Are clinical trials with mesenchymal stem/progenitor cells too far ahead of the science? lessons from experimental hematology

Stem Cells

Volumn 32, Issue 12, 2014, Pages 3055-3061

  Prockop, Darwin J ^a   Prockop, Susan E ^b   Bertoncello, Ivan ^c  

^a SCOTT AND WHITE MEMORIAL HOSPITAL   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Hematopoietic stem cells; Need for scientific dialogue; New clinical therapies

Indexed keywords

ACETYLSALICYLIC ACID; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ANTINEOPLASTIC AGENT; BISPHOSPHONIC ACID DERIVATIVE; CELL ADHESION MOLECULE; CORTICOSTEROID; CORTISONE; CYTOKINE; DIGITALIS; GROWTH FACTOR; HYDROXYAPATITE; HYPOCALCIN; INDOLEAMINE 2,3 DIOXYGENASE; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE; PYROPHOSPHATE; SALICYLIC ACID DERIVATIVE; SILDENAFIL;

ACUTE LEUKEMIA; ANEMIA; ANGINA PECTORIS; APLASTIC ANEMIA; ARTICLE; B LYMPHOCYTE; BONE MARROW CELL; BONE MARROW TRANSPLANTATION; CANCER CHEMOTHERAPY; CANCER RISK; CANCER THERAPY; CARTILAGE CELL; CLINICAL EFFECTIVENESS; CLINICAL TRIAL (TOPIC); CRITICALLY ILL PATIENT; DENDRITIC CELL; DILUTION; EMBRYONIC STEM CELL; ENDOTHELIAL PROGENITOR CELL; ENGRAFTMENT; FEEDER CELL; FIBROBLAST; GERMLINE STEM CELL; GRAFT VERSUS HOST REACTION; HEART FAILURE; HEMATOLOGIC DISEASE; HEMATOLOGY; HEMATOPOIETIC CELL; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; IMMUNITY; IRRADIATION; LYMPHOCYTE; MEDICAL HISTORY; MESENCHYMAL STEM CELL; NONHUMAN; OSTEOCLAST; OSTEOGENESIS IMPERFECTA; OSTEOPOROSIS; PLURIPOTENT STEM CELL; RADIOTHERAPY; RHEUMATOID ARTHRITIS; SCIENCE; SICKLE CELL ANEMIA; SPLEEN CELL; SPLEEN TRANSPLANTATION; STEM CELL NICHE; STEM CELL TRANSPLANTATION; SYNOVIUM; T LYMPHOCYTE; TERATOMA; THALASSEMIA; THYMUS; TISSUE CULTURE; TISSUE TYPING; UMBILICAL CORD; UMBILICAL CORD BLOOD; ANIMAL; BIOLOGICAL THERAPY; CELL DIFFERENTIATION; CYTOLOGY; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMA CELL; PHYSIOLOGY; PROCEDURES;

ANIMALS; CELL DIFFERENTIATION; CELL- AND TISSUE-BASED THERAPY; CLINICAL TRIALS AS TOPIC; HEMATOPOIETIC STEM CELLS; HUMANS; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS;

EID: 84912141871     PISSN: 10665099     EISSN: 15494918     Source Type: Journal    
DOI: 10.1002/stem.1806     Document Type: Article

References (51)

1. Tyndall A,. Mesenchymal stem cell treatments in rheumatology-A glass half full? Nat Rev Rheumatol 2014; 10: 117-124.
2. Bianco P, Cao X, Frenette PS, et al. The meaning, the sense and the significance: Translating the science of mesenchymal stem cells into medicine. Nat Med 2013; 19: 35-42.
3. Phinney DG, Galipeau J, Krampera M, et al. MSCs: Science and trials. Nat Med 2013; 19: 812.
4. Gratwohl A, Niederwieser D,. History of hematopoietic stem cell transplantation: Evolution and perspectives. Curr Probl Dermatol 2012; 43: 81-90.
5. Papayannopoulou T, Scadden DT,. Stem-cell ecology and stem cells in motion. Blood 2008; 111: 3923-3930.
6. Thomas ED,. The evolution of the scientific foundation of marrow transplantation based on human studies. In:, Forman SJ, Blume KG, Donnall Thomas E, eds. Bone Marrow Transplantation. Boston, MA: Blackwell Scientific Publications, 1994: 12-15.
7. Jacobson LO, Marks EK, et al. The role of the spleen in radiation injury. Proc Soc Exp Biol Med 1949; 70: 740-742.
8. Lorenz E, Uphoff D, Reid TR, et al. Modification of irradiation injury in mice and guinea pigs by bone marrow injections. J Natl Cancer Inst 1951; 12: 197-201.
9. Friedenstein AJ, Piatetzky-Shapiro II, Petrakova KV,. Osteogenesis in transplants of bone marrow cells. J Embryol Exp Morphol 1966; 16: 381-390.
10. Owen M, Friedenstein AJ,. Stromal stem cells: Marrow-derived osteogenic precursors. Ciba Found Symp 1988; 136: 42-60.
11. Dexter TM, Spooncer E, Schofield R, et al. Haemopoietic stem cells and the problem of self-renewal. Blood Cells 1984; 10: 315-339.
12. Gatti RA, Meuwissen HJ, Allen HD, et al. Immunological reconstitution of sex-linked lymphopenic immunological deficiency. Lancet 1968; 2: 1366-1369.
13. Bach FH, Albertini RJ, Joo P, Anderson JL, Bortin MM,. Bone-marrow transplantation in a patient with the Wiskott-Aldrich syndrome. Lancet. 1968; 2: 1364-1366.
14. Prockop DJ, Kota DJ, Bazhanov N, et al. Evolving paradigms for repair of tissues by adult stem/progenitor cells (MSCs). J Cell Mol Med. 2010; 14: 2190-2199.
15. Uphoff DE,. Genetic factors influencing irradiation protection by bone marrow. I. The F1 hybrid effect. J Natl Cancer Inst 1957; 19: 123-130.
16. Good RA, Kapoor N, Reisner Y,. Bone marrow transplantation-An expanding approach to treatment of many diseases. Cell Immunol 1983; 82: 36-54.
17. Till JE, McCulloch EA,. A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. Radiat Res 1961; 14: 213-222.
18. Jones RJ, Sharkis SJ, Celano P, et al. Progenitor cell assays predict hematopoietic reconstitution after syngeneic transplantation in mice. Blood 1987; 70: 1186-1192.
19. Bertoncello I, Bradford G,. Surrogate assays for hematopoietic stem cell activity. In:, Garland J, Quesenberry P, Hilton D, eds. Colony-Stimulating Factors. 2nd ed. New York: Marcel Dekker Inc., 1997: 35-47; Chapter 2.
20. Maximow AA,. Relation of blood cells to connective tissues and endothelium. Physiol Rev 1924; IV: 533-563.
21. Schofield R,. The relationship between the spleen colony-forming cell and the haemopoietic stem cell. Blood Cells 1978; 4: 7-25.
22. Xie T, Spradling AC,. Decapentaplegic is essential for the maintenance and division of germline stem cells in the Drosophila ovary. Cell 1998; 94: 251-260.
23. Orkin SH, Zon LI,. Hematopoiesis: An evolving paradigm for stem cell biology. Cell 2008; 132: 631-644.
24. Méndez-Ferrer S, Michurina TV, Ferraro F, et al. Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. Nature 2010; 466: 829-834.
25. Zhao H, Feng J, Seidel K, et al. Secretion of shh by a neurovascular bundle niche supports mesenchymal stem cell homeostasis in the adult mouse incisor. Cell Stem Cell 2014; 14: 160-173.
26. Prockop DJ, Keating A,. Relearning the lessons of genomic stability of human cells during expansion in culture: Implications for clinical research. Stem Cells 2012; 30: 1051-1052.
27. Ben-David U, Kopper O, Benvenisty N,. Expanding the boundaries of embryonic stem cells. Cell Stem Cell 2012; 10: 666-677.
28. Chade AR, Zhu XY, Krier JD, et al. Endothelial progenitor cells homing and renal repair in experimental renovascular disease. Stem Cells 2010; 28: 1039-10347.
29. Yi D, Appel S,. Current status and future perspectives of dendritic cell-based cancer immunotherapy. Scand J Immunol. 2013; 78: 167-171.
30. Brenner MK,. Will T-cell therapy for cancer ever be a standard of care? Cancer Gene Ther 2012; 19: 818-821.
31. Syed BA, Evans JB,. Stem cell therapy market. Nat Rev Drug Discov 2013; 12: 185-186.
32. Horwitz EM, Prockop DJ, Fitzpatrick LA, et al. Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta. Nat Med 1999; 5: 309-313.
33. Prockop DJ,. Marrow stromal cells as stem cells for nonhematopoietic tissues. Science 1997; 276: 71-74.
34. Keating A,. Mesenchymal stromal cells: New directions. Cell Stem Cell 2012; 10: 709-716.
35. Bernardo ME, Fibbe WE,. Mesenchymal stromal cells: Sensors and switchers of inflammation. Cell Stem Cell 2013; 13: 392-402.
36. Ylöstalo J, Bazhanov N, Prockop DJ,. Reversible commitment to differentiation by human multipotent stromal cells in single-cell-derived colonies. Exp Hematol 2008; 36: 1390-1402.
37. Quesenberry PJ, Aliotta JM,. The paradoxical dynamism of marrow stem cells: Considerations of stem cells, niches, and microvesicles. Stem Cell Rev 2008; 4: 137-147.
38. Spees JL, Olson SD, Whitney MJ, et al. Mitochondrial transfer between cells can rescue aerobic respiration. Proc Natl Acad Sci USA 2006; 103: 1283-1288.
39. Islam MN, Das SR, Emin MT, et al. Mitochondrial transfer from bone-marrow-derived stromal cells to pulmonary alveoli protects against acute lung injury. Nat Med 2012; 18: 759-765.
40. Lee RH, Yoon N, Reneau JC, et al. Preactivation of human MSCs with TNF-α enhances tumor-suppressive activity. Cell Stem Cell 2012; 11: 825-835.
41. Waterman RS, Henkle SL, Betancourt AM,. Mesenchymal stem cell 1 (MSC1)-based therapy attenuates tumor growth whereas MSC2-treatment promotes tumor growth and metastasis. PLoS One 2012; 7: e45590.
42. Caplan AI,. Mesenchymal stem cells. J Orthop Res 1991; 9: 641-650.
43. Pereira RF, O'Hara MD, Laptev AV, et al. Marrow stromal cells as a source of progenitor cells for nonhematopoietic tissues in transgenic mice with a phenotype of osteogenesis imperfecta. Proc Natl Acad Sci USA 1998; 95: 1142-1147.
44. Reger RL, Prockop DJ,. Should publications on mesenchymal stem/progenitor cells include in-process data on the preparation of the cells? Stem Cells Transl Med 2014; 3: 632-635.
45. Viswanathan S, Keating A, Deans R, et al. Soliciting strategies for developing cell-based reference materials to advance mesenchymal stromal cell research and clinical translation. Stem Cells Dev 2014; 23: 1157-1167.
46. Ala-Kokko L, Günzler V, Hoek JB, et al. Hepatic fibrosis in rats produced by carbon tetrachloride and dimethylnitrosamine: Observations suggesting immunoassays of serum for the 7S fragment of type IV collagen are a more sensitive index of liver damage than immunoassays for the NH2-terminal propeptide of type III procollagen. Hepatology 1992; 16: 167-172.
47. Davidson JM, Yu F, Opalenik SR,. Splinting strategies to overcome confounding wound contraction in experimental animal models. Adv Wound Care (New Rochelle) 2013; 2: 142-148.
48. Oh JY, Roddy GW, Choi H, et al. Anti-inflammatory protein TSG-6 reduces inflammatory damage to the cornea following chemical and mechanical injury. Proc Natl Acad Sci USA 2010 28; 107: 16875-16880.
49. Roddy GW, Oh JY, Lee RH, et al. Action at a distance: Systemically administered adult stem/progenitor cells (MSCs) reduce inflammatory damage to the cornea without engraftment and primarily by secretion of TNF-α stimulated gene/protein 6. Stem Cells 2011; 29: 1572-1579.
50. Zeitouni S, Krause U, Clough BH, Halderman H, Falster A, Blalock DT, Chaput CD, Sampson HW, Gregory CA,. Human mesenchymal stem cell-derived matrices for enhanced osteoregeneration. Sci Transl Med 2012; 4: 132ra55.
51. Kota DJ, Wiggins LL, Yoon N, Lee RH,. TSG-6 produced by hMSCs delays the onset of autoimmune diabetes by suppressing Th1 development and enhancing tolerogenicity. Diabetes. 2013; 62: 2048-2058.