Autoimmune diabetes: Caught in a NET

Diabetes

Volumn 63, Issue 12, 2014, Pages 4018-4020

  Leslie, Richard David G ^a   Bradford, C ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADVANCED GLYCATION END PRODUCT; ALPHA INTERFERON; AUTOANTIBODY; AUTOANTIGEN; MYELOBLASTIN; PHOSPHATIDYLCHOLINE; PROINSULIN; SERINE PROTEINASE; SUCCINIC ACID; TRIACYLGLYCEROL; ALPHA 1 ANTITRYPSIN; LEUKOCYTE ELASTASE; SERPINA1 PROTEIN, HUMAN;

ADAPTIVE IMMUNITY; ADOPTIVE TRANSFER; AEROBIC METABOLISM; ANTIGEN PRESENTATION; AUTOIMMUNE DIABETES MELLITUS; AUTOIMMUNE DISEASE; BIOENERGY; DENDRITIC CELL; DIABETES MELLITUS; DIABETIC PATIENT; EFFECTOR CELL; ENZYME ACTIVITY; GENETIC SUSCEPTIBILITY; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MACROPHAGE; MONOCYTE; NECROSIS; NEUTROPHIL; NEUTROPHIL COUNT; NONHUMAN; NOTE; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PERIPHERAL BLOOD MONONUCLEAR CELL; PEROXIDATION; PROTEIN EXPRESSION; SIBLING; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE; TRIACYLGLYCEROL BLOOD LEVEL; TWINS; ANIMAL; EXTRACELLULAR TRAP; FEMALE; IMMUNOLOGY; MALE; METABOLISM;

ALPHA 1-ANTITRYPSIN; ANIMALS; AUTOANTIBODIES; DIABETES MELLITUS, TYPE 1; EXTRACELLULAR TRAPS; FEMALE; HUMANS; INSULIN-SECRETING CELLS; LEUKOCYTE ELASTASE; MALE; MYELOBLASTIN; NEUTROPHILS;

EID: 84911939195     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db14-1382     Document Type: Note

References (20)

1. Atkinson MA, Eisenbarth GS, Michels AW. Type 1 diabetes. Lancet 2014;383:69-82
2. Ziegler AG, Nepom GT. Prediction and pathogenesis in type 1 diabetes. Immunity 2010;32:468-478
3. Parkes M, Cortes A, van Heel DA, Brown MA. Genetic insights into common pathways and complex relationships among immune-mediated diseases. Nat Rev Genet 2013;14:661-673
4. Bulek AM, Cole DK, Skowera A, et al. Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes. Nat Immunol 2012;13:283-289
5. Sutherland DE, Sibley R, Xu XZ, et al. Twin-to-twin pancreas transplantation: reversal and reenactment of the pathogenesis of type I diabetes. Trans Assoc Am Physicians 1984;97:80-87
6. Ferreira RC, Guo H, Coulson RM, et al. A type I interferon transcriptional signature precedes autoimmunity in children genetically at risk for type 1 diabetes. Diabetes 2014;63:2538-2550
7. Litherland SA, Xie XT, Hutson AD, et al. Aberrant prostaglandin synthase 2 expression defines an antigen-presenting cell defect for insulin-dependent diabetes mellitus. J Clin Invest 1999;104:515-523
8. Beyan H, Drexhage RC, van der Heul Nieuwenhuijsen L, et al. Monocyte gene-expression profiles associated with childhood-onset type 1 diabetes and disease risk: a study of identical twins. Diabetes 2010;59:1751-1755
9. Campbell-Thompson M, Wasserfall C, Montgomery EL, Atkinson MA, Kaddis JS. Pancreas organ weight in individuals with disease-associated autoantibodies at risk for type 1 diabetes. JAMA 2012;308:2337-2339
10. Heaton DA, Millward BA, Gray P, et al. Evidence of beta cell dysfunction which does not lead on to diabetes: a study of identical twins of insulin dependent diabetics. Br Med J (Clin Res Ed) 1987;294:145-146
11. Beyan H, Riese H, Hawa MI, et al. Glycotoxin and autoantibodies are additive environmentally determined predictors of type 1 diabetes: a twin and population study. Diabetes 2012;61:1192-1198
12. Oresic M, Simell S, Sysi-Aho M, et al. Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes. J Exp Med 2008;205:2975-2984
13. La Torre D, Seppänen-Laakso T, Larsson HE, et al.; DiPiS Study Group. Decreased cord-blood phospholipids in young age-at-onset type 1 diabetes. Diabetes 2013;62:3951-3956
14. Foulis AK, Farquharson MA, Meager A. Immunoreactive α-interferon in insulin-secreting β cells in type 1 diabetes mellitus. Lancet 1987;2:1423-1427
15. Diana J, Simoni Y, Furio L, et al. Crosstalk between neutrophils, B-1a cells and plasmacytoid dendritic cells initiates autoimmune diabetes. Nat Med 2013;19:65-73
16. Valle A, Giamporcaro GM, Scavini M, et al. Reduction of circulating neutrophils precedes and accompanies type 1 diabetes. Diabetes 2013;62:2072-2077
17. Wang Y, Xiao Y, Zhong L, et al. Increased neutrophil elastase and proteinase 3 and augmented NETosis are closely associated with β-cell autoimmunity in patients with type 1 diabetes. Diabetes 2014;63:423924248
18. Galluzzi L, Vitale I, Abrams JM, et al. Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ 2012;19:107-120
19. Schauer C, Janko C, Munoz LE, et al. Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines. Nat Med 2014;20:511-517
20. Darrah E, Andrade F. NETs: the missing link between cell death and systemic autoimmune diseases? Front Immunol 2012;3:428