Hsp90-peptide complexes stimulate antigen presentation through the class II pathway after binding scavenger receptor SREC-I

Immunobiology

Volumn 219, Issue 12, 2014, Pages 924-931

  Murshid, Ayesha ^a   Gong, Jianlin ^b   Calderwood, Stuart K ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BOSTON UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Antigen presentation; Dendritic cell; Hsp90; Ova; SREC I

Indexed keywords

HEAT SHOCK PROTEIN 90; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PEPTIDE DERIVATIVE; PROTEIN CDC42; PROTEIN SREC I; SCAVENGER RECEPTOR; UNCLASSIFIED DRUG; HLA ANTIGEN CLASS 2; PEPTIDE; PROTEIN BINDING; SCARF1 PROTEIN, HUMAN; SCAVENGER RECEPTOR F; TUMOR ANTIGEN;

ANIMAL CELL; ANIMAL TISSUE; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; CD4+ T LYMPHOCYTE; CELL SURFACE; CONTROLLED STUDY; CROSS PRESENTATION; ENDOSOME; HELA CELL LINE; IMMUNOPRECIPITATION; IN VITRO STUDY; INTERNALIZATION; MOUSE; NONHUMAN; PLASMID; RECEPTOR BINDING; WESTERN BLOTTING; ANIMAL; BIOLOGICAL MODEL; CELL LINE; CELL MEMBRANE; CHEMISTRY; GENETICS; HUMAN; IMMUNOLOGY; INTRACELLULAR SPACE; METABOLISM; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

ANIMALS; ANTIGEN PRESENTATION; ANTIGENS, NEOPLASM; CDC42 GTP-BINDING PROTEIN; CELL LINE; CELL MEMBRANE; CROSS-PRIMING; HISTOCOMPATIBILITY ANTIGENS CLASS II; HSP90 HEAT-SHOCK PROTEINS; HUMANS; INTRACELLULAR SPACE; MICE; MODELS, BIOLOGICAL; PEPTIDES; PROTEIN BINDING; PROTEIN TRANSPORT; SCAVENGER RECEPTORS, CLASS F; SIGNAL TRANSDUCTION;

EID: 84912133607     PISSN: 01712985     EISSN: 18783279     Source Type: Journal    
DOI: 10.1016/j.imbio.2014.08.001     Document Type: Article

References (19)

1. Berger A.C., Roche P.A. MHC class II transport at a glance. J. Cell Sci. 2009, 122:1-4. 10.1242/jcs.035089.
2. Bonifaz L., et al. Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance. J. Exp. Med. 2002, 196:1627-1638.
3. Burgdorf S., Kurts C. Endocytosis mechanisms and the cell biology of antigen presentation. Curr. Opin. Immunol. 2008, 20:89-95.
4. Busch R., et al. Achieving stability through editing and chaperoning: regulation of MHC class II peptide binding and expression. Immunol. Rev. 2005, 207:242-260. 10.1111/j.0105-2896.2005.00306.x.
5. Calderwood S.K., Murshid A., Prince T. The shock of aging: molecular chaperones and the heat shock response in longevity and aging-a mini-review. Gerontology 2009, 55:550-558. 10.1159/000225957.
6. Chen X.Q., Tan I., Leung T., Lim L. The myotonic dystrophy kinase-related Cdc42-binding kinase is involved in the regulation of neurite outgrowth in PC12 cells. J. Biol. Chem. 1999, 274:19901-19905.
7. Delneste Y., et al. Involvement of LOX-1 in dendritic cell-mediated antigen cross presentation. Immunity 2002, 17:353-362.
8. Gong J., et al. T cell activation by heat shock protein 70 vaccine requires TLR signaling and scavenger receptor expressed by endothelial cells-1. J. Immunol. 2009, 183:3092-3098. 10.4049/jimmunol.0901235.
9. Gong J., et al. A heat shock protein 70-based vaccine with enhanced immunogenicity for clinical use. J. Immunol. 2010, 184:488-496. 10.4049/jimmunol.0902255.
10. Kunisawa J., Shastri N. Hsp90alpha chaperones large C-terminally extended proteolytic intermediates in the MHC class I antigen processing pathway. Immunity 2006, 24:523-534.
11. Kurts C., Robinson B.W., Knolle P.A. Cross-priming in health and disease. Nat. Rev. Immunol. 2010, 10:403-414.
12. Murshid A., Gong J., Calderwood S.K. Heat shock protein 90 mediates efficient antigen cross presentation through the scavenger receptor expressed by endothelial cells-I. J. Immunol. 2010, 185:2903-2917. 10.4049/jimmunol.0903635.
13. Murshid A., Gong J., Stevenson M.A., Calderwood S.K. Heat shock proteins and cancer vaccines: developments in the past decade and chaperoning in the decade to come. Expert Rev. Vaccines 2011, 10:1553-1568. 10.1586/erv.11.124.
14. Murshid A., Theriault J., Gong J., Calderwood S.K. Investigating receptors for extracellular heat shock proteins. Methods Mol. Bio. 2011, 787:289-302. 10.1007/978-1-61779-295-3_22.
15. Murshid A., Gong J., Calderwood S.K. The role of heat shock proteins in antigen cross presentation. Front. Immunol. 2012, 3:63. 10.3389/fimmu.2012.00063.
16. Srivastava P.K. Heat shock protein-based novel immunotherapies. Drug News Perspect. 2000, 13:517-522.
17. Theriault J.R., Adachi H., Calderwood S.K. Role of scavenger receptors in the binding and internalization of heat shock protein 70. J. Immunol. 2006, 177:8604-8611.
18. Walseng E., Bakke O., Roche P.A. Major histocompatibility complex class II-peptide complexes internalize using a clathrin- and dynamin-independent endocytosis pathway. J. Biol. Chem. 2008, 283:14717-14727. 10.1074/jbc.M801070200.
19. Yamaguchi Y., Katoh H., Yasui H., Mori K., Negishi M. RhoA inhibits the nerve growth factor-induced Rac1 activation through Rho-associated kinase-dependent pathway. J. Biol. Chem. 2001, 276:18977-18983. Epub 2001 Mar 15.