A simple dried blood spot method for therapeutic drug monitoring of the tricyclic antidepressants amitriptyline, nortriptyline, imipramine, clomipramine, and their active metabolites using LC-MS/MS

Talanta

Volumn 134, Issue , 2015, Pages 165-172

  Berm, E J J ^a   Paardekooper, J ^b   Brummel Mulder, E ^b   Hak, E ^a   Wilffert, B ^a,c   Maring, J G ^b  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b Bethesda Hospital   (Netherlands)

^c UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

dried blood spot; LC MS MS; Therapeutic drug monitoring; tricyclic antidepressants

Indexed keywords

PATIENT MONITORING;

ACCURACY AND PRECISION; DRIED BLOOD SPOTS; LC-MS/MS; LOWER LIMIT OF QUANTIFICATIONS; MAJOR DEPRESSIVE DISORDERS; SIMULTANEOUS DETERMINATIONS; THERAPEUTIC DRUG MONITORING; TRICYCLIC ANTIDEPRESSANTS;

BLOOD;

AMITRIPTYLINE; CLOMIPRAMINE; IMIPRAMINE; NORTRIPTYLINE; TRICYCLIC ANTIDEPRESSANT AGENT;

BIOTRANSFORMATION; BLOOD; CALIBRATION; DEPRESSIVE DISORDER, MAJOR; DRIED BLOOD SPOT TESTING; DRUG MONITORING; HEMATOCRIT; HUMAN; LIMIT OF DETECTION; LIQUID CHROMATOGRAPHY; PROCEDURES; REPRODUCIBILITY; TANDEM MASS SPECTROMETRY;

AMITRIPTYLINE; ANTIDEPRESSIVE AGENTS, TRICYCLIC; BIOTRANSFORMATION; CALIBRATION; CHROMATOGRAPHY, LIQUID; CLOMIPRAMINE; DEPRESSIVE DISORDER, MAJOR; DRIED BLOOD SPOT TESTING; DRUG MONITORING; HEMATOCRIT; HUMANS; IMIPRAMINE; LIMIT OF DETECTION; NORTRIPTYLINE; REPRODUCIBILITY OF RESULTS; TANDEM MASS SPECTROMETRY;

EID: 84912144978     PISSN: 00399140     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.talanta.2014.10.041     Document Type: Article

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