Mechanical compression upregulates MMP9 through SMAD3 but not SMAD2 modulation in hypertrophic scar fibroblasts

Connective Tissue Research

Volumn 55, Issue 5-6, 2014, Pages 391-396

  Huang, Dong ^a   Liu, Yingping ^a   Huang, Yongjun ^a   Xie, Youfu ^b   Shen, Kuanhong ^a   Zhang, Dawei ^a   Mou, Yong ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b GUANGZHOU RED CROSS HOSPITAL   (China)

Author keywords

Compression therapy; Hypertrophic scars; MMP2; MMP9; SMAD2 3; TGF

Indexed keywords

COLLAGEN TYPE 1; COLLAGEN TYPE 3; GELATINASE B; MESSENGER RNA; SMAD2 PROTEIN; SMAD3 PROTEIN; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA; MMP9 PROTEIN, HUMAN; PRIMER DNA; SMAD3 PROTEIN, HUMAN;

ADULT; ARTICLE; CELL ISOLATION; CLINICAL ARTICLE; COMPARATIVE STUDY; COMPRESSION INSTRUMENT; COMPRESSION THERAPY; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; FEMALE; FIBROBLAST; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERTROPHIC SCAR; IN VITRO STUDY; MALE; MECHANICAL STRESS; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING; BIOMECHANICS; CICATRIX, HYPERTROPHIC; GENE EXPRESSION REGULATION; GENETICS; IMMUNOHISTOCHEMISTRY; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; PROCEDURES; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SOFT TISSUE THERAPY;

BIOMECHANICAL PHENOMENA; BLOTTING, WESTERN; CICATRIX, HYPERTROPHIC; DNA PRIMERS; FIBROBLASTS; GENE EXPRESSION REGULATION; HUMANS; IMMUNOHISTOCHEMISTRY; MATRIX METALLOPROTEINASE 9; REAL-TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SMAD3 PROTEIN; THERAPY, SOFT TISSUE; TRANSFORMING GROWTH FACTOR BETA;

EID: 84911146447     PISSN: 03008207     EISSN: 16078438     Source Type: Journal    
DOI: 10.3109/03008207.2014.959118     Document Type: Article

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