Excessive Lowering of Blood Pressure Is Not Beneficial for Progression of Brain White Matter Hyperintensive and Cognitive Impairment in Elderly Hypertensive Patients: 4-Year Follow-Up Study

Journal of the American Medical Directors Association

Volumn 15, Issue 12, 2014, Pages 904-910

  Peng, Jie ^a   Lu, Fanghong ^b   Wang, Zhihao ^a   Zhong, Ming ^a   Sun, Lixin ^c   Hu, Na ^c   Liu, Zhendong ^b   Zhang, Wei ^a  

^a SHANDONG UNIVERSITY   (China)

^b SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG FIRST MEDICAL UNIVERSITY   (China)

^c SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG UNIVERSITY   (China)

Author keywords

Brain white matter lesions; Cognitive impairment; Excessive old age; Systolic blood pressure

Indexed keywords

ANGIOTENSIN RECEPTOR ANTAGONIST; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; GLUCOSE; HYDROCHLOROTHIAZIDE;

AGED; ALCOHOL CONSUMPTION; ANTIHYPERTENSIVE THERAPY; ARTICLE; ATTENTION; BLOOD PRESSURE REGULATION; BODY MASS; BRAIN SIZE; COGNITION; COGNITIVE DEFECT; DIASTOLIC BLOOD PRESSURE; FEMALE; FOLLOW UP; GLUCOSE BLOOD LEVEL; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; MINI MENTAL STATE EXAMINATION; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; SYSTOLIC BLOOD PRESSURE; WHITE MATTER; ADVERSE EFFECTS; BLOOD PRESSURE; COGNITION DISORDERS; DISEASE COURSE; DRINKING BEHAVIOR; DRUG EFFECTS; LONGITUDINAL STUDY; NEUROPSYCHOLOGICAL TEST; PATHOLOGY; RISK FACTOR; VERY ELDERLY;

AGED, 80 AND OVER; ALCOHOL DRINKING; BLOOD PRESSURE; BODY MASS INDEX; COGNITION DISORDERS; DISEASE PROGRESSION; FEMALE; FOLLOW-UP STUDIES; HUMANS; HYPERTENSION; LONGITUDINAL STUDIES; MAGNETIC RESONANCE IMAGING; MALE; NEUROPSYCHOLOGICAL TESTS; RISK FACTORS; WHITE MATTER;

EID: 84912127166     PISSN: 15258610     EISSN: 15389375     Source Type: Journal    
DOI: 10.1016/j.jamda.2014.07.005     Document Type: Article

References (39)

1. Peters R., Beckett N., Forette F., et al. Vascular risk factors and cognitive function among 3763 participants in the Hypertension in the Very Elderly Trial (HYVET): A cross-sectional analysis. Int Psychogeriatr 2009, 21:359-368.
2. Poon L.W., Woodard J.L., Stephen Miller L., et al. Understanding dementia prevalence among centenarians. JGerontol A Biol Sci Med Sci 2012, 67:358-365.
3. Savva G.M., Wharton S.B., Ince P.G., et al. Age, neuropathology, and dementia. NEngl J Med 2009, 360:2302-2309.
4. Murray M.E., Senjem M.L., Petersen R.C., et al. Functional impact of white matter hyperintensities in cognitively normal elderly subjects. Arch Neurol 2010, 67:1379-1385.
5. Debette S., Markus H.S. The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: Systematic review and meta-analysis. BMJ 2010, 341:c3666.
6. Gunning-Dixon F.M., Brickman A.M., Cheng J.C., Alexopoulos G.S. Aging of cerebral white matter: A review of MRI findings. Int J Geriatr Psychiatry 2009, 24:109-117.
7. Au R., Massaro J.M., Wolf P.A., et al. Association of white matter hyperintensity volume with decreased cognitive functioning: The Framingham Heart Study. Arch Neurol 2006, 63:246-250.
8. Silbert L.C., Dodge H.H., Perkins L.G., et al. Trajectory of white matter hyperintensity burden preceding mild cognitive impairment. Neurology 2012, 79:741-747.
9. Patankar T., Widjaja E., Chant H., et al. Relationship of deep white matter hyperintensities and cerebral blood flow in severe carotid artery stenosis. Eur J Neurol 2006, 13:10-16.
10. Godin O., Tzourio C., Maillard P., et al. Antihypertensive treatment and change in blood pressure are associated with the progression of white matter lesion volumes: The Three-City (3C)-Dijon Magnetic Resonance Imaging Study. Circulation 2011, 123:266-273.
11. Tzourio C., Anderson C., Chapman N., et al. Effects of blood pressure lowering with perindopril and indapamide therapy on dementia and cognitive decline in patients with cerebrovascular disease. Arch Intern Med 2003, 163:1069-1075.
12. Verhaaren B.F., Vernooij M.W., de Boer R., et al. High blood pressure and cerebral white matter lesion progression in the general population. Hypertension 2013, 61:1354-1359.
13. Lawes C.M., Vander Hoorn S., Rodgers A. International Society of Hypertension. Global burden of blood-pressure-related disease, 2001. Lancet 2008, 371:1513-1518.
14. Whitmer R.A., Sidney S., Selby J., et al. Midlife cardiovascular risk factors and risk of dementia in late life. Neurology 2005, 64:277-281.
15. Egan B.M., Zhao Y., Axon R.N. US trends in prevalence, awareness, treatment, and control of hypertension, 1988-2008. JAMA 2010, 303:2043-2050.
16. Peters R., Beckett N., Geneva M., et al. Sociodemographic and lifestyle risk factors for incident dementia and cognitive decline in the HYVET. Age Ageing 2009, 38:521-527.
17. Peters R., Pinto E., Beckett N., et al. Association of depression with subsequent mortality, cardiovascular morbidity and incident dementia in people aged 80 and over and suffering from hypertension. Data from the Hypertension in the Very Elderly Trial (HYVET). Age Ageing 2010, 39:439-445.
18. Friedewald W.T., Levy R.I., Fredrickson D.S. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972, 18:499-502.
19. Jenkinson M., Beckmann C.F., Behrens T.E., et al. FSL. Neuroimage 2012, 62:782-790.
20. Fischl B., Salat D.H., Busa E., et al. Whole brain segmentation: Automated labeling of neuroanatomical structures in the human brain. Neuron 2002, 33:341-355.
21. White W.B., Wolfson L., Wakefield D.B., et al. Average daily blood pressure, not office blood pressure, is associated with progression of cerebrovascular disease and cognitive decline in older people. Circulation 2011, 124:2312-2319.
22. Yaneva-Sirakova T., Tarnovska-Kadreva R., Traykov L. The role of suboptimal home-measured blood pressure control for cognitive decline. Dement Geriatr Cogn Dis Extra 2012, 2:112-119.
23. Celle S., Annweiler C., Pichot V., et al. Association between ambulatory 24-hour blood pressure levels and brain volume reduction: A cross-sectional elderly population-based study. Hypertension 2012, 60:1324-1331.
24. Elias P.K., Elias M.F., Robbins M.A., Budge M.M. Blood pressure-related cognitive decline: Does age make a difference?. Hypertension 2004, 44:631-636.
25. Manolio T.A., Olson J., Longstreth W.T. Hypertension and cognitive function: Pathophysiologic effects of hypertension on the brain. Curr Hypertens Rep 2003, 5:255-261.
26. Peters R., Beckett N., Forette F., et al. Incident dementia and blood pressure lowering in the Hypertension in the Very Elderly Trial cognitive function assessment (HYVET-COG): A double-blind, placebo controlled trial. Lancet Neurol 2008, 7:683-689.
27. de Leeuw F.E., de Groot J.C., Oudkerk M., et al. Afollow-up study of blood pressure and cerebral white matter lesions. Ann Neurol 1999, 46:827-833.
28. Heijer T., Skoog I., Oudkerk M., et al. Association between blood pressure levelsover time and brain atrophy in the elderly. Neurobiol Aging 2003, 24:307-313.
29. White W.B. Systolic versus diastolic blood pressure versus pulse pressure. Curr Cardiol Rep 2002, 4:463-467.
30. Beishon L.C., Harrison J.K., Harwood R.H., et al. The evidence for treating hypertension in older people with dementia: A systematic review. JHum Hypertens 2014, 28:283-287.
31. Maule S., Caserta M., Bertello C., et al. Cognitive decline and low blood pressure: The other side of the coin. Clin Exp Hypertens 2008, 30:711-719.
32. Verghese J., Lipton R.B., Hall C.B., et al. Low blood pressure and the risk of dementia in very old individuals. Neurology 2003, 61:1667-1672.
33. Molander L., Gustafson Y., Lovheim H. Longitudinal associations between blood pressure and dementia in the very old. Dement Geriatr Cogn Disord 2010, 30:269-276.
34. Richmond R., Law J., Kay-Lambkin F. Higher blood pressure associated with higher cognition and functionality among centenarians in Australia. Am J Hypertens 2011, 24:299-303.
35. de la Torre J.C. How do heart disease and stroke become risk factors for Alzheimer's disease?. Neurol Res 2006, 28:637-644.
36. Sabayan B., Oleksik A.M., Maier A.B., et al. High blood pressure and resilience to physical and cognitive decline in the oldest old: The Leiden 85-plus Study. JAm Geriatr Soc 2012, 60:2014-2019.
37. Castilla-Guerra L., Fernandez-Moreno Mdel C. Letter by Castilla-Guerra and Fernandez-Moreno regarding article, "Average Daily Blood Pressure, Not Office Blood Pressure, Is Associated With Progression of Cerebrovascular Disease and Cognitive Decline in Older People". Circulation 2012, 125:e1017. author reply e1018.
38. Reshef S., Fried L., Beauchamp N., et al. Diastolic blood pressure levels and ischemic stroke incidence in older adults with white matter lesions. JGerontol A Biol Sci Med Sci 2011, 66:74-81.
39. Li R., Cui J., Shen Y. Brain sex matters: Estrogen in cognition and Alzheimer's disease. Mol Cell Endocrinol 2014, 389:13-21.