Management of Lymph Nodes During Resection of Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma: A Systematic Review

Journal of Gastrointestinal Surgery

Volumn 18, Issue 12, 2014, Pages 2136-2148

  Amini, Neda ^a   Ejaz, Aslam ^a,b   Spolverato, Gaya ^a   Maithel, Shishir K ^c   Kim, Yuhree ^a   Pawlik, Timothy M ^a  

^a JOHNS HOPKINS HOSPITAL   (United States)

^b UNIVERSITY OF ILLINOIS HOSPITAL AND HEALTH SCIENCES SYSTEM   (United States)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Hepatocellular carcinoma; Intrahepatic cholangiocarcinoma; Lymphadenectomy

Indexed keywords

BILE DUCT NEOPLASMS; CARCINOMA, HEPATOCELLULAR; CHOLANGIOCARCINOMA; CHOLECYSTECTOMY; HUMAN; INTRAHEPATIC BILE DUCT; LIVER NEOPLASMS; LIVER RESECTION; LYMPH NODE; LYMPH NODE DISSECTION; LYMPH NODE METASTASIS; PATHOLOGY; PROCEDURES; PROGNOSIS; SECONDARY;

BILE DUCT NEOPLASMS; BILE DUCTS, INTRAHEPATIC; CARCINOMA, HEPATOCELLULAR; CHOLANGIOCARCINOMA; CHOLECYSTECTOMY; HEPATECTOMY; HUMANS; LIVER NEOPLASMS; LYMPH NODE EXCISION; LYMPH NODES; LYMPHATIC METASTASIS; PROGNOSIS;

EID: 84911988370     PISSN: 1091255X     EISSN: 18734626     Source Type: Journal    
DOI: 10.1007/s11605-014-2667-1     Document Type: Article

References (93)

1. Jemal A, Bray F, Center M M, Ferlay J, Ward E, and Forman D. Global cancer statistics. CA: A Cancer Journal for Clinicians 2011; 61:69–90.
2. Venook A P, Papandreou C, Furuse J, and de Guevara L L. The incidence and epidemiology of hepatocellular carcinoma: a global and regional perspective. The Oncologist 2010; 15:5–13.
3. Aljiffry M, Abdulelah A, Walsh M, Peltekian K, Alwayn I, and Molinari M. Evidence-Based Approach to Cholangiocarcinoma: A Systematic Review of the Current Literature. J Am Coll Surg 2009; 208:134–147.
4. Bektas H, Schrem H, Kleine M, Tamac A, Vondran F, Uzunyayla S, and Klempnauer J. Primary Liver Tumours–Presentation, Diagnosis and Surgical Treatment. Liver Tumors-Epidemiology, Diagnosis, Prevention and Treatment. In Tech 2013:91–116.
5. Feliu J, Sastre J, Maurel J, and Isla D. Hepatocellular and biliary tract carcinomas: SEOM clinical guidelines. Clinical and Translational Oncology 2011; 13:536–544.
6. Al-Bahrani R, Abuetabh Y, Zeitouni N, and Sergi C. Cholangiocarcinoma: risk factors, environmental influences and oncogenesis. Ann Clin Lab Sci 2013; 43:195–210.
7. Ly K N, Xing J, Klevens R M, Jiles R B, Ward J W, and Holmberg S D. The increasing burden of mortality from viral hepatitis in the United States between 1999 and 2007. Ann Intern Med 2012; 156:271–8.
8. Venook A P, Papandreou C, Furuse J, and de Guevara L L. The incidence and epidemiology of hepatocellular carcinoma: a global and regional perspective. Oncologist 2010; 15 Suppl 4:5–13.
9. El-Serag H B and Rudolph K L. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 2007;132:2557–76.
10. Prevention C f D C a. Viral Hepatitis Surveillance-United States, 2011. 2011;
11. Llovet J M. Updated treatment approach to hepatocellular carcinoma. J Gastroenterol 2005; 40:225–35.
12. Ascha M S, Hanouneh I A, Lopez R, Tamimi T A, Feldstein A F, and Zein N N. The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis. Hepatology 2010; 51:1972–8.
13. Sun B and Karin M. Obesity, inflammation, and liver cancer. J Hepatol 2012; 56:704–13.
14. Calle E E, Rodriguez C, Walker-Thurmond K, and Thun M J. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med 2003; 348:1625–38.
15. Polesel J, Zucchetto A, Montella M, Dal Maso L, Crispo A, La Vecchia C, Serraino D, Franceschi S, and Talamini R. The impact of obesity and diabetes mellitus on the risk of hepatocellular carcinoma. Ann Oncol 2009; 20:353–7.
16. Wong J B, McQuillan G M, McHutchison J G, and Poynard T. Estimating future hepatitis C morbidity, mortality, and costs in the United States. Am J Public Health 2000; 90:1562–9.
17. Cho S Y, Park S J, Kim S H, Han S S, Kim Y K, Lee K W, Lee S A, Hong E K, Lee W J, and Woo S M. Survival analysis of intrahepatic cholangiocarcinoma after resection. Annals of Surgical Oncology 2010; 17:1823–1830.
18. Charbel H and Al-Kawas F. Cholangiocarcinoma: Epidemiology, Risk Factors, Pathogenesis, and Diagnosis. Current Gastroenterology Reports 2011; 13:182–187.
19. Altekruse S F, McGlynn K A, Dickie L A, and Kleiner D E. Hepatocellular Carcinoma Confirmation, Treatment, and Survival in Surveillance, Epidemiology, and End Results Registries, 1992–2008. Hepatology 2012; 55:476–482.
20. Llovet J M, Bustamante J, Castells A, Vilana R, Ayuso M D C, Sala M, Brú C, Rodés J, and Bruix J. Natural history of untreated nonsurgical hepatocellular carcinoma: Rationale for the design and evaluation of therapeutic trials. Hepatology 1999; 29:62–67.
21. Weinmann A, Koch S, Niederle I M, Schulze-Bergkamen H, König J, Hoppe-Lotichius M, Hansen T, Pitton M B, Düber C, Otto G, Schuchmann M, Galle P R, and Wörns M A. Trends in Epidemiology, Treatment, and Survival of Hepatocellular Carcinoma Patients Between 1998 and 2009: An Analysis of 1066 Cases of a German HCC Registry. Journal of clinical gastroenterology 2013;
22. Uzzau A, Pertoldeo M L, Cherchi V, Bertozzi S, Avellini C, and Soardo G. Surgical Treatment Strategies and Prognosis of Hepatocellular Carcinoma. 2013
23. Morimoto Y, Tanaka Y, Ito T, Nakahara M, Nakaba H, Nishida T, Fujikawa M, Ito T, Yamamoto S, and Kitagawa T. Long-term survival and prognostic factors in the surgical treatment for intrahepatic cholangiocarcinoma. J Hepatobiliary Pancreat Surg 2003; 10:432–440.
24. Konstadoulakis M M, Roayaie S, Gomatos I P, Labow D, Fiel M-I, Miller C M, and Schwartz M E. Fifteen-year, single-center experience with the surgical management of intrahepatic cholangiocarcinoma: operative results and long-term outcome. Surgery 2008; 143:366–374.
25. Choi S-B, Kim K-S, Choi J-Y, Park S-W, Choi J-S, Lee W-J, and Chung J-B. The prognosis and survival outcome of intrahepatic cholangiocarcinoma following surgical resection: association of lymph node metastasis and lymph node dissection with survival. Ann Surg Oncol 2009; 16:3048–3056.
26. Herman J M and Pawlik T M, Hepatocellular Carcinoma, Gallbladder Cancer, and Cholangiocarcinoma, in Radiation Oncology: An Evidence-Based Approach, J.J. Lu and L.W. Brady, Editors. 2008. p. 221–243.
27. Tan J C, Coburn N G, Baxter N N, and Law C H. Surgical Management of Intrahepatic Cholangiocarcinoma-A Population-Based Study. Ann Surg Oncol 2008; 15:600–608.
28. Nathan H, Segev D L, Mayo S C, Choti M A, Cameron A M, Wolfgang C L, Hirose K, Edil B H, Schulick R D, and Pawlik T M. National trends in surgical procedures for hepatocellular carcinoma: 1998–2008. Cancer 2012; 118:1838–1844.
29. Cance W G, Stewart A K, and Menck H R. The National Cancer Data Base Report on treatment patterns for hepatocellular carcinomas: improved survival of surgically resected patients, 1985–1996. Cancer 2000; 88:912–20.
30. Dodson R M, Weiss M J, Cosgrove D, Herman J M, Kamel I, Anders R, Geschwind J F, and Pawlik T M. Intrahepatic cholangiocarcinoma: management options and emerging therapies. J Am Coll Surg 2013; 217:736–750 e4.
31. Pawlik T M, Delman K A, Vauthey J-N, Nagorney D M, Ng I O-L, Ikai I, Yamaoka Y, Belghiti J, Lauwers G Y, Poon R T, and Abdalla E K. Tumor size predicts vascular invasion and histologic grade: Implications for selection of surgical treatment for hepatocellular carcinoma. Liver Transplantation 2005; 11:1086–1092.
32. Ishii T, Hatano E, Yasuchika K, Taura K, Seo S, and Uemoto S. High risk of lung metastasis after resection of hepatocellular carcinoma more than 7 cm in diameter. Surg Today 2013:1–6.
33. Hyder O, Marques H, Pulitano C, Marsh J W, Alexandrescu S, Bauer T W, Gamblin T C, Sotiropoulos G C, Paul A, Barroso E, Clary B M, Aldrighetti L, Ferrone C R, Zhu A X, Popescu I, Gigot J F, Mentha G, Feng S, and Pawlik T M. A Nomogram to Predict Long-term Survival After Resection for Intrahepatic Cholangiocarcinoma: An Eastern and Western Experience. JAMA Surg 2014;
34. de Jong M C, Nathan H, Sotiropoulos G C, Paul A, Alexandrescu S, Marques H, Pulitano C, Barroso E, Clary B M, Aldrighetti L, Ferrone C R, Zhu A X, Bauer T W, Walters D M, Gamblin T C, Nguyen K T, Turley R, Popescu I, Hubert C, Meyer S, Schulick R D, Choti M A, Gigot J F, Mentha G, and Pawlik T M. Intrahepatic cholangiocarcinoma: an international multi-institutional analysis of prognostic factors and lymph node assessment. J Clin Oncol 2011; 29:3140–5.
35. Morine Y, Shimada M, Utsunomiya T, Imura S, Ikemoto T, Mori H, Hanaoka J, Kanamoto M, and Miyake H. Clinical impact of lymph node dissection in surgery for peripheral-type intrahepatic cholangiocarcinoma. Surg Today 2012; 42:147–51.
36. Kokudo N, Sato T, Seki M, Ohta H, Azekura K, Ueno M, Matsubara T, Yanagisawa A, Kato Y, and Takahashi T. Hepatic lymph node involvement in resected cases of liver metastases from colorectal cancer. Dis Colon Rectum 1999; 42:1285–90; discussion 1290–1.
37. Abdel-Wahab M, El-Husseiny T, Hanafy E, Shobary M, and Hamdy E. Prognostic factors affecting survival and recurrence after hepatic resection for hepatocellular carcinoma in cirrhotic liver. Langenbeck’s Archives of Surgery 2010; 395:625–632.
38. Kitagawa Y, Nagino M, Kamiya J, Uesaka K, Sano T, Yamamoto H, Hayakawa N, and Nimura Y. Lymph node metastasis from hilar cholangiocarcinoma: audit of 110 patients who underwent regional and paraaortic node dissection. Ann Surg 2001; 233:385–92.
39. Shimada H, Endo I, Togo S, Nakano A, Izumi T, and Nakagawara G. The role of lymph node dissection in the treatment of gallbladder carcinoma. Cancer 1997; 79:892–899.
40. Mavros M N, Mayo S C, Hyder O, and Pawlik T M. A systematic review: treatment and prognosis of patients with fibrolamellar hepatocellular carcinoma. J Am Coll Surg 2012; 215:820–30.
41. Ercolani G, Grazi G L, Ravaioli M, Grigioni W F, Cescon M, Gardini A, Del Gaudio M, and Cavallari A. The role of lymphadenectomy for liver tumors: further considerations on the appropriateness of treatment strategy. Ann Surg 2004; 239:202–9.
42. Kobayashi S, Takahashi S, Kato Y, Gotohda N, Nakagohri T, Konishi M, and Kinoshita T. Surgical treatment of lymph node metastases from hepatocellular carcinoma. J Hepatobiliary Pancreat Sci 2011; 18:559–66.
43. Miwa S, Miyagawa S, Kobayashi A, Akahane Y, Nakata T, Mihara M, Kusama K, Soeda J, and Ogawa S. Predictive factors for intrahepatic cholangiocarcinoma recurrence in the liver following surgery. Journal of Gastroenterology 2006; 41:893–900.
44. Shimada M, Yamashita Y, Aishima S, Shirabe K, Takenaka K, and Sugimachi K. Value of lymph node dissection during resection of intrahepatic cholangiocarcinoma. Br J Surg 2001; 88:1463–6.
45. Sun H C, Zhuang P Y, Qin L X, Ye Q H, Wang L, Ren N, Zhang J B, Qian Y B, Lu L, Fan J, and Tang Z Y. Incidence and prognostic values of lymph node metastasis in operable hepatocellular carcinoma and evaluation of routine complete lymphadenectomy. J Surg Oncol 2007; 96:37–45.
46. Attias J, Karawani H, Shemesh R, and Nageris B. Predicting hearing thresholds in occupational noise-induced hearing loss by auditory steady state responses. Ear Hear 2014; 35:330–8.
47. DerSimonian R and Laird N. Meta-analysis in clinical trials. Controlled Clinical Trials 1986; 7:177–188.
48. Higgins J P T and Thompson S G. Quantifying heterogeneity in a meta-analysis. Statistics in Medicine 2002; 21:1539–1558.
49. Hozo S P, Djulbegovic B, and Hozo I. Estimating the mean and variance from the median, range, and the size of a sample. BMC medical research methodology 2005; 5:13.
50. Aalaei-Andabili S H and Alavian S M. Important steps for a reliable meta-analysis. The Lancet Infectious Diseases 2012; 12:663.
51. Grobmyer S R, Wang L, Gonen M, Fong Y, Klimstra D, D’Angelica M, DeMatteo R P, Schwartz L, Blumgart L H, and Jarnagin W R. Perihepatic lymph node assessment in patients undergoing partial hepatectomy for malignancy. Ann Surg 2006; 244:260–4.
52. Hashimoto M, Matsuda M, and Watanabe G. Metachronous resection of metastatic lymph nodes in patients with hepatocellular carcinoma. Hepato-Gastroenterology 2009; 56:788–792.
53. Abe T, Furuse J, Yoshino M, Kinoshita T, Konishi M, Inoue K, and Hasebe T. Clinical characteristics of hepatocellular carcinoma with an extensive lymph node metastasis at diagnosis. American journal of clinical oncology 2002; 25:318–323.
54. Awazu M, Fukumoto T, Takebe A, Ajiki T, Matsumoto I, Kido M, Tanaka M, Kuramitsu K, and Ku Y. Lymphadenectomy combined with locoregional treatment for multiple advanced hepatocellular carcinoma with lymph node metastases. Kobe Journal of Medical Sciences 2013; 59:E17-E27.
55. Ravaioli M, Ercolani G, Grazi G L, Cescon M, Dazzi A, Zanfi C, and Pinna A D. Safety and prognostic role of regional lymphadenectomy for primary and metastatic liver tumors. Updates Surg 2010; 62:27–34.
56. Xiaohong S, Huikai L, Feng W, Ti Z, Yunlong C, and Qiang L. Clinical significance of lymph node metastasis in patients undergoing partial hepatectomy for hepatocellular carcinoma. World J Surg 2010; 34:1028–33.
57. Lee C W, Chan K M, Lee C F, Yu M C, Lee W C, Wu T J, and Chen M F. Hepatic resection for hepatocellular carcinoma with lymph node metastasis: clinicopathological analysis and survival outcome. Asian J Surg 2011; 34:53–62.
58. Hyder O, Hatzaras I, Sotiropoulos G C, Paul A, Alexandrescu S, Marques H, Pulitano C, Barroso E, Clary B M, Aldrighetti L, Ferrone C R, Zhu A X, Bauer T W, Walters D M, Groeschl R, Gamblin T C, Marsh J W, Nguyen K T, Turley R, Popescu I, Hubert C, Meyer S, Choti M A, Gigot J F, Mentha G, and Pawlik T M. Recurrence after operative management of intrahepatic cholangiocarcinoma. Surgery (United States) 2013; 153:811–818.
59. Sulpice L, Rayar M, Boucher E, Pele F, Pracht M, Meunier B, and Boudjema K. Intrahepatic cholangiocarcinoma: impact of genetic hemochromatosis on outcome and overall survival after surgical resection. Journal of Surgical Research 2013; 180:56–61.
60. Nanashima A, Shibata K, Nakayama T, Tobinaga S, Araki M, Kunizaki M, Takeshita H, Hidaka S, Sawai T, Nagayasu T, and Tagawa T. Relationship Between Microvessel Count and Postoperative Survival in Patients with Intrahepatic Cholangiocarcinoma. Ann Surg Oncol 2009; 16:2123–2129.
61. Zhou X-D, Tang Z-Y, Fan J, Zhou J, Wu Z-Q, Qin L-X, Ma Z-C, Sun H-C, Qiu S-J, Yu Y, Ren N, Ye Q-H, Wang L, and Ye S-L. Intrahepatic cholangiocarcinoma: report of 272 patients compared with 5,829 patients with hepatocellular carcinoma. Journal of Cancer Research and Clinical Oncology 2009; 135:1073–1080.
62. Guglielmi A, Ruzzenente A, Campagnaro T, Pachera S, Valdegamberi A, Nicoli P, Cappellani A, Malfermoni G, and Iacono C. Intrahepatic Cholangiocarcinoma: Prognostic Factors After Surgical Resection. World J Surg 2009; 33:1247–1254.
63. Shimada K, Sano T, Sakamoto Y, Esaki M, Kosuge T, and Ojima H. Clinical impact of the surgical margin status in hepatectomy for solitary mass-forming type intrahepatic cholangiocarcinoma without lymph node metastases. J Surg Oncol 2007; 96:160–165.
64. Tajima Y, Kuroki T, Fukuda K, Tsuneoka N, Furui J, and Kanematsu T. An intraductal papillary component is associated with prolonged survival after hepatic resection for intrahepatic cholangiocarcinoma. Br J Surg 2004; 91:99–104.
65. Morimoto Y, Tanaka Y, Ito T, Nakahara M, Nakaba H, Nishida T, Fujikawa M, Ito T, Yamamoto S, and Kitagawa T. Long-term survival and prognostic factors in the surgical treatment for intrahepatic cholangiocarcinoma. Journal of Hepato-Biliary-Pancreatic Surgery 2003; 10:432–440.
66. Igami T, Ebata T, Yokoyama Y, Sugawara G, Takahashi Y, and Nagino M. Staging of Peripheral-Type Intrahepatic Cholangiocarcinoma: Appraisal of the New TNM Classification and its Modifications. World J Surg 2011; 35:2501–2509.
67. Saxena A, Chua T, Sarkar A, Chu F, and Morris D. Clinicopathologic and Treatment-Related Factors Influencing Recurrence and Survival after Hepatic Resection of Intrahepatic Cholangiocarcinoma: A 19-Year Experience from an Established Australian Hepatobiliary Unit. Journal of Gastrointestinal Surgery 2010; 14:1128–1138.
68. Shirabe K, Mano Y, Taketomi A, Soejima Y, Uchiyama H, Aishima S, Kayashima H, Ninomiya M, and Maehara Y. Clinicopathological prognostic factors after hepatectomy for patients with mass-forming type intrahepatic cholangiocarcinoma: Relevance of the lymphatic invasion index. Annals of Surgical Oncology 2010; 17:1816–1822.
69. Portolani N, Baiocchi G L, Coniglio A, Piardi T, Grazioli L, Benetti A, Ferrari Bravo A, and Giulini S M. Intrahepatic cholangiocarcinoma and combined hepatocellular-cholangiocarcinoma: a Western experience. Ann Surg Oncol 2008; 15:1880–90.
70. Ercolani G, Grazi G L, Ravaioli M, Grigioni W F, Cescon M, Gardini A, Del Gaudio M, and Cavallari A. The role of lymphadenectomy for liver tumors - Further considerations on the appropriateness of treatment strategy. Annals of Surgery 2004; 239:202–209.
71. Ribero D, Pinna A D, Guglielmi A, Ponti A, Nuzzo G, Giulini S M, Aldrighetti L, Calise F, Gerunda G E, Tomatis M, Amisano M, Berloco P, Torzilli G, Capussotti L, and Italian Intrahepatic C. Surgical Approach for Long-term Survival of Patients With Intrahepatic Cholangiocarcinoma A Multi-institutional Analysis of 434 Patients. Archives of Surgery 2012; 147:1107–1113.
72. Uchiyama K, Yamamoto M, Yamaue H, Ariizumi S I, Aoki T, Kokudo N, Ebata T, Nagino M, Ohtsuka M, Miyazaki M, Tanaka E, Kondo S, Uenishi T, Kubo S, Yoshida H, Unno M, Imura S, Shimada M, Ueno M, and Takada T. Impact of nodal involvement on surgical outcomes of intrahepatic cholangiocarcinoma: A multicenter analysis by the Study Group for Hepatic Surgery of the Japanese Society of Hepato-Biliary-Pancreatic Surgery. Journal of Hepato-Biliary-Pancreatic Sciences 2011; 18:443–452.
73. Yamamoto M, Takasaki K, and Yoshikawa T. Lymph node metastasis in intrahepatic cholangiocarcinoma. Jpn J Clin Oncol 1999; 29:147–50.
74. Ali S M, Clark C J, Zaydfudim V M, Que F G, and Nagorney D M. Role of major vascular resection in patients with intrahepatic cholangiocarcinoma. Annals of Surgical Oncology 2013; 20:2023–2028.
75. Guglielmi A, Ruzzenente A, Campagnaro T, Valdegamberi A, Bagante F, Bertuzzo F, Conci S, and Iacono C. Patterns and Prognostic Significance of Lymph Node Dissection for Surgical Treatment of Perihilar and Intrahepatic Cholangiocarcinoma. Journal of Gastrointestinal Surgery 2013; 17:1917–1928.
76. Li S Q, Liang L J, Hua Y P, Peng B G, He Q, Lu M D, and Chen D. Long-term outcome and prognostic factors of intrahepatic cholangiocarcinoma. Chin Med J (Engl) 2009; 122:2286–91.
77. Murakami Y, Uemura K, Sudo T, Hashimoto Y, Nakashima A, and Sueda T. Intrahepatic Cholangiocarcinoma: Clinicopathological Differences Between Peripheral Type and Hilar Type. Journal of Gastrointestinal Surgery 2012; 16:540–548.
78. Shimada K, Sano T, Nara S, Esaki M, Sakamoto Y, Kosuge T, and Ojima H. Therapeutic value of lymph node dissection during hepatectomy in patients with intrahepatic cholangiocellular carcinoma with negative lymph node involvement. Surgery 2009; 145:411–6.
79. Suzuki S, Sakaguchi T, Yokoi Y, Okamoto K, Kurachi K, Tsuchiya Y, Okumura T, Konno H, Baba S, and Nakamura S. Clinicopathological prognostic factors and impact of surgical treatment of mass-forming intrahepatic cholangiocarcinoma. World J Surg 2002; 26:687–93.
80. Tamandl D, Kaczirek K, Gruenberger B, Koelblinger C, Maresch J, Jakesz R, and Gruenberger T. Lymph node ratio after curative surgery for intrahepatic cholangiocarcinoma. Br J Surg 2009; 96:919–25.
81. Tsuji T, Hiraoka T, Kanemitsu K, Takamori H, Tanabe D, and Tashiro S. Lymphatic spreading pattern of intrahepatic cholangiocarcinoma. Surgery 2001; 129:401–7.
82. Uenishi T, Kubo S, Yamazaki O, Yamada T, Sasaki Y, Nagano H, and Monden M. Indications for surgical treatment of intrahepatic cholangiocarcinoma with lymph node metastases. Journal of Hepato-Biliary-Pancreatic Surgery 2008; 15:417–22.
83. Yedibela S, Demir R, Zhang W, Meyer T, Hohenberger W, and Schonleben F. Surgical treatment of mass-forming intrahepatic cholangiocarcinoma: An 11-year western single-center experience in 107 patients. Annals of Surgical Oncology 2009; 16:404–412.
84. Yonemori A, Kondo S, Matsuno Y, Ito T, Nakanishi Y, Miyamoto M, Tanaka E, and Hirano S. Prognostic Impact of Regional Lymph Node Micrometastasis in Patients With Node-Negative Biliary Cancer. Annals of Surgery 2010; 252:99–106.
85. Nakagawa T, Kamiyama T, Kurauchi N, Matsushita M, Nakanishi K, Kamachi H, Kudo T, and Todo S. Number of lymph node metastases is a significant prognostic factor in intrahepatic cholangiocarcinoma. World J Surg 2005; 29:728–33.
86. Jiang L, Yang K-H, Guan Q-L, Zhao P, Chen Y, and Tian J-H. Survival and recurrence free benefits with different lymphadenectomy for resectable gastric cancer: A meta-analysis. J Surg Oncol 2013; 107:807–814.
87. Pavlidis T E, Pavlidis E T, and Sakantamis A K. Current opinion on lymphadenectomy in pancreatic cancer surgery. Hepatobiliary Pancreat Dis Int 2011; 10:21–5.
88. Hueman M T, Vollmer C M, Jr., and Pawlik T M. Evolving treatment strategies for gallbladder cancer. Ann Surg Oncol 2009; 16:2101–15.
89. Isa T, Kusano T, Shimoji H, Takeshima Y, Muto Y, and Furukawa M. Predictive factors for long-term survival in patients with intrahepatic cholangiocarcinoma. The American journal of surgery 2001; 181:507–511.
90. NCCN Guidelines(R) Updates. J Natl Compr Canc Netw 2013; 11:xxxii-xxxiii.
91. Klintmalm G B. Liver transplantation for hepatocellular carcinoma: a registry report of the impact of tumor characteristics on outcome. Ann Surg 1998; 228:479.
92. Marsh J W, Dvorchik I, Bonham C A, and Iwatsuki S. Is the pathologic TNM staging system for patients with hepatoma predictive of outcome? Cancer 2000; 88:538–543.
93. Japan L C S G o. Primary liver cancer of Japan: clinicopathological features and results of surgical treatment. Ann Surg Oncol 1990; 211:277–287.