Constitutive expression of gsar201c in mice produces a heritable, direct replica of human fibrous dysplasia bone pathology and demonstrates its natural history

Journal of Bone and Mineral Research

Volumn 29, Issue 11 S1, 2014, Pages 2357-2368

  Saggio, Isabella ^a   Remoli, Cristina ^b   Spica, Emanuela ^b   Sacchetti, Benedetto ^b   Robey, Pamela G ^c   Holmbeck, Kenn ^c   Cumano, Ana ^d   Boyde, Alan ^e   Bianco, Paolo ^b   Riminucci, Mara ^b  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d INSTITUT PASTEUR   (France)

^e QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Fibrous dysplasia; Genetic skeletal diseases; Gnas; Gs alpha; Mouse models

Indexed keywords

CYCLIC AMP; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN; ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; ALKALINE PHOSPHATASE; ELONGATION FACTOR 1ALPHA; PHOSPHOGLYCERATE KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE LESION; BONE REMODELING; CELL DIFFERENTIATION; CONSTITUTIVE EXPRESSION; CONTROLLED STUDY; CYTOCHEMISTRY; EMBRYO; EMBRYO DEVELOPMENT; EMBRYONAL TISSUE; EMBRYONIC STEM CELL; FEMALE; FIBROUS DYSPLASIA; GENE EXPRESSION; GENE MUTATION; HISTOPATHOLOGY; INHERITANCE; MOUSE; NEWBORN; NONHUMAN; OSSIFICATION; PATHOGENESIS; SPATIOTEMPORAL ANALYSIS; TRANSGENIC MOUSE; AGE; AMINO ACID SUBSTITUTION; ANIMAL; BIOSYNTHESIS; BONE DEVELOPMENT; DISEASE MODEL; ENZYMOLOGY; GENETICS; HUMAN; MAMMALIAN EMBRYO; MISSENSE MUTATION; PATHOLOGY; GENOTYPE; GERMLINE MUTATION; OSTEOBLAST; OSTEOCLAST; PROMOTER REGION; PROTEIN EXPRESSION; TISSUE DIFFERENTIATION; TRANSGENE; UPREGULATION;

AGE FACTORS; AMINO ACID SUBSTITUTION; ANIMALS; BONE REMODELING; DISEASE MODELS, ANIMAL; EMBRYO, MAMMALIAN; FIBROUS DYSPLASIA OF BONE; GENE EXPRESSION; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; HUMANS; MICE; MICE, TRANSGENIC; MUTATION, MISSENSE; OSTEOGENESIS;

EID: 84911194498     PISSN: 08840431     EISSN: 15234681     Source Type: Journal    
DOI: 10.1002/jbmr.2267     Document Type: Article

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