-
1
-
-
79955856369
-
Discovery of 1-[2-(2,4- dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): A novel multimodal compound for the treatment of major depressive disorder
-
Bang-Andersen B, Ruhland T, Jorgensen M, et al. Discovery of 1-[2-(2,4- dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder. J Med Chem 2011; 54(9):3206-21
-
(2011)
J Med Chem
, vol.54
, Issue.9
, pp. 3206-3221
-
-
Bang-Andersen, B.1
Ruhland, T.2
Jorgensen, M.3
-
2
-
-
33845897129
-
Differentiating antidepressants of the future: Efficacy and safety
-
Rosenzweig-Lipson S, Beyer CE, Hughes ZA, et al. Differentiating antidepressants of the future: efficacy and safety. Pharmacol Ther 2007;113(1):134-53
-
(2007)
Pharmacol Ther
, vol.113
, Issue.1
, pp. 134-153
-
-
Rosenzweig-Lipson, S.1
Beyer, C.E.2
Hughes, Z.A.3
-
3
-
-
0031005410
-
Selective activation of postsynaptic 5-HT1A receptors induces rapid antidepressant response
-
Blier P, Bergeron R, de Montigny C. Selective activation of postsynaptic 5-HT1A receptors induces rapid antidepressant response. Neuropsychopharmacology 1997;16(5): 333-8
-
(1997)
Neuropsychopharmacology
, vol.16
, Issue.5
, pp. 333-338
-
-
Blier, P.1
Bergeron, R.2
De Montigny, C.3
-
4
-
-
0027225830
-
Behavioural pharmacology of 5-HT3 receptor antagonists: A critical update on therapeutic potential
-
Greenshaw AJ. Behavioural pharmacology of 5-HT3 receptor antagonists: a critical update on therapeutic potential. Trends Pharmacol Sci 1993;14(7):265-70
-
(1993)
Trends Pharmacol Sci
, vol.14
, Issue.7
, pp. 265-270
-
-
Greenshaw, A.J.1
-
5
-
-
77950445050
-
The auspicious role of the 5-HT3 receptor in depression: A probable neuronal target?
-
Rajkumar R, Mahesh R. The auspicious role of the 5-HT3 receptor in depression: a probable neuronal target? J Psychopharm 2010;24(4):455-69
-
(2010)
J Psychopharm
, vol.24
, Issue.4
, pp. 455-469
-
-
Rajkumar, R.1
Mahesh, R.2
-
6
-
-
67649452096
-
Amisulpride is a potent 5-HT7 antagonist: Relevance for antidepressant actions in vivo
-
Abbas AI, Hedlund PB, Huang XP, et al. Amisulpride is a potent 5-HT7 antagonist: relevance for antidepressant actions in vivo. Psychopharmacology (Berl) 2009;205(1): 119-28
-
(2009)
Psychopharmacology (Berl)
, vol.205
, Issue.1
, pp. 119-128
-
-
Abbas, A.I.1
Hedlund, P.B.2
Huang, X.P.3
-
7
-
-
27944496843
-
5-HT7 receptor inhibition and inactivation induce antidepressant-like behavior and sleep pattern
-
Hedlund PB, Huitron-Resendiz S, Henriksen SJ, Sutcliffe JG. 5-HT7 receptor inhibition and inactivation induce antidepressant-like behavior and sleep pattern. Biol Psychiatry 2005;58(10):831-7
-
(2005)
Biol Psychiatry
, vol.58
, Issue.10
, pp. 831-837
-
-
Hedlund, P.B.1
Huitron-Resendiz, S.2
Henriksen, S.J.3
Sutcliffe, J.G.4
-
8
-
-
33747075753
-
Effect of the selective 5-HT7 receptor antagonist SB 269970 in animal models of anxiety and depression
-
Wesolowska A, Nikiforuk A, Stachowicz K, Tatarczynska E. Effect of the selective 5-HT7 receptor antagonist SB 269970 in animal models of anxiety and depression. Neuropharmacology 2006;51(3):578-86
-
(2006)
Neuropharmacology
, vol.51
, Issue.3
, pp. 578-586
-
-
Wesolowska, A.1
Nikiforuk, A.2
Stachowicz, K.3
Tatarczynska, E.4
-
9
-
-
3042744118
-
A 5-HT7 heteroreceptor-mediated inhibition of [3H]serotonin release in raphe nuclei slices of the rat: Evidence for a serotonergic-glutamatergic interaction
-
Harsing LG Jr, Prauda I, Barkoczy J, et al. A 5-HT7 heteroreceptor-mediated inhibition of [3H]serotonin release in raphe nuclei slices of the rat: evidence for a serotonergic-glutamatergic interaction. Neurochem Res 2004;29(8):1487-97
-
(2004)
Neurochem Res
, vol.29
, Issue.8
, pp. 1487-1497
-
-
Harsing, L.G.1
Prauda, I.2
Barkoczy, J.3
-
10
-
-
84874182123
-
Vortioxetine (Lu AA21004), a novel multimodal antidepressant, enhances memory in rats
-
Mørk A, Montezinho LP, Miller S, et al. Vortioxetine (Lu AA21004), a novel multimodal antidepressant, enhances memory in rats. Pharmacol Biochem Behav 2013;105:41-50
-
(2013)
Pharmacol Biochem Behav
, vol.105
, pp. 41-50
-
-
Mørk, A.1
Montezinho, L.P.2
Miller, S.3
-
11
-
-
11344259757
-
Effects of a selective 5-HT1B receptor agonist and antagonists in animal models of anxiety and depression
-
Tatarczynska E, Klodzinska A, Stachowicz K, Chojnacka-Wojcik E. Effects of a selective 5-HT1B receptor agonist and antagonists in animal models of anxiety and depression. Behav Pharmacol 2004;15(8):523-34
-
(2004)
Behav Pharmacol
, vol.15
, Issue.8
, pp. 523-534
-
-
Tatarczynska, E.1
Klodzinska, A.2
Stachowicz, K.3
Chojnacka-Wojcik, E.4
-
12
-
-
56349083775
-
Serotonin1B heteroreceptor activation induces an antidepressant-like effect in mice with an alteration of the serotonergic system
-
Chenu F, David DJ, Leroux-Nicollet I, et al. Serotonin1B heteroreceptor activation induces an antidepressant-like effect in mice with an alteration of the serotonergic system. J Psychiatry Neurosci 2008;33(6): 541-50
-
(2008)
J Psychiatry Neurosci
, vol.33
, Issue.6
, pp. 541-550
-
-
Chenu, F.1
David, D.J.2
Leroux-Nicollet, I.3
-
13
-
-
0035132570
-
Role of 5-HT (1A) and 5-HT(1B) receptors in the mediation of behavior in the forced swim test in mice
-
O'Neill MF, Conway MW. Role of 5-HT (1A) and 5-HT(1B) receptors in the mediation of behavior in the forced swim test in mice. Neuropsychopharmacology 2001;24(4):391-8
-
(2001)
Neuropsychopharmacology
, vol.24
, Issue.4
, pp. 391-398
-
-
O'neill, M.F.1
Conway, M.W.2
-
14
-
-
0038693666
-
Role of extracellular serotonin levels in the effect of 5-HT1B receptor blockade
-
de Groote L, Klompmakers AA, Olivier B, Westenberg HG. Role of extracellular serotonin levels in the effect of 5-HT1B receptor blockade. Psychopharmacology (Berl) 2003;167(2):153-8
-
(2003)
Psychopharmacology (Berl)
, vol.167
, Issue.2
, pp. 153-158
-
-
De Groote, L.1
Klompmakers, A.A.2
Olivier, B.3
Westenberg, H.G.4
-
15
-
-
84863403855
-
Pharmacological effects of Lu AA21004: A novel multimodal compound for the treatment of major depressive disorder
-
Mork A, Pehrson A, Brennum LT, et al. Pharmacological effects of Lu AA21004: a novel multimodal compound for the treatment of major depressive disorder. J Pharmacol Exp Ther 2012;340(3):666-75
-
(2012)
J Pharmacol Exp Ther
, vol.340
, Issue.3
, pp. 666-675
-
-
Mork, A.1
Pehrson, A.2
Brennum, L.T.3
-
16
-
-
84873523331
-
Lu AA21004, a novel multimodal antidepressant, produces regionally selective increases of multiple neurotransmitters - A rat microdialysis and electrophysiology study
-
Pehrson AL, Cremers T, Betry C, et al. Lu AA21004, a novel multimodal antidepressant, produces regionally selective increases of multiple neurotransmitters - a rat microdialysis and electrophysiology study. Eur Neuropsychopharmacol 2013; 23(2):133-45
-
(2013)
Eur Neuropsychopharmacol
, vol.23
, Issue.2
, pp. 133-145
-
-
Pehrson, A.L.1
Cremers, T.2
Betry, C.3
-
17
-
-
73549123839
-
Are the dorsal and ventral hippocampus functionally distinct structures?
-
Fanselow MS, Dong HW. Are the dorsal and ventral hippocampus functionally distinct structures? Neuron 2010;65(1):7-19
-
(2010)
Neuron
, vol.65
, Issue.1
, pp. 7-19
-
-
Fanselow, M.S.1
Dong, H.W.2
-
18
-
-
0028287265
-
Current advances and trends in the treatment of depression
-
Blier P, de Montigny C. Current advances and trends in the treatment of depression. Trends Pharmacol Sci 1994;15(7):220-6
-
(1994)
Trends Pharmacol Sci
, vol.15
, Issue.7
, pp. 220-226
-
-
Blier, P.1
De Montigny, C.2
-
19
-
-
84877994064
-
The rapid recovery of 5-HT cell firing induced by the antidepressant vortioxetine involves 5-HT(3) receptor antagonism
-
Betry C, Pehrson AL, Etievant A, et al. The rapid recovery of 5-HT cell firing induced by the antidepressant vortioxetine involves 5-HT(3) receptor antagonism. Int J Neuropsychopharmacol 2013;16(5):1115-27
-
(2013)
Int J Neuropsychopharmacol
, vol.16
, Issue.5
, pp. 1115-1127
-
-
Betry, C.1
Pehrson, A.L.2
Etievant, A.3
-
20
-
-
84867213664
-
Depression and hippocampal neurogenesis: A road to remission?
-
Eisch AJ, Petrik D. Depression and hippocampal neurogenesis: a road to remission? Science 2012;338(6103):72-5
-
(2012)
Science
, vol.338
, Issue.6103
, pp. 72-75
-
-
Eisch, A.J.1
Petrik, D.2
-
21
-
-
84876831167
-
Adult hippocampal neurogenesis: An actor in the antidepressant-like action
-
Mendez-David I, Hen R, Gardier AM, David DJ. Adult hippocampal neurogenesis: an actor in the antidepressant-like action. Ann Pharm Fr 2013;71(3):143-9
-
(2013)
Ann Pharm Fr
, vol.71
, Issue.3
, pp. 143-149
-
-
Mendez-David, I.1
Hen, R.2
Gardier, A.M.3
David, D.J.4
-
22
-
-
84885163818
-
Antidepressant and anxiolytic potential of the multimodal antidepressant vortioxetine (Lu AA21004) assessed by behavioural and neurogenesis outcomes in mice
-
Guilloux JP, Mendez-David I, Pehrson A, et al. Antidepressant and anxiolytic potential of the multimodal antidepressant vortioxetine (Lu AA21004) assessed by behavioural and neurogenesis outcomes in mice. Neuropharmacology 2013;73:147-59
-
(2013)
Neuropharmacology
, vol.73
, pp. 147-159
-
-
Guilloux, J.P.1
Mendez-David, I.2
Pehrson, A.3
-
23
-
-
84901720404
-
Serotonergic modulation of glutamate neurotransmission as a strategy for treating depression and cognitive dysfunction
-
Pehrson AL, Sanchez C. Serotonergic modulation of glutamate neurotransmission as a strategy for treating depression and cognitive dysfunction. CNS Spectr 2014; 19(2):121-33
-
(2014)
CNS Spectr
, vol.19
, Issue.2
, pp. 121-133
-
-
Pehrson, A.L.1
Sanchez, C.2
-
24
-
-
0035042482
-
Psychogenic, neurogenic, and systemic stressor effects on plasma corticosterone and behavior: Mouse strain-dependent outcomes
-
Anisman H, Hayley S, Kelly O, et al. Psychogenic, neurogenic, and systemic stressor effects on plasma corticosterone and behavior: mouse strain-dependent outcomes. Behav Neurosci 2001;115(2):443-54
-
(2001)
Behav Neurosci
, vol.115
, Issue.2
, pp. 443-454
-
-
Anisman, H.1
Hayley, S.2
Kelly, O.3
-
25
-
-
0036847525
-
Comparative analysis of the anxiety-related behaviors in four inbred mice
-
Kim S, Lee S, Ryu S, et al. Comparative analysis of the anxiety-related behaviors in four inbred mice. Behav Processes 2002; 60(2):181-90
-
(2002)
Behav Processes
, vol.60
, Issue.2
, pp. 181-190
-
-
Kim, S.1
Lee, S.2
Ryu, S.3
-
26
-
-
79960446683
-
Animal models of depression and anxiety: What do they tell us about human condition?
-
Neumann ID, Wegener G, Homberg JR, et al. Animal models of depression and anxiety: what do they tell us about human condition? Prog Neuropsychopharmacol Biol Psychiatry 2011;35(6):1357-75
-
(2011)
Prog Neuropsychopharmacol Biol Psychiatry
, vol.35
, Issue.6
, pp. 1357-1375
-
-
Neumann, I.D.1
Wegener, G.2
Homberg, J.R.3
-
27
-
-
84877837445
-
The flinders sensitive line rat model of depression - 25 years and still producing
-
Overstreet DH, Wegener G. The flinders sensitive line rat model of depression - 25 years and still producing. Pharmacol Rev 2013;65(1):143-55
-
(2013)
Pharmacol Rev
, vol.65
, Issue.1
, pp. 143-155
-
-
Overstreet, D.H.1
Wegener, G.2
-
28
-
-
84884359677
-
Serotonergic receptor mechanisms underlying antidepressant-like action in the progesterone withdrawal model of hormonally induced depression in rats
-
Li Y, Raaby KF, Sanchez C, Gulinello M. Serotonergic receptor mechanisms underlying antidepressant-like action in the progesterone withdrawal model of hormonally induced depression in rats. Behav Brain Res 2013;256:520-8
-
(2013)
Behav Brain Res
, vol.256
, pp. 520-528
-
-
Li, Y.1
Raaby, K.F.2
Sanchez, C.3
Gulinello, M.4
-
29
-
-
84892481016
-
Vortioxetine, but not escitalopram or duloxetine, reverses memory impairment induced by central 5-HT depletion in rats: Evidence for direct 5-HT receptor modulation
-
Jensen JB, du Jardin KG, Song D, et al. Vortioxetine, but not escitalopram or duloxetine, reverses memory impairment induced by central 5-HT depletion in rats: evidence for direct 5-HT receptor modulation. Eur Neuropsychopharmacol 2014;24(1):148-59
-
(2014)
Eur Neuropsychopharmacol
, vol.24
, Issue.1
, pp. 148-159
-
-
Jensen, J.B.1
Du Jardin, K.G.2
Song, D.3
-
30
-
-
84892475914
-
Vortioxetine dose-dependently reverses 5-HT depletion-induced deficits in spatial working and object recognition memory: A potential role for 5-HT1A receptor agonism and 5-HT3 receptor antagonism
-
du Jardin KG, Jensen JB, Sanchez C, Pehrson AL. Vortioxetine dose-dependently reverses 5-HT depletion-induced deficits in spatial working and object recognition memory: a potential role for 5-HT1A receptor agonism and 5-HT3 receptor antagonism. Eur Neuropsychopharmacol 2014;24(1):160-71
-
(2014)
Eur Neuropsychopharmacol
, vol.24
, Issue.1
, pp. 160-171
-
-
Du Jardin, K.G.1
Jensen, J.B.2
Sanchez, C.3
Pehrson, A.L.4
-
31
-
-
84930247852
-
Vortioxetine restores reversal learning impaired by 5-HT depletion or chronic intermittent cold stress in rats
-
Wallace A, Pehrson AL, Sanchez C, Morilak DA. Vortioxetine restores reversal learning impaired by 5-HT depletion or chronic intermittent cold stress in rats. Int J Neuropsychopharmacol 2014;1-12
-
(2014)
Int J Neuropsychopharmacol
, pp. 1-12
-
-
Wallace, A.1
Pehrson, A.L.2
Sanchez, C.3
Morilak, D.A.4
-
32
-
-
84906840118
-
The multimodal antidepressant vortioxetine increases frontal cortical oscillations unlike escitalopram and duloxetine - A quantitative electroencephalographic study in the rat
-
In press
-
Leiser SC, Pehrson AL, Robichaud PJ, Sanchez C. The multimodal antidepressant vortioxetine increases frontal cortical oscillations unlike escitalopram and duloxetine - a quantitative electroencephalographic study in the rat. Br J Pharmacol 2014;In press
-
(2014)
Br J Pharmacol
-
-
Leiser, S.C.1
Pehrson, A.L.2
Robichaud, P.J.3
Sanchez, C.4
-
33
-
-
23844500078
-
Chronic mild stress (CMS) revisited: Consistency and behavioural-neurobiological concordance in the effects of CMS
-
Willner P. Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS. Neuropsychobiology 2005;52(2):90-110
-
(2005)
Neuropsychobiology
, vol.52
, Issue.2
, pp. 90-110
-
-
Willner, P.1
-
34
-
-
84868195322
-
Chronic social defeat stress model: Behavioral features, antidepressant action, and interaction with biological risk factors
-
Venzala E, Garcia-Garcia AL, Elizalde N, et al. Chronic social defeat stress model: behavioral features, antidepressant action, and interaction with biological risk factors. Psychopharmacology (Berl) 2012;224(2): 313-25
-
(2012)
Psychopharmacology (Berl)
, vol.224
, Issue.2
, pp. 313-325
-
-
Venzala, E.1
Garcia-Garcia, A.L.2
Elizalde, N.3
-
35
-
-
65649125633
-
Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression
-
David DJ, Samuels BA, Rainer Q, et al. Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression. Neuron 2009;62(4): 479-93
-
(2009)
Neuron
, vol.62
, Issue.4
, pp. 479-493
-
-
David, D.J.1
Samuels, B.A.2
Rainer, Q.3
-
36
-
-
34247137134
-
Imaging the serotonin transporter during major depressive disorder and antidepressant treatment
-
Meyer JH. Imaging the serotonin transporter during major depressive disorder and antidepressant treatment. J Psychiatry Neurosci 2007;32(2):86-102
-
(2007)
J Psychiatry Neurosci
, vol.32
, Issue.2
, pp. 86-102
-
-
Meyer, J.H.1
-
37
-
-
2442457724
-
Serotonin transporter occupancy of five selective serotonin reuptake inhibitors at different doses: An [11C] DASB positron emission tomography study
-
Meyer JH, Wilson AA, Sagrati S, et al. Serotonin transporter occupancy of five selective serotonin reuptake inhibitors at different doses: an [11C] DASB positron emission tomography study. Am J Psychiatry 2004;161(5):826-35
-
(2004)
Am J Psychiatry
, vol.161
, Issue.5
, pp. 826-835
-
-
Meyer, J.H.1
Wilson, A.A.2
Sagrati, S.3
-
38
-
-
84858618643
-
Occupancy of the serotonin transporter after administration of Lu AA21004 and its relation to plasma concentration in healthy subjects
-
Areberg J, Luntang-Jensen M, Sogaard B, Nilausen DO. Occupancy of the serotonin transporter after administration of Lu AA21004 and its relation to plasma concentration in healthy subjects. Basic Clin Pharmacol Toxicol 2012;110(4):401-4
-
(2012)
Basic Clin Pharmacol Toxicol
, vol.110
, Issue.4
, pp. 401-404
-
-
Areberg, J.1
Luntang-Jensen, M.2
Sogaard, B.3
Nilausen, D.O.4
-
39
-
-
84861065050
-
A double-blind, randomized, placebo-controlled, active reference study of Lu AA21004 in patients with major depressive disorder
-
Alvarez E, Perez V, Dragheim M, et al. A double-blind, randomized, placebo-controlled, active reference study of Lu AA21004 in patients with major depressive disorder. Int Clin Psychopharmacol 2012;15(5):589-600
-
(2012)
Int Clin Psychopharmacol
, vol.15
, Issue.5
, pp. 589-600
-
-
Alvarez, E.1
Perez, V.2
Dragheim, M.3
-
40
-
-
84861481738
-
A randomised, double-blind, placebo controlled, duloxetine-referenced, fixed-dose study of three dosages of Lu AA21004 in acute treatment of major depressive disorder (MDD)
-
Baldwin DS, Loft H, Dragheim M. A randomised, double-blind, placebo controlled, duloxetine-referenced, fixed-dose study of three dosages of Lu AA21004 in acute treatment of major depressive disorder (MDD). Eur Neuropsychopharmacol 2012; 22(7):482-91
-
(2012)
Eur Neuropsychopharmacol
, vol.22
, Issue.7
, pp. 482-491
-
-
Baldwin, D.S.1
Loft, H.2
Dragheim, M.3
-
41
-
-
84864409459
-
A randomized, double-blind, placebo-controlled 8-week trial of the efficacy and tolerability of multiple doses of Lu AA21004 in adults with major depressive disorder
-
Henigsberg N, Mahableshwarkar AR, Jacobsen P, et al. A randomized, double-blind, placebo-controlled 8-week trial of the efficacy and tolerability of multiple doses of Lu AA21004 in adults with major depressive disorder. J Clin Psychiatry 2012;73(7):953-9
-
(2012)
J Clin Psychiatry
, vol.73
, Issue.7
, pp. 953-959
-
-
Henigsberg, N.1
Mahableshwarkar, A.R.2
Jacobsen, P.3
-
42
-
-
84862132965
-
A randomized, double-blind, placebo-controlled, duloxetine-referenced, fixed-dose study comparing the efficacy and safety of Lu AA21004 in elderly patients with major depressive disorder
-
Katona C, Hansen T, Olsen CK. A randomized, double-blind, placebo-controlled, duloxetine-referenced, fixed-dose study comparing the efficacy and safety of Lu AA21004 in elderly patients with major depressive disorder. Int Clin Psychopharmacol 2012;27(4):215-23
-
(2012)
Int Clin Psychopharmacol
, vol.27
, Issue.4
, pp. 215-223
-
-
Katona, C.1
Hansen, T.2
Olsen, C.K.3
-
43
-
-
84885166351
-
Pharmacokinetic drug interactions involving vortioxetine (Lu AA21004), a multimodal antidepressant
-
Chen G, Lee R, Hojer AM, et al. Pharmacokinetic drug interactions involving vortioxetine (Lu AA21004), a multimodal antidepressant. Clin Drug Investig 2013; 33(10):727-36
-
(2013)
Clin Drug Investig
, vol.33
, Issue.10
, pp. 727-736
-
-
Chen, G.1
Lee, R.2
Hojer, A.M.3
-
45
-
-
84862698575
-
Identification of the cytochrome P450 and other enzymes involved in the in vitro oxidative metabolism of a novel antidepressant, Lu AA21004
-
Hvenegaard MG, Bang-Andersen B, Pedersen H, et al. Identification of the cytochrome P450 and other enzymes involved in the in vitro oxidative metabolism of a novel antidepressant, Lu AA21004. Drug Metab Dispos 2012;40(7): 1357-65
-
(2012)
Drug Metab Dispos
, vol.40
, Issue.7
, pp. 1357-1365
-
-
Hvenegaard, M.G.1
Bang-Andersen, B.2
Pedersen, H.3
-
46
-
-
79952774424
-
Effect of Lu AA21004 on the pharmacokinetics and pharmacodynamics of ethinyl estradiol (30 lg) and levonorgestrel (150 lg) in healthy adult women
-
Wang Y, Wojtkowski T, Devoti A, et al. Effect of Lu AA21004 on the pharmacokinetics and pharmacodynamics of ethinyl estradiol (30 lg) and levonorgestrel (150 lg) in healthy adult women. J Clin Pharmacol 2009;49:1114
-
(2009)
J Clin Pharmacol
, vol.49
, pp. 1114
-
-
Wang, Y.1
Wojtkowski, T.2
Devoti, A.3
-
47
-
-
84865132386
-
Lack of effect of multiple doses of Lu AA21004 on the pharmacodynamics and pharmacokinetics of aspirin
-
Wang Y, Zhang W, Agyeman A, et al. Lack of effect of multiple doses of Lu AA21004 on the pharmacodynamics and pharmacokinetics of aspirin. J Clin Pharmacol 2010;50:1082
-
(2010)
J Clin Pharmacol
, vol.50
, pp. 1082
-
-
Wang, Y.1
Zhang, W.2
Agyeman, A.3
-
49
-
-
79955486643
-
Exploratory analyses of efficacy data from major depressive disorder trials submitted to the US Food and Drug Administration in support of new drug applications
-
Khin NA, Chen YF, Yang Y, et al. Exploratory analyses of efficacy data from major depressive disorder trials submitted to the US Food and Drug Administration in support of new drug applications. J Clin Psychiatry 2011;72(4):464-72
-
(2011)
J Clin Psychiatry
, vol.72
, Issue.4
, pp. 464-472
-
-
Khin, N.A.1
Chen, Y.F.2
Yang, Y.3
-
50
-
-
84870717545
-
Vortioxetine (Lu AA21004) in generalized anxiety disorder: Results of an 8-week, multinational, randomized, double-blind, placebo-controlled clinical trial
-
Bidzan L, Mahableshwarkar AR, Jacobsen P, et al. Vortioxetine (Lu AA21004) in generalized anxiety disorder: results of an 8-week, multinational, randomized, double-blind, placebo-controlled clinical trial. Eur Neuropsychopharmacol 2012; 22(12):847-57
-
(2012)
Eur Neuropsychopharmacol
, vol.22
, Issue.12
, pp. 847-857
-
-
Bidzan, L.1
Mahableshwarkar, A.R.2
Jacobsen, P.3
-
51
-
-
84862131007
-
A randomized clinical study of Lu AA21004 in the prevention of relapse in patients with major depressive disorder
-
Boulenger JP, Loft H, Florea I. A randomized clinical study of Lu AA21004 in the prevention of relapse in patients with major depressive disorder. J Psychopharmacol 2012;26(11):1408-16
-
(2012)
J Psychopharmacol
, vol.26
, Issue.11
, pp. 1408-1416
-
-
Boulenger, J.P.1
Loft, H.2
Florea, I.3
-
52
-
-
84875933121
-
A randomized, double-blind, placebo-controlled 6-wk trial of the efficacy and tolerability of 5 mg vortioxetine in adults with major depressive disorder
-
Jain R, Mahableshwarkar AR, Jacobsen PL, et al. A randomized, double-blind, placebo-controlled 6-wk trial of the efficacy and tolerability of 5 mg vortioxetine in adults with major depressive disorder. Int Clin Psychopharmacol 2013;16(2):313-21
-
(2013)
Int Clin Psychopharmacol
, vol.16
, Issue.2
, pp. 313-321
-
-
Jain, R.1
Mahableshwarkar, A.R.2
Jacobsen, P.L.3
-
53
-
-
84873618031
-
A randomized, double-blind trial of 2.5 mg and 5 mg vortioxetine (Lu AA21004) versus placebo for 8 weeks in adults with major depressive disorder
-
Mahableshwarkar AR, Jacobsen PL, Chen Y. A randomized, double-blind trial of 2.5 mg and 5 mg vortioxetine (Lu AA21004) versus placebo for 8 weeks in adults with major depressive disorder. Curr Med Res Opin 2013;29(3):217-26
-
(2013)
Curr Med Res Opin
, vol.29
, Issue.3
, pp. 217-226
-
-
Mahableshwarkar, A.R.1
Jacobsen, P.L.2
Chen, Y.3
-
54
-
-
84911931498
-
-
Available from
-
ClinicalTrials.gov. Available from: www. ClinicalTrials.gov database
-
-
-
-
58
-
-
84897528985
-
Efficacy and safety of vortioxetine (Lu AA21004), 15 and 20 mg/day: A randomized, double-blind, placebo-controlled, duloxetine-referenced study in the acute treatment of adult patients with major depressive disorder
-
Boulenger JP, Loft H, Olsen CK. Efficacy and safety of vortioxetine (Lu AA21004), 15 and 20 mg/day: a randomized, double-blind, placebo-controlled, duloxetine-referenced study in the acute treatment of adult patients with major depressive disorder. Int Clin Psychopharmacol 2014;29(3):138-49
-
(2014)
Int Clin Psychopharmacol
, vol.29
, Issue.3
, pp. 138-149
-
-
Boulenger, J.P.1
Loft, H.2
Olsen, C.K.3
-
59
-
-
84938074907
-
A randomized, double-blind, placebo-controlled study of vortioxetine on cognitive function in depressed adults
-
McIntyre RS, Lophaven S, Olsen CK. A randomized, double-blind, placebo-controlled study of vortioxetine on cognitive function in depressed adults. Int Clin Psychopharmacol 2014;1-11
-
(2014)
Int Clin Psychopharmacol
, pp. 1-11
-
-
McIntyre, R.S.1
Lophaven, S.2
Olsen, C.K.3
-
61
-
-
84889088182
-
Cognitive dysfunction in unipolar depression: Implications for treatment
-
Trivedi MH, Greer TL. Cognitive dysfunction in unipolar depression: implications for treatment. J Affect Disord 2014;152-154:19-27
-
(2014)
J Affect Disord
, vol.152-154
, pp. 19-27
-
-
Trivedi, M.H.1
Greer, T.L.2
-
62
-
-
84879355954
-
The role of serotonin in cognitive function: Evidence from recent studies and implications for understanding depression
-
Cowen P, Sherwood AC. The role of serotonin in cognitive function: evidence from recent studies and implications for understanding depression. J Psychopharmacol 2013;27(7):575-83
-
(2013)
J Psychopharmacol
, vol.27
, Issue.7
, pp. 575-583
-
-
Cowen, P.1
Sherwood, A.C.2
-
63
-
-
84878256637
-
A randomized trial on the acute and steady-state effects of a new antidepressant, vortioxetine (Lu AA21004), on actual driving and cognition
-
Theunissen EL, Street D, Hojer AM, et al. A randomized trial on the acute and steady-state effects of a new antidepressant, vortioxetine (Lu AA21004), on actual driving and cognition. Clin Pharmacol Ther 2013;93(6):493-501
-
(2013)
Clin Pharmacol Ther
, vol.93
, Issue.6
, pp. 493-501
-
-
Theunissen, E.L.1
Street, D.2
Hojer, A.M.3
-
64
-
-
0036252382
-
Paroxetine and fluoxetine effects on mood and cognitive functions in depressed nondemented elderly patients
-
Cassano GB, Puca F, Scapicchio PL, Trabucchi M. Paroxetine and fluoxetine effects on mood and cognitive functions in depressed nondemented elderly patients. J Clin Psychiatry 2002;63(5):396-402
-
(2002)
J Clin Psychiatry
, vol.63
, Issue.5
, pp. 396-402
-
-
Cassano, G.B.1
Puca, F.2
Scapicchio, P.L.3
Trabucchi, M.4
-
65
-
-
33644998293
-
Memory impairment in patients with late-onset major depression: The effect of antidepressant therapy
-
Gallassi R, Di Sarro R, Morreale A, Amore M. Memory impairment in patients with late-onset major depression: the effect of antidepressant therapy. J Affect Disord 2006;91(2-3):243-50
-
(2006)
J Affect Disord
, vol.91
, Issue.2-3
, pp. 243-250
-
-
Gallassi, R.1
Di Sarro, R.2
Morreale, A.3
Amore, M.4
-
66
-
-
0035993389
-
The SSRIs drug Fluoxetine, but not the noradrenergic tricyclic drug Desipramine, improves memory performance during acute major depression
-
Levkovitz Y, Caftori R, Avital A, Richter-Levin G. The SSRIs drug Fluoxetine, but not the noradrenergic tricyclic drug Desipramine, improves memory performance during acute major depression. Brain Res Bull 2002;58(4): 345-50
-
(2002)
Brain Res Bull
, vol.58
, Issue.4
, pp. 345-350
-
-
Levkovitz, Y.1
Caftori, R.2
Avital, A.3
Richter-Levin, G.4
-
67
-
-
0028107268
-
Verbal learning by major depressive disorder patients during treatment with fluoxetine or amitriptyline
-
Richardson JS, Keegan DL, Bowen RC, et al. Verbal learning by major depressive disorder patients during treatment with fluoxetine or amitriptyline. Int Clin Psychopharmacol 1994;9(1):35-40
-
(1994)
Int Clin Psychopharmacol
, vol.9
, Issue.1
, pp. 35-40
-
-
Richardson, J.S.1
Keegan, D.L.2
Bowen, R.C.3
-
68
-
-
84932147798
-
Efficacy of vortioxetine on cognitive function in adult patients with major depressive disorder: Results of a randomized, double blind, active referenced, placebo-controlled trial
-
Presented at Vaccouver, Canada Poster LP-02
-
Mahableshwarkar AR, Zajecka J, Jacobson W, et al. Efficacy of vortioxetine on cognitive function in adult patients with major depressive disorder: results of a randomized, double blind, active referenced, placebo-controlled trial. Presented at the 29th World Congress of the International College of Neuropsychopharmacology; Vaccouver, Canada; 2014; Poster LP-02
-
(2014)
The 29th World Congress of the International College of Neuropsychopharmacology
-
-
Mahableshwarkar, A.R.1
Zajecka, J.2
Jacobson, W.3
-
69
-
-
84890436260
-
Safety, tolerability, and efficacy of vortioxetine (Lu AA21004) in major depressive disorder: Results of an open-label, flexible-dose, 52-week extension study
-
Alam MY, Jacobsen PL, Chen Y, et al. Safety, tolerability, and efficacy of vortioxetine (Lu AA21004) in major depressive disorder: results of an open-label, flexible-dose, 52-week extension study. Int Clin Psychopharmacol 2014;29(1):36-44
-
(2014)
Int Clin Psychopharmacol
, vol.29
, Issue.1
, pp. 36-44
-
-
Alam, M.Y.1
Jacobsen, P.L.2
Chen, Y.3
-
70
-
-
84867885144
-
Vortioxetine (Lu AA21004) in the long-term open-label treatment of major depressive disorder
-
Baldwin DS, Hansen T, Florea I. Vortioxetine (Lu AA21004) in the long-term open-label treatment of major depressive disorder. Curr Med Res Opin 2012;28(10):1717-24
-
(2012)
Curr Med Res Opin
, vol.28
, Issue.10
, pp. 1717-1724
-
-
Baldwin, D.S.1
Hansen, T.2
Florea, I.3
-
71
-
-
84892624637
-
A randomized, double-blind, fixed-dose study comparing the efficacy and tolerability of vortioxetine 2.5 and 10 mg in acute treatment of adults with generalized anxiety disorder
-
Mahableshwarkar AR, Jacobsen PL, Serenko M, Chen Y. A randomized, double-blind, fixed-dose study comparing the efficacy and tolerability of vortioxetine 2.5 and 10 mg in acute treatment of adults with generalized anxiety disorder. Hum Psychopharmacol 2014;29(1):64-72
-
(2014)
Hum Psychopharmacol
, vol.29
, Issue.1
, pp. 64-72
-
-
Mahableshwarkar, A.R.1
Jacobsen, P.L.2
Serenko, M.3
Chen, Y.4
-
72
-
-
84911870010
-
The safety and tolerability of vortioxetine (LuAA21004) in the treatment of adults with major depressive disorder (MDD): Pooled analysis
-
Baldwin DS, Serenko M, Palo W, et al. The safety and tolerability of vortioxetine (LuAA21004) in the treatment of adults with major depressive disorder (MDD): pooled analysis. Int J Psychiatry 2013;17: 16-17
-
(2013)
Int J Psychiatry
, vol.17
, pp. 16-17
-
-
Baldwin, D.S.1
Serenko, M.2
Palo, W.3
-
73
-
-
67649351934
-
Sexual dysfunction, depression, and the impact of antidepressants
-
Kennedy SH, Rizvi S. Sexual dysfunction, depression, and the impact of antidepressants. J Clin Psychopharmacol 2009;29(2):157-64
-
(2009)
J Clin Psychopharmacol
, vol.29
, Issue.2
, pp. 157-164
-
-
Kennedy, S.H.1
Rizvi, S.2
-
74
-
-
84911860799
-
A head to head, randomized, comparison study of vortioxetine vs escitalopram in patients well treated for MDD and experiencing treatment-emergent sexual dysfunction
-
Presented at 16 - 19 June Hollywood, FL, USA; Poster 41
-
Jacobsen PL, Mahableswarkar AR, Chen Y, et al. A head to head, randomized, comparison study of vortioxetine vs. escitalopram in patients well treated for MDD and experiencing treatment-emergent sexual dysfunction. Presented at the Annual Meeting Of The American Society of Clinical Psychopharmacology; 16 - 19 June 2014; Hollywood, FL, USA; Poster 41
-
(2014)
The Annual Meeting of the American Society of Clinical Psychopharmacology
-
-
Jacobsen, P.L.1
Mahableswarkar, A.R.2
Chen, Y.3
-
75
-
-
84881295193
-
Sleep disorders and depression: Brief review of the literature, case report, and nonpharmacologic interventions for depression
-
Luca A, Luca M, Calandra C. Sleep disorders and depression: brief review of the literature, case report, and nonpharmacologic interventions for depression. Clin Interv Aging 2013;8: 1033-9
-
(2013)
Clin Interv Aging
, vol.8
, pp. 1033-1039
-
-
Luca, A.1
Luca, M.2
Calandra, C.3
-
76
-
-
30344434008
-
Antidepressants and their effect on sleep
-
Mayers AG, Baldwin DS. Antidepressants and their effect on sleep. Hum Psychopharmacol 2005;20(8):533-59
-
(2005)
Hum Psychopharmacol
, vol.20
, Issue.8
, pp. 533-559
-
-
Mayers, A.G.1
Baldwin, D.S.2
-
77
-
-
84899746962
-
A randomized, double-blind, placebo-controlled study of the efficacy and safety of vortioxetine 10 mg and 20 mg in adult with major depressive disorder
-
Presented at 18 - 22 May San Francisco, CA, USA Poster NR9-06
-
Jacobsen PL, Mahableswarkar AR, Serenko M, et al. A randomized, double-blind, placebo-controlled study of the efficacy and safety of vortioxetine 10 mg and 20 mg in adult with major depressive disorder. Presented at the American Psychiatric Association 166th Annual Meeting; 18 - 22 May 2013; San Francisco, CA, USA Poster NR9-06
-
(2013)
The American Psychiatric Association 166th Annual Meeting
-
-
Jacobsen, P.L.1
Mahableswarkar, A.R.2
Serenko, M.3
-
78
-
-
84898476386
-
A duloxetine-referenced, fixed-dose study comparing efficacy and safety of 2 vortioxetine doses in the acute treatment of adult MDD patients
-
Presented at 18 - 22 May San Francisco, CA, USA; Poster NR9-01
-
Mahableshwarkar AR, Chen MY, Trivedi MH. A duloxetine-referenced, fixed-dose study comparing efficacy and safety of 2 vortioxetine doses in the acute treatment of adult MDD patients. Presented at the American Psychiatric Association 166th Annual Meeting; 18 - 22 May 2013; San Francisco, CA, USA; Poster NR9-01
-
(2013)
The American Psychiatric Association 166th Annual Meeting
-
-
Mahableshwarkar, A.R.1
Chen, M.Y.2
Trivedi, M.H.3
-
79
-
-
84890570648
-
Vortioxetine for major depressive disorder: A systematic review of the efficacy and safety profile for this newly approved antidepressant - What is the number needed to treat, number needed to harm and likelihood to be helped or harmed?
-
Citrome L. Vortioxetine for major depressive disorder: a systematic review of the efficacy and safety profile for this newly approved antidepressant - what is the number needed to treat, number needed to harm and likelihood to be helped or harmed? Int J Clin Pract 2014;68(1):60-82
-
(2014)
Int J Clin Pract
, vol.68
, Issue.1
, pp. 60-82
-
-
Citrome, L.1
-
81
-
-
84911944090
-
The efficacy and safety of 5 mg/d Vortioxetine compared to placebo for major depressive disorder: A meta-analysis
-
In press
-
Fu J, Chen Y. The efficacy and safety of 5 mg/d Vortioxetine compared to placebo for major depressive disorder: a meta-analysis. Psychopharmacology (Berl) 2014. In press
-
(2014)
Psychopharmacology (Berl)
-
-
Fu, J.1
Chen, Y.2
|