Abnormal accumulation of intestinal fluid following ingestion of an unabsorbable carbohydrate in patients with irritable bowel syndrome: An MRI study

Neurogastroenterology and Motility

Volumn 26, Issue 12, 2014, Pages 1686-1693

  Undseth, R ^a   Berstad, A ^a   Klow N E ^b   Arnljot, K ^a   Moi, K S ^a   Valeur, J ^a  

^a LOVISENBERG DIAKONALE HOSPITAL   (Norway)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

FODMAP; Carbohydrate intolerance; Colonic accommodation; Irritable bowel syndrome; Magnetic resonance imaging

Indexed keywords

CARBOHYDRATE DIET; LACTULOSE;

ADULT; ADVERSE EFFECTS; AGED; CARBOHYDRATE DIET; EDEMA; FEMALE; HUMAN; INTESTINE; IRRITABLE COLON; MALE; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY; YOUNG ADULT;

ADULT; AGED; DIETARY CARBOHYDRATES; EDEMA; FEMALE; HUMANS; INTESTINES; IRRITABLE BOWEL SYNDROME; LACTULOSE; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; YOUNG ADULT;

EID: 84911477821     PISSN: 13501925     EISSN: 13652982     Source Type: Journal    
DOI: 10.1111/nmo.12449     Document Type: Article

References (26)

1. Lovell RM, Ford AC. Global prevalence of and risk factors for irritable bowel syndrome: a meta-analysis. Clin Gastroenterol Hepatol 2012; 10: 712-21.
2. Berstad A, Undseth R, Lind R, Valeur J. Functional bowel symptoms, fibromyalgia and fatigue: a food-induced triad? Scand J Gastroenterol 2012; 47: 914-9.
3. Ragnarsson G, Bodemar G. Pain is temporally related to eating but not to defaecation in the irritable bowel syndrome (IBS). Patients' description of diarrhea, constipation and symptom variation during a prospective 6-week study. Eur J Gastroenterol Hepatol 1998; 10: 415-21.
4. Kanazawa M, Fukudo S. Effects of fasting therapy on irritable bowel syndrome. Int J Behav Med 2006; 13: 214-20.
5. Bohn L, Storsrud S, Tornblom H, Bengtsson U, Simren M. Self-reported food-related gastrointestinal symptoms in IBS are common and associated with more severe symptoms and reduced quality of life. Am J Gastroenterol 2013; 108: 634-41.
6. Eswaran S, Tack J, Chey WD. Food: the forgotten factor in the irritable bowel syndrome. Gastroenterol Clin North Am 2011; 40: 141-62.
7. Staudacher HM, Irving PM, Lomer MC, Whelan K. Mechanisms and efficacy of dietary FODMAP restriction in IBS. Nat Rev Gastroenterol Hepatol 2014; 11: 256-66.
8. Valeur J, Morken MH, Norin E, Midtvedt T, Berstad A. Carbohydrate intolerance in patients with self-reported food hypersensitivity: comparison of lactulose and glucose. Scand J Gastroenterol 2009; 44: 1416-23.
9. Le NB, Posserud I, Bohn L, Guyonnet D, Rondeau P, Tillisch K, Naliboff B, Mayer EA et al. A combined nutrient and lactulose challenge test allows symptom-based clustering of patients with irritable bowel syndrome. Am J Gastroenterol 2013; 108: 786-95.
10. Barrett JS, Gearry RB, Muir JG, Irving PM, Rose R, Rosella O, Haines ML, Shepherd SJ et al. Dietary poorly absorbed, short-chain carbohydrates increase delivery of water and fermentable substrates to the proximal colon. Aliment Pharmacol Ther 2010; 31: 874-82.
11. Hoad CL, Marciani L, Foley S, Totman JJ, Wright J, Bush D, Cox EF, Campbell E et al. Non-invasive quantification of small bowel water content by MRI: a validation study. Phys Med Biol 2007; 52: 6909-22.
12. Murray K, Wilkinson-Smith V, Hoad C, Costigan C, Cox E, Lam C, Marciani L, Gowland P et al. Differential effects of FODMAPs (fermentable oligo-, di-, mono-saccharides and polyols) on small and large intestinal contents in healthy subjects shown by MRI. Am J Gastroenterol 2014; 109: 110-9.
13. Longstreth GF, Thompson WG, Chey WD, Houghton LA, Mearin F, Spiller RC. Functional bowel disorders. Gastroenterology 2006; 130: 1480-91.
14. Francis CY, Morris J, Whorwell PJ. The irritable bowel severity scoring system: a simple method of monitoring irritable bowel syndrome and its progress. Aliment Pharmacol Ther 1997; 11: 395-402.
15. Huchzermeyer H, Schumann C. Lactulose-a multifaceted substance. Z Gastroenterol 1997; 35: 945-55.
16. Marciani L, Cox EF, Hoad CL, Pritchard S, Totman JJ, Foley S, Mistry A, Evans S et al. Postprandial changes in small bowel water content in healthy subjects and patients with irritable bowel syndrome. Gastroenterology 2010; 138: 469-77, 477.
17. Trotman IF, Price CC. Bloated irritable bowel syndrome defined by dynamic 99mTc bran scan. Lancet 1986; 2: 364-6.
18. Santos J, Saperas E, Nogueiras C, Mourelle M, Antolin M, Cadahia A, Malagelada JR. Release of mast cell mediators into the jejunum by cold pain stress in humans. Gastroenterology 1998; 114: 640-8.
19. Malagelada C, De LF, Segui S, Mendez S, Drozdzal M, Vitria J, Radeva P, Santos J et al. Functional gut disorders or disordered gut function? Small bowel dysmotility evidenced by an original technique. Neurogastroenterol Motil 2012; 24: 223-5.
20. Mawe GM, Hoffman JM. Serotonin signalling in the gut-functions, dysfunctions and therapeutic targets. Nat Rev Gastroenterol Hepatol 2013; 10: 473-86.
21. Atkinson W, Lockhart S, Whorwell PJ, Keevil B, Houghton LA. Altered 5-hydroxytryptamine signaling in patients with constipation- and diarrhea-predominant irritable bowel syndrome. Gastroenterology 2006; 130: 34-43.
22. Dunlop SP, Coleman NS, Blackshaw E, Perkins AC, Singh G, Marsden CA, Marsden CA, Spiller RC. Abnormalities of 5-hydroxytryptamine metabolism in irritable bowel syndrome. Clin Gastroenterol Hepatol 2005; 3: 349-57.
23. Keszthelyi D, Troost FJ, Jonkers DM, Kruimel JW, Leue C, Masclee AA. Decreased levels of kynurenic acid in the intestinal mucosa of IBS patients: relation to serotonin and psychological state. J Psychosom Res 2013; 74: 501-4.
24. El-Salhy M, Gilja OH, Gundersen D, Hatlebakk JG, Hausken T. Endocrine cells in the ileum of patients with irritable bowel syndrome. World J Gastroenterol 2014; 20: 2383-91.
25. Pritchard SE, Marciani L, Garsed KC, Hoad CL, Thongborisute W, Roberts E, Gowland PA, Spiller RC. Fasting and postprandial volumes of the undisturbed colon: normal values and changes in diarrhea-predominant irritable bowel syndrome measured using serial MRI. Neurogastroenterol Motil 2014; 26: 124-30.
26. Undseth R, Berstad A, Valeur J. FODMAP-intolerance in IBS: visualization by magnetic resonance imaging. United Eur Gastroenterol J 2013; 1(Suppl. 1): A110.