Early bone apposition to hydrophilic and hydrophobic titanium implant surfaces: A histologic and histomorphometric study in minipigs

Clinical Oral Implants Research

Volumn 25, Issue 12, 2014, Pages 1378-1385

  Vasak, Christoph ^a,b   Busenlechner, Dieter ^c   Schwarze, Uwe Y ^a,b   Leitner, Herbert F ^a,b   Munoz Guzon, Fernando ^d   Hefti, Thomas ^e   Schlottig, Falko ^e   Gruber, Reinhard ^a,b,f  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b Austrian Cluster for Tissue Regeneration   (Austria)

^c Academy of Oral Implantology   (Austria)

^d UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^e Thommen Medical AG   (Switzerland)

^f UNIVERSITY OF BERN   (Switzerland)

Author keywords

Animal experiments; Bone implant interactions; Morphometric analysis

Indexed keywords

DENTAL MATERIAL; NITROGEN; SODIUM HYDROXIDE; TITANIUM; TOOTH IMPLANT;

ANIMAL; ANIMAL MODEL; BONE DEVELOPMENT; BONE IMPLANT INTERFACE; BONE REGENERATION; CHEMICAL PHENOMENA; CHEMISTRY; COMPARATIVE STUDY; DENTAL ACID ETCHING; DENTAL ETCHING; FEMALE; MANDIBLE; MAXILLA; MINIPIG; OSTEOLYSIS; PATHOLOGY; PHYSIOLOGY; PIG; PILOT STUDY; PROCEDURES; STOMATITIS; SURFACE PROPERTY; TIME FACTOR; TOOTH IMPLANT;

ACID ETCHING, DENTAL; ANIMALS; BONE RESORPTION; BONE-IMPLANT INTERFACE; DENTAL ETCHING; DENTAL IMPLANTS; DENTAL MATERIALS; FEMALE; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MANDIBLE; MAXILLA; MODELS, ANIMAL; NITROGEN; OSSEOINTEGRATION; OSTEOGENESIS; PILOT PROJECTS; SODIUM HYDROXIDE; STOMATITIS; SURFACE PROPERTIES; SWINE; SWINE, MINIATURE; TIME FACTORS; TITANIUM;

EID: 84912005958     PISSN: 09057161     EISSN: 16000501     Source Type: Journal    
DOI: 10.1111/clr.12277     Document Type: Article

References (36)

1. Abuhussein, H., Pagni, G., Rebaudi, A. & Wang, H.L. (2010) The effect of thread pattern upon implant osseointegration. Clinical Oral Implants Research 21: 129-136.
2. Albrektsson, T. (1983) Direct bone anchorage of dental implants. Journal of Prosthetic Dentistry 50: 255-261.
3. Berglundh, T., Abrahamsson, I., Lang, N.P. & Lindhe, J. (2003) De novo alveolar bone formation adjacent to endosseous implants. Clinical Oral Implants Research 14: 251-262.
4. Bornstein, M.M., Schmid, B., Belser, U.C., Lussi, A. & Buser, D. (2005) Early loading of non-submerged titanium implants with a sandblasted and acid-etched surface. 5-year results of a prospective study in partially edentulous patients. Clinical Oral Implants Research 16: 631-638.
5. Bosshardt, D.D., Salvi, G.E., Huynh-Ba, G., Ivanovski, S., Donos, N. & Lang, N.P. (2011) The role of bone debris in early healing adjacent to hydrophilic and hydrophobic implant surfaces in man. Clinical Oral Implants Research 22: 357-364.
6. Buser, D., Broggini, N., Wieland, M., Schenk, R.K., Denzer, A.J., Cochran, D.L., Hoffmann, B., Lussi, A. & Steinemann, S.G. (2004) Enhanced bone apposition to a chemically modified SLA titanium surface. Journal of Dental Research 83: 529-533.
7. Calvo-Guirado, J.L., Ortiz-Ruiz, A.J., Negri, B., Lopez-Mari, L., Rodriguez-Barba, C. & Schlottig, F. (2010) Histological and histomorphometric evaluation of immediate implant placement on a dog model with a new implant surface treatment. Clinical Oral Implants Research 21: 308-315.
8. Cochran, D.L., Buser, D., ten Bruggenkate, C.M., Weingart, D., Taylor, T.M., Bernard, J.P., Peters, F. & Simpson, J.P. (2002) The use of reduced healing times on ITI implants with a sandblasted and acid-etched (SLA) surface: early results from clinical trials on ITI SLA implants. Clinical Oral Implants Research 13: 144-153.
9. Donath, K. & Breuner, G. (1982) A method for the study of undecalcified bones and teeth with attached soft tissues. The Sage-Schliff (sawing and grinding) technique. Journal of Oral Pathology and Medicine 11: 318-326.
10. Donos, N., Hamlet, S., Lang, N.P., Salvi, G.E., Huynh-Ba, G., Bosshardt, D.D. & Ivanovski, S. (2011) Gene expression profile of osseointegration of a hydrophilic compared with a hydrophobic microrough implant surface. Clinical Oral Implants Research 22: 365-372.
11. Gottlow, J., Barkamo, S. & Sennerby, L. (2012) An experimental comparison of two different clinically used implant designs and surfaces. Clinical Implant Dentistry and Related Research 14(Suppl. 1): e204-e212.
12. Hamlet, S., Alfarsi, M., George, R. & Ivanovski, S. (2012) The effect of hydrophilic titanium surface modification on macrophage inflammatory cytokine gene expression. Clinical Oral Implants Research 23: 584-590.
13. Hong, J., Kurt, S. & Thor, A. (2013) A hydrophilic dental implant surface exhibit thrombogenic properties in vitro. Clinical Implant Dentistry and Related Research 15: 105-112.
14. Hothorn, T., Bretz, F. & Westfall, P. (2008) Simultaneous inference in general parametric models. Biometrical Journal 50: 346-363.
15. Junker, R., Dimakis, A., Thoneick, M. & Jansen, J.A. (2009) Effects of implant surface coatings and composition on bone integration: a systematic review. Clinical Oral Implants Research 20(Suppl. 4): 185-206.
16. Lang, N.P., Salvi, G.E., Huynh-Ba, G., Ivanovski, S., Donos, N. & Bosshardt, D.D. (2011) Early osseointegration to hydrophilic and hydrophobic implant surfaces in humans. Clinical Oral Implants Research 22: 349-356.
17. R for Mixed Models, 2nd edition, p. 755. Cary, NC, USA: SAS Institute Inc., ISBN-13: 978-1-59047-500-3
18. Milleret, V., Tugulu, S., Schlottig, F. & Hall, H. (2011) Alkali treatment of microrough titanium surfaces affects macrophage/monocyte adhesion, platelet activation and architecture of blood clot formation. European Cells and Materials 21: 430-444.
19. Nicolau, P., Korostoff, J., Ganeles, J., Jackowski, J., Krafft, T., Neves, M., Divi, J., Rasse, M., Guerra, F. & Fischer, K. (2013) Immediate and early loading of chemically modified implants in posterior jaws: 3-year results from a prospective randomized multicenter study. Clinical Implant Dentistry and Related Research 15: 600-612.
20. Oates, T.W., Valderrama, P., Bischof, M., Nedir, R., Jones, A., Simpson, J., Toutenburg, H. & Cochran, D.L. (2007) Enhanced implant stability with a chemically modified SLA surface: a randomized pilot study. International Journal of Oral and Maxillofacial Implants 22: 755-760.
21. Orsini, E., Giavaresi, G., Trire, A., Ottani, V. & Salgarello, S. (2012) Dental implant thread pitch and its influence on the osseointegration process: an in vivo comparison study. International Journal of Oral and Maxillofacial Implants 27: 383-392.
22. Orsini, E., Salgarello, S., Bubalo, M., Lazic, Z., Trire, A., Martini, D., Franchi, M. & Ruggeri, A. (2009) Histomorphometric evaluation of implant design as a key factor in peri-implant bone response: a preliminary study in a dog model. Minerva Stomatologica 58: 263-275.
23. R Core Team (2012) R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. ISBN 3-900051-07-0, URL http://www.R-project.org.
24. Raghavendra, S., Wood, M.C. & Taylor, T.D. (2005) Early wound healing around endosseous implants: a review of the literature. International Journal of Oral and Maxillofacial Implants 20: 425-431.
25. Schenk, R.K. & Buser, D. (1998) Osseointegration: a reality. Periodontology 2000 17: 22-35.
26. Schlegel, K.A., Prechtl, C., Most, T., Seidl, C., Lutz, R. & von Wilmowsky, C. (2013) Osseointegration of SLActive implants in diabetic pigs. Clinical Oral Implants Research 24: 128-134.
27. Schwarz, F., Herten, M., Sager, M., Wieland, M., Dard, M. & Becker, J. (2007a) Histological and immunohistochemical analysis of initial and early osseous integration at chemically modified and conventional SLA titanium implants: preliminary results of a pilot study in dogs. Clinical Oral Implants Research 18: 481-488.
28. Schwarz, F., Herten, M., Sager, M., Wieland, M., Dard, M. & Becker, J. (2007b) Bone regeneration in dehiscence-type defects at chemically modified (SLActive) and conventional SLA titanium implants: a pilot study in dogs. Journal of Clinical Periodontology 34: 78-86.
29. Schwarz, F., Jung, R.E., Fienitz, T., Wieland, M., Becker, J. & Sager, M. (2010) Impact of guided bone regeneration and defect dimension on wound healing at chemically modified hydrophilic titanium implant surfaces: an experimental study in dogs. Journal of Clinical Periodontology 37: 474-485.
30. Schwarz, F., Wieland, M., Schwartz, Z., Zhao, G., Rupp, F., Geis-Gerstorfer, J., Schedle, A., Broggini, N., Bornstein, M.M., Buser, D., Ferguson, S.J., Becker, J., Boyan, B.D. & Cochran, D.L. (2009) Potential of chemically modified hydrophilic surface characteristics to support tissue integration of titanium dental implants. Journal of Biomedical Materials Research Part B: Applied Biomaterials 88: 544-557.
31. Stadlinger, B., Lode, A.T., Eckelt, U., Range, U., Schlottig, F., Hefti, T. & Mai, R. (2009) Surface-conditioned dental implants: an animal study on bone formation. Journal of Clinical Periodontology 36: 882-891.
32. Tugulu, S., Lowe, K., Scharnweber, D. & Schlottig, F. (2010) Preparation of superhydrophilic microrough titanium implant surfaces by alkali treatment. Journal of Material Science: Materials in Medicine 21: 2751-2763.
33. Wall, I., Donos, N., Carlqvist, K., Jones, F. & Brett, P. (2009) Modified titanium surfaces promote accelerated osteogenic differentiation of mesenchymal stromal cells in vitro. Bone 45: 17-26.
34. Weber, H.P., Morton, D., Gallucci, G.O., Roccuzzo, M., Cordaro, L. & Grutter, L. (2009) Consensus statements and recommended clinical procedures regarding loading protocols. International Journal of Oral and Maxillofacial Implants 24(Suppl.): 180-183.
35. Wennerberg, A. & Albrektsson, T. (2009) Effects of titanium surface topography on bone integration: a systematic review. Clinical Oral Implants Research 20(Suppl. 4): 172-184.
36. Westfall, P.H. (1997) Multiple testing of general contrasts using logical constraints and correlations. Journal of the American Statistical Association 92: 299-306.