A novel aerosol generator for homogenous distribution of powder over the lungs after pulmonary administration to small laboratory animals

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 88, Issue 3, 2014, Pages 1056-1063

  Tonnis, Wouter F ^a   Bagerman, Marieke ^a   Weij, Michel ^b   Sjollema, Jelmer ^b   Frijlink, Henderik W ^a   Hinrichs, Wouter L J ^a   De Boer, Anne H ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

Deagglomeration; Device; Fluorescence; Imaging; Inhalation powder; Lungs; Mice; Powder formulations; Pre clinical research

Indexed keywords

AEROSOL; AEROSOL GENERATOR; ARTICLE; CONTROLLED STUDY; DRY POWDER INHALER; EXPERIMENTAL ANIMAL; FEMALE; INHALATIONAL DRUG ADMINISTRATION; MOUSE; NONHUMAN; PARTICLE SIZE; SCANNING ELECTRON MICROSCOPY; SPRAY DRYING; TOMOGRAPHY; ADMINISTRATION AND DOSAGE; ANIMAL; BAGG ALBINO MOUSE; DEVICES; DRUG EFFECTS; LUNG; METABOLISM; PROCEDURES;

AEROSOL;

ADMINISTRATION, INHALATION; AEROSOLS; ANIMALS; ANIMALS, LABORATORY; DRY POWDER INHALERS; FEMALE; LUNG; MICE; MICE, INBRED BALB C;

EID: 84912570654     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2014.10.011     Document Type: Article

References (24)

1. S.A. Shoyele, and A. Slowey Prospects of formulating proteins/peptides as aerosols for pulmonary drug delivery Int. J. Pharm. 314 2006 1 8
2. W.F. Tonnis, A.J. Lexmond, H.W. Frijlink, A.H. de Boer, and W.L.J. Hinrichs Devices and formulations for pulmonary vaccination Expert Opin. Drug Deliv. 10 2013 1383 1397
3. V. Saluja, J.-P. Amorij, J.C. Kapteyn, A.H. de Boer, H.W. Frijlink, and W.L.J. Hinrichs A comparison between spray drying and spray freeze drying to produce an influenza subunit vaccine powder for inhalation J. Control. Release 144 2010 127 133
4. W.F. Tonnis, A.J. Lexmond, H.W. Frijlink, A.H. de Boer, and W.L.J. Hinrichs Comment on: devices and formulations for pulmonary vaccination Expert Opin. Drug Deliv. 10 2013 1593 1595
5. W.-H. Lin, D.E. Griffin, P.A. Rota, M. Papania, S.P. Cape, D. Bennett, B. Quinn, R.E. Sievers, C. Shermer, K. Powell, R.J. Adams, S. Godin, and S. Winston Successful respiratory immunization with dry powder live-attenuated measles virus vaccine in rhesus macaques Proc. Natl. Acad. Sci. 108 2011 2987 2992
6. J.S. Patton, and P.R. Byron Inhaling medicines: delivering drugs to the body through the lungs Nat. Rev. Drug Discov. 6 2007 67 74
7. O.S. Usmani, M.F. Biddiscombe, and P.J. Barnes Regional lung deposition and bronchodilator response as a function of beta2-agonist particle size Am. J. Respir. Crit. Care Med. 172 2005 1497 1504
8. H.W. Frijlink, and A.H. De Boer Dry powder inhalers for pulmonary drug delivery Expert Opin. Drug Deliv. 1 2004 67 86
9. S.-A. Cryan, N. Sivadas, and L. Garcia-Contreras In vivo animal models for drug delivery across the lung mucosal barrier Adv. Drug Deliv. Rev. 59 2007 1133 1151
10. L. Garcia-Contreras, J.C. Sung, P. Muttil, D. Padilla, M. Telko, J.L. Verberkmoes, K.J. Elbert, A.J. Hickey, and D.A. Edwards Dry powder PA-824 aerosols for treatment of tuberculosis in guinea pigs Antimicrob. Agents Chemother. 54 2010 1436 1442
11. D. Rahmel, G. Pohlmann, P. Iwatschenko, J. Volland, S. Liebisch, H. Kock, L. Mecklenburg, C. Maurer, J. Kemkowski, and F.J.H. Taut The non-intubated, spontaneously breathing, continuous positive airway pressure (CPAP) ventilated pre-term lamb: a unique animal model Reprod. Toxicol. 34 2012 204 215
12. L. Garcia-Contreras, J. Fiegel, M.J. Telko, K. Elbert, A. Hawi, M. Thomas, J. VerBerkmoes, W.A. Germishuizen, P.B. Fourie, A.J. Hickey, and D. Edwards Inhaled large porous particles of capreomycin for treatment of tuberculosis in a guinea pig model Antimicrob. Agents Chemother. 51 2007 2830 2836
13. P. Muttil, J. Kaur, K. Kumar, A.B. Yadav, R. Sharma, and A. Misra Inhalable microparticles containing large payload of anti-tuberculosis drugs Eur. J. Pharm. Sci. 32 2007 140 150
14. G.S. Zijlstra, C.A. Brandsma, M.F.H. Harpe, G.M. Van Dam, D.J. Slebos, H.A.M. Kerstjens, A.H. De Boer, and H.W. Frijlink Dry powder inhalation of hemin to induce heme oxygenase expression in the lung Eur. J. Pharm. Biopharm. 67 2007 667 675
15. B. Sinha, and B. Mukherjee Development of an inhalation chamber and a dry powder inhaler device for administration of pulmonary medication in animal model Drug Dev. Ind. Pharm. 38 2012 171 179
16. A.M. Ischenko, B.P. Nikolaev, T.V. Kotova, E.V. Vorobeychikov, V.G. Konusova, and L.Y. Yakovleva IL-1 receptor antagonist as an aerosol in inflammation J. Aerosol Med. 20 2007 445 459
17. C. Duret, N. Wauthoz, R. Merlos, J. Goole, C. Maris, I. Roland, T. Sebti, F. Vanderbist, and K. Amighi In vitro and in vivo evaluation of a dry powder endotracheal insufflator device for use in dose-dependent preclinical studies in mice Eur. J. Pharm. Biopharm. 81 2012 627 634
18. H. Okamoto, M. Aoki, and K. Danjo A novel apparatus for rat in vivo evaluation of dry powder formulations for pulmonary administration J. Pharm. Sci. 89 2000 1028 1035
19. F. Komada, S. Iwakawa, N. Yamamoto, H. Sakakibara, and K. Okumura Intratracheal delivery of peptide and protein agents: absorption from solution and dry powder by rat lung J. Pharm. Sci. 83 1994 4 8
20. M. Hoppentocht, C. Hoste, P. Hagendoorn, H.W. Frijlink, and A.H. de Boer In vitro evaluation of the DP-4M PennCentury™ insufflator Eur. J. Pharm. Biopharm. 88 2014 153 159
21. V. Saluja, J.P. Amorij, J.C. Kapteyn, A.H. de Boer, H.W. Frijlink, and W.L.J. Hinrichs A comparison between spray drying and spray freeze drying to produce an influenza subunit vaccine powder for inhalation J. Control. Release 144 2010 127 133
22. A. Soubret, J. Ripoll, and V. Ntziachristos Accuracy of fluorescent tomography in the presence of heterogeneities: study of the normalized Born ratio IEEE Trans. Med. Imaging 24 2005 1377 1386
23. G. Pohlmann, P. Iwatschenko, W. Koch, H. Windt, M. Rast, M. Gama de Abreu, F.J.H. Taut, and C. De Muynck A novel Continuous Powder Aerosolizer (CPA) for inhalation administration of highly concentrated recombinant surfactant protein-C (rSP-C) surfactant to preterm neonates J. Aerosol. Med. Pulm. Drug Deliv. 26 2013 370 379
24. W. Hinds Aerosol Technology. Properties, Behavior, and Measurement of Airborne Particles 1982 John Wiley & Sons New York