Vitamin D insufficiency in Arabs and South Asians positively associates with polymorphisms in GC and CYP2R1 genes

PLoS ONE

Volumn 9, Issue 11, 2014, Pages

  Elkum, Naser ^a,b   Alkayal, Fadi ^a   Noronha, Fiona ^a   Ali, Maisa M ^a   Melhem, Motasem ^a   Al Arouj, Monira ^a   Bennakhi, Abdullah ^a   Behbehani, Kazem ^a   Alsmadi, Osama ^a   Abubaker, Jehad ^a  

^a DASMAN DIABETES INSTITUTE   (Kuwait)

^b SIDRA MEDICAL AND RESEARCH CENTER   (Qatar)

Author keywords

[No Author keywords available]

Indexed keywords

25 HYDROXYVITAMIN D; 7 DEHYDROCHOLESTEROL REDUCTASE; CYTOCHROME P450; CYTOCHROME P450 2R1; NICOTINAMIDE ADENINE DINUCLEOTIDE SYNTHETASE 1; OXIDOREDUCTASE; SYNTHETASE; UNCLASSIFIED DRUG; VITAMIN D BINDING PROTEIN; 7-DEHYDROCHOLESTEROL REDUCTASE; CHOLESTANETRIOL 26 MONOOXYGENASE; CYP2R1 PROTEIN, HUMAN;

ADULT; AGE DISTRIBUTION; ALLELE; ARAB; ARTICLE; BODY MASS; CHEMILUMINESCENCE IMMUNOASSAY KIT; CONTROLLED STUDY; CYP2R1 GENE; DATA ANALYSIS; DHCR7 GENE; ETHNIC DIFFERENCE; FEMALE; GC GENE; GENE; GENE EXPRESSION; GENE FREQUENCY; GENE FUNCTION; GENE IDENTIFICATION; GENETIC ASSOCIATION; GENETIC CORRELATION; GENETIC VARIABILITY; GENOTYPE; GEOGRAPHIC DISTRIBUTION; HEALTH SURVEY; HUMAN; KUWAIT; MAJOR CLINICAL STUDY; MALE; NADSYN1 GENE; POPULATION GENETICS; SINGLE NUCLEOTIDE POLYMORPHISM; SOUTH ASIAN; SOUTHEAST ASIAN; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY; VITAMIN D METABOLISM; ANALYSIS OF VARIANCE; ASIAN CONTINENTAL ANCESTRY GROUP; BLOOD; GENETICS; IMMUNOASSAY;

ANALYSIS OF VARIANCE; ARABS; ASIAN CONTINENTAL ANCESTRY GROUP; CHOLESTANETRIOL 26-MONOOXYGENASE; GENE FREQUENCY; HUMANS; IMMUNOASSAY; KUWAIT; OXIDOREDUCTASES ACTING ON CH-CH GROUP DONORS; POLYMORPHISM, SINGLE NUCLEOTIDE; VITAMIN D DEFICIENCY; VITAMIN D-BINDING PROTEIN;

EID: 84912100065     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0113102     Document Type: Article

References (32)

1. Simonelli C (2005) The role of vitamin D deficiency in osteoporosis and fractures. Minn Med 88: 34-36.
2. Borkar VV, Devidayal, Verma S, Bhalla AK (2010) Low levels of vitamin D in North Indian children with newly diagnosed type 1 diabetes. Pediatr Diabetes 11: 345-350.
3. Kilkkinen A, Knekt P, Aro A, Rissanen H, Marniemi J, et al. (2009) Vitamin D status and the risk of cardiovascular disease death. Am J Epidemiol 170: 1032-1039.
4. Bosse Y, Lemire M, Poon AH, Daley D, He JQ, et al. (2009) Asthma and genes encoding components of the vitamin D pathway. Respir Res 10: 98.
5. Heist RS, Zhou W, Wang Z, Liu G, Neuberg D, et al. (2008) Circulating 25-hydroxyvitamin D, VDR polymorphisms, and survival in advanced non-small-cell lung cancer. J Clin Oncol 26: 5596-5602.
6. Jones G, Strugnell SA, DeLuca HF (1998) Current understanding of the molecular actions of vitamin D. Physiol Rev 78: 1193-1231.
7. Gannage-Yared MH, Chemali R, Yaacoub N, Halaby G (2000) Hypovitaminosis D in a sunny country: relation to lifestyle and bone markers. J Bone Miner Res 15: 1856-1862.
8. Brustad M, Alsaker E, Engelsen O, Aksnes L, Lund E (2004) Vitamin D status of middle-aged women at 65-71 degrees N in relation to dietary intake and exposure to ultraviolet radiation. Public Health Nutr 7: 327-335.
9. Saliba W, Rennert HS, Kershenbaum A, Rennert G (2012) Serum 25(OH)D concentrations in sunny Israel. Osteoporos Int 23: 687-694.
10. Ardawi MS, Sibiany AM, Bakhsh TM, Qari MH, Maimani AA (2012) High prevalence of vitamin D deficiency among healthy Saudi Arabian men: relationship to bone mineral density, parathyroid hormone, bone turnover markers, and lifestyle factors. Osteoporos Int 23: 675-686.
11. Dawodu A, Absood G, Patel M, Agarwal M, Ezimokhai M, et al. (1998) Biosocial factors affecting vitamin D status of women of childbearing age in the United Arab Emirates. J Biosoc Sci 30: 431-437.
12. Allali F, El Aichaoui S, Khazani H, Benyahia B, Saoud B, et al. (2009) High prevalence of hypovitaminosis D in Morocco: relationship to lifestyle, physical performance, bone markers, and bone mineral density. Semin Arthritis Rheum 38: 444-451.
13. Hobbs RD, Habib Z, Alromaihi D, Idi L, Parikh N, et al. (2009) Severe vitamin D deficiency in Arab-American women living in Dearborn, Michigan. Endocr Pract 15: 35-40.
14. Hunter D, De Lange M, Snieder H, MacGregor AJ, Swaminathan R, et al. (2001) Genetic contribution to bone metabolism, calcium excretion, and vitamin D and parathyroid hormone regulation. J Bone Miner Res 16: 371-378.
15. Shea MK, Benjamin EJ, Dupuis J, Massaro JM, Jacques PF, et al. (2009) Genetic and non-genetic correlates of vitamins K and D. Eur J Clin Nutr 63: 458-464.
16. McGrath JJ, Saha S, Burne TH, Eyles DW (2010) A systematic review of the association between common single nucleotide polymorphisms and 25-hydroxyvitamin D concentrations. J Steroid Biochem Mol Biol 121: 471-477.
17. Ahn J, Yu K, Stolzenberg-Solomon R, Simon KC, McCullough ML, et al. (2010) Genome-wide association study of circulating vitamin D levels. Hum Mol Genet 19: 2739-2745.
18. Wang TJ, Zhang F, Richards JB, Kestenbaum B, van Meurs JB, et al. (2010) Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet 376: 180-188.
19. Zhang Z, He JW, Fu WZ, Zhang CQ, Zhang ZL (2013) An analysis of the association between the vitamin D pathway and serum 25-hydroxyvitamin D levels in a healthy Chinese population. J Bone Miner Res 28: 1784-1792.
20. Kurylowicz A, Ramos-Lopez E, Bednarczuk T, Badenhoop K (2006) Vitamin D-binding protein (DBP) gene polymorphism is associated with Graves' disease and the vitamin D status in a Polish population study. Exp Clin Endocrinol Diabetes 114: 329-335.
21. Ramos-Lopez E, Bruck P, Jansen T, Herwig J, Badenhoop K (2007) CYP2R1 (vitamin D 25-hydroxylase) gene is associated with susceptibility to type 1 diabetes and vitamin D levels in Germans. Diabetes Metab Res Rev 23: 631-636.
22. Engelman CD, Fingerlin TE, Langefeld CD, Hicks PJ, Rich SS, et al. (2008) Genetic and environmental determinants of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels in Hispanic and African Americans. J Clin Endocrinol Metab 93: 3381-3388.
23. Signorello LB, Shi J, Cai Q, Zheng W, Williams SM, et al. (2011) Common variation in vitamin D pathway genes predicts circulating 25-hydroxyvitamin D Levels among African Americans. PLoS One 6: e28623.
24. Zhang Y, Wang X, Liu Y, Qu H, Qu S, et al. (2012) The GC, CYP2R1 and DHCR7 genes are associated with vitamin D levels in northeastern Han Chinese children. Swiss Med Wkly 142: w13636.
25. Elkum N, Al-Arouj M, Sharifi M, Behbehani K, Bennakhi A (2014) Cardiovascular disease risk factors in the South Asian population living in Kuwait: a cross-sectional study. Diabet Med 31: 531-539.
26. Uitterlinden AG, Fang Y, Van Meurs JB, Pols HA, Van Leeuwen JP (2004) Genetics and biology of vitamin D receptor polymorphisms. Gene 338: 143-156.
27. Larcombe L, Mookherjee N, Slater J, Slivinski C, Singer M, et al. (2012) Vitamin D in a northern Canadian first nation population: dietary intake, serum concentrations and functional gene polymorphisms. PLoS One 7: e49872.
28. Speeckaert M, Huang G, Delanghe JR, Taes YE (2006) Biological and clinical aspects of the vitamin D binding protein (Gc-globulin) and its polymorphism. Clin Chim Acta 372: 33-42.
29. Sinotte M, Diorio C, Berube S, Pollak M, Brisson J (2009) Genetic polymorphisms of the vitamin D binding protein and plasma concentrations of 25-hydroxyvitamin D in premenopausal women. Am J Clin Nutr 89: 634-640.
30. Ahn J, Albanes D, Berndt SI, Peters U, Chatterjee N, et al. (2009) Vitamin Drelated genes, serum vitamin D concentrations and prostate cancer risk. Carcinogenesis 30: 769-776.
31. Bu FX, Armas L, Lappe J, Zhou Y, Gao G, et al. (2010) Comprehensive association analysis of nine candidate genes with serum 25-hydroxy vitamin D levels among healthy Caucasian subjects. Hum Genet 128: 549-556.
32. Cooper JD, Smyth DJ, Walker NM, Stevens H, Burren OS, et al. (2011) Inherited variation in vitamin D genes is associated with predisposition to autoimmune disease type 1 diabetes. Diabetes 60: 1624-1631.