Derivatization of (±) dihydrotetrabenazine for copper-64 labeling towards long-lived radiotracers for PET imaging of the vesicular monoamine transporter 2

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 24, 2014, Pages 5663-5665

  Kumar, Amit ^a   Lo, Su Tang ^a   Öz, Orhan K ^a   Sun, Xiankai ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Bifunctional chelator; Copper 64; Positron emission tomography; VMAT2

Indexed keywords

2,2' (1,4,8,11 TETRAAZABICYCLO[6.6.2]HEXADECANE 4,11 DIYL)DIACETIC ACID DIHYDROTETRABENAZINE CU 64; CARBON 11; FLUORINE 18; TRACER; UNCLASSIFIED DRUG; VESICULAR MONOAMINE TRANSPORTER 2; COPPER; DIHYDROTETRABENAZINE; RADIOPHARMACEUTICAL AGENT; TETRABENAZINE; VESICULAR MONOAMINE TRANSPORTER;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BRAIN HOMOGENATE; CONTROLLED STUDY; DERIVATIZATION; DRUG CONJUGATION; DRUG HALF LIFE; DRUG PROTEIN BINDING; EX VIVO STUDY; IC50; ISOTOPE LABELING; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS ISLET; PANCREAS ISLET BETA CELL; POSITRON EMISSION TOMOGRAPHY; PROTEIN EXPRESSION; PROTEIN TARGETING; RADIOACTIVITY; RAT; SWINE; ANALOGS AND DERIVATIVES; ANIMAL; BRAIN; CHEMISTRY; DIAGNOSTIC IMAGING; METABOLISM; PIG; SCINTISCANNING;

ANIMALS; BRAIN; COPPER RADIOISOTOPES; DIAGNOSTIC IMAGING; INSULIN-SECRETING CELLS; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; RATS; SWINE; TETRABENAZINE; VESICULAR MONOAMINE TRANSPORT PROTEINS;

EID: 84911895419     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.10.070     Document Type: Article

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