Determination of pinocembrin in human plasma by solid-phase extraction and LC/MS/MS: Application to pharmacokinetic studies

Biomedical Chromatography

Volumn 28, Issue 12, 2014, Pages 1601-1606

  Yan, Bei ^a   Cao, Guoying ^a   Sun, Taohua ^a   Zhao, Xi ^b   Hu, Xin ^a   Yan, Jiling ^b   Peng, Yueying ^b   Shi, Aixin ^a   Li, Yang ^a   Xue, Wei ^a   Li, Min ^a   Li, Kexin ^a   Liu, Yingfa ^b  

^a Beijing Engineering Research Center of Laboratory Medicine   (China)

^b CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co Ltd   (China)

Author keywords

Human plasma; LC MS MS; Method validation; Pharmacokinetics; Pinocembrin

Indexed keywords

ELECTROSPRAY IONIZATION; EXTRACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PHASE SEPARATION; PLASMA (HUMAN);

HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; HUMAN PLASMAS; INTERNAL STANDARDS; LC-MS-MS; LC.MS/MS; LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY; METHOD VALIDATIONS; PHARMACOKINETIC STUDIES; PINOCEMBRIN; SOLID-PHASE EXTRACTION;

PHARMACOKINETICS;

ACETONITRILE; AMMONIUM ACETATE; CLONAZEPAM; PINOCEMBRINE; FLAVANONE DERIVATIVE;

AREA UNDER THE CURVE; ARTICLE; CALIBRATOR; CELL MEMBRANE POTENTIAL; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG HALF LIFE; DRUG STRUCTURE; ELECTROSPRAY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; MALE; MAXIMUM PLASMA CONCENTRATION; MEASUREMENT ACCURACY; NORMAL HUMAN; QUADRUPOLE MASS SPECTROMETRY; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION; VALIDATION PROCESS; VOLUME OF DISTRIBUTION; BLOOD; CHEMISTRY; DRUG STABILITY; PROCEDURES; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; STATISTICAL MODEL;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; FLAVANONES; HUMANS; LINEAR MODELS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY;

EID: 84911951734     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.3186     Document Type: Article

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