Vaginal microbiome-pregnant host interactions determine a significant proportion of preterm labour

Fetal and Maternal Medicine Review

Volumn 25, Issue 1, 2014, Pages 73-78

  Chandiramani, Manju ^a   Bennett, Phillip R ^a   Brown, Richard ^a   Lee, Yun S ^a   Macintyre, David A ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMNION FLUID; ARTICLE; FEMALE; FETUS MEMBRANE; GESTATIONAL AGE; HUMAN; HYPOTHESIS; IMMUNE RESPONSE; MEMBRANE RUPTURE; PREGNANCY; PREMATURE LABOR; RISK FACTOR; SECOND TRIMESTER PREGNANCY; UTERINE CERVIX DILATATION; UTERINE CERVIX RIPENING; VAGINA FLORA;

EID: 84911452560     PISSN: 09655395     EISSN: 14695065     Source Type: Journal    
DOI: 10.1017/S0965539514000059     Document Type: Article

References (34)

1. Blencowe H, Cousens S, Chou D, Oestergaard M, Say L, Moller A-B, et al. Born too soon: the global epidemiology of 15 million preterm births. Reprod Health 2013; 10: S2.
2. Chang HH, Larson J, Blencowe H, Spong CY, Howson CP, Cairns-Smith S, et al. Preventing preterm births: analysis of trends and potential reductions with interventions in 39 countries with very high human development index. Lancet 2013; 381: 223-34.
3. Born Too Soon: Global Action Report for PretermBirth.New York:MoD, PMNCH, Save the Children, WHO, 2012.
4. CDC. Preliminary births for 2004. 2005. http://www.cdc.gov/nchs/product/pubs/pubd/hcstats/ prelimbirths04/prelimbirths.
5. Goldenberg RL, Culhane JF, Romero R. Epidemiology and causes of preterm birth. Lancet 2008; 371: 75-84.
6. Watts DH, Krohn MA, Hillier SL, Eschenbach DA. The association of occult amniotic fluid infection with gestational age and neonatal outcome among women in preterm labor. Obstet Gynecol 1992; 79: 351-7.
7. Romero R, Gonzalez R, Sepulveda W, Brandt F, Ramirez M, Sorokin Y, et al. Infection and labour. VIII. Microbial invasion of the amniotic cavity in patients with suspected cervical incompetence: prevalence and clinical significance. Am J Obstet Gynecol 1992; 167: 1086-91.
8. Goldenberg RL, Hauth JC, Andrews WW. Intrauterine infection and preterm delivery. N Engl J Med 2000; 342: 1500-7.
9. Lindstrom TM, Bennett PR. The role of Nuclear Factor Kappa B in human labour. Reproduction 2005; 130: 569-81.
10. Gotsch F, Romero R, Kusanovic JP, Mazaki-Tovi S, Pineles B, Erez O, et al. The fetal inflammatory response syndrome. Clin Obstet Gynecol 2007; 50: 652-83.
11. Lamont RF, Sobel JD, Akins RA, Hassan SS, Chaiworapongsa T, Kusanovic JP, et al. The vaginal microbiome: new information about genital tract flora using molecular based techniques. BJOG 2011; 118: 533-49.
12. Cunnington M, Kortsalioudaki C, Heath P. Genitourinary pathogens and preterm birth. Curr Opin Infect Dis 2013; 26: 219-30.
13. Breugelmans M, Vancutsem E, Naessens A, Laubach M, Foulon W. Association of abnormal vaginal flora and Ureaplasma species as risk factors for preterm birth: a cohort species. Acta Obstet Gynecol Scand 2010; 89: 256-60.
14. Nicholson JK, Lindon JC, Holmes E. 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica 1999; 29: 1181-9.
15. Simcox R, Sin WT, Seed PT, Briley A, Shennan AH. Prophylactic antibiotics for the prevention of preterm birth in women at risk: a meta-analysis. Aust N Z J Obstet Gynaecol 2007; 47: 368-77.
16. Brocklehurst P, Gordon A, Heatley E,Milan SJ. Antibiotics for treating bacterial vaginosis in pregnancy. Cochrane Database Syst Rev 2013; 1: CD000262.
17. Kenyon SL, Taylor DJ, Tarnow-Mordi W. Broad-spectrum antibiotics for preterm, prelabour rupture of the fetal membranes: the ORACLE I randomised trial. Lancet 2001; 357: 981-90.
18. Kenyon S, Pike K, Jones DR, Brocklehurst P, Marlow N, Salt A, et al. Childhood outcomes after prescription of antibiotics to pregnant women with spontaneous preterm labour: 7-year follow-up of the ORACLE II trial. Lancet 2008; 372: 1276-8.
19. Morency A, Bujold E. The effect of second-trimester antibiotic therapy on the rate of preterm birth. J Obstet Gynaecol Can 2007; 29: 35-44.
20. Shennan AH, Crawshaw S, Briley A, Hawken J, Seed PT, Jones G, et al. A randomised controlled trial of metronidazole for the prevention of preterm birth in women positive for cervicovaginal fetal fibronectin: the PREMET Study. BJOG 2006; 113: 65-74.
21. Lamont RF, Nhan-Chang CL, Sobel JD, Workowski K, Conde-Agudelo A, Romero R. Treatment of abnormal vaginal flora in early pregnancy with clindamycin for the prevention of spontaneous preterm birth: a systematic review and metaanalysis. Am J Obstet Gynecol 2011; 205: 177-90.
22. Zhou X, Brotman RM, Gajer P, Abdo Z, Schuette U, Ma S, et al. Recent advances in understanding the microbiology of the female reproductive tract and the causes of premature birth. Infect Dis Obstet Gynecol 2010; 2010: 737425.
23. Ganu RS, Ma J, Aagard KM. The role of microbial communities in parturition: is there evidence of association with preterm birth and perinatal morbidity and mortality? Am J Perinatol 2013; 30: 613-24.
24. Petrosino JF, Highlander S, Luna RA, Gibbs RA, Versalovic J. Metagenomic pyrosequencing and microbial identification. Clin Chem 2009; 55: 856-66.
25. Fettweis JM, Serrano MG, Sheth NU, Mayer CM, Glascock AL, Brooks JP, et al. Species-level classification of the vaginal microbiome. BMC Genomics 2012; 13: S17.
26. Jia B, Xuan L, Cai K, Hu Z, Ma L, Wei C. NeSSM: A next-generation sequencing simulator for metagenomics. PLoS One 2013; 8: e75448.
27. Verstraelen H, Verhelst R, Claeys G, De Backer E, Temmerman M, Vaneechoutte M. Longitudinal analysis of the vaginal microflora in pregnancy suggests that L. crispatus promotes the stability of the normal vaginal microflora and that L. gasseri and/or L. iners are more conducive to the occurrence of abnormal vaginal microflora. BMC Microbiol 2009; 9:116.
28. Ravel J, Gajer P, Abdo Z, Schneider M, Koenig SSK, McCulle SL, et al. Vaginal microbiome of reproductive-age women. PNAS 2011; 108: 4680-7.
29. MossopH, Linhares IM, Bongiovanni AM, Ledger WJ,Witkin SS. Influence of lactic acid on endogenous and viral RNA-induced immune mediator production by vaginal epithelial cells. Obstet Gynecol 2011; 118: 840-6.
30. Witkin SS, Mendes-Soares H, Linhares IM, Jayaram A, Ledger WJ, Forney LJ. Influence of vaginal bacteria and D-and L-lactic acid isomers on vaginal extracellular matrix metalloproteinase inducer: implications for protection against upper genital tract infections. mBio 2013; 4: e00460-13.
31. Lindsay KL, Walsh CA, Brennan L, McAuliffe FM. Probiotics in pregnancy and maternal outcomes: a systematic review. J Matern Fetal Neonatal Med 2013; 26: 772-8.
32. Othman M, Neilson JP, Alfirevic Z. Probiotics for preventing pretermlabour. Cochrane Database Syst Rev 2007: CD005941.
33. Krauss-Silva L, Moreira ME, Alves MB, Braga A, Camacho KG, Batista MR, et al. A randomised controlled trial of probiotics for the prevention of spontaneous preterm delivery associated with bacterial vaginosis: preliminary results. Trials 2011; 12: 239.
34. Vitali B, Cruciani F, Baldassarre ME, Capursi T, Spisni E, Valerii MC, et al. Dietary supplementation with probiotics during later pregnancy: outcome on vaginal microbiota and cytokine secretion. BMC Microbiol 2012; 12:236.