MiR-199a is overexpressed in plasma of type 2 diabetes patients which contributes to type 2 diabetes by targeting GLUT4

Molecular and Cellular Biochemistry

Volumn 397, Issue 1-2, 2014, Pages 45-51

  Yan, Shuang Tong ^a   Li, Chun Lin ^a   Tian, Hui ^a   Li, Jian ^a   Pei, Yu ^a   Liu, Yu ^a   Gong, Yan Ping ^a   Fang, Fu Sheng ^a   Sun, Ban Ruo ^a  

^a CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

Glucose uptake; GLUT4; MiRNA; Plasma; Type 2 diabetes mellitus

Indexed keywords

GLUCOSE; GLUCOSE TRANSPORTER 4; MICRORNA; MICRORNA 146A; MICRORNA 199A; MICRORNA 31; MICRORNA 93; UNCLASSIFIED DRUG; 3' UNTRANSLATED REGION; BIOLOGICAL MARKER; MIRN199 MICRORNA, HUMAN; SLC2A4 PROTEIN, HUMAN;

3' UNTRANSLATED REGION; ADULT; ANIMAL CELL; ARTICLE; BINDING SITE; BLOOD LEVEL; BLOOD SAMPLING; CONTROLLED STUDY; DIABETIC PATIENT; DIABETOGENESIS; GAIN OF FUNCTION MUTATION; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENE REPRESSION; GLUCOSE TRANSPORT; HEK293 CELL LINE; HUMAN; INSULIN RESISTANCE; LOSS OF FUNCTION MUTATION; MAJOR CLINICAL STUDY; MOUSE; MYOBLAST; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PROTEIN RNA BINDING; PROTEIN TARGETING; RAT; SUSCEPTIBLE POPULATION; ANIMAL; BLOOD; FEMALE; MALE; METABOLISM; MIDDLE AGED;

3' UNTRANSLATED REGIONS; ANIMALS; BIOLOGICAL MARKERS; DIABETES MELLITUS, TYPE 2; FEMALE; GENE EXPRESSION REGULATION; GLUCOSE; GLUCOSE TRANSPORTER TYPE 4; HEK293 CELLS; HUMANS; INSULIN RESISTANCE; MALE; MICRORNAS; MIDDLE AGED; RATS;

EID: 84911993238     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-014-2170-8     Document Type: Article

References (19)

1. Stenbit AE, Tsao TS, Li J et al (1997) GLUT4 heterozygous knockout mice develop muscle insulin resistance and diabetes. Nat Med 3:1096–1101
2. Brozinick JT Jr, McCoid SC, Reynolds TH et al (2001) GLUT4 overexpression in db/db mice dose-dependently ameliorates diabetes but is not a lifelong cure. Diabetes 50:593–600
3. Maes OC, Chertkow HM, Wang E et al (2009) MicroRNA: implications for Alzheimer disease and other human CNS disorders. Curr Genomics 10:154–168
4. Xu J, Li Y, Wang F et al (2013) Suppressed miR-424 expression via upregulation of target gene Chk1 contributes to the progression of cervical cancer. Oncogene 32:976–987
5. Farazi TA, Hoell JI, Morozov P et al (2013) MicroRNAs in human cancer. Adv Exp Med Biol 774:1–20
6. Mitchell PS, Parkin RK, Kroh EM et al (2008) Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci USA 105:10513–10518
7. Arroyo JD, Chevillet JR, Kroh EM et al (2011) Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma. Proc Natl Acad Sci USA 108:5003–5008
8. Tanaka M, Oikawa K, Takanashi M et al (2009) Down-regulation of miR-92 in human plasma is a novel marker for acute leukemia patients. PLoS One 4:e5532
9. Laterza OF, Lim L, Garrett-Engele PW et al (2009) Plasma MicroRNAs as sensitive and specific biomarkers of tissue injury. Clin Chem 55:1977–1983
10. Wang K, Zhang S, Marzolf B et al (2009) Circulating microRNAs, potential biomarkers for drug-induced liver injury. Proc Natl Acad Sci USA 106:4402–4407
11. Kantharidis P, Wang B, Carew RM, Lan HY (2011) Diabetes complications: the microRNA perspective. Diabetes 60:1832–1837
12. Bell GI, Kayano T, Buse JB et al (1990) Molecular biology of mammalian glucose transporters. Diabetes Care 13:198–208
13. Marshall BA, Ren JM, Johnson DW et al (1993) Germline manipulation of glucose homeostasis via alteration of glucose transporter levels in skeletal muscle. J Biol Chem 268:18442–18445
14. Ren JM, Marshall BA, Gulve EA et al (1993) Evidence from transgenic mice that glucose transport is rate-limiting for glycogen deposition and glycolysis in skeletal muscle. J Biol Chem 268:16113–16115
15. Andersen PH, Lund S, Vestergaard H et al (1993) Expression of the major insulin regulatable glucose transporter (GLUT4) in skeletal muscle of noninsulin-dependent diabetic patients and healthy subjects before and after insulin infusion. J Clin Endocrinol Metab 77:27–32
16. Pedersen O, Bak JF, Andersen PH et al (1990) Evidence against altered expression of GLUT1 or GLUT4 in skeletal muscle of patients with obesity or NIDDM. Diabetes 39:865–870
17. Garvey WT, Maianu L, Hancock JA et al (1992) Gene expression of GLUT4 in skeletal muscle from insulin-resistant patients with obesity, IGT, GDM, and NIDDM. Diabetes 41:465–475
18. Lund S, Vestergaard H, Andersen PH et al (1993) GLUT-4 content in plasma membrane of muscle from patients with non-insulin-dependent diabetes mellitus. Am J Physiol 265:E889–E897
19. Garvey WT, Maianu L, Zhu JH et al (1998) Evidence for defects in the trafficking and translocation of GLUT4 glucose transporters in skeletal muscle as a cause of human insulin resistance. J Clin Invest 101:2377–2386