Low Serum Vitamin D Levels Are Associated with Severe Histological Features and Poor Response to Therapy in Patients with Autoimmune Hepatitis

Digestive Diseases and Sciences

Volumn 59, Issue 12, 2014, Pages 3035-3042

  Efe, Cumali ^a,e   Kav, Taylan ^a   Aydin, Cisel ^a   Cengiz, Mustafa ^b   Imga, Narin Nasıroglu ^c   Purnak, Tugrul ^c   Smyk, Daniel S ^d   Torgutalp, Murat ^a   Turhan, Turan ^c   Ozenirler, Seren ^b   Ozaslan, Ersan ^c   Bogdanos, Dimitrios P ^d  

^a HACETTEPE UNIVERSITY   (Turkey)

^b GAZI UNIVERSITY   (Turkey)

^c ANKARA TRAINING AND RESEARCH HOSPITAL   (Turkey)

^d KING'S COLLEGE LONDON   (United Kingdom)

^e NONE   (Turkey)

Author keywords

Autoimmune hepatitis; Fibrosis; Noninvasive marker; Therapy response; Vitamin D

Indexed keywords

25 HYDROXYVITAMIN D; AZATHIOPRINE; BIOLOGICAL MARKER; COLECALCIFEROL; PREDNISONE; CALCIFEDIOL; IMMUNOSUPPRESSIVE AGENT; STEROID;

ADULT; AREA UNDER THE CURVE; ARTICLE; AUTOIMMUNE HEPATITIS; AUTUMN; COHORT ANALYSIS; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE SEVERITY; FEMALE; HUMAN; LIVER FIBROSIS; LIVER HISTOLOGY; MAJOR CLINICAL STUDY; MALE; PREDICTIVE VALUE; RECEIVER OPERATING CHARACTERISTIC; SEASONAL VARIATION; SPRING; SUMMER; THROMBOCYTE COUNT; TREATMENT RESPONSE; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY; VITAMIN SUPPLEMENTATION; WINTER; BLOOD; CASE CONTROL STUDY; HEPATITIS, AUTOIMMUNE; MIDDLE AGED;

ADULT; CALCIFEDIOL; CASE-CONTROL STUDIES; FEMALE; HEPATITIS, AUTOIMMUNE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MALE; MIDDLE AGED; STEROIDS; VITAMIN D DEFICIENCY;

EID: 84912532963     PISSN: 01632116     EISSN: 15732568     Source Type: Journal    
DOI: 10.1007/s10620-014-3267-3     Document Type: Article

References (21)

1. Krawitt EL. Autoimmune hepatitis. N Engl J Med. 2006;354:54–66.
2. Vergani D, Longhi MS, Bogdanos DP, et al. Autoimmune hepatitis. Semin Immunopathol. 2009;31:421–435.
3. Efe C, Ozaslan E, Wahlin S, et al. Antibodies to soluble liver antigen in patients with various liver diseases: a multicentre study. Liver Int. 2013;33:190–196.
4. Alvarez F, Berg PA, Bianchi FB, et al. International autoimmune hepatitis group report: review of criteria for diagnosis of autoimmune hepatitis. J Hepatol. 1999;31:929–938.
5. Hennes EM, Zeniya M, Czaja AJ, et al. Simplified criteria for the diagnosis of autoimmune hepatitis. Hepatology. 2008;48:169–176.
6. Manns MP, Czaja AJ, Gorham JD, et al. Diagnosis and management of autoimmune hepatitis. Hepatology. 2010;51:2193–2213.
7. Liberal R, Longhi MS, Mieli-Vergani G, et al. Pathogenesis of autoimmune hepatitis. Best Pract Res Clin Gastroenterol. 2011;25:653–664.
8. Smyk DS, Orfanidou T, Invernizzi P, et al. Vitamin D in autoimmune liver disease. Clin Res Hepatol Gastroenterol. 2013;37:535–545.
9. Arnson Y, Amital H, Shoenfeld Y. Vitamin D and autoimmunity: new aetiological and therapeutic considerations. Ann Rheum Dis. 2007;66:1137–1142.
10. Stokes CS, Volmer DA, Grunhage F, et al. Vitamin D in chronic liver disease. Liver Int. 2013;33:338–352.
11. Stokes CS, Krawczyk M, Reichel C, et al. Vitamin D deficiency is associated with mortality in patients with advanced liver cirrhosis. Eur J Clin Invest. 2013. doi:10.1111/eci.12205.
12. Dasarathy J, Periyalwar P, Allampati S, et al. Hypovitaminosis D is associated with increased whole body fat mass and greater severity of non-alcoholic fatty liver disease. Liver Int. 2013. doi:10.1111/liv.12312.
13. Petta S, Camma C, Scazzone C, et al. Low vitamin D serum level is related to severe fibrosis and low responsiveness to interferon-based therapy in genotype 1 chronic hepatitis C. Hepatology. 2010;51:1158–1167.
14. Farnik H, Bojunga J, Berger A, et al. Low vitamin D serum concentration is associated with high levels of hepatitis B virus replication in chronically infected patients. Hepatology. 2013;58:1270–1276.
15. Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96:1911–1930.
16. Bedossa P, Poynard T. An algorithm for the grading of activity in chronic hepatitis C. The METAVIR Cooperative Study Group. Hepatology. 1996;24:289–293.
17. Vogel A, Strassburg CP, Manns MP. Genetic association of vitamin D receptor polymorphisms with primary biliary cirrhosis and autoimmune hepatitis. Hepatology. 2002;35:126–131.
18. Trépo E, Ouziel R, Pradat P, et al. Marked 25-hydroxyvitamin D deficiency is associated with poor prognosis in patients with alcoholic liver disease. J Hepatol. 2013;59:344–350.
19. Ma Y, Longhi MS, Bogdanos DP, et al. 17 Functional impairment of CD25+CD4+ regulatory T cells characterizes autoimmune hepatitis type 2. Hepatology. 2003;38:163.
20. Efe C, Purnak T, Ozaslan E. Anti TNF-alpha therapy can be a novel treatment option in patients with autoimmune hepatitis. Aliment Pharmacol Ther. 2010;32:115.
21. Weiler-Normann C, Schramm C, Quaas A, et al. Infliximab as a rescue treatment in difficult-to-treat autoimmune hepatitis. J Hepatol. 2013;58:529–534.