Plasma growth arrest-specific protein 6 levels in premenopausal and postmenopausal women: the role of endogenous estrogen

Endocrine

Volumn 47, Issue 3, 2014, Pages 923-929

  Hung, Yi Jen ^a   Lee, Chien Hsing ^a   Shieh, Yi Shing ^a,b   Hsiao, Fone Ching ^a   Lin, Fu Huang ^b   Hsieh, Chang Hsun ^a  

^a TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^b NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

Author keywords

Estradiol; Free estrogen index; Gas6; Postmenopausal women; Premenopausal; Sex hormone binding globulin

Indexed keywords

ESTRADIOL; ESTROGEN; FOLLITROPIN RELEASING FACTOR; GROWTH ARREST SPECIFIC PROTEIN 6; LOW DENSITY LIPOPROTEIN CHOLESTEROL; SEX HORMONE BINDING GLOBULIN; GROWTH ARREST-SPECIFIC PROTEIN 6; SIGNAL PEPTIDE;

ADULT; AGE; AGED; ANALYTICAL PARAMETERS; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CORRELATIONAL STUDY; CROSS-SECTIONAL STUDY; FEMALE; FREE ESTROGEN INDEX; HORMONE ACTION; HUMAN; POSTMENOPAUSE; PREMENOPAUSE; PROTEIN BLOOD LEVEL; BLOOD; BODY MASS; METABOLISM; MIDDLE AGED; VERY ELDERLY; YOUNG ADULT;

ADULT; AGED; AGED, 80 AND OVER; BODY MASS INDEX; ESTRADIOL; FEMALE; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MIDDLE AGED; POSTMENOPAUSE; PREMENOPAUSE; SEX HORMONE-BINDING GLOBULIN; YOUNG ADULT;

EID: 84911951636     PISSN: 1355008X     EISSN: 15590100     Source Type: Journal    
DOI: 10.1007/s12020-014-0234-x     Document Type: Article

References (28)

1. G. Manfioletti, C. Brancolini, G. Avanzi, C. Schneider, The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascade. Mol. Cell. Biol. 13, 4976–4985 (1993)
2. C. Ekman, J. Stenhoff, B. Dahlback, Gas6 is complexed to the soluble tyrosine kinase receptor Axl in human blood. J. Thromb. Haemost. 8, 838–844 (2010)
3. I. Balogh, S. Hafizi, J. Stenhoff, K. Hansson, B. Dahlback, Analysis of Gas6 in human platelets and plasma. Arterioscler. Thromb. Vasc. Biol. 25, 1280–1286 (2005)
4. M. Yanagita, Y. Ishimoto, H. Arai, K. Nagai, T. Ito, T. Nakano, D.J. Salant, A. Fukatsu, T. Doi, T. Kita, Essential role of Gas6 for glomerular injury in nephrotoxic nephritis. J. Clin. Investig. 110, 239–246 (2002)
5. E. Lutgens, M. Tjwa, P. Garcia de Frutos, E. Wijnands, L. Beckers, B. Dahlback, M.J. Daemen, P. Carmeliet, L. Moons, Genetic loss of Gas6 induces plaque stability in experimental atherosclerosis. J. Pathol. 216, 55–63 (2008)
6. E. Maquoi, G. Voros, P. Carmeliet, D. Collen, H.R. Lijnen, Role of Gas-6 in adipogenesis and nutritionally induced adipose tissue development in mice. Arterioscler. Thromb. Vasc. Biol. 25, 1002–1007 (2005)
7. M. Tjwa, L. Bellido-Martin, Y. Lin, E. Lutgens, S. Plaisance, F. Bono, N. Delesque-Touchard, C. Herve, R. Moura, A.D. Billiau, C. Aparicio, M. Levi, M. Daemen, M. Dewerchin, F. Lupu, J. Arnout, J.M. Herbert, M. Waer, P. Garcia de Frutos, B. Dahlback, P. Carmeliet, M.F. Hoylaerts, L. Moons, Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets, and leukocytes. Blood 111, 4096–4105 (2008)
8. P.J. Godowski, M.R. Mark, J. Chen, M.D. Sadick, H. Raab, R.G. Hammonds, Reevaluation of the roles of protein S and Gas6 as ligands for the receptor tyrosine kinase Rse/Tyro 3. Cell 82, 355–358 (1995)
9. S. Goruppi, E. Ruaro, C. Schneider, Gas6, the ligand of Axl tyrosine kinase receptor, has mitogenic and survival activities for serum starved NIH3T3 fibroblasts. Oncogene 12, 471–480 (1996)
10. E.C. Shugart, A.S. Levenson, C.M. Constance, R.M. Umek, Differential expression of gas and gadd genes at distinct growth arrest points during adipocyte development. Cell Growth Differ. 6, 1541–1547 (1995)
11. C. Ekman, A. Gottsater, B. Lindblad, B. Dahlback, Plasma concentrations of Gas6 and soluble Axl correlate with disease and predict mortality in patients with critical limb ischemia. Clin. Biochem. 43, 873–876 (2010)
12. C. Ekman, A. Linder, P. Akesson, B. Dahlback, Plasma concentrations of Gas6 (growth arrest specific protein 6) and its soluble tyrosine kinase receptor sAxl in sepsis and systemic inflammatory response syndromes. Crit. Care (London, England) 14, R158 (2010)
13. S. Gibot, F. Massin, A. Cravoisy, R. Dupays, D. Barraud, L. Nace, P.E. Bollaert, Growth arrest-specific protein 6 plasma concentrations during septic shock. Crit. Care (London, England) 11, R8 (2007)
14. L. Jiang, C.Y. Liu, Q.F. Yang, P. Wang, W. Zhang, Plasma level of growth arrest-specific 6 (GAS6) protein and genetic variations in the GAS6 gene in patients with acute coronary syndrome. Am. J. Clin. Pathol. 131, 738–743 (2009)
15. C. Ekman, A. Jonsen, G. Sturfelt, A.A. Bengtsson, B. Dahlback, Plasma concentrations of Gas6 and sAxl correlate with disease activity in systemic lupus erythematosus. Rheumatology 50, 1064–1069 (2011)
16. P. Recarte-Pelz, D. Tassies, G. Espinosa, B. Hurtado, N. Sala, R. Cervera, J.C. Reverter, P.G. de Frutos, Vitamin K-dependent proteins GAS6 and Protein S and TAM receptors in patients of systemic lupus erythematosus: correlation with common genetic variants and disease activity. Arthritis Res. Ther. 15, R41 (2013)
17. C.H. Suh, B. Hilliard, S. Li, J.T. Merrill, P.L. Cohen, TAM receptor ligands in lupus: protein S but not Gas6 levels reflect disease activity in systemic lupus erythematosus. Arthritis Res. Ther. 12, R146 (2010)
18. T.A. Gheita, I.H. Bassyouni, R.H. Bassyouni, Plasma concentrations of growth arrest specific protein 6 and the soluble form of its tyrosine kinase receptor Axl in patients with systemic lupus erythematosus and Behcets disease. J. Clin. Immunol. 32, 1279–1286 (2012)
19. H.A. Kim, J.Y. Nam, J.Y. Jeon, J.M. An, J.Y. Jung, C.B. Bae, C.H. Suh, Serum growth arrest-specific protein 6 levels are a reliable biomarker of disease activity in systemic lupus erythematosus. J. Clin. Immunol. 33, 143–150 (2013)
20. Y.J. Hung, C.H. Lee, N.F. Chu, Y.S. Shieh, Plasma protein growth arrest-specific 6 levels are associated with altered glucose tolerance, inflammation, and endothelial dysfunction. Diabetes Care 33, 1840–1844 (2010)
21. F.C. Hsiao, Y.F. Lin, P.S. Hsieh, N.F. Chu, Y.S. Shieh, C.H. Hsieh, C.H. Lee, Y.J. Hung, Circulating growth arrest-specific 6 protein is associated with adiposity, systemic inflammation, and insulin resistance among overweight and obese adolescents. J. Clin. Endocrinol. Metab. 98, E267–E274 (2013)
22. B.K. Son, M. Akishita, K. Iijima, S. Ogawa, K. Maemura, J. Yu, K. Takeyama, S. Kato, M. Eto, Y. Ouchi, Androgen receptor-dependent transactivation of growth arrest-specific gene 6 mediates inhibitory effects of testosterone on vascular calcification. J. Biol. Chem. 285, 7537–7544 (2010)
23. S. Clauser, S. Peyrard, P. Gaussem, M. Crespin, J. Emmerich, M. Aiach, D. Borgel, Development of a novel immunoassay for the assessment of plasma Gas6 concentrations and their variation with hormonal status. Clin. Chem. 53, 1808–1813 (2007)
24. M. Agirbasli, N.B. Agaoglu, N. Orak, H. Caglioz, T. Ocek, N. Poci, A. Salaj, S. Maya, Sex hormones and metabolic syndrome in children and adolescents. Metabolism 58, 1256–1262 (2009)
25. K. Nagai, H. Arai, M. Yanagita, T. Matsubara, H. Kanamori, T. Nakano, N. Iehara, A. Fukatsu, T. Kita, T. Doi, Growth arrest-specific gene 6 is involved in glomerular hypertrophy in the early stage of diabetic nephropathy. J. Biol. Chem. 278, 18229–18234 (2003)
26. R. Mo, Y. Tony Zhu, Z. Zhang, S.M. Rao, Y.J. Zhu, GAS6 is an estrogen-inducible gene in mammary epithelial cells. Biochem. Biophys. Res. Commun. 353, 189–194 (2007)
27. Y. Miki, T. Suzuki, S. Nagasaki, S. Hata, J. Akahira, H. Sasano, Comparative effects of raloxifene, tamoxifen and estradiol on human osteoblasts in vitro: estrogen receptor dependent or independent pathways of raloxifene. J. Steroid Biochem. Mol. Biol. 113, 281–289 (2009)
28. B.K. Son, K. Kozaki, K. Iijima, M. Eto, T. Nakano, M. Akishita, Y. Ouchi, Gas6/Axl-PI3K/Akt pathway plays a central role in the effect of statins on inorganic phosphate-induced calcification of vascular smooth muscle cells. Eur. J. Pharmacol. 556, 1–8 (2007)