Inhibition of ESCRT-II-CHMP6 interactions impedes cytokinetic abscission and leads to cell death

Molecular Biology of the Cell

Volumn 25, Issue 23, 2014, Pages 3740-3748

  Goliand, Inna ^a   Nachmias, Dikla ^a   Gershony, Ofir ^a   Elia, Natalie ^a  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CHMP6 PROTEIN; ESCRT II PROTEIN; PROTEIN; UNCLASSIFIED DRUG; CHMP6 PROTEIN, HUMAN; ESCRT PROTEIN; PROTEIN BINDING;

ABSCISSION; ANIMAL CELL; ANIMAL CELL CULTURE; ANTIBODY LABELING; ARTICLE; CELL DEATH; CELL JUNCTION; CONTROLLED STUDY; CYTOKINESIS; IMAGE PROCESSING; IMAGING; IMMUNOHISTOCHEMISTRY; MAMMAL CELL; MDCK CELL LINE; MICROTUBULE; NONHUMAN; PHENOTYPE; POINT MUTATION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; QUANTITATIVE ANALYSIS; ANIMAL; DOG; ENDOSOME; GENETICS; HUMAN; MEMBRANE FUSION; METABOLISM; ULTRASTRUCTURE;

ANIMALS; CELL DEATH; CYTOKINESIS; DOGS; ENDOSOMAL SORTING COMPLEXES REQUIRED FOR TRANSPORT; ENDOSOMES; HUMANS; MADIN DARBY CANINE KIDNEY CELLS; MEMBRANE FUSION; PROTEIN BINDING;

EID: 84911406750     PISSN: 10591524     EISSN: 19394586     Source Type: Journal    
DOI: 10.1091/mbc.E14-08-1317     Document Type: Article

References (33)

1. Babst M, Katzmann DJ, Snyder WB, Wendland B, Emr SD (2002). Endosome-associated complex, ESCRT-II, recruits transport machinery for protein sorting at the multivesicular body. Dev Cell 3, 283-289.
2. Carlson LA, Hurley JH (2012). In vitro reconstitution of the ordered assembly of the endosomal sorting complex required for transport at membranebound HIV-1 Gag clusters. Proc Natl Acad Sci USA 109, 16928-16933.
3. Carlton JG, Martin-Serrano J (2007). Parallels between cytokinesis and retroviral budding: a role for the ESCRT machinery. Sci 316, 1908-1912.
4. Cashikar AG, Shim S, Roth R, Maldazys MR, Heuser JE, Hanson PI (2014). Structure of cellular ESCRT-III spirals and their relationship to HIV budding. eLife e02184.
5. Chircop M, Perera S, Mariana A, Lau H, Ma MP, Gilbert J, Jones NC, Gordon CP, Young KA, Morokoff A, et al. (2011). Inhibition of dynamin by dynole 34-2 induces cell death following cytokinesis failure in cancer cells. Mol Cancer Ther 10, 1553-1562.
6. Dambournet D, Machicoane M, Chesneau L, Sachse M, Rocancourt M, El Marjou A, Formstecher E, Salomon R, Goud B, Echard A (2011). Rab35 GTPase and OCRL phosphatase remodel lipids and F-actin for successful cytokinesis. Nat Cell Biol 13, 981-988.
7. Elia N, Fabrikant G, Kozlov M, Lippincott-Schwartz J (2012). Computational model of cytokinetic abscission driven by ESCRT-III polymerization and remodeling. Biophys J 102, 2309-2320.
8. Elia N, Ott C, Lippincott-Schwartz J (2013). Incisive imaging and computation for cellular mysteries: lessons from abscission. Cell 155, 1220-1231.
9. Elia N, Sougrat R, Spurlin TA, Hurley JH, Lippincott-Schwartz J (2011). Dynamics of endosomal sorting complex required for transport (ESCRT) machinery during cytokinesis and its role in abscission. Proc Natl Acad Sci USA 108, 4846-4851.
10. Florindo C, Perdigao J, Fesquet D, Schiebel E, Pines J, Tavares AA (2012). Human Mob1 proteins are required for cytokinesis by controlling microtubule stability. J Cell Sci 125, 3085-3090.
11. Fyfe I, Schuh AL, Edwardson JM, Audhya A (2011). Association of the endosomal sorting complex ESCRT-II with the Vps20 subunit of ESCRT-III generates a curvature-sensitive complex capable of nucleating ESCRT-III filaments. J Biol Chem 286, 34262-34270.
12. Green RA, Paluch E, Oegema K (2012). Cytokinesis in animal cells. Annu Rev Cell Dev Biol 28, 29-58.
13. Guizetti J, Schermelleh L, Mantler J, Maar S, Poser I, Leonhardt H, Muller-Reichert T, Gerlich DW (2011). Cortical constriction during abscission involves helices of ESCRT-III-dependent filaments. Science 331, 1616-1620.
14. Hanson PI, Roth R, Lin Y, Heuser JE (2008). Plasma membrane deformation by circular arrays of ESCRT-III protein filaments. J Cell Biol 180, 389-402.
15. Heintzmann R, Cremer CG (1999). Laterally modulated excitation microscopy: improvement of resolution by using a diffraction grating. Proc SPIE 3568, 185-196.
16. Henne WM, Buchkovich NJ, Zhao Y, Emr SD (2012). The endosomal sorting complex ESCRT-II mediates the assembly and architecture of ESCRT-III helices. Cell 151, 356-371.
17. Hurley JH, Hanson PI (2010). Membrane budding and scission by the ESCRT machinery: it's all in the neck. Nat Rev Mol Cell Biol 11, 556-566.
18. Im YJ, Wollert T, Boura E, Hurley JH (2009). Structure and function of the ESCRT-II-III interface in multivesicular body biogenesis. Dev Cell 17, 234-243.
19. Jimenez AJ, Maiuri P, Lafaurie-Janvore J, Divoux S, Piel M, Perez F (2014). ESCRT machinery is required for plasma membrane repair. Science 343, 1247136.
20. Langelier C, von Schwedler UK, Fisher RD, De Domenico I, White PL, Hill CP, Kaplan J, Ward D, Sundquist WI (2006). Human ESCRT-II complex and its role in human immunodeficiency virus type 1 release. J Virol 80, 9465-9480.
21. Lata S, Schoehn G, Jain A, Pires R, Piehler J, Gottlinger HG, Weissenhorn W (2008). Helical structures of ESCRT-III are disassembled by VPS4. Science 321, 1354-1357.
22. Malerod L, Stuffers S, Brech A, Stenmark H (2007). Vps22/EAP30 in ESCRT-II mediates endosomal sorting of growth factor and chemokine receptors destined for lysosomal degradation. Traffic 8, 1617-1629.
23. McCullough J, Colf LA, Sundquist WI (2013). Membrane fission reactions of the mammalian ESCRT pathway. Annu Rev Biochem 82, 663-692.
24. Morita E, Colf LA, Karren MA, Sandrin V, Rodesch CK, Sundquist WI (2010). Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenance. Proc Natl Acad Sci USA 107, 12889-12894.
25. Morita E, Sandrin V, Chung HY, Morham SG, Gygi SP, Rodesch CK, Sundquist WI (2007). Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis. EMBO J 26, 4215-4227.
26. Morita E, Sandrin V, McCullough J, Katsuyama A, Baci Hamilton I, Sundquist WI (2011). ESCRT-III protein requirements for HIV-1 budding. Cell Host Microbe 9, 235-242.
27. Peel S, Macheboeuf P, Martinelli N, Weissenhorn W (2011). Divergent pathways lead to ESCRT-III-catalyzed membrane fission. Trends Biochem Sci 36, 199-210.
28. Saksena S, Sun J, Chu T, Emr SD (2007). ESCRTing proteins in the endocytic pathway. Trends Biochem Sci 32, 561-573.
29. Soetedjo L, Jin H (2014). Agonist-induced GPCR shedding from the ciliary surface is dependent on ESCRT-III and VPS4. Curr Biol 24, 509-518.
30. Teis D, Saksena S, Judson BL, Emr SD (2010). ESCRT-II coordinates the assembly of ESCRT-III filaments for cargo sorting and multivesicular body vesicle formation. EMBO J 29, 871-883.
31. Wollert T, Hurley JH (2010). Molecular mechanism of multivesicular body biogenesis by ESCRT complexes. Nature 464, 864-869.
32. Wollert T, Wunder C, Lippincott-Schwartz J, Hurley JH (2009). Membrane scission by the ESCRT-III complex. Nature 458, 172-177.
33. Zhadina M, Bieniasz PD (2010). Functional interchangeability of late domains, late domain cofactors and ubiquitin in viral budding. PLoS Pathog 6, e1001153.