Polyphosphate: A target for thrombosis attenuation

Blood

Volumn 124, Issue 22, 2014, Pages 3177-3178

  Docampo, Roberto ^a  

^a UNIVERSITY OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICOAGULANT AGENT; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 11; BLOOD CLOTTING FACTOR 5; BRADYKININ; COMPLEMENT COMPONENT C5B; COMPLEMENT COMPONENT C6; COMPLEMENT MEMBRANE ATTACK COMPLEX; HEPARIN; HIGH MOLECULAR WEIGHT KININOGEN; KALLIKREIN; POLYPHOSPHATE; POLYPHOSPHATE INHIBITOR; THROMBIN; TISSUE FACTOR PATHWAY INHIBITOR; UNCLASSIFIED DRUG; DENDRIMER; FIBRINOLYTIC AGENT; UHRA-10; UHRA-9;

ANTICOAGULATION; ATTENUATION; BLEEDING; BLOOD CLOTTING; FIBRIN POLYMERIZATION; HUMAN; NONHUMAN; NOTE; THROMBOCYTE ACTIVATION; THROMBOSIS; ANIMAL; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; HEMOSTASIS;

ANIMALS; DENDRIMERS; FIBRINOLYTIC AGENTS; HEMOSTASIS; HUMANS; POLYPHOSPHATES; THROMBOSIS;

EID: 84911408177     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2014-09-601641     Document Type: Note

References (9)

1. Travers RJ, Shenoi RA, Kalathottukaren MT, Kizhakkedathu JN, Morrissey JH. Nontoxic polyphosphate inhibitors reduce thrombosis while sparing hemostasis. Blood. 2014;124(22):3183-3190.
2. Rao NN, Gómez-García MR, Kornberg A. Inorganic polyphosphate: essential for growth and survival. Annu Rev Biochem. 2009;78:605-647.
3. Docampo R, de Souza W, Miranda K, Rohloff P, Moreno SN. Acidocalcisomes - conserved from bacteria to man. Nat Rev Microbiol. 2005;3(3):251-261.
4. Ruiz FA, Lea CR, Oldfield E, Docampo R. Human platelet dense granules contain polyphosphate and are similar to acidocalcisomes of bacteria and unicellular eukaryotes. J Biol Chem. 2004;279(43):44250-44257.
5. Moreno-Sanchez D, Hernandez-Ruiz L, Ruiz FA, Docampo R. Polyphosphate is a novel pro-inflammatory regulator of mast cells and is located in acidocalcisomes. J Biol Chem. 2012;287(34):28435-28444.
6. Moreno SN, Docampo R. Polyphosphate and its diverse functions in host cells and pathogens. PLoS Pathog. 2013;9(5):e1003230.
7. Smith SA, Mutch NJ, Baskar D, Rohloff P, Docampo R, Morrissey JH. Polyphosphate modulates blood coagulation and fibrinolysis. Proc Natl Acad Sci USA. 2006;103(4):903-908.
8. Smith SA, Morrissey JH. Polyphosphate: a new player in the field of hemostasis. Curr Opin Hematol. 2014;21(5):388-394.
9. Müller F, Mutch NJ, Schenk WA, et al. Platelet polyphosphates are proinflammatory and procoagulant mediators in vivo. Cell. 2009;139(6):1143-1156.