Reasons for low thrombolysis rate in a Norwegian ischemic stroke population

Neurological Sciences

Volumn 35, Issue 12, 2014, Pages 1977-1982

  Faiz, Kashif Waqar ^a,b   Sundseth, Antje ^b   Thommessen, Bente ^b   Rønning, Ole Morten ^a,b  

^a UNIVERSITY OF OSLO   (Norway)

^b AKERSHUS UNIVERSITY HOSPITAL   (Norway)

Author keywords

In hospital delay; Ischemic stroke; Minor symptoms; Prehospital delay; Recombinant tissue plasminogen activator; Thrombolysis

Indexed keywords

ALTEPLASE;

ADULT; AGED; ARTICLE; BLOOD CLOT LYSIS; BRAIN ISCHEMIA; CONTROLLED STUDY; FEMALE; FIBRINOLYTIC THERAPY; HOSPITAL ADMISSION; HUMAN; MAJOR CLINICAL STUDY; MALE; THERAPY DELAY; COMPLICATION; MIDDLE AGED; NORWAY; PATIENT SELECTION; PROCEDURES; RETROSPECTIVE STUDY; STATISTICS AND NUMERICAL DATA; STROKE; TIME; VERY ELDERLY;

AGED; AGED, 80 AND OVER; BRAIN ISCHEMIA; FEMALE; HUMANS; MALE; MIDDLE AGED; NORWAY; PATIENT SELECTION; RETROSPECTIVE STUDIES; STROKE; THROMBOLYTIC THERAPY; TIME FACTORS;

EID: 84911960872     PISSN: 15901874     EISSN: 15903478     Source Type: Journal    
DOI: 10.1007/s10072-014-1876-4     Document Type: Article

References (28)

1. Hacke W, Kaste M, Bluhmki E, Brozman M, Davalos A, Guidetti D et al (2008) Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med 359:1317–1329
2. Lees KR, Bluhmki E, von Kummer R, Brott TG, Toni D, Grotta JC et al (2010) Time to treatment with intravenous alteplase and outcome in stroke: an updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials. Lancet 375:1695–1703
3. Hacke W, Donnan G, Fieschi C, Kaste M, Von KR, Broderick JP et al (2004) Association of outcome with early stroke treatment: pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trials. Lancet 363:768–774
4. Reeves MJ, Arora S, Broderick JP, Frankel M, Heinrich JP, Hickenbottom S et al (2005) Acute stroke care in the US: results from 4 pilot prototypes of the Paul Coverdell National Acute Stroke Registry. Stroke 36:1232–1240
5. Barber PA, Zhang J, Demchuk AM, Hill MD, Buchan AM (2001) Why are stroke patients excluded from TPA therapy? An analysis of patient eligibility. Neurology 56:1015–1020
6. Tong D, Reeves MJ, Hernandez AF, Zhao X, Olson DM, Fonarow GC et al (2012) Times from symptom onset to hospital arrival in the Get With The Guidelines-Stroke Program 2002 to 2009: temporal trends and implications. Stroke 43:1912–1917
7. Bouckaert M, Lemmens R, Thijs V (2009) Reducing prehospital delay in acute stroke. Nat Rev Neurol 5:477–483
8. Saver JL, Smith EE, Fonarow GC, Reeves MJ, Zhao X, Olson DM et al (2010) The “golden hour” and acute brain ischemia: presenting features and lytic therapy in >30,000 patients arriving within 60 minutes of stroke onset. Stroke 41:1431–1439
9. Evenson KR, Foraker RE, Morris DL, Rosamond WD (2009) A comprehensive review of prehospital and in-hospital delay times in acute stroke care. Int J Stroke 4:187–199
10. Faiz KW, Sundseth A, Thommessen B, Rønning OM (2013) Prehospital delay in acute stroke and TIA. Emerg Med J 30:669–674
11. Brott T, Adams HP Jr, Olinger CP, Marler JR, Barsan WG, Biller J et al (1989) Measurements of acute cerebral infarction: a clinical examination scale. Stroke 20:864–870
12. Adams HP Jr, Bendixen BH, Kappelle LJ, Biller J, Love BB, Gordon DL et al (1993) Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke 24:35–41
13. Bamford J, Sandercock P, Dennis M, Burn J, Warlow C (1991) Classification and natural history of clinically identifiable subtypes of cerebral infarction. Lancet 337:1521–1526
14. European Stroke Organisation (ESO) Executive Committee, ESO Writing Committee (2008) Guidelines for management of ischaemic stroke and transient ischaemic attack 2008. Cerebrovasc Dis 25:457–507
15. Nedeltchev K, Schwegler B, Haefeli T, Brekenfeld C, Gralla J, Fischer U et al (2007) Outcome of stroke with mild or rapidly improving symptoms. Stroke 38:2531–2535
16. Smith EE, Fonarow GC, Reeves MJ, Cox M, Olson DM, Hernandez AF et al (2011) Outcomes in mild or rapidly improving stroke not treated with intravenous recombinant tissue-type plasminogen activator: findings from Get With The Guidelines-Stroke. Stroke 42:3110–3115
17. Smith EE, Abdullah AR, Petkovska I, Rosenthal E, Koroshetz WJ, Schwamm LH (2005) Poor outcomes in patients who do not receive intravenous tissue plasminogen activator because of mild or improving ischemic stroke. Stroke 36:2497–2499
18. Willey JZ, Stillman J, Rivolta JA, Vieira J, Doyle MM, Linares G et al (2012) Too good to treat? Outcomes in patients not receiving thrombolysis due to mild deficits or rapidly improving symptoms. Int J Stroke 7:202–206
19. Baumann CR, Baumgartner RW, Gandjour J, von Budingen HC, Siegel AM, Georgiadis D (2006) Good outcomes in ischemic stroke patients treated with intravenous thrombolysis despite regressing neurological symptoms. Stroke 37:1332–1333
20. Kohrmann M, Nowe T, Huttner HB, Engelhorn T, Struffert T, Kollmar R et al (2009) Safety and outcome after thrombolysis in stroke patients with mild symptoms. Cerebrovasc Dis 27:160–166
21. Chernyshev OY, Martin-Schild S, Albright KC, Barreto A, Misra V, Acosta I et al (2010) Safety of tPA in stroke mimics and neuroimaging-negative cerebral ischemia. Neurology 74:1340–1345
22. Lecouturier J, Rodgers H, Murtagh MJ, White M, Ford GA, Thomson RG (2010) Systematic review of mass media interventions designed to improve public recognition of stroke symptoms, emergency response and early treatment. BMC Public Health 10:784
23. Alberts MJ (2012) Improving public education about stroke. Ann N Y Acad Sci 1268:45–50
24. Saver JL, Fonarow GC, Smith EE, Reeves MJ, Grau-Sepulveda MV, Pan W et al (2013) Time to treatment with intravenous tissue plasminogen activator and outcome from acute ischemic stroke. JAMA 309:2480–2488
25. Kleindorfer DO, Broderick JP, Khoury J, Flaherty ML, Woo D, Alwell K et al (2007) Emergency department arrival times after acute ischemic stroke during the 1990s. Neurocrit Care 7:31–35
26. Addo J, Ayis S, Leon J, Rudd AG, McKevitt C, Wolfe CD (2012) Delay in presentation after an acute stroke in a multiethnic population in South London: the South London Stroke Register. J Am Heart Assoc 1:e001685
27. Agyeman O, Nedeltchev K, Arnold M, Fischer U, Remonda L, Isenegger J et al (2006) Time to admission in acute ischemic stroke and transient ischemic attack. Stroke 37:963–966
28. Jungehulsing GJ, Rossnagel K, Nolte CH, Muller-Nordhorn J, Roll S, Klein M et al (2006) Emergency department delays in acute stroke–analysis of time between ED arrival and imaging. Eur J Neurol 13:225–232