Melanocytic naevi with globular and reticular dermoscopic patterns display distinct BRAF V600E expression profiles and histopathological patterns

British Journal of Dermatology

Volumn 171, Issue 5, 2014, Pages 1060-1065

  Marchetti, M A ^a   Kiuru, M H ^a   Busam, K J ^a   Marghoob, A A ^a   Scope, A ^a,b   Dusza, S W ^a   Cordova, M A ^a   Fonseca, M ^a   Wu, X ^a   Halpern, A C ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; BRAF PROTEIN, HUMAN;

ADULT; ARTICLE; CLINICAL ARTICLE; FEMALE; HISTOPATHOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; MELANOCYTIC NEVUS; PROTEIN EXPRESSION; RETROSPECTIVE STUDY; EPILUMINESCENCE MICROSCOPY; GENE EXPRESSION; GENETICS; METABOLISM; MIDDLE AGED; MUTATION; PATHOLOGY; PIGMENTED NEVUS; SKIN TUMOR;

ADULT; DERMOSCOPY; FEMALE; GENE EXPRESSION; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; MUTATION; NEVUS, PIGMENTED; PROTO-ONCOGENE PROTEINS B-RAF; RETROSPECTIVE STUDIES; SKIN NEOPLASMS;

EID: 84911457498     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/bjd.13260     Document Type: Article

References (38)

1. Gandini S, Sera F, Cattaruzza MS, et al,. Meta-analysis of risk factors for cutaneous melanoma: I. Common and atypical naevi. Eur J Cancer 2005; 41: 28-44.
2. Tsao H, Bevona C, Goggins W, et al,. The transformation rate of moles (melanocytic nevi) into cutaneous melanoma: a population-based estimate. Arch Dermatol 2003; 139: 282-8.
3. Yadav S, Vossaert KA, Kopf AW, et al,. Histopathologic correlates of structures seen on dermoscopy (epiluminescence microscopy). Am J Dermatopathol 1993; 15: 297-305.
4. Argenziano G, Zalaudek I, Ferrara G, et al,. Proposal of a new classification system for melanocytic naevi. Br J Dermatol 2007; 157: 217-27.
5. Pozzobon FC, Puig-Butillé JA, González-Alvarez T, et al,. Dermoscopic criteria associated with BRAF and NRAS mutation status in primary cutaneous melanoma. Br J Dermatol 2014; 171: 754-9.
6. Sanchez MI, Rabinovitz HS, Oliviero MC, et al,. Dark homogeneous streak dermoscopic pattern correlating with specific KIT mutations in melanoma. JAMA Dermatol 2014; 150: 633-9.
7. Pollock PM, Harper UL, Hansen KS, et al,. High frequency of BRAF mutations in nevi. Nat Genet 2003; 33: 19-20.
8. Zalaudek I, Guelly C, Pellacani G, et al,. The dermoscopical and histopathological patterns of nevi correlate with the frequency of BRAF mutations. J Invest Dermatol 2011; 131: 542-5.
9. Barnhill RL,. Melanocytic proliferations with architectural disorder and cytologic atypia. In: Pathology of Melanocytic Nevi and Malignant Melanoma (, Barnhill RL, Piepkorn M, Busam K, eds), 2nd edn. New York: Springer, 2004.
10. Capper D, Preusser M, Habel A, et al,. Assessment of BRAF V600E mutation status by immunohistochemistry with a mutation-specific monoclonal antibody. Acta Neuropathol 2011; 122: 11-19.
11. Busam KJ, Hedvat C, Pulitzer M, et al,. Immunohistochemical analysis of BRAF(V600E) expression of primary and metastatic melanoma and comparison with mutation status and melanocyte differentiation antigens of metastatic lesions. Am J Surg Pathol 2013; 37: 413-20.
12. Zalaudek I, Grinschgl S, Argenziano G, et al,. Age-related prevalence of dermoscopy patterns in acquired melanocytic naevi. Br J Dermatol 2006; 154: 299-304.
13. Scope A, Marghoob AA, Dusza SW, et al,. Dermoscopic patterns of naevi in fifth grade children of the Framingham school system. Br J Dermatol 2008; 158: 1041-9.
14. Zalaudek I, Schmid K, Marghoob AA, et al,. Frequency of dermoscopic nevus subtypes by age and body site: a cross-sectional study. Arch Dermatol 2011; 147: 663-70.
15. Fonseca M, Burnett M, Dusza S, et al,. Dermoscopic patterns of nevi have a distinct anatomical distribution in adolescents. Abstract #315 presented at the 2014 Society for Investigative Dermatology Meeting in Albuquerque, New Mexico. J Invest Dermatol 2014; 134 (Suppl. 1): S49-60.
16. Orlow I, Satagopan J, Cheung K, et al,. Host genetic factors are associated with nevus count and dermoscopic patterns: preliminary results from the study of nevi in children (SONIC). Abstract #698 presented at the 2014 Society for Investigative Dermatology Meeting in Albuquerque, New Mexico. J Invest Dermatol 2014; 134 (Suppl. 1): S121-31.
17. Scope A, Dusza SW, Marghoob AA, et al,. Clinical and dermoscopic stability and volatility of melanocytic nevi in a population-based cohort of children in Framingham school system. J Invest Dermatol 2011; 131: 1615-21.
18. Karram S, Novy M, Saroufim M, et al,. Predictors of BRAF mutation in melanocytic nevi: analysis across regions with different UV radiation exposure. Am J Dermatopathol 2013; 35: 412-18.
19. Qi RQ, He L, Zheng S, et al,. BRAF exon 15 T1799A mutation is common in melanocytic nevi, but less prevalent in cutaneous malignant melanoma, in Chinese Han. J Invest Dermatol 2011; 131: 1129-38.
20. Hafner C, Stoehr R, van Oers JM, et al,. The absence of BRAF, FGFR3, and PIK3CA mutations differentiates lentigo simplex from melanocytic nevus and solar lentigo. J Invest Dermatol 2009; 129: 2730-5.
21. Tschandl P, Berghoff AS, Preusser M, et al,. NRAS and BRAF mutations in melanoma-associated nevi and uninvolved nevi. PLoS One 2013; 8: e69639.
22. Beer J, Xu L, Tschandl P, Kittler H,. Growth rate of melanoma in vivo and correlation with dermatoscopic and dermatopathologic findings. Dermatol Pract Concept 2011; 1: 59-67.
23. Argenziano G, Kittler H, Ferrara G, et al,. Slow-growing melanoma: a dermoscopy follow-up study. Br J Dermatol 2010; 162: 267-73.
24. Wu X, Fonseca M, Marchetti MA, et al,. Longitudinally followed nevi in children and adolescents show significant size changes. Abstract #300 presented at the 2014 Society for Investigative Dermatology in Albuquerque, New Mexico. J Invest Dermatol 2014; 134 (Suppl. 1): S49-60.
25. Loewe R, Kittler H, Fischer G, et al,. BRAF kinase gene V599E mutation in growing melanocytic lesions. J Invest Dermatol 2004; 123: 733-6.
26. Viros A, Fridlyand J, Bauer J, et al,. Improving melanoma classification by integrating genetic and morphologic features. PLoS Med 2008; 5: e120.
27. Broekaert SM, Roy R, Okamoto I, et al,. Genetic and morphologic features for melanoma classification. Pigment Cell Melanoma Res 2010; 23: 763-70.
28. Nagore E, Requena C, Traves V, et al,. Prognostic value of BRAF mutations in localized cutaneous melanoma. J Am Acad Dermatol 2014; 70: 858-62.e2.
29. Schoenewolf NL, Belloni B, Simcock M, et al,. Clinical implications of distinct metastasizing preferences of different melanoma subtypes. Eur J Dermatol 2014; 24: 236-41.
30. Picard M, Pham DN, D'Incan M, et al,. Is BRAF a prognostic factor in stage III skin melanoma? A retrospective study of 72 patients after positive sentinel lymph node dissection. Br J Dermatol 2014; 171: 108-14.
31. Perier-Muzet M, Thomas L, Poulalhon N, et al,. Melanoma patients under vemurafenib: prospective follow-up of melanocytic lesions by digital dermoscopy. J Invest Dermatol 2014; 134: 1351-8.
32. Hatzivassiliou G, Song K, Yen I, et al,. RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth. Nature 2010; 464: 431-5.
33. Haenssle HA, Kraus SL, Brehmer F, et al,. Dynamic changes in nevi of a patient with melanoma treated with vemurafenib: importance of sequential dermoscopy. Arch Dermatol 2012; 148: 1183-5.
34. McClenahan P, Lin LL, Tan JM, et al,. BRAFV600E mutation status of involuting and stable nevi in dabrafenib therapy with or without trametinib. JAMA Dermatol 2014; 150: 1079-82.
35. Weatherhead SC, Haniffa M, Lawrence CM,. Melanomas arising from naevi and de novo melanomas-does origin matter? Br J Dermatol 2007; 156: 72-6.
36. Curtin JA, Fridlyand J, Kageshita T, et al,. Distinct sets of genetic alterations in melanoma. N Engl J Med 2005; 353: 2135-47.
37. Longo C, Rito C, Beretti F, et al,. De novo melanoma and melanoma arising from pre-existing nevus: in vivo morphologic differences as evaluated by confocal microscopy. J Am Acad Dermatol 2011; 65: 604-14.
38. Zalaudek I, Marghoob AA, Scope A, et al,. Age distribution of biopsied junctional nevi-Unna's concept versus a dual concept of nevogenesis. J Am Acad Dermatol 2007; 57: 1096-7.