Blood serum atherogenicity and coronary artery calcification

Current Pharmaceutical Design

Volumn 20, Issue 37, 2014, Pages 5884-5888

  Sobenin, Igor A ^a,b   Myasoedova, Veronica A ^b,c   Anisimova, Elena V ^c   Pavlova, Xenia N ^c   Möhlenkamp, Stefan ^d   Schmermund, Axel ^d   Seibel, Rainer ^e,f   Berenbein, Sina ^e,f   Lehmann, Nils ^g   Moebus, Susanne ^g   Jöckel, Karl Heinz ^g   Orekhov, Alexander N ^b,c   Erbel, Raimund ^d  

^a INSTITUTE OF EXPERIMENTAL CARDIOLOGY   (Russian Federation)

^b INSTITUTE OF GENERAL PATHOLOGY AND PATHOPHYSIOLOGY   (Russian Federation)

^c Institute for Atherosclerosis Research   (Russian Federation)

^d UNIVERSITY HOSPITAL ESSEN   (Germany)

^e Institute for Diagnostic and Interventional Radiology   (Germany)

^f UNIVERSITY OF WITTEN HERDECKE   (Germany)

^g UNIVERSITY OF DUISBURG ESSEN   (Germany)

Author keywords

Biomarkers; Coronary artery calcification; Intracellular cholesterol accumulation; Lipids; Serum atherogenicity; Subclinical atherosclerosis

Indexed keywords

CALCIUM;

ADULT; ARTERIAL WALL THICKNESS; ARTERY WALL; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; BLOOD SAMPLING; CLINICAL TRIAL; CORONARY ARTERY CALCIFICATION; CORONARY ARTERY CALCIUM SCORE; FEMALE; HUMAN; LIPID STORAGE; MAJOR CLINICAL STUDY; MALE; SERUM; AGED; ARTERIOSCLEROSIS; BLOOD; BLOOD VESSEL CALCIFICATION; CORONARY BLOOD VESSEL; MIDDLE AGED; PATHOLOGY;

AGED; ARTERIOSCLEROSIS; CORONARY VESSELS; FEMALE; HUMANS; MALE; MIDDLE AGED; VASCULAR CALCIFICATION;

EID: 84911488209     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/1381612820666140212194614     Document Type: Article

References (26)

1. Schwartz CJ, Valente AJ, Sprague EA. A modern view of athero-genesis. Am J Cardiol 1993; 71: 9B-14.
2. Orekhov AN, Tertov VV, Novikov ID, et al. Lipids in cells of atherosclerotic and uninvolved human aorta. I. Lipid composition of aortic tissue and enzyme-isolated and cultured cells. Exp Mol Pathol 1985; 42: 117-37.
3. Haberland ME, Fogelman AM. The role of altered lipoproteins in the pathogenesis of atherosclerosis. Am Heart J 1987; 113: 573-7.
4. Tertov VV, Orekhov AN, Ryong LH, et al. Intracellular cholesterol accumulation is accompanied by enhanced proliferative activity of human aortic intimal cells. Tissue Cell 1988; 20: 849-54.
5. Orekhov AN, Tertov VV, Kudryashov SA, et al. Triggerlike stimulation of cholesterol accumulation and DNA and extracellular matrix synthesis induced by atherogenic serum or low density lipoprotein in cultured cells. Circ Res 1990; 66: 311-20.
6. Orekhov AN, Andreeva ER, Mikhailova IA, et al. Cell proliferation in normal and atherosclerotic human aorta: proliferative splash in lipid-rich lesions. Atherosclerosis 1998; 139: 41-8.
7. Andreeva ER, Pugach IM, Orekhov AN. Collagen-synthesizing cells in initial and advanced atherosclerotic lesions of human aorta. Atherosclerosis 1997; 130: 133-42.
8. Chazov EI, Tertov VV, Orekhov AN, et al. Atherogenicity of blood serum from patients with coronary heart disease. Lancet 1986; 2: 595-8.
9. Tertov VV, Orekhov AN, Martsenyuk ON, et al. Low-density lipoproteins isolated from the blood of patients with coronary heart disease induce the accumulation of lipids in human aortic cells. Exp Mol Pathol 1989; 50: 337-47.
10. Tertov VV, Sobenin IA, Gabbasov ZA, et al. Multiple-modified desialylated low density lipoproteins that cause intracellular lipid accumulation. Isolation, fractionation and characterization. Lab Invest 1992; 67: 665-75.
11. Tertov VV, Sobenin IA, Orekhov AN. Characterization of desialy-lated low-density lipoproteins which cause intracellular lipid accumulation. Int J Tissue React 1992; 14: 155-62.
12. Orekhov AN, Tertov VV, Lyakishev AA, et al. Use of cultured atherosclerotic cells for investigation of antiatherosclerotic effects of anipamil and other calcium antagonists. J Hum Hypertens 1991; 5: 425-30.
13. Orekhov AN, Sobenin IA, Korneev NV, et al. Anti-atherosclerotic therapy based on botanicals. Recent Pat Cardiovasc Drug Discov 2012; 8: 56-66.
14. Sobenin IA, Chistiakov DA, Bobryshev YV, Orekhov AN. Blood atherogenicity as a target for anti-atherosclerotic therapy. Curr Pharm Des 2013; 19: 5954-62.
15. Schmermund A, Möhlenkamp S, Erbel R. Coronary artery calcium and its relationship to coronary artery disease. Cardiol Clin 2003; 21: 521-34.
16. Stary HC, Chandler AB, Glagov S, et al. A definition of initial, fatty streak, and intermediate lesions of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Circulation 1994; 89: 2462-78.
17. Stary HC, Chandler AB, Dinsmore RE, et al. A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Arterioscler Thromb Vasc Biol 1995; 15: 1512-31.
18. Schmermund A, Möhlenkamp S, Stang A, et al. Assessment of clinically silent atherosclerotic disease and established and novel risk factors for predicting myocardial infarction and cardiac death in healthy middle-aged subjects: Rationale and design of the Heinz Nixdorf RECALL Study. Am Heart J 2002; 144: 212-8.
19. Agatston AS, Janowitz WR, Hildner FJ, et al. Quantification of coronary artery calcium using ultrafast computed tomography. J Am Coll Cardiol 1990; 15: 827-32.
20. Hara A, Radin NS. Lipid extraction of tissues with a low-toxicity solvent. Anal Biochem 1978; 90: 420-6.
21. Gratchev A, Ovsiy I, Manousaridis I, et al. Novel monocyte biomarkers of atherogenic conditions. Curr Pharm Des 2013; 19: 5859-64.
22. Orekhov AN. Direct anti-atherosclerotic therapy; development of natural anti-atherosclerotic drugs preventing cellular cholesterol retention. Curr Pharm Des 2013; 19: 5909-28.
23. Sobenin IA, Tertov VV, Koschinsky T, et al. Modified low density lipoprotein from diabetic patients causes cholesterol accumulation in human intimal aortic cells. Atherosclerosis 1993; 100: 41-54.
24. Kabakov AE, Tertov VV, Saenko VA, et al. The atherogenic effect of lupus sera: systemic lupus erythematosus-derived immune complexes stimulate the accumulation of cholesterol in cultured smooth muscle cells from human aorta. Clin Immunol Immunopathol 1992; 63: 214-20.
25. Orekhov AN, Tertov VV, Pokrovsky SN, et al. Blood serum atherogenicity associated with coronary atherosclerosis. Evidence for nonlipid factor providing atherogenicity of low-density lipoproteins and an approach to its elimination. Circ Res 1988; 62: 421-9.
26. Orekhov AN, Tertov VV, Kabakov AE, et al. Autoantibodies against modified low density lipoprotein. Nonlipid factor of blood plasma that stimulates foam cell formation. Arterioscler Thromb 1991; 11: 316-26.