MR cholangiography demonstrates unsuspected rapid biliary clearance of nanoparticles in rodents: Implications for clinical translation

Nanomedicine: Nanotechnology, Biology, and Medicine

Volumn 10, Issue 7, 2014, Pages 1385-1388

  Bulte, Jeff W M ^a   Schmieder, Anne H ^b   Keupp, Jochen ^d   Caruthers, Shelton D ^b,c   Wickline, Samuel A ^b   Lanza, Gregory M ^b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c PHILIPS HEALTHCARE   (United States)

^d PHILIPS RESEARCH LABORATORIES   (Germany)

Author keywords

Cholangiography; Hepatobiliary clearance; MR contrast agent; MRI; Nanoparticle; Rat

Indexed keywords

CELL PROLIFERATION; GADOLINIUM; MAGNETIC RESONANCE IMAGING; MAMMALS; MEDICAL NANOTECHNOLOGY; RATING;

CHOLANGIOGRAPHY; CLINICAL TRANSLATION; COMMON BILE DUCTS; GENETIC MANIPULATIONS; HEPATOBILIARY; MR CONTRAST AGENTS; PERFLUOROCARBONS; PHARMACEUTICAL DEVELOPMENT;

NANOPARTICLES;

FLUOROCARBON; GADOLINIUM PENTETATE; NANOPARTICLE; CONTRAST MEDIUM;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BILIARY EXCRETION; CHOLANGIOGRAPHY; COMMON BILE DUCT; CONTRAST ENHANCEMENT; CONTROLLED STUDY; DRUG CLEARANCE; DRUG ELIMINATION; FEMALE; FLUORINE NUCLEAR MAGNETIC RESONANCE; HEART; LIVER; LIVER CLEARANCE; MAGNETIC RESONANCE CHOLANGIOGRAPHY; MALE; NANOMEDICINE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; SMALL INTESTINE; SPLEEN; ANIMAL; HEPATOBILIARY SYSTEM; METABOLISM; PROCEDURES; TRANSLATIONAL RESEARCH;

RATTUS; RODENTIA;

ANIMALS; BILIARY TRACT; CHOLANGIOGRAPHY; CONTRAST MEDIA; FEMALE; GADOLINIUM DTPA; MAGNETIC RESONANCE IMAGING; NANOPARTICLES; RATS; TRANSLATIONAL MEDICAL RESEARCH;

EID: 84912150200     PISSN: 15499634     EISSN: 15499642     Source Type: Journal    
DOI: 10.1016/j.nano.2014.05.001     Document Type: Article

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