The window period of NEUROGENIN3 during human gestation

Islets

Volumn 6, Issue 3, 2014, Pages

  Salisbury, Rachel J ^a   Blaylock, Jennifer ^a   Berry, Andrew A ^a   Jennings, Rachel E ^a,b   De Krijger, Ronald ^c,d   Hanley, Karen Piper ^a   Hanley, Neil A ^a,b  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b MANCHESTER UNIVERSITY NHS FOUNDATION TRUST   (United Kingdom)

^c ERASMUS MEDICAL CENTER   (Netherlands)

^d REINIER DE GRAAF HOSPITAL   (Netherlands)

Author keywords

Development; Endocrine; Fetal; Human; Neurogenin 3 (NEUROG3); Pancreas; Sex determining region Y box 9 (SOX9)

Indexed keywords

MESSENGER RNA; NEUROGENIN 3; TRANSCRIPTION FACTOR SOX9; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; NERVE PROTEIN; NEUROG3 PROTEIN, HUMAN; RNA;

ARTICLE; CELL POPULATION; FETUS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; PANCREAS; PANCREAS CELL; PREGNANCY; PROTEIN ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE SECTION; BIOSYNTHESIS; CELL DIFFERENTIATION; CHEMISTRY; CYTOLOGY; EMBRYOLOGY; FEMALE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PANCREAS ISLET BETA CELL; PHYSIOLOGY;

BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL DIFFERENTIATION; FEMALE; FETUS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; IMMUNOHISTOCHEMISTRY; INSULIN-SECRETING CELLS; NERVE TISSUE PROTEINS; PANCREAS; PREGNANCY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA;

EID: 84912096949     PISSN: 19382014     EISSN: 19382022     Source Type: Journal    
DOI: 10.4161/19382014.2014.954436     Document Type: Article

References (16)

1. Kulkarni RN, Mizrachi EB, Ocana AG, Stewart AF. Human beta-cell proliferation and intracellular signaling: driving in the dark without a road map. Diabetes 2012; 61:2205-13; PMID:22751699; http://dx.doi.org/10.2337/db12-0018
2. Bernal-Mizrachi E, Kulkarni RN, Scott DK, Mauvais-Jarvis F, Stewart AF, Garcia-Ocana A. Human beta-cell proliferation and intracellular signaling part 2: still driving in the dark without a road map. Diabetes 2014; 63:819-31; PMID:24556859; http://dx.doi.org/10.2337/db13-1146
3. Gittes GK. Developmental biology of the pancreas: a comprehensive review. Dev Biol 2009; 326:4-35; PMID:19013144; http://dx.doi.org/10.1016/j.ydbio.2008.10.024
4. Murtaugh LC. Pancreas and beta-cell development: from the actual to the possible. Development 2007; 134:427-38; PMID:17185316; http://dx.doi.org/10.1242/dev.02770
5. Villasenor A, Chong DC, Cleaver O. Biphasic Ngn3 expression in the developing pancreas. Dev Dyn 2008; 237:3270-9; PMID:18924236; http://dx.doi.org/10.1002/dvdy.21740
6. Schwitzgebel VM, Scheel DW, Conners JR, Kalamaras J, Lee JE, Anderson DJ, Sussel L, Johnson JD, German MS. Expression of neurogenin3 reveals an islet cell precursor population in the pancreas. Development 2000; 127:3533-42; PMID:10903178
7. Rubio-Cabezas O, Jensen JN, Hodgson MI, Codner E, Ellard S, Serup P, Hattersley AT. Permanent neonatal diabetes and enteric anendocrinosis associated with biallelic mutations in NEUROG3. Diabetes 2011; 60:1349-53; PMID:21378176; http://dx.doi.org/10.2337/db10-1008
8. Jennings RE, Berry AA, Kirkwood-Wilson R, Roberts NA, Hearn T, Salisbury RJ, Blaylock J, Piper Hanley K, Hanley NA. Development of the human pancreas from foregut to endocrine commitment. Diabetes 2013; 62:3514-22; PMID:23630303; http://dx.doi.org/10.2337/db12-1479
9. Lyttle BM, Li J, Krishnamurthy M, Fellows F, Wheeler MB, Goodyer CG, Wang R. Transcription factor expression in the developing human fetal endocrine pancreas. Diabetologia 2008; 51:1169-80; PMID:18491072; http://dx.doi.org/10.1007/s00125-008-1006-z
10. Piper Hanley K, Hearn T, Berry A, Carvell MJ, Patch AM, Williams LJ, Sugden SA, Wilson DI, Ellard S, Hanley NA. In vitro expression of NGN3 identifies RAB3B as the predominant Ras-associated GTPbinding protein 3 family member in human islets. J Endocrinol 2010; 207:151-61; PMID:20807725; http://dx.doi.org/10.1677/JOE-10-0120
11. Sugiyama T, Rodriguez RT, McLean GW, Kim SK. Conserved markers of fetal pancreatic epithelium permit prospective isolation of islet progenitor cells by FACS. Proc Natl Acad Sci U S A 2007; 104:175-80; PMID:17190805; http://dx.doi.org/10.1073/pnas.0609490104
12. Dror V, Nguyen V, Walia P, Kalynyak TB, Hill JA, Johnson JD. Notch signalling suppresses apoptosis in adult human and mouse pancreatic islet cells. Diabetologia 2007; 50:2504-15; PMID:17922104; http://dx.doi.org/10.1007/s00125-007-0835-5
13. Wang S, Jensen JN, Seymour PA, Hsu W, Dor Y, Sander M, Magnuson MA, Serup P, Gu G. Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function. Proc Natl Acad Sci U S A 2009; 106:9715-20; PMID:19487660; http://dx.doi.org/10.1073/pnas.0904247106
14. Sarkar SA, Kobberup S, Wong R, Lopez AD, Quayum N, Still T, Kutchma A, Jensen JN, Gianani R, Beattie GM, et al. Global gene expression profiling and histochemical analysis of the developing human fetal pancreas. Diabetologia 2008; 51:285-97; PMID:18094957; http://dx.doi.org/10.1007/s00125-007-0880-0
15. Capito C, SimonMT, Aiello V, Clark A, Aigrain Y, Ravassard P, Scharfmann R.Mousemuscle as an ectopic permissive site for human pancreatic development. Diabetes 2013; 62:3479-87; PMID:23835344; http://dx.doi.org/10.2337/db13-0554
16. Piper K, Brickwood S, Turnpenny LW, Cameron IT, Ball SG, Wilson DI, Hanley NA. Beta cell differentiation during early human pancreas development. J Endocrinol 2004; 181:11-23; PMID:15072563; http://dx.doi.org/10.1677/joe.0.1810011