메뉴 건너뛰기




Volumn 12, Issue 10, 2014, Pages

Immunoglobulin Fc-fusion proteins part 2: Therapeutic uses and clinical development

Author keywords

[No Author keywords available]

Indexed keywords

ABATACEPT; AFLIBERCEPT; ALEFACEPT; B CELL ACTIVATING FACTOR; B7 ANTIGEN; BELATACEPT; BIOSIMILAR AGENT; BLISIBIMOD; BLOOD CLOTTING FACTOR; CASPASE 3; CD28 ANTIGEN; CD86 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; ETANERCEPT; FAS LIGAND; FC RECEPTOR; HYBRID PROTEIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN M; INFLIXIMAB; MONOCLONAL ANTIBODY; RECOMBINANT BLOOD CLOTTING FACTOR 9; RECOMBINANT GAMMA INTERFERON; RILONACEPT; ROMIPLOSTIM; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; TREBANANIB; TUMOR NECROSIS FACTOR ALPHA;

EID: 84910686053     PISSN: 15426319     EISSN: None     Source Type: Trade Journal    
DOI: None     Document Type: Article
Times cited : (6)

References (43)
  • 2
    • 84889806818 scopus 로고    scopus 로고
    • Fc-fusion proteins and FcRn: Structural insights for longer-lasting and more effective therapeutics
    • Rath T, et al. Fc-Fusion Proteins and FcRn: Structural Insights for Longer-Lasting and More Effective Therapeutics. Crit. Rev. Biotechnol. 2013: 1-20.
    • (2013) Crit. Rev. Biotechnol. , pp. 1-20
    • Rath, T.1
  • 3
    • 35648977687 scopus 로고    scopus 로고
    • Alefacept for the treatment of psoriasis and other dermatologic diseases
    • Strober BE, Menon K. Alefacept for the Treatment of Psoriasis and Other Dermatologic Diseases. Dermatol. Ther. 20, 2007: 270-276.
    • (2007) Dermatol. Ther. , vol.20 , pp. 270-276
    • Strober, B.E.1    Menon, K.2
  • 4
    • 34547615153 scopus 로고    scopus 로고
    • Alefacept: Its safety profile, off-label uses, and potential as part of combination therapies for psoriasis
    • Scheinfeld N. Alefacept: Its Safety Profile, Off-Label Uses, and Potential As Part of Combination Therapies for Psoriasis. J. Dermatol. Treat. 18, 2007: 197-208.
    • (2007) J. Dermatol. Treat. , vol.18 , pp. 197-208
    • Scheinfeld, N.1
  • 5
    • 0029031518 scopus 로고
    • Binding stoichiometry of the cytotoxic T lymphocyte-associated molecule-4 (CTLA-4): A disulfide-linked homodimer binds two CD86 molecules
    • Linsley PS, et al. Binding Stoichiometry of the Cytotoxic T Lymphocyte-Associated Molecule-4 (CTLA-4): A Disulfide-Linked Homodimer Binds Two CD86 Molecules. J. Biolog. Chem. 270(25) 1995: 15417-15424.
    • (1995) J. Biolog. Chem. , vol.270 , Issue.25 , pp. 15417-15424
    • Linsley, P.S.1
  • 6
    • 62549154024 scopus 로고    scopus 로고
    • Abatacept, a novel CD80/86-CD28 T cell co-stimulation modulator, in the treatment of rheumatoid arthritis
    • Korhonen R, Moilanen E. Abatacept, a Novel CD80/86-CD28 T Cell Co-Stimulation Modulator, in the Treatment of Rheumatoid Arthritis. Bas. Clin. Pharmacol. Toxicol. 104(4) 2009: 276-284.
    • (2009) Bas. Clin. Pharmacol. Toxicol. , vol.104 , Issue.4 , pp. 276-284
    • Korhonen, R.1    Moilanen, E.2
  • 7
    • 67649122193 scopus 로고    scopus 로고
    • Costimulatory blockade with belatacept in clinical and experimental transplantation: A review
    • Emamaullee J, et al. Costimulatory Blockade with Belatacept in Clinical and Experimental Transplantation: A Review. Exp. Opin. Biol. Ther. 9(6) 2009: 789-796.
    • (2009) Exp. Opin. Biol. Ther. , vol.9 , Issue.6 , pp. 789-796
    • Emamaullee, J.1
  • 8
    • 84867377973 scopus 로고    scopus 로고
    • Long-term efficacy and safety profile of rilonacept in the treatment of cryopryin-associated periodic syndromes: Results of a 72-week open-label extension study
    • Hoffman HM, et al. Long-Term Efficacy and Safety Profile of Rilonacept in the Treatment of Cryopryin-Associated Periodic Syndromes: Results of a 72-Week Open-Label Extension Study. Clin. Ther. 34(10) 2012: 2091-2103.
    • (2012) Clin. Ther. , vol.34 , Issue.10 , pp. 2091-2103
    • Hoffman, H.M.1
  • 9
    • 0037143764 scopus 로고    scopus 로고
    • VEGF-trap: A VEGF blocker with potent antitumor effects
    • Holash J, et al. VEGF-Trap: A VEGF Blocker with Potent Antitumor Effects. Proc. Nat. Acad. Sci. USA 99(17) 2002: 11393-11398.
    • (2002) Proc. Nat. Acad. Sci. USA , vol.99 , Issue.17 , pp. 11393-11398
    • Holash, J.1
  • 10
    • 55349124018 scopus 로고    scopus 로고
    • Romiplostim
    • Cines D, et al. Romiplostim. Nat. Rev. Drug Disc. 7(11) 2008: 887-888.
    • (2008) Nat. Rev. Drug Disc. , vol.7 , Issue.11 , pp. 887-888
    • Cines, D.1
  • 11
    • 38649120593 scopus 로고    scopus 로고
    • Efficacy of romiplostim in patients with chronic immune thrombocytopenic purpura: A double-blind randomised controlled trial
    • Kuter D, et al. Efficacy of Romiplostim in Patients with Chronic Immune Thrombocytopenic Purpura: A Double-Blind Randomised Controlled Trial. Lancet 371(9610) 2008: 395-403.
    • (2008) Lancet , vol.371 , Issue.9610 , pp. 395-403
    • Kuter, D.1
  • 12
    • 0036229932 scopus 로고    scopus 로고
    • Binding and functional comparisons of two types of tumor necrosis factor antagonists
    • Scallon B, et al. Binding and Functional Comparisons of Two Types of Tumor Necrosis Factor Antagonists. J. Pharmacol. Exper. Therapeut. 301(2) 2002: 418-426.
    • (2002) J. Pharmacol. Exper. Therapeut. , vol.301 , Issue.2 , pp. 418-426
    • Scallon, B.1
  • 13
    • 0034232080 scopus 로고    scopus 로고
    • Tumour necrosis factor-alpha blockade: A new era for effective management of rheumatoid arthritis
    • Hamilton K, Clair EW. Tumour Necrosis Factor-Alpha Blockade: A New Era for Effective Management of Rheumatoid Arthritis. Exp. Opin. Pharmacother. 1(5) 2000: 1041-1052.
    • (2000) Exp. Opin. Pharmacother. , vol.1 , Issue.5 , pp. 1041-1052
    • Hamilton, K.1    Clair, E.W.2
  • 14
    • 0034754477 scopus 로고    scopus 로고
    • Etanercept for active crohn's disease: A randomized, double-blind, placebo-controlled trial
    • Sandborn WJ, et al. Etanercept for Active Crohn's Disease: A Randomized, Double-Blind, Placebo-Controlled Trial. Gastroenterol. 121(5) 2001: 1088-1094.
    • (2001) Gastroenterol. , vol.121 , Issue.5 , pp. 1088-1094
    • Sandborn, W.J.1
  • 15
    • 0038047689 scopus 로고    scopus 로고
    • Infliximab but not etanercept induces apoptosis in lamina propria T-lymphocytes from patients with crohn's disease
    • Van den Brande JM, et al. Infliximab but Not Etanercept Induces Apoptosis in Lamina Propria T-Lymphocytes from Patients with Crohn's Disease. Gastroenterol. 124(7) 2003: 1774-1785.
    • (2003) Gastroenterol. , vol.124 , Issue.7 , pp. 1774-1785
    • Van Den Brande, J.M.1
  • 16
    • 80052339245 scopus 로고    scopus 로고
    • Haemophilia B: Impact on patients and economic burden of disease
    • Gater A, et al. Haemophilia B: Impact on Patients and Economic Burden of Disease. Thrombosis Haemostasis 106(3) 2011: 398-404.
    • (2011) Thrombosis Haemostasis , vol.106 , Issue.3 , pp. 398-404
    • Gater, A.1
  • 17
    • 84859197329 scopus 로고    scopus 로고
    • Safety and prolonged activity of recombinant factor VIII fc fusion protein in hemophilia A patients
    • 3
    • Powell JS, et al. Safety and Prolonged Activity of Recombinant Factor VIII Fc Fusion Protein in Hemophilia A Patients. Blood 119(13) 2012: 3031-3037. 3
    • (2012) Blood , vol.119 , Issue.13 , pp. 3031-3037
    • Powell, J.S.1
  • 18
    • 77950391547 scopus 로고    scopus 로고
    • Prolonged activity of factor IX as a monomeric fc fusion protein
    • Peters RT, et al. Prolonged Activity of Factor IX As a Monomeric Fc Fusion Protein. Blood 115(10) 2010: 2057-2064.
    • (2010) Blood , vol.115 , Issue.10 , pp. 2057-2064
    • Peters, R.T.1
  • 19
    • 0035159198 scopus 로고    scopus 로고
    • Structural and functional characteristics of the B-domain-deleted recombinant factor VIII protein, r-VIII SQ
    • Sandberg H, et al. Structural and Functional Characteristics of the B-Domain-Deleted Recombinant Factor VIII Protein, r-VIII SQ. Thrombosis Haemostasis 85(1) 2001: 93-100.
    • (2001) Thrombosis Haemostasis , vol.85 , Issue.1 , pp. 93-100
    • Sandberg, H.1
  • 20
    • 84893123337 scopus 로고    scopus 로고
    • Phase 3 study of recombinant factor VIII fc fusion protein in severe hemophilia A
    • Mahlangu J, et al. Phase 3 Study of Recombinant Factor VIII Fc Fusion Protein in Severe Hemophilia A. Blood 123(3) 2014: 317-325.
    • (2014) Blood , vol.123 , Issue.3 , pp. 317-325
    • Mahlangu, J.1
  • 21
    • 84894036626 scopus 로고    scopus 로고
    • Incorporation of anti-angiogenesis therapy in the management of advanced ovarian carcinoma: Mechanistics, review of phase III randomized clinical trials, and regulatory implications
    • Eskander RN, Tewari KS. Incorporation of Anti-Angiogenesis Therapy in the Management of Advanced Ovarian Carcinoma: Mechanistics, Review of Phase III Randomized Clinical Trials, and Regulatory Implications. Gynecol. Oncol. 132(2) 2014: 496-505.
    • (2014) Gynecol. Oncol. , vol.132 , Issue.2 , pp. 496-505
    • Eskander, R.N.1    Tewari, K.S.2
  • 22
    • 84896338154 scopus 로고    scopus 로고
    • Therapeutic targeting of the BAFF/APRIL axis in systemic lupus erythematosus
    • Stohl W. Therapeutic Targeting of the BAFF/APRIL Axis in Systemic Lupus Erythematosus. Exp. Opin. Therapeut. Targets 18(4) 2014: 473-489.
    • (2014) Exp. Opin. Therapeut. Targets , vol.18 , Issue.4 , pp. 473-489
    • Stohl, W.1
  • 23
    • 84904992244 scopus 로고    scopus 로고
    • Efficacy and safety of dulaglutide versus sitagliptin after 52 weeks in type 2 diabetes in a randomized controlled trial (AWARD-5)
    • Nauck M, et al. Efficacy and Safety of Dulaglutide Versus Sitagliptin After 52 Weeks in Type 2 Diabetes in a Randomized Controlled Trial (AWARD-5). Diabetes Care 37(8) 2014: 2149-2158.
    • (2014) Diabetes Care , vol.37 , Issue.8 , pp. 2149-2158
    • Nauck, M.1
  • 24
    • 9444236174 scopus 로고    scopus 로고
    • Small peptides as potent mimetics of the protein hormone erythropoietin
    • Wrighton NC, et al. Small Peptides As Potent Mimetics of the Protein Hormone Erythropoietin. Science 273(5274) 1996: 458-464.
    • (1996) Science , vol.273 , Issue.5274 , pp. 458-464
    • Wrighton, N.C.1
  • 25
    • 66549127370 scopus 로고    scopus 로고
    • CNTO 530 functions as a potent EPO mimetic via unique sustained effects on bone marrow proerythroblast pools
    • Sathyanarayana P, et al. CNTO 530 Functions As a Potent EPO Mimetic Via Unique Sustained Effects on Bone Marrow Proerythroblast Pools. Blood 113(20) 2009: 4955-4962.
    • (2009) Blood , vol.113 , Issue.20 , pp. 4955-4962
    • Sathyanarayana, P.1
  • 26
    • 64749098836 scopus 로고    scopus 로고
    • Development of mammalian production cell lines expressing CNTO736, a glucagon like peptide-1-MIMETIBODY: Factors that influence productivity and product quality
    • Dorai H, et al. Development of Mammalian Production Cell Lines Expressing CNTO736, a Glucagon Like Peptide-1-MIMETIBODY: Factors that Influence Productivity and Product Quality. Biotechnol. Bioeng. 103(1) 2009: 162-176.
    • (2009) Biotechnol. Bioeng. , vol.103 , Issue.1 , pp. 162-176
    • Dorai, H.1
  • 27
    • 84859508524 scopus 로고    scopus 로고
    • Pharmacokinetics, pharmacodynamics, safety and tolerability of APG101, a CD95-fc fusion protein, in healthy volunteers and two glioma patients
    • Tuettenberg J, et al. Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of APG101, a CD95-Fc Fusion Protein, in Healthy Volunteers and Two Glioma Patients. Internat. Immunopharmacol. 13(1) 2012: 93-100.
    • (2012) Internat. Immunopharmacol. , vol.13 , Issue.1 , pp. 93-100
    • Tuettenberg, J.1
  • 28
    • 0036042603 scopus 로고    scopus 로고
    • Bi-functional cytokine fusion proteins for gene therapy and antibody-targeted treatment of cancer
    • Gillies SD, et al. Bi-Functional Cytokine Fusion Proteins for Gene Therapy and Antibody-Targeted Treatment of Cancer. Cancer Immunol. Immunother. 51(8) 2002: 449-460.
    • (2002) Cancer Immunol. Immunother. , vol.51 , Issue.8 , pp. 449-460
    • Gillies, S.D.1
  • 29
    • 79955440692 scopus 로고    scopus 로고
    • Therapeutic assessment of SEED: A new engineered antibody platform designed to generate mono- and bispecific antibodies
    • Muda M, et al. Therapeutic Assessment of SEED: A New Engineered Antibody Platform Designed to Generate Mono- and Bispecific Antibodies. PEDS 24(5) 2011: 447-454.
    • (2011) PEDS , vol.24 , Issue.5 , pp. 447-454
    • Muda, M.1
  • 30
    • 79952296306 scopus 로고    scopus 로고
    • TNF receptor II fusion protein with tandemly repeated fc domains
    • Nagashima H, et al. TNF Receptor II Fusion Protein with Tandemly Repeated Fc Domains. J. Biochem. 149(3) 2011: 337-346.
    • (2011) J. Biochem. , vol.149 , Issue.3 , pp. 337-346
    • Nagashima, H.1
  • 31
    • 84859760033 scopus 로고    scopus 로고
    • Polymeric human fc-fusion proteins with modified effector functions
    • 19 October
    • Mekhaiel DN, et al. Polymeric Human Fc-Fusion Proteins with Modified Effector Functions. Scientif. Reports 19 October 2011: 124.
    • (2011) Scientif. Reports , pp. 124
    • Mekhaiel, D.N.1
  • 32
    • 84856568116 scopus 로고    scopus 로고
    • Natural IgM in immune equilibrium and harnessing their therapeutic potential
    • Kaveri SV, et al. Natural IgM in Immune Equilibrium and Harnessing Their Therapeutic Potential. J. Immunol. 188(3) 2012: 939-945.
    • (2012) J. Immunol. , vol.188 , Issue.3 , pp. 939-945
    • Kaveri, S.V.1
  • 33
    • 48549094102 scopus 로고    scopus 로고
    • Effector mechanisms of therapeutic antibodies against ErbB receptors
    • Peipp M, et al. Effector Mechanisms of Therapeutic Antibodies Against ErbB Receptors. Curr. Opin. Immunol. 20(4) 2008: 436-443.
    • (2008) Curr. Opin. Immunol. , vol.20 , Issue.4 , pp. 436-443
    • Peipp, M.1
  • 34
    • 77953653252 scopus 로고    scopus 로고
    • Antibody fragments: Hope and hype
    • Nelson AL. Antibody Fragments: Hope and Hype. MAbs 2(1) 2010: 77-83.
    • (2010) MAbs , vol.2 , Issue.1 , pp. 77-83
    • Nelson, A.L.1
  • 35
    • 84855446659 scopus 로고    scopus 로고
    • Single-chain fv-based anti-HIV proteins: Potential and limitations
    • West AP Jr., et al. Single-Chain Fv-Based Anti-HIV Proteins: Potential and Limitations. J. Virol. 86(1) 2012: 195-202.
    • (2012) J. Virol. , vol.86 , Issue.1 , pp. 195-202
    • West, A.P.1
  • 36
    • 80053438315 scopus 로고    scopus 로고
    • Non-immunoglobulin based protein scaffolds
    • Löfblom J, et al. Non-Immunoglobulin Based Protein Scaffolds. Curr. Opin. Biotechnol. 22(6) 2011: 843-848.
    • (2011) Curr. Opin. Biotechnol. , vol.22 , Issue.6 , pp. 843-848
    • Löfblom, J.1
  • 37
    • 79960086767 scopus 로고    scopus 로고
    • Immunoglobulin A: A next generation of therapeutic antibodies?
    • Bakema JE, van Egmond M. Immunoglobulin A: A Next Generation of Therapeutic Antibodies? MAbs 3(4) 2011: 352-361.
    • (2011) MAbs , vol.3 , Issue.4 , pp. 352-361
    • Bakema, J.E.1    Van Egmond, M.2
  • 38
    • 84860351761 scopus 로고    scopus 로고
    • Detection of weak receptor-ligand interactions using IgM and J-chain-based fusion proteins
    • Ammann JU, et al. Detection of Weak Receptor-Ligand Interactions Using IgM and J-Chain-Based Fusion Proteins. Euro. J. Immunol. 42(5) 2012: 1354-1356.
    • (2012) Euro. J. Immunol. , vol.42 , Issue.5 , pp. 1354-1356
    • Ammann, J.U.1
  • 39
    • 84869757230 scopus 로고    scopus 로고
    • Characterization and comparison of commercially available TNF receptor 2-fc fusion protein products
    • Tan Q, et al. Characterization and Comparison of Commercially Available TNF Receptor 2-Fc Fusion Protein Products. MAbs 4(6) 2012: 761-774.
    • (2012) MAbs , vol.4 , Issue.6 , pp. 761-774
    • Tan, Q.1
  • 41
    • 84910616470 scopus 로고    scopus 로고
    • Amgen issued new patent on RA drug enbrel
    • 1 December
    • Daghlian M. Amgen Issued New Patent on RA Drug Enbrel. The Burrill Report 1 December 2011; www.burrillreport.com/article-amgen-issued-new-patent-on-ra-drug-enbrel.html.
    • (2011) The Burrill Report
    • Daghlian, M.1
  • 42
    • 80055051682 scopus 로고    scopus 로고
    • A non-innovator version of etanercept for treatment of arthritis
    • Maity S, et al. A Non-Innovator Version of Etanercept for Treatment of Arthritis. Biologicals 39(6) 2011: 384-395.
    • (2011) Biologicals , vol.39 , Issue.6 , pp. 384-395
    • Maity, S.1
  • 43
    • 77649206428 scopus 로고    scopus 로고
    • A variant of TNFR2-fc fusion protein exhibits improved efficacy in treating experimental rheumatoid arthritis
    • Yang T, et al. A Variant of TNFR2-Fc Fusion Protein Exhibits Improved Efficacy in Treating Experimental Rheumatoid Arthritis. PLoS Comput. Biol. 6(2) 2010.
    • (2010) PLoS Comput. Biol. , vol.6 , Issue.2
    • Yang, T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.