Reflectance confocal microscopy as a second-level examination in skin oncology improves diagnostic accuracy and saves unnecessary excisions: A longitudinal prospective study

British Journal of Dermatology

Volumn 171, Issue 5, 2014, Pages 1044-1051

  Pellacani, G ^a   Pepe, P ^a   Casari, A ^a   Longo, C ^b  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b S MARIA NUOVA HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CONFOCAL MICROSCOPE; CONFOCAL MICROSCOPY; CONSULTATION; DERMATOSCOPE; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; EPILUMINESCENCE MICROSCOPY; FEMALE; FOLLOW UP; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; MEDICAL DOCUMENTATION; MELANOMA; NON INVASIVE PROCEDURE; OUTPATIENT DEPARTMENT; PATIENT REFERRAL; PROSPECTIVE STUDY; REFLECTANCE CONFOCAL MICROSCOPY; WORKFLOW; ADULT; BASAL CELL CARCINOMA; EVALUATION STUDY; MIDDLE AGED; NEVUS; NUMBERS NEEDED TO TREAT; PATHOLOGY; PROCEDURES; SKIN TUMOR; UNNECESSARY PROCEDURE;

ADULT; CARCINOMA, BASAL CELL; FEMALE; HUMANS; MALE; MELANOMA; MICROSCOPY, CONFOCAL; MIDDLE AGED; NEVUS; NUMBERS NEEDED TO TREAT; PROSPECTIVE STUDIES; SKIN NEOPLASMS; UNNECESSARY PROCEDURES;

EID: 84911447422     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/bjd.13148     Document Type: Article

References (21)

1. Argenziano G, Soyer HP,. Dermoscopy of pigmented skin lesions-a valuable tool for early diagnosis of melanoma. Lancet Oncol 2001; 2: 443-9.
2. Vestergaard ME, Macaskill P, Holt PE, Menzies SW,. Dermoscopy compared with naked eye examination for the diagnosis of primary melanoma: a meta-analysis of studies performed in a clinical setting. Br J Dermatol 2008; 159: 669-76.
3. Argenziano G, Cerroni L, Zalaudek I,. Accuracy in melanoma detection: a 10-year multicenter survey. J Am Acad Dermatol 2012; 67: 54-9.
4. Stanganelli I, Serafini M, Bucch L,. A cancer-registry-assisted evaluation of the accuracy of digital epiluminescence microscopy associated with clinical examination of pigmented skin lesions. Dermatology 2000; 200: 11-16.
5. Carli P, Ghigliotti G, Gnone M, et al,. Baseline factors influencing decisions on digital follow-up of melanocytic lesions in daily practice: an Italian multicenter survey. J Am Acad Dermatol 2006; 55: 256-62.
6. Salerni G, Terán T, Puig S, et al,. Meta-analysis of digital dermoscopy follow-up of melanocytic skin lesions: a study on behalf of the International Dermoscopy Society. J Eur Acad Dermatol Venereol 2013; 27: 805-14.
7. Pellacani G, Guitera P, Longo C, et al,. The impact of in vivo reflectance confocal microscopy for the diagnostic accuracy of melanoma and equivocal melanocytic lesions. J Invest Dermatol 2007; 127: 2759-65.
8. Guitera P, Pellacani G, Longo C, et al,. In vivo reflectance confocal microscopy enhances secondary evaluation of melanocytic lesions. J Invest Dermatol 2009; 129: 131-8.
9. Segura S, Puig S, Carrera C, et al,. Development of a two-step method for the diagnosis of melanoma by reflectance confocal microscopy. J Am Acad Dermatol 2009; 61: 216-29.
10. Guitera P, Menzies SW, Longo C, et al,. In vivo confocal microscopy for diagnosis of melanoma and basal cell carcinoma using a two-step method: analysis of 710 consecutive clinically equivocal cases. J Invest Dermatol 2012; 132: 2386-94.
11. Guitera P, Pellacani G, Crotty KA, et al,. The impact of in vivo reflectance confocal microscopy on the diagnostic accuracy of lentigo maligna and equivocal pigmented and nonpigmented macules of the face. J Invest Dermatol 2010; 130: 2080-91.
12. Scope A, Benvenuto-Andrade C, Agero AL, et al,. In vivo reflectance confocal microscopy imaging of melanocytic skin lesions: consensus terminology glossary and illustrative images. J Am Acad Dermatol 2007; 57: 644-58.
13. Pellacani G, Vinceti M, Bassoli S, et al,. Reflectance confocal microscopy and features of melanocytic lesions: an internet-based study of the reproducibility of terminology. Arch Dermatol 2009; 145: 1137-43.
14. Gur D, Bandos AI, Cohen CS, et al,. The 'laboratory' effect: comparing radiologists' performance and variability during prospective clinical and laboratory mammography interpretations. Radiology 2008; 249: 47-53.
15. Alarcon I, Carrera C, Palou J, et al,. Impact of in vivo reflectance confocal microscopy on the number needed to treat melanoma in doubtful lesions. Br J Dermatol 2014; 170: 802-8.
16. Rajadhyaksha M, Grossman M, Esterowitz D, et al,. In vivo confocal scanning laser microscopy of human skin: melanin provides strong contrast. J Invest Dermatol 1995; 104: 946-52.
17. Longo C, Rito C, Beretti F, et al,. De novo melanoma and melanoma arising from pre-existing nevus: in vivo morphologic differences as evaluated by confocal microscopy. J Am Acad Dermatol 2011; 65: 604-14.
18. Pellacani G, Cesinaro AM, Seidenari S,. Reflectance-mode confocal microscopy of pigmented skin lesions-improvement in melanoma diagnostic specificity. J Am Acad Dermatol 2005; 53: 979-85.
19. Longo C, Farnetani F, Ciardo S, et al,. Is confocal microscopy a valuable tool in diagnosing nodular lesions? A study of 140 cases. Br J Dermatol 2013; 169: 58-67.
20. Argenziano G, Mordente I, Ferrara G, et al,. Dermoscopic monitoring of melanocytic skin lesions: clinical outcome and patient compliance vary according to follow-up protocols. Br J Dermatol 2008; 159: 331-6.
21. Seidenari S, Longo C, Giusti F, Pellacani G,. Clinical selection of melanocytic lesions for dermoscopy decreases the identification of suspicious lesions in comparison with dermoscopy without clinical preselection. Br J Dermatol 2006; 154: 873-9.