메뉴 건너뛰기




Volumn 21, Issue 12, 2014, Pages 909-916

Decline in intrahepatic cccDNA and increase in immune cell reactivity after 12 weeks of antiviral treatment were associated with HBeAg loss

Author keywords

antiviral therapy; chronic hepatitis B; HBeAg loss; T cell reactivity; viral decline

Indexed keywords

ADEFOVIR DIPIVOXIL; GAMMA INTERFERON; HEPATITIS B(E) ANTIGEN; ADENINE; ANTIVIRUS AGENT; HEPATITIS B ANTIGEN; PHOSPHONIC ACID DERIVATIVE; VIRUS DNA;

EID: 84911374800     PISSN: 13520504     EISSN: 13652893     Source Type: Journal    
DOI: 10.1111/jvh.12261     Document Type: Article
Times cited : (19)

References (20)
  • 1
    • 58149296156 scopus 로고    scopus 로고
    • EASL Clinical Practice Guidelines: Management of chronic hepatitis B
    • European Association For The Study Of The L
    • European Association For The Study Of The L. EASL Clinical Practice Guidelines: management of chronic hepatitis B. J Hepatol 2009; 50 (2): 227-242.
    • (2009) J Hepatol , vol.50 , Issue.2 , pp. 227-242
  • 2
    • 51049121362 scopus 로고    scopus 로고
    • The Roadmap concept: Using early on-treatment virologic responses to optimize long-term outcomes for patients with chronic hepatitis B
    • Gane EJ,. The Roadmap concept: using early on-treatment virologic responses to optimize long-term outcomes for patients with chronic hepatitis B. Hepatol Int 2008; 2 (3): 304-307.
    • (2008) Hepatol Int , vol.2 , Issue.3 , pp. 304-307
    • Gane, E.J.1
  • 3
    • 63749086565 scopus 로고    scopus 로고
    • Bio-mathematical models of viral dynamics to tailor antiviral therapy in chronic viral hepatitis
    • Brunetto MR, Colombatto P, Bonino F,. Bio-mathematical models of viral dynamics to tailor antiviral therapy in chronic viral hepatitis. World J Gastroenterol 2009; 15 (5): 531-537.
    • (2009) World J Gastroenterol , vol.15 , Issue.5 , pp. 531-537
    • Brunetto, M.R.1    Colombatto, P.2    Bonino, F.3
  • 4
    • 34547768137 scopus 로고    scopus 로고
    • Impact of early viral kinetics on T-cell reactivity during antiviral therapy in chronic hepatitis B
    • Lau GK, Cooksley H, Ribeiro RM, et al,. Impact of early viral kinetics on T-cell reactivity during antiviral therapy in chronic hepatitis B. Antivir Ther 2007; 12 (5): 705-718.
    • (2007) Antivir Ther , vol.12 , Issue.5 , pp. 705-718
    • Lau, G.K.1    Cooksley, H.2    Ribeiro, R.M.3
  • 5
    • 34247117935 scopus 로고    scopus 로고
    • Characterization of hepatitis B virus (HBV)-specific T-cell dysfunction in chronic HBV infection
    • Boni C, Fisicaro P, Valdatta C, et al,. Characterization of hepatitis B virus (HBV)-specific T-cell dysfunction in chronic HBV infection. J Virol 2007; 81 (8): 4215-4225.
    • (2007) J Virol , vol.81 , Issue.8 , pp. 4215-4225
    • Boni, C.1    Fisicaro, P.2    Valdatta, C.3
  • 6
    • 2442682870 scopus 로고    scopus 로고
    • Longitudinal analysis of CD8 + T cells specific for structural and nonstructural hepatitis B virus proteins in patients with chronic hepatitis B: Implications for immunotherapy
    • Webster GJ, Reignat S, Brown D, et al,. Longitudinal analysis of CD8 + T cells specific for structural and nonstructural hepatitis B virus proteins in patients with chronic hepatitis B: implications for immunotherapy. J Virol 2004; 78 (11): 5707-5719.
    • (2004) J Virol , vol.78 , Issue.11 , pp. 5707-5719
    • Webster, G.J.1    Reignat, S.2    Brown, D.3
  • 7
    • 12444252951 scopus 로고    scopus 로고
    • Transient restoration of anti-viral T cell responses induced by lamivudine therapy in chronic hepatitis B
    • Boni C, Penna A, Bertoletti A, et al,. Transient restoration of anti-viral T cell responses induced by lamivudine therapy in chronic hepatitis B. J Hepatol 2003; 39 (4): 595-605.
    • (2003) J Hepatol , vol.39 , Issue.4 , pp. 595-605
    • Boni, C.1    Penna, A.2    Bertoletti, A.3
  • 8
    • 0034678435 scopus 로고    scopus 로고
    • The role of virus-specific CD8(+) cells in liver damage and viral control during persistent hepatitis B virus infection
    • Maini MK, Boni C, Lee CK, et al,. The role of virus-specific CD8(+) cells in liver damage and viral control during persistent hepatitis B virus infection. J Exp Med 2000; 191 (8): 1269-1280.
    • (2000) J Exp Med , vol.191 , Issue.8 , pp. 1269-1280
    • Maini, M.K.1    Boni, C.2    Lee, C.K.3
  • 9
    • 20444436447 scopus 로고    scopus 로고
    • Intrahepatic CD8 + T-lymphocyte response is important for therapy-induced viral clearance in chronic hepatitis B infection
    • Tang TJ, Kwekkeboom J, Mancham S, et al,. Intrahepatic CD8 + T-lymphocyte response is important for therapy-induced viral clearance in chronic hepatitis B infection. J Hepatol 2005; 43 (1): 45-52.
    • (2005) J Hepatol , vol.43 , Issue.1 , pp. 45-52
    • Tang, T.J.1    Kwekkeboom, J.2    Mancham, S.3
  • 10
    • 78751582170 scopus 로고    scopus 로고
    • Viral load reduction improves activation and function of natural killer cells in patients with chronic hepatitis B
    • Tjwa ET, van Oord GW, Hegmans JP, Janssen HL, Woltman AM,. Viral load reduction improves activation and function of natural killer cells in patients with chronic hepatitis B. J Hepatol 2011; 54 (2): 209-218.
    • (2011) J Hepatol , vol.54 , Issue.2 , pp. 209-218
    • Tjwa, E.T.1    Van Oord, G.W.2    Hegmans, J.P.3    Janssen, H.L.4    Woltman, A.M.5
  • 11
    • 67349186530 scopus 로고    scopus 로고
    • Early kinetics of innate and adaptive immune responses during hepatitis B virus infection
    • Fisicaro P, Valdatta C, Boni C, et al,. Early kinetics of innate and adaptive immune responses during hepatitis B virus infection. Gut 2009; 58 (7): 974-982.
    • (2009) Gut , vol.58 , Issue.7 , pp. 974-982
    • Fisicaro, P.1    Valdatta, C.2    Boni, C.3
  • 12
    • 84897365739 scopus 로고    scopus 로고
    • [Relationship between the changes in immune cells and HBeAg loss following antiviral treatment in chronic hepatitis B patients]
    • Zheng Q, Zhu YY, Chen J, et al,. [Relationship between the changes in immune cells and HBeAg loss following antiviral treatment in chronic hepatitis B patients]. Zhonghua Gan Zang Bing Za Zhi 2012; 20 (11): 801-806.
    • (2012) Zhonghua Gan Zang Bing Za Zhi , vol.20 , Issue.11 , pp. 801-806
    • Zheng, Q.1    Zhu, Y.Y.2    Chen, J.3
  • 13
    • 33745323050 scopus 로고    scopus 로고
    • Circulating and liver resident CD4 + CD25 + regulatory T cells actively influence the antiviral immune response and disease progression in patients with hepatitis B
    • Xu D, Fu J, Jin L, et al,. Circulating and liver resident CD4 + CD25 + regulatory T cells actively influence the antiviral immune response and disease progression in patients with hepatitis B. J Immunol 2006; 177 (1): 739-747.
    • (2006) J Immunol , vol.177 , Issue.1 , pp. 739-747
    • Xu, D.1    Fu, J.2    Jin, L.3
  • 14
    • 69349092791 scopus 로고    scopus 로고
    • Rapid HBV DNA decrease (week 12) is an important prognostic factor for first-line treatment with adefovir dipivoxil for chronic hepatitis B
    • Hass HG, Bock T, Nehls O, Kaiser S,. Rapid HBV DNA decrease (week 12) is an important prognostic factor for first-line treatment with adefovir dipivoxil for chronic hepatitis B. J Gastroenterol 2009; 44 (8): 871-877.
    • (2009) J Gastroenterol , vol.44 , Issue.8 , pp. 871-877
    • Hass, H.G.1    Bock, T.2    Nehls, O.3    Kaiser, S.4
  • 15
    • 37849001718 scopus 로고    scopus 로고
    • Hepatitis B virus e antigen loss during adefovir dipivoxil therapy is associated with enhanced virus-specific CD4 + T-cell reactivity
    • Cooksley H, Chokshi S, Maayan Y, et al,. Hepatitis B virus e antigen loss during adefovir dipivoxil therapy is associated with enhanced virus-specific CD4 + T-cell reactivity. Antimicrob Agents Chemother 2008; 52 (1): 312-320.
    • (2008) Antimicrob Agents Chemother , vol.52 , Issue.1 , pp. 312-320
    • Cooksley, H.1    Chokshi, S.2    Maayan, Y.3
  • 16
    • 79957523611 scopus 로고    scopus 로고
    • Effect of telbivudine therapy on the cellular immune response in chronic hepatitis B
    • Chen Y, Li X, Ye B, et al,. Effect of telbivudine therapy on the cellular immune response in chronic hepatitis B. Antiviral Res 2011; 91 (1): 23-31.
    • (2011) Antiviral Res , vol.91 , Issue.1 , pp. 23-31
    • Chen, Y.1    Li, X.2    Ye, B.3
  • 17
    • 0026527586 scopus 로고
    • Acute exacerbations of chronic type B hepatitis are accompanied by increased T cell responses to hepatitis B core and e antigens. Implications for hepatitis B e antigen seroconversion
    • Tsai SL, Chen PJ, Lai MY, et al,. Acute exacerbations of chronic type B hepatitis are accompanied by increased T cell responses to hepatitis B core and e antigens. Implications for hepatitis B e antigen seroconversion. J Clin Invest 1992; 89 (1): 87-96.
    • (1992) J Clin Invest , vol.89 , Issue.1 , pp. 87-96
    • Tsai, S.L.1    Chen, P.J.2    Lai, M.Y.3
  • 18
    • 70449724811 scopus 로고    scopus 로고
    • Host immunity influences disease progression and antiviral efficacy in humans infected with hepatitis B virus
    • Wang FS, Zhang Z,. Host immunity influences disease progression and antiviral efficacy in humans infected with hepatitis B virus. Expert Rev Gastroenterol Hepatol 2009; 3 (5): 499-512.
    • (2009) Expert Rev Gastroenterol Hepatol , vol.3 , Issue.5 , pp. 499-512
    • Wang, F.S.1    Zhang, Z.2
  • 19
    • 73949112938 scopus 로고    scopus 로고
    • Increased killing of liver NK cells by Fas/Fas ligand and NKG2D/NKG2D ligand contributes to hepatocyte necrosis in virus-induced liver failure
    • Zou Y, Chen T, Han M, et al,. Increased killing of liver NK cells by Fas/Fas ligand and NKG2D/NKG2D ligand contributes to hepatocyte necrosis in virus-induced liver failure. J Immunol 2010; 184 (1): 466-475.
    • (2010) J Immunol , vol.184 , Issue.1 , pp. 466-475
    • Zou, Y.1    Chen, T.2    Han, M.3
  • 20
    • 33947411395 scopus 로고    scopus 로고
    • Cytokines induced during chronic hepatitis B virus infection promote a pathway for NK cell-mediated liver damage
    • Dunn C, Brunetto M, Reynolds G, et al,. Cytokines induced during chronic hepatitis B virus infection promote a pathway for NK cell-mediated liver damage. J Exp Med 2007; 204 (3): 667-680.
    • (2007) J Exp Med , vol.204 , Issue.3 , pp. 667-680
    • Dunn, C.1    Brunetto, M.2    Reynolds, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.