam ^a   Capozzi, Megan E ^c   Craft, Jason R ^a   Sulikowski, Gary A ^b   Jayagopal, Ashwath ^a,c  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b VANDERBILT UNIVERSITY   (United States)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALS; CELL CULTURE; EYE PROTECTION; MOLECULAR IMAGING; SIGNAL TO NOISE RATIO;

AGE-RELATED MACULAR DEGENERATION; ANIMAL MODEL; CELL CULTURE MODELS; DIABETIC RETINOPATHY; IMAGING AGENT; MOLECULAR PROBES; NITROIMIDAZOLES; RETINAL DISEASE; RETINOPATHY OF PREMATURITY; VISION LOSS;

OPHTHALMOLOGY;

2 NITRO 1 (OXIRAN 2 YLMETHYL) 1H IMIDAZOLE; 2 NITROIMIDAZOLE; DIAGNOSTIC AGENT; FLUORESCEIN ISOTHIOCYANATE; PIMONIDAZOLE; TERT BUTYL [5 (2 NITRO 1H IMIDAZOL 1 YL)PENTYL]CARBAMATE; UNCLASSIFIED DRUG; MOLECULAR PROBE; NITROIMIDAZOLE DERIVATIVE;

ADULT; ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG CONJUGATION; DRUG SPECIFICITY; EX VIVO STUDY; FEMALE; HUMAN; HUMAN CELL; HYPOXIA; HYPOXIC CELL; IN VIVO STUDY; MOLECULAR IMAGING; MOLECULAR PROBE; MOUSE; NONHUMAN; OXYGEN-INDUCED RETINOPATHY; RETINA CELL; RETINA HYPOXIA; SIGNAL NOISE RATIO; ANIMAL; ANOXIA; CELL LINE; CELL SURVIVAL; CHEMISTRY; METABOLISM; PATHOLOGY; PROCEDURES; RETINA; RETINA NERVE CELL;

ANIMALS; ANOXIA; CELL LINE; CELL SURVIVAL; FLUORESCEIN-5-ISOTHIOCYANATE; HUMANS; MICE; MOLECULAR IMAGING; MOLECULAR PROBES; NITROIMIDAZOLES; RETINA; RETINAL NEURONS;

EID: 84913542999     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc500400z     Document Type: Article

References (31)

1. Cunha-Vaz, J. G. (2004) The blood-retinal barriers system. Basic concepts and clinical evaluation Exp. Eye Res. 78, 715-21
2. Linsenmeier, R. A., Braun, R. D., McRipley, M. A., Padnick, L. B., Ahmed, J., Hatchell, D. L., McLeod, D. S., and Lutty, G. A. (1998) Retinal hypoxia in long-term diabetic cats Invest. Ophthalmol. Vis. Sci. 39, 1647-57
3. Poulaki, V., Qin, W., Joussen, A. M., Hurlbut, P., Wiegand, S. J., Rudge, J., Yancopoulos, G. D., and Adamis, A. P. (2002) Acute intensive insulin therapy exacerbates diabetic blood-retinal barrier breakdown via hypoxia-inducible factor-1alpha and VEGF J. Clin. Invest. 109, 805-15
4. Grunwald, J. E., Metelitsina, T. I., Dupont, J. C., Ying, G. S., and Maguire, M. G. (2005) Reduced foveolar choroidal blood flow in eyes with increasing AMD severity Invest. Ophthalmol. Vis. Sci. 46, 1033-8
5. Metelitsina, T. I., Grunwald, J. E., DuPont, J. C., and Ying, G. S. (2006) Effect of systemic hypertension on foveolar choroidal blood flow in age related macular degeneration Br. J. Ophthalmol. 90, 342-6
6. Traustason, S., Kiilgaard, J. F., Karlsson, R. A., Hardarson, S. H., Stefansson, E., and la Cour, M. (2013) Spectrophotometric retinal oximetry in pigs Invest. Ophthalmol. Vis. Sci. 54, 2746-51
7. Hardarson, S. H., Elfarsson, A., Agnarsson, B. A., and Stefansson, E. (2013) Retinal oximetry in central retinal artery occlusion Acta Ophthalmol. 91, 189-90
8. Hammer, M., Vilser, W., Riemer, T., and Schweitzer, D. (2008) Retinal vessel oximetry-calibration, compensation for vessel diameter and fundus pigmentation, and reproducibility J. Biomed. Opt. 13, 054015
9. Hardarson, S. H., Harris, A., Karlsson, R. A., Halldorsson, G. H., Kagemann, L., Rechtman, E., Zoega, G. M., Eysteinsson, T., Benediktsson, J. A., Thorsteinsson, A., Jensen, P. K., Beach, J., and Stefansson, E. (2006) Automatic retinal oximetry Invest. Ophthalmol. Vis. Sci. 47, 5011-6
10. Kristjansdottir, J. V., Hardarson, S. H., Harvey, A. R., Olafsdottir, O. B., Eliasdottir, T. S., and Stefansson, E. (2013) Choroidal oximetry with a noninvasive spectrophotometric oximeter Invest. Ophthalmol. Vis. Sci. 54, 3234-9
11. Wanek, J., Teng, P. Y., Blair, N. P., and Shahidi, M. (2013) Inner retinal oxygen delivery and metabolism under normoxia and hypoxia in rat Invest. Ophthalmol. Vis. Sci. 54, 5012-9
12. Dai, C., Liu, X., Zhang, H. F., Puliafito, C. A., and Jiao, S. (2013) Absolute retinal blood flow measurement with a dual-beam Doppler optical coherence tomography Invest. Ophthalmol. Vis. Sci. 54, 7998-8003
13. Ljungkvist, A. S., Bussink, J., Rijken, P. F., Raleigh, J. A., Denekamp, J., and Van Der Kogel, A. J. (2000) Changes in tumor hypoxia measured with a double hypoxic marker technique Int. J. Radiat. Oncol. Biol. Phys. 48, 1529-38
14. Varia, M. A., Calkins-Adams, D. P., Rinker, L. H., Kennedy, A. S., Novotny, D. B., Fowler, W. C., Jr., and Raleigh, J. A. (1998) Pimonidazole: a novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in cervical carcinoma Gynecol. Oncol. 71, 270-7
15. Arteel, G. E., Thurman, R. G., and Raleigh, J. A. (1998) Reductive metabolism of the hypoxia marker Pimonidazole is regulated by oxygen tension independent of the pyridine nucleotide redox state Eur. J. Biochem. 253, 743-50
16. Nordsmark, M., Loncaster, J., Aquino-Parsons, C., Chou, S. C., Ladekarl, M., Havsteen, H., Lindegaard, J. C., Davidson, S. E., Varia, M., West, C., Hunter, R., Overgaard, J., and Raleigh, J. A. (2003) Measurements of hypoxia using Pimonidazole and polarographic oxygen-sensitive electrodes in human cervix carcinomas Radiother. Oncol. 67, 35-44
17. Seigel, G. M. (1996) Establishment of an E1A-immortalized retinal cell culture In Vitro Cell. Dev. Biol.: Anim. 32, 66-8
18. Seigel, G. M., Mutchler, A. L., Adamus, G., and Imperato-Kalmar, E. L. (1997) Recoverin expression in the R28 retinal precursor cell line In Vitro Cell. Dev. Biol.: Anim. 33, 499-502
19. Capozzi, M. E., McCollum, G. W., and Penn, J. S. (2014) The role of cytochrome P450 epoxygenases in retinal angiogenesis Invest. Ophthalmol. Vis. Sci. 55, 4253-60
20. Penn, J. S., Madan, A., Caldwell, R. B., Bartoli, M., Caldwell, R. W., and Hartnett, M. E. (2008) Vascular endothelial growth factor in eye disease Prog. Retin. Eye Res. 27, 331-71
21. Yu, S. J., Yoon, J. H., Lee, J. H., Myung, S. J., Jang, E. S., Kwak, M. S., Cho, E. J., Jang, J. J., Kim, Y. J., and Lee, H. S. (2011) Inhibition of hypoxia-inducible carbonic anhydrase-IX enhances hexokinase II inhibitor-induced hepatocellular carcinoma cell apoptosis Acta Pharmacol. Sin. 32, 912-20
22. Yaromina, A., Zips, D., Thames, H. D., Eicheler, W., Krause, M., Rosner, A., Haase, M., Petersen, C., Raleigh, J. A., Quennet, V., Walenta, S., Mueller-Klieser, W., and Baumann, M. (2006) Pimonidazole labelling and response to fractionated irradiation of five human squamous cell carcinoma (hSCC) lines in nude mice: the need for a multivariate approach in biomarker studies Radiother. Oncol. 81, 122-9
23. Nordsmark, M., Loncaster, J., Chou, S. C., Havsteen, H., Lindegaard, J. C., Davidson, S. E., Varia, M., West, C., Hunter, R., Overgaard, J., and Raleigh, J. A. (2001) Invasive oxygen measurements and Pimonidazole labeling in human cervix carcinoma Int. J. Radiat. Oncol. Biol. Phys. 49, 581-6
24. Gass, J. D., Sever, R. J., Sparks, D., and Goren, J. (1967) A combined technique of fluorescein funduscopy and angiography of the eye Arch. Ophthalmol. 78, 455-61
25. Smith, L. E., Wesolowski, E., McLellan, A., Kostyk, S. K., D'Amato, R., Sullivan, R., and D'Amore, P. A. (1994) Oxygen-induced retinopathy in the mouse Invest. Ophthalmol. Vis. Sci. 35, 101-11
26. Mowat, F. M., Luhmann, U. F., Smith, A. J., Lange, C., Duran, Y., Harten, S., Shukla, D., Maxwell, P. H., Ali, R. R., and Bainbridge, J. W. (2010) HIF-1alpha and HIF-2alpha are differentially activated in distinct cell populations in retinal ischaemia PLoS One 5, e11103
27. Mezu-Ndubuisi, O. J., Wanek, J., Chau, F. Y., Teng, P. Y., Blair, N. P., Reddy, N. M., Raj, J. U., Reddy, S. P., and Shahidi, M. (2014) Correspondence of retinal thinning and vasculopathy in mice with oxygen-induced retinopathy Exp. Eye Res. 122, 119-22
28. Piao, W., Tsuda, S., Tanaka, Y., Maeda, S., Liu, F., Takahashi, S., Kushida, Y., Komatsu, T., Ueno, T., Terai, T., Nakazawa, T., Uchiyama, M., Morokuma, K., Nagano, T., and Hanaoka, K. (2013) Development of azo-based fluorescent probes to detect different levels of hypoxia Angew. Chem., Int. Ed. 52, 13028-32
29. Kiyose, K., Hanaoka, K., Oushiki, D., Nakamura, T., Kajimura, M., Suematsu, M., Nishimatsu, H., Yamane, T., Terai, T., Hirata, Y., and Nagano, T. (2010) Hypoxia-sensitive fluorescent probes for in vivo real-time fluorescence imaging of acute ischemia J. Am. Chem. Soc. 132, 15846-8
30. Takahashi, S., Piao, W., Matsumura, Y., Komatsu, T., Ueno, T., Terai, T., Kamachi, T., Kohno, M., Nagano, T., and Hanaoka, K. (2012) Reversible off-on fluorescence probe for hypoxia and imaging of hypoxia-normoxia cycles in live cells J. Am. Chem. Soc. 134, 19588-91
31. Dai, Y., Bae, K., and Siemann, D. W. (2011) Impact of hypoxia on the metastatic potential of human prostate cancer cells Int. J. Radiat. Oncol. Biol. Phys. 81, 521-8