Analysis and characterization of the novel psychoactive drug 4-chloromethcathinone (clephedrone)

Forensic Science International

Volumn 244, Issue , 2014, Pages e56-e59

  Taschwer, Magdalena ^a   Weiß, Jennifer A ^a   Kunert, Olaf ^a   Schmid, Martin G ^a  

^a UNIVERSITY OF GRAZ   (Austria)

Author keywords

4 Chloromethcathinone; Cathinones; Clephedrone; Novel Psychoactive Substances (NPS)

Indexed keywords

4 CHLOROMETHCATHINONE; CATHINONE; CLEPHEDRONE; PSYCHOTROPIC AGENT; UNCLASSIFIED DRUG; METHYLAMINE; PROPIOPHENONE DERIVATIVE; STREET DRUG;

ARTICLE; CAPILLARY ELECTROPHORESIS; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL ANALYSIS; CHIRALITY; DERIVATIZATION; ELECTROSPRAY MASS SPECTROMETRY; ENANTIOSELECTIVITY; HUMAN; MASS FRAGMENTOGRAPHY; MOLECULAR WEIGHT; NUCLEAR MAGNETIC RESONANCE; PROTON NUCLEAR MAGNETIC RESONANCE; SEPARATION TECHNIQUE; CHEMISTRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

ELECTROPHORESIS, CAPILLARY; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; MAGNETIC RESONANCE SPECTROSCOPY; METHYLAMINES; PROPIOPHENONES; PSYCHOTROPIC DRUGS; STREET DRUGS;

EID: 84911077823     PISSN: 03790738     EISSN: 18726283     Source Type: Journal    
DOI: 10.1016/j.forsciint.2014.09.007     Document Type: Article

References (16)

1. Gibbons S. 'Legal highs'-novel and emerging psychoactive drugs: a chemical overview for the toxicologist. Clin. Toxicol. (Phila) 2012, 50:15-24.
2. Sumnall H.R., Evans-Brown M., McVeigh J. Social, policy, and public health perspectives on new psychoactive substances. Drug Test Anal. 2011, 3:515-523.
3. Gibbons S., Zloh M. An analysis of the 'legal high' mephedrone. Bioorg. Med. Chem. Lett. 2010, 20:4135-4139.
4. EMCDDA. Europol-EMCDDA Joint Report on a new psychoactive substance: 4-methylmethcathinone (mephedrone), 2010.
5. EMCDDA. Report on the risk assessment of mephedrone in the framework of the Council Decision on new psychoactive substances, 2011.
6. Jirovsky D., Lemr K., Sevcik J., Smysl B., Stransky Z. Methamphetamine-properties and analytical methods of enantiomer determination. Forensic Sci. Int. 1998, 96:61-70.
7. Rasmussen L.B., Olsen K.H., Johansen S.S. Chiral separation and quantification of R/S-amphetamine, R/S-methamphetamine, R/S-MDA, R/S-MDMA, and R/S-MDEA in whole blood by GC-EI-MS. J. Chromatogr. B: Analyt. Technol. Biomed. Life Sci. 2006, 842:136-141.
8. Glennon R.A., Young R., Martin B.R., Dal Cason T.A. Methcathione (cat"): an enantiomeric potency comparison. Pharmacol. Biochem. Behav. 1995, 50:601-606.
9. Elliott S., Evans J. A 3-year review of new psychoactive substances in casework. Forensic Sci Int. 2014, 243C:55-60.
10. Archer R.P., Treble R., Williams K. Reference materials for new psychoactive substances. Drug Test Anal. 2011, 3:505-514.
11. Mohr S., Taschwer M., Schmid M.G. Chiral separation of cathinone derivatives used as recreational drugs by HPLC-UV using a CHIRALPAK(R) AS-H column as stationary phase. Chirality 2012, 24:486-492.
12. Taschwer M., Seidl Y., Mohr S., Schmid M.G. Chiral separation of cathinone and amphetamine derivatives by HPLC/UV using sulfated ß-cyclodextrin as chiral mobile phase additive. Chirality 2014.
13. Aturki Z., Schmid M.G., Chankvetadze B., Fanali S. Enantiomeric separation of new cathinone derivatives designer drugs by capillary electrochromatography using a chiral stationary phase, based on amylose tris(5-chloro-2-methylphenylcarbamate). Electrophoresis 2014.
14. Mohr S., Pilaj S., Schmid M.G. Chiral separation of cathinone derivatives used as recreational drugs by cyclodextrin-modified capillary electrophoresis. Electrophoresis 2012, 33:1624-1630.
15. Taschwer M., Hofer M.G., Schmid M.G. Enantioseparation of benzofurys and other novel psychoactive compounds by CE and sulfobutylether ß-cyclodextrin as chiral selector added to the BGE. Electrophoresis 2014, (in press). 10.1002/elps.201400164.
16. Mohr S., Weiss J.A., Spreitz J., Schmid M.G. Chiral separation of new cathinone- and amphetamine-related designer drugs by gas chromatography-mass spectrometry using trifluoroacetyl-l-prolyl chloride as chiral derivatization reagent. J. Chromatogr. A 2012, 1269:352-359.